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Conserved domains on  [gi|2462606557|ref|XP_054210482|]
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adenylate kinase 9 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 958-1126 9.61e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 97.69  E-value: 9.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1037
Cdd:cd01428      1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1114
Cdd:cd01428     44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                          170
                   ....*....|..
gi 2462606557 1115 QVDDQDIFDRLL 1126
Cdd:cd01428    112 DVPDEVLIERIL 123
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 105-348 1.41e-20

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 91.53  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428      2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428     81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428    144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                   ....*
gi 2462606557  344 PAEEL 348
Cdd:cd01428    190 DIDEV 194
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 1378-1505 1.10e-19

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 88.83  E-value: 1.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:cd01428      1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606557 1458 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1505
Cdd:cd01428     74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 895-950 7.20e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.20e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606557  895 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 950
Cdd:COG3350      3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 958-1126 9.61e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 97.69  E-value: 9.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1037
Cdd:cd01428      1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1114
Cdd:cd01428     44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                          170
                   ....*....|..
gi 2462606557 1115 QVDDQDIFDRLL 1126
Cdd:cd01428    112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 105-348 1.41e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.53  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428      2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428     81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428    144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                   ....*
gi 2462606557  344 PAEEL 348
Cdd:cd01428    190 DIDEV 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1378-1505 1.10e-19

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 88.83  E-value: 1.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:cd01428      1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606557 1458 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1505
Cdd:cd01428     74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 105-349 2.61e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.48  E-value: 2.61e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:COG0563      3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSrdqwdpeVIENH 256
Cdd:COG0563     77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYH-------VKFNP 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  257 RKKKKEAQKDGKGeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 334
Cdd:COG0563    144 PKVEGVCDKCGGE----------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                          250
                   ....*....|....*
gi 2462606557  335 yLIELNGNKPAEELF 349
Cdd:COG0563    192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
107-252 5.35e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 5.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  107 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 186
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462606557  187 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1378-1505 1.74e-16

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 79.97  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQ-----AKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462606557 1458 SVCNTAGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1505
Cdd:TIGR01351   74 NDDNENGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
PLN02842 PLN02842
nucleotide kinase
 109-349 4.65e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 83.37  E-value: 4.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  109 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 188
Cdd:PLN02842     4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  189 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 268
Cdd:PLN02842    84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  269 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 345
Cdd:PLN02842   140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                   ....
gi 2462606557  346 EELF 349
Cdd:PLN02842   190 EVVF 193
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1378-1505 2.60e-14

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 74.01  E-value: 2.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:COG0563      2 RIILLGPPGAGKGT-----QAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462606557 1458 SVCnTAGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1505
Cdd:COG0563     75 PDC-ANGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
AAA_17 pfam13207
AAA domain;
1382-1509 2.56e-13

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 68.81  E-value: 2.56e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1382 VGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCN 1461
Cdd:pfam13207    1 TGVPGSGKTTQ-----LKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462606557 1462 TAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1509
Cdd:pfam13207   71 EGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 1378-1505 3.09e-13

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 70.95  E-value: 3.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:PRK00279     2 RLILLGPPGAGKGT-----QAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462606557 1458 SVCNTaGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1505
Cdd:PRK00279    75 PDCKN-GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 958-1126 4.90e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.07  E-value: 4.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1037
Cdd:COG0563      2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1113
Cdd:COG0563     50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                          170
                   ....*....|...
gi 2462606557 1114 IQVDDQDIFDRLL 1126
Cdd:COG0563    113 LDVDDEELVERLS 125
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 895-950 7.20e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.20e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606557  895 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 950
Cdd:COG3350      3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 958-1126 1.18e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.16  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1037
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1116
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 2462606557 1117 DDQDIFDRLL 1126
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 958-1126 7.98e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.29  E-value: 7.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1037
Cdd:PRK02496     3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1110
Cdd:PRK02496    52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                          170
                   ....*....|....*.
gi 2462606557 1111 AVFIQVDDQDIFDRLL 1126
Cdd:PRK02496   111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
962-1126 1.15e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 49.55  E-value: 1.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  962 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1040
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1041 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1114
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 2462606557 1115 QVDDQDIFDRLL 1126
Cdd:pfam13207  109 EADPEEILERRL 120
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 900-948 7.43e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.33  E-value: 7.43e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606557  900 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 948
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 958-1126 9.61e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 97.69  E-value: 9.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1037
Cdd:cd01428      1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1114
Cdd:cd01428     44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                          170
                   ....*....|..
gi 2462606557 1115 QVDDQDIFDRLL 1126
Cdd:cd01428    112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 105-348 1.41e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.53  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428      2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428     81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428    144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                   ....*
gi 2462606557  344 PAEEL 348
Cdd:cd01428    190 DIDEV 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1378-1505 1.10e-19

