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Conserved domains on  [gi|2462613735|ref|XP_054213893|]
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transcriptional activator GLI3 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 541-631 6.95e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 6.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613735  541 GEKPHKCTFEGCTKAYSRLENLKTHLRshtgekpyvceHEGCNKAFSNASDRAKHQNRTHSNeKPYVCkiPGCTKRYTDP 620
Cdd:COG5189    346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKD-KPYRC--EVCDKRYKNL 411

                           90
                   ....*....|.
gi 2462613735  621 SSLRKHVKTVH 631
Cdd:COG5189    412 NGLKYHRKHSH 422
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 541-631 6.95e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 6.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613735  541 GEKPHKCTFEGCTKAYSRLENLKTHLRshtgekpyvceHEGCNKAFSNASDRAKHQNRTHSNeKPYVCkiPGCTKRYTDP 620
Cdd:COG5189    346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKD-KPYRC--EVCDKRYKNL 411

                           90
                   ....*....|.
gi 2462613735  621 SSLRKHVKTVH 631
Cdd:COG5189    412 NGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-558 7.22e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 7.22e-05
                           10        20
                   ....*....|....*....|....*...
gi 2462613735  531 MLVVHMRRHTGEKPHKCTFegCTKAYSR 558
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 541-631 6.95e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 6.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613735  541 GEKPHKCTFEGCTKAYSRLENLKTHLRshtgekpyvceHEGCNKAFSNASDRAKHQNRTHSNeKPYVCkiPGCTKRYTDP 620
Cdd:COG5189    346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKD-KPYRC--EVCDKRYKNL 411

                           90
                   ....*....|.
gi 2462613735  621 SSLRKHVKTVH 631
Cdd:COG5189    412 NGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-558 7.22e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 7.22e-05
                           10        20
                   ....*....|....*....|....*...
gi 2462613735  531 MLVVHMRRHTGEKPHKCTFegCTKAYSR 558
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-588 9.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 9.23e-05
                           10        20
                   ....*....|....*....|....*...
gi 2462613735  561 NLKTHLRSHTGEKPYVCEHegCNKAFSN 588
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
550-623 4.72e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 4.72e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462613735  550 EGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNaSDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSL 623
Cdd:COG5048     37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSR-PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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