protein THEMIS isoform X4 [Homo sapiens]
Protein Classification
CABIT domain-containing protein( domain architecture ID 12119421)
CABIT domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| CABIT | pfam12736 | Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ... |
17-265 | 3.24e-63 | |||||
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2. : Pssm-ID: 463686 Cd Length: 261 Bit Score: 209.99 E-value: 3.24e-63
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| CABIT | pfam12736 | Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ... |
281-529 | 3.95e-40 | |||||
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2. : Pssm-ID: 463686 Cd Length: 261 Bit Score: 147.59 E-value: 3.95e-40
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| Name | Accession | Description | Interval | E-value | |||||
| CABIT | pfam12736 | Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ... |
17-265 | 3.24e-63 | |||||
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2. Pssm-ID: 463686 Cd Length: 261 Bit Score: 209.99 E-value: 3.24e-63
|
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| CABIT | pfam12736 | Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ... |
281-529 | 3.95e-40 | |||||
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2. Pssm-ID: 463686 Cd Length: 261 Bit Score: 147.59 E-value: 3.95e-40
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| Name | Accession | Description | Interval | E-value | |||||
| CABIT | pfam12736 | Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ... |
17-265 | 3.24e-63 | |||||
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2. Pssm-ID: 463686 Cd Length: 261 Bit Score: 209.99 E-value: 3.24e-63
|
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| CABIT | pfam12736 | Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- ... |
281-529 | 3.95e-40 | |||||
Cell-cycle sustaining, positive selection,; The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2. Pssm-ID: 463686 Cd Length: 261 Bit Score: 147.59 E-value: 3.95e-40
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| Blast search parameters | ||||
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