Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
18-344
0e+00
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.
:
Pssm-ID: 462070 Cd Length: 330 Bit Score: 524.22 E-value: 0e+00
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
355-470
1.29e-66
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.
The actual alignment was detected with superfamily member pfam19675:
Pssm-ID: 466140 Cd Length: 233 Bit Score: 213.87 E-value: 1.29e-66
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
18-344
0e+00
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.
Pssm-ID: 462070 Cd Length: 330 Bit Score: 524.22 E-value: 0e+00
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
42-344
1.41e-92
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.
Pssm-ID: 412052 [Multi-domain] Cd Length: 387 Bit Score: 286.00 E-value: 1.41e-92
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
355-470
1.29e-66
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.
Pssm-ID: 466140 Cd Length: 233 Bit Score: 213.87 E-value: 1.29e-66
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
18-344
0e+00
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.
Pssm-ID: 462070 Cd Length: 330 Bit Score: 524.22 E-value: 0e+00
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
42-344
1.41e-92
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.
Pssm-ID: 412052 [Multi-domain] Cd Length: 387 Bit Score: 286.00 E-value: 1.41e-92
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
355-470
1.29e-66
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.
Pssm-ID: 466140 Cd Length: 233 Bit Score: 213.87 E-value: 1.29e-66
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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