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Conserved domains on  [gi|2462611237|ref|XP_054212692|]
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E3 ubiquitin-protein ligase E3D isoform X2 [Homo sapiens]

Protein Classification

HECT-type E3 ubiquitin transferase( domain architecture ID 10561263)

HECT-type E3 ubiquitin transferase such as mammalian E3 ubiquitin-protein ligase E3D that accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 13-384 2.31e-92

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


:

Pssm-ID: 462911  Cd Length: 362  Bit Score: 282.04  E-value: 2.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237  13 EVRGQLQSALLILGEPKEggmPMNISIMPS---SLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKL 89
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSP---LKSTRVSLSddgLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237  90 GTKLISMFNQSSQTQEC-------------CTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPF------- 149
Cdd:pfam09814  78 SKFGSFDLESSLSAQKElevpwsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatk 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 150 ---ANKSLHPQENDCFIGDSFFLVNLRTSLWQQRpelspvemccvssdnhCKLEPKANTKVICKRCKVMLGETVSSETTK 226
Cdd:pfam09814 158 gygANSKLVPQEGDGLVGLTFFLLNESDCQGLKL----------------SSKPPKDNLSVSCKRCGALLGEVDSLDGLK 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 227 FYMTEIIIQSSERSFPiIPRSWFVQSVIAQCLVQLSSARSTFRFTIQGQDD-KVYILLWLLNSDSLVIESLRNskyikkf 305
Cdd:pfam09814 222 LYKWALSLQPSEGSDS-IPRSFPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVSSSSSS------- 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462611237 306 pllentfkaDSSSAWSAVKVLYQPCIKSrNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQA 384
Cdd:pfam09814 294 ---------NSLIAKRAMKVLYKDCIDS-EEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 13-384 2.31e-92

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 282.04  E-value: 2.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237  13 EVRGQLQSALLILGEPKEggmPMNISIMPS---SLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKL 89
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSP---LKSTRVSLSddgLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237  90 GTKLISMFNQSSQTQEC-------------CTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPF------- 149
Cdd:pfam09814  78 SKFGSFDLESSLSAQKElevpwsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatk 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 150 ---ANKSLHPQENDCFIGDSFFLVNLRTSLWQQRpelspvemccvssdnhCKLEPKANTKVICKRCKVMLGETVSSETTK 226
Cdd:pfam09814 158 gygANSKLVPQEGDGLVGLTFFLLNESDCQGLKL----------------SSKPPKDNLSVSCKRCGALLGEVDSLDGLK 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 227 FYMTEIIIQSSERSFPiIPRSWFVQSVIAQCLVQLSSARSTFRFTIQGQDD-KVYILLWLLNSDSLVIESLRNskyikkf 305
Cdd:pfam09814 222 LYKWALSLQPSEGSDS-IPRSFPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVSSSSSS------- 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462611237 306 pllentfkaDSSSAWSAVKVLYQPCIKSrNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQA 384
Cdd:pfam09814 294 ---------NSLIAKRAMKVLYKDCIDS-EEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
108-228 1.43e-05

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 46.57  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 108 TFYCQSCGEVIIKDRKLLRvlpLPSENWGALVGEWCCHPDPFANKS-------LHPQENDCFIGDSFFLVNLrtslwqqr 180
Cdd:COG5629    87 GFRCKQGNEILHSIRSMND---LPSEGWEELIDCWSCHNDYCEFKSmlggpltPRPREGGLLLGDSYLLIND-------- 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462611237 181 pelspvemccvsSDNHCKLEPKANTKVICKRCKVMLGETVSSETTKFY 228
Cdd:COG5629   156 ------------ADLEGKVAYGPNFKLHCSFCNARLGLPNDSSIRKLF 191
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 13-384 2.31e-92

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 282.04  E-value: 2.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237  13 EVRGQLQSALLILGEPKEggmPMNISIMPS---SLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKL 89
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSP---LKSTRVSLSddgLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237  90 GTKLISMFNQSSQTQEC-------------CTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPF------- 149
Cdd:pfam09814  78 SKFGSFDLESSLSAQKElevpwsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatk 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 150 ---ANKSLHPQENDCFIGDSFFLVNLRTSLWQQRpelspvemccvssdnhCKLEPKANTKVICKRCKVMLGETVSSETTK 226
Cdd:pfam09814 158 gygANSKLVPQEGDGLVGLTFFLLNESDCQGLKL----------------SSKPPKDNLSVSCKRCGALLGEVDSLDGLK 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 227 FYMTEIIIQSSERSFPiIPRSWFVQSVIAQCLVQLSSARSTFRFTIQGQDD-KVYILLWLLNSDSLVIESLRNskyikkf 305
Cdd:pfam09814 222 LYKWALSLQPSEGSDS-IPRSFPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVSSSSSS------- 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462611237 306 pllentfkaDSSSAWSAVKVLYQPCIKSrNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQA 384
Cdd:pfam09814 294 ---------NSLIAKRAMKVLYKDCIDS-EEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
108-228 1.43e-05

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 46.57  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611237 108 TFYCQSCGEVIIKDRKLLRvlpLPSENWGALVGEWCCHPDPFANKS-------LHPQENDCFIGDSFFLVNLrtslwqqr 180
Cdd:COG5629    87 GFRCKQGNEILHSIRSMND---LPSEGWEELIDCWSCHNDYCEFKSmlggpltPRPREGGLLLGDSYLLIND-------- 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462611237 181 pelspvemccvsSDNHCKLEPKANTKVICKRCKVMLGETVSSETTKFY 228
Cdd:COG5629   156 ------------ADLEGKVAYGPNFKLHCSFCNARLGLPNDSSIRKLF 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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