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Conserved domains on  [gi|2462613164|ref|XP_054213617|]
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kelch domain-containing protein 10 isoform X2 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
68-240 1.68e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 110.63  E-value: 1.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  68 AMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPnnlscdLPEERYRHEIA--HDGqRIYILGGGTSWTAYS--L 143
Cdd:COG3055    17 AAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP------LPGPPRHHAAAvaQDG-KLYVFGGFTGANPSStpL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 144 NKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYF 223
Cdd:COG3055    90 NDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP-LPTPRDH 161

                         170
                  ....*....|....*..
gi 2462613164 224 HCAAVTPAGCMYIHGGV 240
Cdd:COG3055   162 LAAAVLPDGKILVIGGR 178
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
68-240 1.68e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 110.63  E-value: 1.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  68 AMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPnnlscdLPEERYRHEIA--HDGqRIYILGGGTSWTAYS--L 143
Cdd:COG3055    17 AAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP------LPGPPRHHAAAvaQDG-KLYVFGGFTGANPSStpL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 144 NKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYF 223
Cdd:COG3055    90 NDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP-LPTPRDH 161

                         170
                  ....*....|....*..
gi 2462613164 224 HCAAVTPAGCMYIHGGV 240
Cdd:COG3055   162 LAAAVLPDGKILVIGGR 178
PLN02153 PLN02153
epithiospecifier protein
 2-159 1.25e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 64.24  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164   2 GTDGYMPRELASMSLVlhGNNLLVFGGTGIPfGESNGNDVHVCNVKYKRWALLSCRGKKPS-RIYGQAMAIINGSLYVFG 80
Cdd:PLN02153   16 GGKGPGPRCSHGIAVV--GDKLYSFGGELKP-NEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  81 GTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDlPEERYRHEIAHDGQRIYILG----GGTSWTAYSLNKIHAYNLETNAW 156
Cdd:PLN02153   93 GRDEKREFSDFYSYDTVKNEWTFLTKLDEEGG-PEARTFHSMASDENHVYVFGgvskGGLMKTPERFRTIEAYNIADGKW 171


                  ...
gi 2462613164 157 EEI 159
Cdd:PLN02153  172 VQL 174
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 172-218 2.70e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 2.70e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462613164 172 ARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPaTMP 218
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP-SMP 46
Kelch smart00612
Kelch domain;
185-229 6.28e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 6.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613164  185 VFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYFHCAAVT 229
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
68-240 1.68e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 110.63  E-value: 1.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  68 AMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPnnlscdLPEERYRHEIA--HDGqRIYILGGGTSWTAYS--L 143
Cdd:COG3055    17 AAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP------LPGPPRHHAAAvaQDG-KLYVFGGFTGANPSStpL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 144 NKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYF 223
Cdd:COG3055    90 NDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP-LPTPRDH 161

