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Conserved domains on  [gi|2462612120|ref|XP_054213109|]
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zinc finger protein 273 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 5.80e-12

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.68  E-value: 5.80e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462612120    1 MLDNYRNLVFLGIAVSKPDLITCLEQGKEPCN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-472 9.87e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 9.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 126 SNSNIHKKRQTGKKPFKC--KECGKSCCILSQLTQHKKTAT-RVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEEC 202
Cdd:COG5048    47 EHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 203 GKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFSVF-----------------------SVLTKHKIIHTGTKPYNCEECG 259
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 260 KgFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGE----- 334
Cdd:COG5048   207 S-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekg 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 335 --KPYKCEECGKAFKRSTTLTKHKRIYTKE----KPYKCEE--CGKAFSVFSTLTKHKIIHTGAKPYKCDECGS------ 400
Cdd:COG5048   286 fsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfsp 365

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462612120 401 AFRAFSTLTEHKRVHTGEKPYKC---NECGKAFNWSSTLTKHKRIHTGEKPY--KCEECGKAFNRSSNLTRHKKIHT 472
Cdd:COG5048   366 LLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 5.80e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.68  E-value: 5.80e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462612120    1 MLDNYRNLVFLGIAVSKPDLITCLEQGKEPCN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-472 9.87e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 9.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 126 SNSNIHKKRQTGKKPFKC--KECGKSCCILSQLTQHKKTAT-RVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEEC 202
Cdd:COG5048    47 EHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 203 GKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFSVF-----------------------SVLTKHKIIHTGTKPYNCEECG 259
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 260 KgFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGE----- 334
Cdd:COG5048   207 S-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekg 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 335 --KPYKCEECGKAFKRSTTLTKHKRIYTKE----KPYKCEE--CGKAFSVFSTLTKHKIIHTGAKPYKCDECGS------ 400
Cdd:COG5048   286 fsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfsp 365

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462612120 401 AFRAFSTLTEHKRVHTGEKPYKC---NECGKAFNWSSTLTKHKRIHTGEKPY--KCEECGKAFNRSSNLTRHKKIHT 472
Cdd:COG5048   366 LLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-320 2.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.49e-04
                          10        20
                  ....*....|....*....|....*
gi 2462612120 296 LTKHKRIHTGEKPYKCEECGKAFNQ 320
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 5.80e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.68  E-value: 5.80e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462612120    1 MLDNYRNLVFLGIAVSKPDLITCLEQGKEPCN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-472 9.87e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 9.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 126 SNSNIHKKRQTGKKPFKC--KECGKSCCILSQLTQHKKTAT-RVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEEC 202
Cdd:COG5048    47 EHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 203 GKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFSVF-----------------------SVLTKHKIIHTGTKPYNCEECG 259
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 260 KgFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGE----- 334
Cdd:COG5048   207 S-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekg 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 335 --KPYKCEECGKAFKRSTTLTKHKRIYTKE----KPYKCEE--CGKAFSVFSTLTKHKIIHTGAKPYKCDECGS------ 400
Cdd:COG5048   286 fsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfsp 365

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462612120 401 AFRAFSTLTEHKRVHTGEKPYKC---NECGKAFNWSSTLTKHKRIHTGEKPY--KCEECGKAFNRSSNLTRHKKIHT 472
Cdd:COG5048   366 LLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-492 5.57e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 169 YKCKTCGKAFNQFSNLTKHKIIHPEVNPYKC--EECGKAFNQSLTLTKHKKIHTEEKPYKCED-CGKVFSVFSVLTKHKI 245
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 246 IHTGTKPYNCEECGKGFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEkpykcEECGKAFNQSSTLT 325
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 326 RHKIVHTGEKPYKCEECGKAFKRSTTLTKHKRIYtKEKPYKCEECGKAF-----SVFSTLTKHKIIHTgakpyKCDECGS 400
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSpksllSQSPSSLSSSDSSS-----SASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 401 AFR--AFSTLTEHKRVHTGE-----KPYKCNECGKAFNWSSTLTKHKR--IHTGE--KPYKCEE--CGKAFNRSSNLTRH 467
Cdd:COG5048   263 SSLptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340
                  ....*....|....*....|....*
gi 2462612120 468 KKIHTGEKPYKPKRCDSAFDNTPNF 492
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-469 7.50e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 7.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 307 KPYKCEECGKAFNQSSTLTRHK--IVHTGE--KPYKCEE--CGKAFKRSTTLTKHKRIYTKEKPYKC--EECGKAFSVFS 378
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 379 T------LTKHKIIHTGAKPYKCD-ECGSAFRAFSTLTEHKRVHTGEKPY--KCNECGKAFNWSSTLTKHKRIHTGEKPY 449
Cdd:COG5048   368 NneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 2462612120 450 KCEECGKaFNRSSNLTRHKK 469
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-407 4.90e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 250 TKPYNCEECGKGFSIFSTLTKHK--IIHTGE--KPYKCNE--CGKAFNWSSTLTKHKRIHTGEKPYKC--EECGKAFNQS 321
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPL 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 322 STLTRHKIV--HTGEKPYKCEECGKAFKRSTTLTKHKRIYTKE-------KPYKCEECGKAFSVFSTLTKHKIIHTGAKP 392
Cdd:COG5048   367 LNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIIthlsfrpYNCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                         170
                  ....*....|....*
gi 2462612120 393 YKCDECGSAFRAFST 407
Cdd:COG5048   447 LLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
419-476 1.93e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 419 KPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKC--EECGKAFNRSSNLTRHKKIHTGEKP 476
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-320 2.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.49e-04
                          10        20
                  ....*....|....*....|....*
gi 2462612120 296 LTKHKRIHTGEKPYKCEECGKAFNQ 320
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-460 2.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.64e-04
                          10        20
                  ....*....|....*....|....*
gi 2462612120 436 LTKHKRIHTGEKPYKCEECGKAFNR 460
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 277-360 3.74e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 3.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 277 GEKPYKCN--ECGKAFNWSSTLTKHKrihtgekpyKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTK 354
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 2462612120 355 HKRIYT 360
Cdd:COG5189   417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 305-384 5.12e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 305 GEKPYKCE--ECGKAFNQSSTLTRHKivhtgekpyKCEECGKAFKRSTTLTKHKRIYTKEKPYKCEECGKAFSVFSTLTK 382
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462612120 383 HK 384
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-348 6.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.15e-04
                          10        20
                  ....*....|....*....|....*
gi 2462612120 324 LTRHKIVHTGEKPYKCEECGKAFKR 348
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-360 8.67e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.67e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462612120 307 KPYKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTKHKRIYT 360
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRT 85
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-431 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....
gi 2462612120 408 LTEHKRVHTGEKPYKCNECGKAFN 431
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-291 2.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|....
gi 2462612120 268 LTKHKIIHTGEKPYKCNECGKAFN 291
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 333-412 3.08e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612120 333 GEKPYKCE--ECGKAFKRSTTLTKHKriytkekpyKCEECGKAFSVFSTLTKHKIIHTGAKPYKCDECGSAFRAFSTLTE 410
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462612120 411 HK 412
Cdd:COG5189   417 HR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 449-471 4.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.20e-03
                          10        20
                  ....*....|....*....|...
gi 2462612120 449 YKCEECGKAFNRSSNLTRHKKIH 471
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-328 9.03e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 9.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462612120 279 KPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHK 328
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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