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Conserved domains on  [gi|2462614682|ref|XP_054214333|]
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zinc finger C3HC-type protein 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C3HC super family cl06834
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 14-77 6.85e-16

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


The actual alignment was detected with superfamily member pfam07967:

Pssm-ID: 429759  Cd Length: 132  Bit Score: 73.18  E-value: 6.85e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462614682  14 KQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRP 77
Cdd:pfam07967  69 NKLIEEYAKQLVTGHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 super family cl07279
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 252-299 4.54e-04

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


The actual alignment was detected with superfamily member pfam08600:

Pssm-ID: 369989  Cd Length: 97  Bit Score: 39.00  E-value: 4.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462614682 252 FDPTSQHRDWCPWVNitlgKESRENGGTEPDASAPAEPGWKAVLTILL 299
Cdd:pfam08600  54 LDVLEEHREYCPWVN----PKAQSGTGRSSDALDGLASGWELLAQALK 97
 
Name Accession Description Interval E-value
zf-C3HC pfam07967
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 14-77 6.85e-16

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


Pssm-ID: 429759  Cd Length: 132  Bit Score: 73.18  E-value: 6.85e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462614682  14 KQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRP 77
Cdd:pfam07967  69 NKLIEEYAKQLVTGHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 252-299 4.54e-04

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 39.00  E-value: 4.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462614682 252 FDPTSQHRDWCPWVNitlgKESRENGGTEPDASAPAEPGWKAVLTILL 299
Cdd:pfam08600  54 LDVLEEHREYCPWVN----PKAQSGTGRSSDALDGLASGWELLAQALK 97
 
Name Accession Description Interval E-value
zf-C3HC pfam07967
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 14-77 6.85e-16

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


Pssm-ID: 429759  Cd Length: 132  Bit Score: 73.18  E-value: 6.85e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462614682  14 KQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRP 77
Cdd:pfam07967  69 NKLIEEYAKQLVTGHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 252-299 4.54e-04

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 39.00  E-value: 4.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462614682 252 FDPTSQHRDWCPWVNitlgKESRENGGTEPDASAPAEPGWKAVLTILL 299
Cdd:pfam08600  54 LDVLEEHREYCPWVN----PKAQSGTGRSSDALDGLASGWELLAQALK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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