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 88.83  E-value: 1.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:cd01428      1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606557 1458 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1505
Cdd:cd01428     74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 105-349 2.61e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.48  E-value: 2.61e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:COG0563      3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSrdqwdpeVIENH 256
Cdd:COG0563     77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYH-------VKFNP 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  257 RKKKKEAQKDGKGeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 334
Cdd:COG0563    144 PKVEGVCDKCGGE----------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                          250
                   ....*....|....*
gi 2462606557  335 yLIELNGNKPAEELF 349
Cdd:COG0563    192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
107-252 5.35e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 5.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  107 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 186
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462606557  187 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1378-1505 1.74e-16

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 79.97  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQ-----AKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462606557 1458 SVCNTAGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1505
Cdd:TIGR01351   74 NDDNENGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
PLN02842 PLN02842
nucleotide kinase
 109-349 4.65e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 83.37  E-value: 4.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  109 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 188
Cdd:PLN02842     4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  189 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 268
Cdd:PLN02842    84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  269 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 345
Cdd:PLN02842   140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                   ....
gi 2462606557  346 EELF 349
Cdd:PLN02842   190 EVVF 193
adk PRK00279
adenylate kinase; Reviewed
 105-252 2.11e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 2.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:PRK00279     3 LILLGPPGAGKGTQAKFIAEKYG------IPhistgdMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPD 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606557  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:PRK00279    77 -CKNGFLLDGFPrTIPQaEALD-----EMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKV 146
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 99-244 1.40e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 75.22  E-value: 1.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557   99 LSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:PTZ00088     3 LKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462606557  179 VCHF-GYIITEIPSlsqdamTTLQQIELIKNLNlkPDVIINIKCPDYDLCQRISGQRQHNNTGYIYS 244
Cdd:PTZ00088    83 DDCFkGFILDGFPR------NLKQCKELGKITN--IDLFVNIYLPRNILIKKLLGRRICNTCNRNFN 141
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1378-1505 2.60e-14

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 74.01  E-value: 2.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:COG0563      2 RIILLGPPGAGKGT-----QAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462606557 1458 SVCnTAGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1505
Cdd:COG0563     75 PDC-ANGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
AAA_17 pfam13207
AAA domain;
1382-1509 2.56e-13

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 68.81  E-value: 2.56e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1382 VGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCN 1461
Cdd:pfam13207    1 TGVPGSGKTTQ-----LKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462606557 1462 TAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1509
Cdd:pfam13207   71 EGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 1378-1505 3.09e-13

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 70.95  E-value: 3.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:PRK00279     2 RLILLGPPGAGKGT-----QAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462606557 1458 SVCNTaGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1505
Cdd:PRK00279    75 PDCKN-GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 958-1126 4.90e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.07  E-value: 4.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1037
Cdd:COG0563      2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1113
Cdd:COG0563     50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                          170
                   ....*....|...
gi 2462606557 1114 IQVDDQDIFDRLL 1126
Cdd:COG0563    113 LDVDDEELVERLS 125
ADK pfam00406
Adenylate kinase;
1381-1505 4.05e-10

