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Conserved domains on  [gi|2462616446|ref|XP_054215141|]
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armadillo repeat-containing protein 10 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_2 super family cl27108
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 102-185 1.58e-43

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


The actual alignment was detected with superfamily member pfam04826:

Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 144.86  E-value: 1.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616446 102 LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQ 181
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80


                  ....
gi 2462616446 182 IKIK 185
Cdd:pfam04826  81 KKIK 84
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 102-185 1.58e-43

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 144.86  E-value: 1.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616446 102 LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQ 181
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80


                  ....
gi 2462616446 182 IKIK 185
Cdd:pfam04826  81 KKIK 84
VATPase_H cd00256
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the ...
 103-178 2.12e-03

VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is that of a superhelical spiral, in part the geometry is similar to superhelices composed of armadillo repeat motifs, as found in importins for example.


Pssm-ID: 238159 [Multi-domain]  Cd Length: 429  Bit Score: 38.15  E-value: 2.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462616446 103 NAEQLQKLLYLLESTEDPVIIERALITLGNNA-AFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNV 178
Cdd:cd00256   351 NYELLKILIHLLETSVDPIILAVACHDIGEYVrHYPRGKDVVEQLGGKQRVMRLLNHEDPNVRYEALLAVQKLMVHN 427
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-175 4.50e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 33.94  E-value: 4.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462616446  139 NQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLS 175
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 102-185 1.58e-43

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 144.86  E-value: 1.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616446 102 LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQ 181
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80


                  ....
gi 2462616446 182 IKIK 185
Cdd:pfam04826  81 KKIK 84
VATPase_H cd00256
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the ...
 103-178 2.12e-03

VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is that of a superhelical spiral, in part the geometry is similar to superhelices composed of armadillo repeat motifs, as found in importins for example.


Pssm-ID: 238159 [Multi-domain]  Cd Length: 429  Bit Score: 38.15  E-value: 2.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462616446 103 NAEQLQKLLYLLESTEDPVIIERALITLGNNA-AFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNV 178
Cdd:cd00256   351 NYELLKILIHLLETSVDPIILAVACHDIGEYVrHYPRGKDVVEQLGGKQRVMRLLNHEDPNVRYEALLAVQKLMVHN 427
Atx10homo_assoc pfam09759
Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues ...
 139-181 3.47e-03

Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localization, specifically to the olivocerebellar region.


Pssm-ID: 462885 [Multi-domain]  Cd Length: 99  Bit Score: 35.52  E-value: 3.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462616446 139 NQAIIRELGGIPIVAN--KINHSNQSIKEKALNALNNLSV-NVENQ 181
Cdd:pfam09759  19 VQDEVRELGGLPLILSncNIDDNNPFIREWAIFCIRNLLEgNEENQ 64
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-175 4.50e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 33.94  E-value: 4.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462616446  139 NQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLS 175
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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