                         170
                  ....*....|....*..
gi 2462613164 224 HCAAVTPAGCMYIHGGV 240
Cdd:COG3055   162 LAAAVLPDGKILVIGGR 178
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
7-258 1.31e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 105.24  E-value: 1.31e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164   7 MPRELASMSLVLHGNNLLVFGGTGipfGESNGNDVHVCNVKYKRWALLscrGKKP-SRIYGQAMAIINGSLYVFGGTTG- 84
Cdd:COG3055     9 LPTPRSEAAAALLDGKVYVAGGLS---GGSASNSFEVYDPATNTWSEL---APLPgPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  85 ---YIYSTDLHKLDLNTREWTQLKPnnlscdLPEERYRHEIAHDGQRIYILGGGTSWTAysLNKIHAYNLETNAWEEIAT 161
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAP------MPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 162 KPHEKIGF-------------------------------PAARRCHSCVQIKNDVFICGGYNGevILGDIWKLNLQTFQW 210
Cdd:COG3055   155 LPTPRDHLaaavlpdgkilviggrngsgfsntwttlaplPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTW 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2462613164 211 VKLPaTMPEPVYFHcAAVTPAGCMYIHGGvvnihENKRTGSLFKIWLV 258
Cdd:COG3055   233 TALG-ELPTPRHGH-AAVLTDGKVYVIGG-----ETKPGVRTPLVTSA 273
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
100-247 3.48e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.04  E-value: 3.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 100 EWTQLKpnnlscDLPEERYRHEIAHDGQRIYILGGGTSWTAysLNKIHAYNLETNAWEEIATkphekigFPAARRCHSCV 179
Cdd:COG3055     2 TWSSLP------DLPTPRSEAAAALLDGKVYVAGGLSGGSA--SNSFEVYDPATNTWSELAP-------LPGPPRHHAAA 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462613164 180 Q-IKNDVFICGGYNG----EVILGDIWKLNLQTFQWVKLPaTMPEPVYFHcAAVTPAGCMYIHGGVVNIHENK 247
Cdd:COG3055    67 VaQDGKLYVFGGFTGanpsSTPLNDVYVYDPATNTWTKLA-PMPTPRGGA-TALLLDGKIYVVGGWDDGGNVA 137
PLN02153 PLN02153
epithiospecifier protein
 2-159 1.25e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 64.24  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164   2 GTDGYMPRELASMSLVlhGNNLLVFGGTGIPfGESNGNDVHVCNVKYKRWALLSCRGKKPS-RIYGQAMAIINGSLYVFG 80
Cdd:PLN02153   16 GGKGPGPRCSHGIAVV--GDKLYSFGGELKP-NEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  81 GTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDlPEERYRHEIAHDGQRIYILG----GGTSWTAYSLNKIHAYNLETNAW 156
Cdd:PLN02153   93 GRDEKREFSDFYSYDTVKNEWTFLTKLDEEGG-PEARTFHSMASDENHVYVFGgvskGGLMKTPERFRTIEAYNIADGKW 171


                  ...
gi 2462613164 157 EEI 159
Cdd:PLN02153  172 VQL 174
PLN02193 PLN02193
nitrile-specifier protein
 20-193 7.95e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 59.20  E-value: 7.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  20 GNNLLVFGGTGIPfGESNGNDVHVCNVKYKRWALLSCRGKKPS-RIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNT 98
Cdd:PLN02193  175 GNKIYSFGGEFTP-NQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTT 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  99 REWTQLKPNNlscDLPEERYRHEIAHDGQRIYILgGGTSWTAySLNKIHAYNLETNAWEEIATkPHEKIgfpAARRCHSC 178
Cdd:PLN02193  254 NEWKLLTPVE---EGPTPRSFHSMAADEENVYVF-GGVSATA-RLKTLDSYNIVDKKWFHCST-PGDSF---SIRGGAGL 324

                         170
                  ....*....|....*
gi 2462613164 179 VQIKNDVFICGGYNG 193
Cdd:PLN02193  325 EVVQGKVWVVYGFNG 339
PLN02153 PLN02153
epithiospecifier protein
 58-214 1.62e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 54.99  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  58 GKKPSRIYGQAMAIINGSLYVFGG--TTGYIYSTDLHKLDLNTREWTQLKPNNlscDLPE-ERYRHEIAHDGQRIYILGG 134
Cdd:PLN02153   17 GKGPGPRCSHGIAVVGDKLYSFGGelKPNEHIDKDLYVFDFNTHTWSIAPANG---DVPRiSCLGVRMVAVGTKLYIFGG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 135 GTSWTAYslNKIHAYNLETNAWEeIATKPHEKiGFPAARRCHSCVQIKNDVFICGGYNGEVILG------DIWKLNLQTF 208
Cdd:PLN02153   94 RDEKREF--SDFYSYDTVKNEWT-FLTKLDEE-GGPEARTFHSMASDENHVYVFGGVSKGGLMKtperfrTIEAYNIADG 169