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 60.79  E-value: 4.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1381 IVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVC 1460
Cdd:pfam00406    1 LLGPPGAGKGTQ-----AEKIVQKYGLPHLSTGDLLRAEIKS--GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462606557 1461 NTaGVVIDGYPVTKHQMNLLEA--RSIIPM-VIFELSVPSKEIFKRLL 1505
Cdd:pfam00406   74 KN-GFLLDGFPRTVPQAEALEEllERGIKLdYVIEFDVPDEVLVERLT 120
PRK14528 PRK14528
adenylate kinase; Provisional
 1378-1513 1.09e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 59.64  E-value: 1.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:PRK14528     3 NIIFMGPPGAGKGT-----QAKILCERLSIPQISTGDILREAVKN--QTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIRE 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462606557 1458 SVCNTaGVVIDGYPVTKHQMNLLEA------RSIIPMVifELSVPSKEIFKRLLLEKENEQR 1513
Cdd:PRK14528    76 ADCKN-GFLLDGFPRTVEQADALDAllknegKSIDKAI--NLEVPDGELLKRLLGRAEIEGR 134
PRK14528 PRK14528
adenylate kinase; Provisional
 106-269 1.44e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 59.25  E-value: 1.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYI 185
Cdd:PRK14528     5 IFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREAD-CKNGFL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  186 ITEIPSLSQDAMTTlqqIELIKNLNLKPDVIINIKCPDYDLCQRISGQ-----RQHNNTGYIYSR-DQWDPE---VIENH 256
Cdd:PRK14528    84 LDGFPRTVEQADAL---DALLKNEGKSIDKAINLEVPDGELLKRLLGRaeiegRADDNEATIKNRlDNYNKKtlpLLDFY 160

                          170
                   ....*....|...
gi 2462606557  257 RKKKKEAQKDGKG 269
Cdd:PRK14528   161 AAQKKLSQVNGVG 173
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1375-1505 1.83e-09

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 59.06  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1375 VPIrIIIVGPPKSGKTTvLCfsvaKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELS 1454
Cdd:TIGR01360    3 CKI-IFIVGGPGSGKGT-QC----EKIVEKYGFTHLSTGDLLRAEVAS--GSERGKQLQAIMESGDLVPLDTVLDLLKDA 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606557 1455 LMESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLL 1505
Cdd:TIGR01360   75 MVAALGTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLL 125
adk PRK02496
adenylate kinase; Provisional
 106-267 2.50e-09

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 58.61  E-value: 2.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 185
Cdd:PRK02496     5 IFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN-GWI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  186 ITEIP-SLSQDAmtTLQqiELIKNLNLKPDVIINIKCPDYDLCQRISGQ-RQHNNTGYIYSR-----DQWDPeVIENHRK 258
Cdd:PRK02496    84 LDGFPrKVTQAA--FLD--ELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDTEEVIRRRlevyrEQTAP-LIDYYRD 158


                   ....*....
gi 2462606557  259 KKKEAQKDG 267
Cdd:PRK02496   159 RQKLLTIDG 167
PRK14527 PRK14527
adenylate kinase; Provisional
 1374-1571 2.59e-09

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 58.65  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1374 TVPIRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALR-YVLNNhpeTELALMLNWHLHKGMTAPDELAIQAL- 1451
Cdd:PRK14527     4 TKNKVVIFLGPPGAGKGT-----QAERLAQELGLKKLSTGDILRdHVARG---TELGQRAKPIMEAGDLVPDELILALIr 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1452 -ELSLMESVcntaGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPyplHNSAQIVA 1526
Cdd:PRK14527    76 dELAGMEPV----RVIFDGFPRTLAQAEaldrLLEELGARLLAVVLLEVPDEELIRRIVERARQEGRSD---DNEETVRR 148

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2462606557 1527 VNNVkYRKNIGEIRQYYQEQHQnWYVIDGFHSKWWVWNEVIKNVQ 1571
Cdd:PRK14527   149 RQQV-YREQTQPLVDYYEARGH-LKRVDGLGTPDEVYARILKALG 191
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 895-950 7.20e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.20e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606557  895 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 950
Cdd:COG3350      3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
PRK14530 PRK14530
adenylate kinase; Provisional
 1378-1504 1.11e-07

