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Conserved domains on  [gi|2462613243|ref|XP_054213656|]
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protein cordon-bleu isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cobl pfam09469
Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among ...
 152-228 1.27e-42

Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.


:

Pssm-ID: 462810  Cd Length: 79  Bit Score: 150.04  E-value: 1.27e-42
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613243  152 EKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRR 228
Cdd:pfam09469    1 EKTVRLVVNYKKTQKAVVRVSPHVPLQELLPIICSKCEFDPLHVLLLKDYISQEELDLTKSLNDLGIKELYAMDVNR 77
WH2_Wb_Cobl cd21800
second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in ...
 1185-1228 3.22e-16

second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the second tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wb, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 or W domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the second WH2 domain.


:

Pssm-ID: 409198 [Multi-domain]  Cd Length: 44  Bit Score: 73.42  E-value: 3.22e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613243 1185 EAEGERSALLAAIRGHSGTCSLRKVASSASEELQSFRDAALSAQ 1228
Cdd:cd21800      1 EPENERSALLAAIRGHSGTSKLRKTRSLASEELQPIRPAELSTQ 44
WH2_Wa_Cobl cd21799
first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in ...
 1139-1171 2.21e-13

first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the first tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wa, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


:

Pssm-ID: 409197 [Multi-domain]  Cd Length: 33  Bit Score: 65.16  E-value: 2.21e-13
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462613243 1139 VQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAE 1171
Cdd:cd21799      1 VQKPVQKDTSLHSSLMEAIQSGEGKERLRKVSD 33
WH2_Wc_Cobl cd21801
third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in ...
 1273-1298 4.97e-10

third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the third tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wc, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


:

Pssm-ID: 409199  Cd Length: 26  Bit Score: 55.39  E-value: 4.97e-10
                           10        20
                   ....*....|....*....|....*.
gi 2462613243 1273 NTADARQALMDAIRSGTGAARLRKVP 1298
Cdd:cd21801      1 NPEQARQALLEAIRSGEGAARLKKVP 26
 
Name Accession Description Interval E-value
Cobl pfam09469
Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among ...
 152-228 1.27e-42

Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.


Pssm-ID: 462810  Cd Length: 79  Bit Score: 150.04  E-value: 1.27e-42
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613243  152 EKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRR 228
Cdd:pfam09469    1 EKTVRLVVNYKKTQKAVVRVSPHVPLQELLPIICSKCEFDPLHVLLLKDYISQEELDLTKSLNDLGIKELYAMDVNR 77
WH2_Wb_Cobl cd21800
second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in ...
 1185-1228 3.22e-16

second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the second tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wb, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 or W domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the second WH2 domain.


Pssm-ID: 409198 [Multi-domain]  Cd Length: 44  Bit Score: 73.42  E-value: 3.22e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613243 1185 EAEGERSALLAAIRGHSGTCSLRKVASSASEELQSFRDAALSAQ 1228
Cdd:cd21800      1 EPENERSALLAAIRGHSGTSKLRKTRSLASEELQPIRPAELSTQ 44
WH2_Wa_Cobl cd21799
first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in ...
 1139-1171 2.21e-13

first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the first tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wa, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


Pssm-ID: 409197 [Multi-domain]  Cd Length: 33  Bit Score: 65.16  E-value: 2.21e-13
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462613243 1139 VQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAE 1171
Cdd:cd21799      1 VQKPVQKDTSLHSSLMEAIQSGEGKERLRKVSD 33
WH2_Wc_Cobl cd21801
third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in ...
 1273-1298 4.97e-10

third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the third tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wc, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


Pssm-ID: 409199  Cd Length: 26  Bit Score: 55.39  E-value: 4.97e-10
                           10        20
                   ....*....|....*....|....*.
gi 2462613243 1273 NTADARQALMDAIRSGTGAARLRKVP 1298
Cdd:cd21801      1 NPEQARQALLEAIRSGEGAARLKKVP 26
 
Name Accession Description Interval E-value
Cobl pfam09469
Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among ...
 152-228 1.27e-42

Cordon-bleu ubiquitin-like domain; The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.


Pssm-ID: 462810  Cd Length: 79  Bit Score: 150.04  E-value: 1.27e-42
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613243  152 EKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRR 228
Cdd:pfam09469    1 EKTVRLVVNYKKTQKAVVRVSPHVPLQELLPIICSKCEFDPLHVLLLKDYISQEELDLTKSLNDLGIKELYAMDVNR 77
WH2_Wb_Cobl cd21800
second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in ...
 1185-1228 3.22e-16

second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the second tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wb, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 or W domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the second WH2 domain.


Pssm-ID: 409198 [Multi-domain]  Cd Length: 44  Bit Score: 73.42  E-value: 3.22e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613243 1185 EAEGERSALLAAIRGHSGTCSLRKVASSASEELQSFRDAALSAQ 1228
Cdd:cd21800      1 EPENERSALLAAIRGHSGTSKLRKTRSLASEELQPIRPAELSTQ 44
WH2_Wa_Cobl cd21799
first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in ...
 1139-1171 2.21e-13

first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the first tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wa, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


Pssm-ID: 409197 [Multi-domain]  Cd Length: 33  Bit Score: 65.16  E-value: 2.21e-13
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462613243 1139 VQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAE 1171
Cdd:cd21799      1 VQKPVQKDTSLHSSLMEAIQSGEGKERLRKVSD 33
WH2_Wc_Cobl cd21801
third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in ...
 1273-1298 4.97e-10

third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins; This family contains the third tandem Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2), called Wc, found in protein Cordon-Bleu (Cobl), a potent actin filament nucleator that plays an important role in the reorganization of the actin cytoskeleton. It regulates neuron morphogenesis and increases branching of axons and dendrites. It also modulates dendrite branching in Purkinje cells. Cobl binds to and sequesters actin monomers (G-actin). Cobl contains three tandem WH2 (or W) domains consisting of an N-terminal alpha helix and a C-terminal LRKV motif. The first two WH2 domains have the highest binding affinity for actin. They are functionally active in actin nucleation and polymerization. The model corresponds to the first WH2 domain.


Pssm-ID: 409199  Cd Length: 26  Bit Score: 55.39  E-value: 4.97e-10
                           10        20
                   ....*....|....*....|....*.
gi 2462613243 1273 NTADARQALMDAIRSGTGAARLRKVP 1298
Cdd:cd21801      1 NPEQARQALLEAIRSGEGAARLKKVP 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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