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Conserved domains on  [gi|2462615932|ref|XP_054214893|]
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zinc finger protein isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
36-188 1.76e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615932  36 PYRCPLCGQTFSQQPSLVRHQKAHA-GAGRAAAFVCPE--CGKAFSVKHNLEVHQRTHTGERPFPCPECGRCFSLKQNL- 111
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSVNhSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615932 112 ------LTHQRIHSGEKPHQCA--QCGRCFREPRFLLNHQRTHARMPaphprrpgvfgeRRPYFCPRCGKSFAREGSLKT 183
Cdd:COG5048   369 neppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFR------------PYNCKNPPCSKSFNRHYNLIP 436


                  ....*
gi 2462615932 184 HQRSH 188
Cdd:COG5048   437 HKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
36-188 1.76e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615932  36 PYRCPLCGQTFSQQPSLVRHQKAHA-GAGRAAAFVCPE--CGKAFSVKHNLEVHQRTHTGERPFPCPECGRCFSLKQNL- 111
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSVNhSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615932 112 ------LTHQRIHSGEKPHQCA--QCGRCFREPRFLLNHQRTHARMPaphprrpgvfgeRRPYFCPRCGKSFAREGSLKT 183
Cdd:COG5048   369 neppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFR------------PYNCKNPPCSKSFNRHYNLIP 436


                  ....*
gi 2462615932 184 HQRSH 188
Cdd:COG5048   437 HKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-106 1.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.04e-04
                          10        20
                  ....*....|....*....|....*
gi 2462615932  82 NLEVHQRTHTGERPFPCPECGRCFS 106
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
36-188 1.76e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615932  36 PYRCPLCGQTFSQQPSLVRHQKAHA-GAGRAAAFVCPE--CGKAFSVKHNLEVHQRTHTGERPFPCPECGRCFSLKQNL- 111
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSVNhSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615932 112 ------LTHQRIHSGEKPHQCA--QCGRCFREPRFLLNHQRTHARMPaphprrpgvfgeRRPYFCPRCGKSFAREGSLKT 183
Cdd:COG5048   369 neppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFR------------PYNCKNPPCSKSFNRHYNLIP 436


                  ....*
gi 2462615932 184 HQRSH 188
Cdd:COG5048   437 HKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-146 3.17e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462615932  94 RPFPCPECGRCFSLKQNLLTHQRIHSGEKPHQCAQCGR--CFREPRFLLNHQRTH 146
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-106 1.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.04e-04
                          10        20
                  ....*....|....*....|....*
gi 2462615932  82 NLEVHQRTHTGERPFPCPECGRCFS 106
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 92-190 5.82e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615932  92 GERPFPCP--ECGRCFSlKQNLLTHQRIHsgekphqcaqcGRCfreprfllnHQRTHARmPAPHPRRpGVFGERRPYFCP 169
Cdd:COG5189   346 DGKPYKCPveGCNKKYK-NQNGLKYHMLH-----------GHQ---------NQKLHEN-PSPEKMN-IFSAKDKPYRCE 402

                          90       100
                  ....*....|....*....|.
gi 2462615932 170 RCGKSFAREGSLKTHqRSHGH 190
Cdd:COG5189   403 VCDKRYKNLNGLKYH-RKHSH 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 68-90 7.74e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 7.74e-04
                          10        20
                  ....*....|....*....|...
gi 2462615932  68 FVCPECGKAFSVKHNLEVHQRTH 90
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
110-133 1.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....
gi 2462615932 110 NLLTHQRIHSGEKPHQCAQCGRCF 133
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 166-188 7.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.04  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|...
gi 2462615932 166 YFCPRCGKSFAREGSLKTHQRSH 188
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
68-131 7.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 36.60  E-value: 7.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462615932  68 FVCPECGKAFSVKHNLEVHQRTHTGERPFPCPECGR--CFSLKQNLLTHQRIHSGEKPHQCAQCGR 131
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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