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 54.41  E-value: 1.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALR---YVLNNHPETELALMLNWhLHKGMTAPDELAIQALEls 1454
Cdd:PRK14530     5 RILLLGAPGAGKGTQ-----SSNLAEEFGVEHVTTGDALRankQMDISDMDTEYDTPGEY-MDAGELVPDAVVNEIVE-- 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1455 lmESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFeLSVPSKEIFKRL 1504
Cdd:PRK14530    77 --EALSDADGFVLDGYPRNLEQAEYLESITDLDVVLY-LDVSEEELVDRL 123
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 958-1126 1.18e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.16  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1037
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1116
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 2462606557 1117 DDQDIFDRLL 1126
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 958-1126 7.98e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.29  E-value: 7.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  958 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1037
Cdd:PRK02496     3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1038 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1110
Cdd:PRK02496    52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                          170
                   ....*....|....*.
gi 2462606557 1111 AVFIQVDDQDIFDRLL 1126
Cdd:PRK02496   111 VVNLDVPDDVVVERLL 126
PRK14532 PRK14532
adenylate kinase; Provisional
 1379-1546 1.13e-06

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 50.98  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1379 IIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNHpeTELALMLNWHLHKGMTAPDELAIQALELSLMES 1458
Cdd:PRK14532     3 LILFGPPAAGKGT-----QAKRLVEERGMVQLSTGDMLRAAIASG--SELGQRVKGIMDRGELVSDEIVIALIEERLPEA 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1459 VcNTAGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRlpyPLHNSAQIVaVNNVKYRK 1534
Cdd:PRK14532    76 E-AAGGAIFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKRFEEQGR---PDDNPEVFV-TRLDAYNA 150

                          170
                   ....*....|..
gi 2462606557 1535 NIGEIRQYYQEQ 1546
Cdd:PRK14532   151 QTAPLLPYYAGQ 162
AAA_17 pfam13207
AAA domain;
962-1126 1.15e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 49.55  E-value: 1.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  962 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1040
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1041 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1114
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 2462606557 1115 QVDDQDIFDRLL 1126
Cdd:pfam13207  109 EADPEEILERRL 120
adk PRK02496
adenylate kinase; Provisional
 1377-1555 2.21e-06

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 50.13  E-value: 2.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1377 IRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLM 1456
Cdd:PRK02496     2 TRLIFLGPPGAGKGT-----QAVVLAEHLHIPHISTGDILRQAIKE--QTPLGIKAQGYMDKGELVPDQLVLDLVQERLQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1457 ESvcNTA-GVVIDGYPVTKHQMNLLE------ARSIIPMVifELSVPSKEIFKRLLL---EKENEQrlpyPLHNSAQIva 1526
Cdd:PRK02496    75 QP--DAAnGWILDGFPRKVTQAAFLDellqeiGQSGERVV--NLDVPDDVVVERLLArgrKDDTEE----VIRRRLEV-- 144

                          170       180
                   ....*....|....*....|....*....
gi 2462606557 1527 vnnvkYRKNIGEIRQYYQEQHQnWYVIDG 1555
Cdd:PRK02496   145 -----YREQTAPLIDYYRDRQK-LLTIDG 167
ADK pfam00406
Adenylate kinase;
961-1126 7.50e-06

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 48.46  E-value: 7.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  961 LVGPQGSGK-TMCGRqLAEKLNIFHIQFEEVLQEklllktekkvgpefeedsenEQAAKQELEELAiqanvkveeentKK 1039
Cdd:pfam00406    1 LLGPPGAGKgTQAEK-IVQKYGLPHLSTGDLLRA--------------------EIKSGTELGKEA------------KE 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1040 QLPEVQLTEEEEVIKssLMENEplppeilevilsewwLKEPIRSTGFILDGFPRYPEEAQFLGD---RGFFPDAAVFIQV 1116
Cdd:pfam00406   48 YMDKGELVPDEVVVG--LVKER---------------LEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFDV 110

                          170
                   ....*....|
gi 2462606557 1117 DDQDIFDRLL 1126
Cdd:pfam00406  111 PDEVLVERLT 120
PLN02842 PLN02842
nucleotide kinase
 1380-1503 1.47e-05