                  ....*.
gi 2462613164 209 QWVKLP 214
Cdd:PLN02153  170 KWVQLP 175
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 172-218 2.70e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 2.70e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462613164 172 ARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPaTMP 218
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP-SMP 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
172-219 7.37e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.99  E-value: 7.37e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462613164 172 ARRCHSCVQIKND-VFICGGYNGE-VILGDIWKLNLQTFQWVKLPaTMPE 219
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLG-SLPS 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
126-181 1.77e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.90  E-value: 1.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462613164 126 GQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKphekigfPAARRCHSCVQI 181
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDL-------PPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 16-239 3.64e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 51.11  E-value: 3.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  16 LVLHGNNLLVFGGTGIPFGESNGNDVHVCNVK--YKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGG--TTGYIYSTDL 91
Cdd:PLN02193  116 FVLQGGKIVGFHGRSTDVLHSLGAYISLPSTPklLGKWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGefTPNQPIDKHL 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  92 HKLDLNTREWTqLKPN-----NLSCdlpeerYRHEIAHDGQRIYILGGGTSWTAYslNKIHAYNLETNAWEEIAtkPHEK 166
Cdd:PLN02193  196 YVFDLETRTWS-ISPAtgdvpHLSC------LGVRMVSIGSTLYVFGGRDASRQY--NGFYSFDTTTNEWKLLT--PVEE 264

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462613164 167 igFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWvklpatmpepvyFHCAavTPAGCMYIHGG 239
Cdd:PLN02193  265 --GPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW------------FHCS--TPGDSFSIRGG 321
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 117-163 1.89e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 1.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462613164 117 RYRHEIAHDGQRIYILGGGTSWTaySLNKIHAYNLETNAWEEIATKP 163
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
63-106 2.56e-06

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 43.75  E-value: 2.56e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462613164  63 RIYGQAMAIINGSLYVFGGTT--GYIYStDLHKLDLNTREWTQLKP 106
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGedGTLLS-DLWVFDLSTNEWTRLGS 46
Kelch_6 pfam13964
Kelch motif;
117-164 1.09e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.94  E-value: 1.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462613164 117 RYRHEIAHDGQRIYILGGGTSWTAYSlNKIHAYNLETNAWEEIATKPH 164
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPAL-NKLEVYNPLTKSWEELPPLPT 48
PRK14131 PRK14131
N-acetylneuraminate epimerase;
123-240 1.15e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.16  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 123 AHDGQRIYI-LG-GGTSWTAYSLNKIHAynletnAWEEIATkphekigFPAARRCHS-CVQIKNDVFICGGY-----NGE 194
Cdd:PRK14131   35 AIDNNTVYVgLGsAGTSWYKLDLNAPSK------GWTKIAA-------FPGGPREQAvAAFIDGKLYVFGGIgktnsEGS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462613164 195 VIL-GDIWKLNLQTFQWVKLPATMPEPVYFHcAAVTPAGCM-YIHGGV 240
Cdd:PRK14131  102 PQVfDDVYKYDPKTNSWQKLDTRSPVGLAGH-VAVSLHNGKaYITGGV 148
PHA03098 PHA03098
kelch-like protein; Provisional
 7-157 2.00e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 45.91  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164   7 MPRelASMSLVLHGNNLLVFGGtgIPFGESNGNDVHVCNVKYKRWALLSCrgkKPSRIYGQAMAIINGSLYVFGGTTgyi 86
Cdd:PHA03098  378 FPR--YNPCVVNVNNLIYVIGG--ISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGIS--- 447

