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Conserved domains on  [gi|2462611248|ref|XP_054212697|]
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muscular LMNA-interacting protein isoform X16 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MLIP super family cl21126
Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, ...
 755-932 2.34e-52

Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.


The actual alignment was detected with superfamily member pfam15274:

Pssm-ID: 405866  Cd Length: 253  Bit Score: 184.14  E-value: 2.34e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  755 PHCGSGTLPSRLGksesTTPNHRSPVSTPSLPISLTRTEELISPCALSMSTGPENKKSKQYKTKSSYKAFAAIPTNTLLL 834
Cdd:pfam15274   33 PSNGYGPISAQPK----SLAISSSLVSSVKRPKTQGTDLKTSSHPELSHSMAPQQKHGQQYKIKTSYKAFAAIPTNTLLM 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  835 EQKALDEPAKTESVSKDNTLEPPVE------------------------------------------------TPTTLPR 866
Cdd:pfam15274  109 EQKALEEPTKTASVTEGTALDTHSEmcspaqlrqqteelcavidqvlqdpltmrrcesppsflkmntesdtgkVSTTLQR 188

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462611248  867 AAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKeEEVYEPNPFSKYLEDNSDLFSEQ 932
Cdd:pfam15274  189 AAGRETRYANLYKSTPMVAESQLTKPGVIRPVLVKGRIAQQK-EEPYQPNPFKKYLEEISDQDSEQ 253
MLIP super family cl21126
Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, ...
 204-304 5.83e-32

Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.


The actual alignment was detected with superfamily member pfam15274:

Pssm-ID: 405866  Cd Length: 253  Bit Score: 125.59  E-value: 5.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  204 MQQSDLFKAEYVLIVDSEGEDEAASRKVE-QGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMA 282
Cdd:pfam15274    1 MQENDLFKAEFILITDSGDEDEAAAASINvQRPSNGYGPISAQPKSLAISSSLVSSVKRPKTQGTDLKTSSHPELSHSMA 80

                           90       100
                   ....*....|....*....|..
gi 2462611248  283 PQQKHGQLTSSPTTSEQLACKP 304
Cdd:pfam15274   81 PQQKHGQQYKIKTSYKAFAAIP 102
 
Name Accession Description Interval E-value
MLIP pfam15274
Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, ...
 755-932 2.34e-52

Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.


Pssm-ID: 405866  Cd Length: 253  Bit Score: 184.14  E-value: 2.34e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  755 PHCGSGTLPSRLGksesTTPNHRSPVSTPSLPISLTRTEELISPCALSMSTGPENKKSKQYKTKSSYKAFAAIPTNTLLL 834
Cdd:pfam15274   33 PSNGYGPISAQPK----SLAISSSLVSSVKRPKTQGTDLKTSSHPELSHSMAPQQKHGQQYKIKTSYKAFAAIPTNTLLM 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  835 EQKALDEPAKTESVSKDNTLEPPVE------------------------------------------------TPTTLPR 866
Cdd:pfam15274  109 EQKALEEPTKTASVTEGTALDTHSEmcspaqlrqqteelcavidqvlqdpltmrrcesppsflkmntesdtgkVSTTLQR 188

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462611248  867 AAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKeEEVYEPNPFSKYLEDNSDLFSEQ 932
Cdd:pfam15274  189 AAGRETRYANLYKSTPMVAESQLTKPGVIRPVLVKGRIAQQK-EEPYQPNPFKKYLEEISDQDSEQ 253
MLIP pfam15274
Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, ...
 204-304 5.83e-32

Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.


Pssm-ID: 405866  Cd Length: 253  Bit Score: 125.59  E-value: 5.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  204 MQQSDLFKAEYVLIVDSEGEDEAASRKVE-QGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMA 282
Cdd:pfam15274    1 MQENDLFKAEFILITDSGDEDEAAAASINvQRPSNGYGPISAQPKSLAISSSLVSSVKRPKTQGTDLKTSSHPELSHSMA 80

                           90       100
                   ....*....|....*....|..
gi 2462611248  283 PQQKHGQLTSSPTTSEQLACKP 304
Cdd:pfam15274   81 PQQKHGQQYKIKTSYKAFAAIP 102
 
Name Accession Description Interval E-value
MLIP pfam15274
Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, ...
 755-932 2.34e-52

Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.


Pssm-ID: 405866  Cd Length: 253  Bit Score: 184.14  E-value: 2.34e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  755 PHCGSGTLPSRLGksesTTPNHRSPVSTPSLPISLTRTEELISPCALSMSTGPENKKSKQYKTKSSYKAFAAIPTNTLLL 834
Cdd:pfam15274   33 PSNGYGPISAQPK----SLAISSSLVSSVKRPKTQGTDLKTSSHPELSHSMAPQQKHGQQYKIKTSYKAFAAIPTNTLLM 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  835 EQKALDEPAKTESVSKDNTLEPPVE------------------------------------------------TPTTLPR 866
Cdd:pfam15274  109 EQKALEEPTKTASVTEGTALDTHSEmcspaqlrqqteelcavidqvlqdpltmrrcesppsflkmntesdtgkVSTTLQR 188

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462611248  867 AAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKeEEVYEPNPFSKYLEDNSDLFSEQ 932
Cdd:pfam15274  189 AAGRETRYANLYKSTPMVAESQLTKPGVIRPVLVKGRIAQQK-EEPYQPNPFKKYLEEISDQDSEQ 253
MLIP pfam15274
Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, ...
 204-304 5.83e-32

Muscular LMNA-interacting protein; MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.


Pssm-ID: 405866  Cd Length: 253  Bit Score: 125.59  E-value: 5.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462611248  204 MQQSDLFKAEYVLIVDSEGEDEAASRKVE-QGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMA 282
Cdd:pfam15274    1 MQENDLFKAEFILITDSGDEDEAAAASINvQRPSNGYGPISAQPKSLAISSSLVSSVKRPKTQGTDLKTSSHPELSHSMA 80

                           90       100
                   ....*....|....*....|..
gi 2462611248  283 PQQKHGQLTSSPTTSEQLACKP 304
Cdd:pfam15274   81 PQQKHGQQYKIKTSYKAFAAIP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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