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 49.86  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1380 IIVGPPKSGKTTvLCFSVAKKitseYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESV 1459
Cdd:PLN02842     1 MISGAPASGKGT-QCELIVHK----FGLVHISTGDLLRAEVSA--GTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSRED 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2462606557 1460 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKR 1503
Cdd:PLN02842    74 AKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDR 117
adk PRK00279
adenylate kinase; Reviewed
 957-1126 2.20e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.45  E-value: 2.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  957 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqaakqeleelaiqANVKVEEEN 1036
Cdd:PRK00279     1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR-----------------------------------AAVKAGTEL 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1037 TKKqlpevqlteeeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQ----FLGDRGFFPDAAV 1112
Cdd:PRK00279    46 GKE-------------AKSYMDAGELVPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVI 111

                          170
                   ....*....|....
gi 2462606557 1113 FIQVDDQDIFDRLL 1126
Cdd:PRK00279   112 EIDVPDEELVERLS 125
PLN02200 PLN02200
adenylate kinase family protein
 102-235 8.44e-05

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 46.04  E-value: 8.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  102 PVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCH 181
Cdd:PLN02200    43 PFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK 122

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462606557  182 FgyIITEIPSlsqdamTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQ 235
Cdd:PLN02200   123 F--LIDGFPR------TEENRIAFERIIGAEPNVVLFFDCPEEEMVKRVLNRNQ 168
PLN02674 PLN02674
adenylate kinase
 1378-1481 9.94e-05

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 46.03  E-value: 9.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGMTAPDELAIQALELSLME 1457
Cdd:PLN02674    33 RLILIGPPGSGKGT-----QSPIIKDEYCLCHLATGDMLRAAVA--AKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKK 105

                           90       100
                   ....*....|....*....|....
gi 2462606557 1458 SVCNTaGVVIDGYPVTKHQMNLLE 1481
Cdd:PLN02674   106 PSCQK-GFILDGFPRTVVQAQKLD 128
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1376-1505 1.64e-04

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 45.18  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1376 PIRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSL 1455
Cdd:PTZ00088     6 PLKIVLFGAPGVGKGT-----FAEILSKKENLKHINMGNILREEIKA--KTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606557 1456 MESV-CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIfELSVPSKEIFKRLL 1505
Cdd:PTZ00088    79 AKVTdDCFKGFILDGFPRNLKQCKELGKITNIDLFV-NIYLPRNILIKKLL 128
PRK13808 PRK13808
adenylate kinase; Provisional
 106-230 1.80e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 45.65  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 185
Cdd:PRK13808     4 ILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-GFI 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462606557  186 ITEIPSlsqdamtTLQQIE----LIKNLNLKPDVIINIKCPDYDLCQRI 230
Cdd:PRK13808    83 LDGFPR-------TVPQAEaldaLLKDKQLKLDAVVELRVNEGALLARV 124
PRK14531 PRK14531
adenylate kinase; Provisional
 1378-1505 1.89e-04

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 44.42  E-value: 1.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1378 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGmtapdELAIQALELSLME 1457
Cdd:PRK14531     4 RLLFLGPPGAGKGTQ-----AARLCAAHGLRHLSTGDLLRSEVA--AGSALGQEAEAVMNRG-----ELVSDALVLAIVE 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462606557 1458 S---VCNTAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSvpSKEIFKRLL 1505
Cdd:PRK14531    72 SqlkALNSGGWLLDGFPRTVAQAEALEPlleelkQPIEAVVLLELD--DAVLIERLL 126
AAA_18 pfam13238
AAA domain;
959-1032 4.41e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.03  E-value: 4.41e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462606557  959 ICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKV 1032
Cdd:pfam13238    1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGN 74
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 933-1003 6.00e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 44.52  E-value: 6.00e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462606557  933 EAKEKFLEHPEDYVAHEEPlkaPPLRICLVGPQGSGKTMCGRQLAEKL--NIFHIQFEEVLQeKLLLKTEKKV 1003
Cdd:COG0464    171 ELVALPLKRPELREEYGLP---PPRGLLLYGPPGTGKTLLARALAGELglPLIEVDLSDLVS-KYVGETEKNL 239
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1379-1417 6.97e-04