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613164  87 YSTDLHKL------DLNTREWTQLKPNNLScdlpeeRYRHEIAHDGQRIYILGGGTSwtAYSLNKIHAYNLETNAWE 157
Cdd:PHA03098  448 YIDNIKVYnivesyNPVTNKWTELSSLNFP------RINASLCIFNNKIYVVGGDKY--EYYINEIEVYDDKTNTWT 516
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 65-108 2.88e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.67  E-value: 2.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462613164  65 YGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNN 108
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
70-192 5.96e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  70 AIINGSLYVFGGTTGyiysTDLHKLDLNT--REWTQLKpnnlscDLP-EERYRHEIAHDGQRIYILGG-GTSWTAYSL-- 143
Cdd:PRK14131   35 AIDNNTVYVGLGSAG----TSWYKLDLNApsKGWTKIA------AFPgGPREQAVAAFIDGKLYVFGGiGKTNSEGSPqv 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462613164 144 -NKIHAYNLETNAWEEIATKPhekigfPAARRCHSCVQIKND-VFICGGYN 192
Cdd:PRK14131  105 fDDVYKYDPKTNSWQKLDTRS------PVGLAGHVAVSLHNGkAYITGGVN 149
Kelch smart00612
Kelch domain;
185-229 6.28e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 6.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613164  185 VFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYFHCAAVT 229
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
PHA03098 PHA03098
kelch-like protein; Provisional
 39-214 1.01e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164  39 NDVHVCNVKYKRWallscrGKKPSRIY---GQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPnnlscdLPE 115
Cdd:PHA03098  311 NSVVSYDTKTKSW------NKVPELIYprkNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP------LIF 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 116 ERYRHEIAHDGQRIYILgGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGfpaarrcHSCVQIKNDVFICGGY---N 192
Cdd:PHA03098  379 PRYNPCVVNVNNLIYVI-GGISKNDELLKTVECFSLNTNKWSKGSPLPISHYG-------GCAIYHDGKIYVIGGIsyiD 450

                         170       180
                  ....*....|....*....|..
gi 2462613164 193 GEVILGDIWKLNLQTFQWVKLP 214
Cdd:PHA03098  451 NIKVYNIVESYNPVTNKWTELS 472
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 114-154 1.21e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 38.70  E-value: 1.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462613164 114 PEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETN 154
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPTF 41
Kelch_6 pfam13964
Kelch motif;
172-220 2.31e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 2.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462613164 172 ARRCHSCVQIKNDVFICGGY-NGEVILGDIWKLNLQTFQWVKLPaTMPEP 220
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELP-PLPTP 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
122-164 2.85e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.98  E-value: 2.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2462613164 122 IAHDGQRIYILGGgTSWTAYSLNKIHAYNLETNAWEEIATKPH 164
Cdd:pfam13418   8 TSIPDDTIYLFGG-EGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_6 pfam13964
Kelch motif;
66-104 4.26e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 4.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462613164  66 GQAMAIINGSLYVFGGTTGY-IYSTDLHKLDLNTREWTQL 104
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEEL 43
PHA03098 PHA03098
kelch-like protein; Provisional
 129-249 9.86e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 9.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613164 129 IYILGGGTSwTAYSLNKIHAYNLETNAWEEIAtkpheKIGFPaaRRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTF 208
Cdd:PHA03098  297 IYFIGGMNK-NNLSVNSVVSYDTKTKSWNKVP-----ELIYP--RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGES 368

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462613164 209 QWVKLPaTMPEPVYFHCAAVTpAGCMYIHGGVVNIHENKRT 249
Cdd:PHA03098  369 KWREEP-PLIFPRYNPCVVNV-NNLIYVIGGISKNDELLKT 407
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 65-106 3.95e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.62  E-value: 3.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462613164  65 YGQAMAIINGSLYVFGGTTGY--IYSTDLHKLDLNTREWTQLKP 106
Cdd:pfam07646   3 YPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPR 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
182-228 7.87e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 33.80  E-value: 7.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462613164 182 KNDVFICGGYN--GEVILGDIWKLNLQTFQWVKLpATMPEPVYFHCAAV 228
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQI-GDLPPPRSGHSATY 48
Kelch_3 pfam13415
Galactose oxidase, central domain;
73-120 9.21e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 33.80  E-value: 9.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462613164  73 NGSLYVFGG--TTGYIYSTDLHKLDLNTREWTQLKpnnlscDLPEERYRH 120
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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