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 42.41  E-value: 6.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462606557 1379 IIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALR 1417
Cdd:TIGR02173    3 ITISGPPGSGKTT-----VAKILAEKLSLKLISAGDIFR 36
AAA_17 pfam13207
AAA domain;
108-229 7.38e-04

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 41.46  E-value: 7.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  108 FGKPGVGKTTLARYITQAWKcirveaLPILE--EQIAAETESG--VMLQSMLISGQSIPDELVIKLMLEKLNSpEVCHFG 183
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLG------FPHISagDLLREEAKERglVEDRDEMRKLPLEPQKELQKLAAERIAE-EAGEGG 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2462606557  184 YIITEIPS-LSQDAMTTLQQIELIKnlNLKPDVIINIKCPDYDLCQR 229
Cdd:pfam13207   74 VIVDGHPRiKTPAGYLPGLPVEVLR--ELKPDAIILLEADPEEILER 118
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1379-1513 7.64e-04

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 42.36  E-value: 7.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1379 IIIVGPPKSGKTTVlCfsvaKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNwHLHKGMTAPDELAIQALElSLMES 1458
Cdd:TIGR01359    2 VFVLGGPGSGKGTQ-C----AKIVENFGFTHLSAGDLLRAEIKREGSENGSLIES-YIKEGKIVPSEVTVELLK-KAIQE 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557 1459 VCNTAGVVIDGYPvtKHQMNL-----LEARSIIPMVIFELSVPSKEIFKRLLLEKENEQR 1513
Cdd:TIGR01359   75 DGSSKKFLIDGFP--RNEENLeawekLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGR 132
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 955-1009 7.93e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.88  E-value: 7.93e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462606557  955 PPLRICLVGPQGSGKTMCGRQLAEKLNI--FHIQFEEvLQEKLLLKTEKKVGPEFEE 1009
Cdd:cd19481     25 LPKGILLYGPPGTGKTLLAKALAGELGLplIVVKLSS-LLSKYVGESEKNLRKIFER 80
PRK04182 PRK04182
cytidylate kinase; Provisional
 1378-1413 2.16e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 40.94  E-value: 2.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIG 1413
Cdd:PRK04182     2 IITISGPPGSGKTT-----VARLLAEKLGLKHVSAG 32
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
931-995 2.61e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 41.79  E-value: 2.61e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  931 SAEAKEKFLEHPEDYVAHEEPLK---APPLRICLVGPQGSGKTMCGRQLAEKLN--IFHIQFEEVLQEKL 995
Cdd:COG1223      7 QEEAKKKLKLIIKELRRRENLRKfglWPPRKILFYGPPGTGKTMLAEALAGELKlpLLTVRLDSLIGSYL 76
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
957-1075 3.26e-03

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 42.20  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  957 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllKTEKKVGPEFEEDSEN--EQAAKQELEELAIQANVKV-- 1032
Cdd:PRK13951     1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIER----REGRSVRRIFEEDGEEyfRLKEKELLRELVERDNVVVat 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462606557 1033 --------EEENTKKQLPEVQLTEEEEVIKSSL-MENEPLPPEILEVILSEW 1075
Cdd:PRK13951    77 gggvvidpENRELLKKEKTLFLYAPPEVLMERVtTENRPLLREGKERIREIW 128
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 900-948 7.43e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.33  E-value: 7.43e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462606557  900 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 948
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
PRK14526 PRK14526
adenylate kinase; Provisional
 105-244 8.49e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 39.83  E-value: 8.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606557  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVcHFGY 184
Cdd:PRK14526     3 LVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDNF 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462606557  185 IITEIPSlsqdamTTLQQIELIKNL-NLKpdvIINIKCPDYDLCQRISGQRQHNNTGYIYS 244
Cdd:PRK14526    82 ILDGFPR------NINQAKALDKFLpNIK---IINFLIDEELLIKRLSGRRICKSCNNIFN 133
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 1378-1414 8.63e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 38.62  E-value: 8.63e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462606557 1378 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGG 1414
Cdd:cd02020      1 IIAIDGPAGSGKST-----VAKLLAKKLGLPYLDTGG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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