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Conserved domains on  [gi|2462616998|ref|XP_054215408|]
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engulfment and cell motility protein 1 isoform X3 [Homo sapiens]

Protein Classification

ubiquitin family protein( domain architecture ID 13219096)

ubiquitin family protein such as polyubiquitin, which when attached to a target protein, has different functions depending on the Lys residue of the ubiquitin that is linked

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELMO_ARM pfam11841
ELMO, armadillo-like helical domain; This domain is found in eukaryotes and predominantly in ...
 115-280 1.51e-83

ELMO, armadillo-like helical domain; This domain is found in eukaryotes and predominantly in ELMO (Elongation and Cell motility) proteins and corresponds to the armadillo repeats domain (ARR). It may play an important role in defining the functions of the ELMO family members and may be functionally linked to the ELMO domain in these proteins, being involved in protein-protein interactions.


:

Pssm-ID: 463369  Cd Length: 154  Bit Score: 254.81  E-value: 1.51e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 115 TFAQEFINLDGISLLTQMVESGTeryqklqkimkpCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAID 194
Cdd:pfam11841   1 TFALEFISRNGLKLLISMVEGGT------------ESGEILAYALTAFVELMDHGIVSWDTLSPSFIKKIASYVNKSAQD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 195 ISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSI 274
Cdd:pfam11841  69 ASILQRSLAILESIVLNSSALYQLVEQEVTLESLITHLQSSNQEIQTNAIALINALFLKADDSKRKEIADTLSSKQLRNV 148


                  ....*.
gi 2462616998 275 ILTHVI 280
Cdd:pfam11841 149 ILKNII 154
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 303-481 7.65e-56

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


:

Pssm-ID: 461411  Cd Length: 161  Bit Score: 183.58  E-value: 7.65e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 303 NLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNssgsmekrksmYTRDYKKLGFINHvNPAMDFTqtPPGMLALD 382
Cdd:pfam04727   1 NLLRKRRKTPFDSENPEHERLLKELWKALFPDEPLESR-----------ISEKWKRLGFQGE-DPATDFR--GMGLLGLE 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 383 NMLYFAKHHQDAYIRIVLENSSREDkhECPFGRSSIELTKMLCEILKVGELPSETCNDFhpMFFTHDRSFEEFFCICIQL 462
Cdd:pfam04727  67 NLLYFARNHPDSFQKILLEQSHRPQ--RYPFAVASINLTSLLYELLKIGKLDPEENKSY--LFFPLLLAFEELYCAAFQL 142

                         170
                  ....*....|....*....
gi 2462616998 463 LNKTWKEMRATSEDFNKVM 481
Cdd:pfam04727 143 FDRTWKEMGATIMDFNKVL 161
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 20-105 3.49e-03

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17090:

Pssm-ID: 475130  Cd Length: 111  Bit Score: 37.32  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998  20 KLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQhadssnfyiTEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDA 99
Cdd:cd17090    13 KTVLVDDSQTVSQLVETICTKIGITNPEEFSLV---------REEEEEEKENKATLRKSTSRLRDDKKMESLKKKLHTDD 83


                  ....*.
gi 2462616998 100 KLEALK 105
Cdd:cd17090    84 ELNWLD 89
 
Name Accession Description Interval E-value
ELMO_ARM pfam11841
ELMO, armadillo-like helical domain; This domain is found in eukaryotes and predominantly in ...
 115-280 1.51e-83

ELMO, armadillo-like helical domain; This domain is found in eukaryotes and predominantly in ELMO (Elongation and Cell motility) proteins and corresponds to the armadillo repeats domain (ARR). It may play an important role in defining the functions of the ELMO family members and may be functionally linked to the ELMO domain in these proteins, being involved in protein-protein interactions.


Pssm-ID: 463369  Cd Length: 154  Bit Score: 254.81  E-value: 1.51e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 115 TFAQEFINLDGISLLTQMVESGTeryqklqkimkpCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAID 194
Cdd:pfam11841   1 TFALEFISRNGLKLLISMVEGGT------------ESGEILAYALTAFVELMDHGIVSWDTLSPSFIKKIASYVNKSAQD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 195 ISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSI 274
Cdd:pfam11841  69 ASILQRSLAILESIVLNSSALYQLVEQEVTLESLITHLQSSNQEIQTNAIALINALFLKADDSKRKEIADTLSSKQLRNV 148


                  ....*.
gi 2462616998 275 ILTHVI 280
Cdd:pfam11841 149 ILKNII 154
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 303-481 7.65e-56

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


Pssm-ID: 461411  Cd Length: 161  Bit Score: 183.58  E-value: 7.65e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 303 NLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNssgsmekrksmYTRDYKKLGFINHvNPAMDFTqtPPGMLALD 382
Cdd:pfam04727   1 NLLRKRRKTPFDSENPEHERLLKELWKALFPDEPLESR-----------ISEKWKRLGFQGE-DPATDFR--GMGLLGLE 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 383 NMLYFAKHHQDAYIRIVLENSSREDkhECPFGRSSIELTKMLCEILKVGELPSETCNDFhpMFFTHDRSFEEFFCICIQL 462
Cdd:pfam04727  67 NLLYFARNHPDSFQKILLEQSHRPQ--RYPFAVASINLTSLLYELLKIGKLDPEENKSY--LFFPLLLAFEELYCAAFQL 142

                         170
                  ....*....|....*....
gi 2462616998 463 LNKTWKEMRATSEDFNKVM 481
Cdd:pfam04727 143 FDRTWKEMGATIMDFNKVL 161
FERM_F1_TLN cd17090
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin and ...
 20-105 3.49e-03

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin and similar proteins; Talin is a cytoskeletal protein that activates integrins and couples them to cytoskeletal actin. Talin consists of an N-terminal head and a C-terminal rod. The talin head harbors a FERM (Band 4.1, ezrin, radixin, moesin) domain made up of F1, F2 and F3 domains, as well as an N-terminal region that precedes the FERM domain and has been referred to as the F0 domain. Both F0 and F1 domains have similar ubiquitin-like folds. This family corresponds to the F0 domain that is joined to the F1 domain in a novel fixed orientation by an extensive charged interface. It is required for maximal integrin-activation, by interacting with other FA components; no binding partner has yet been found for it.


Pssm-ID: 340610  Cd Length: 111  Bit Score: 37.32  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998  20 KLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQhadssnfyiTEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDA 99
Cdd:cd17090    13 KTVLVDDSQTVSQLVETICTKIGITNPEEFSLV---------REEEEEEKENKATLRKSTSRLRDDKKMESLKKKLHTDD 83


                  ....*.
gi 2462616998 100 KLEALK 105
Cdd:cd17090    84 ELNWLD 89
 
Name Accession Description Interval E-value
ELMO_ARM pfam11841
ELMO, armadillo-like helical domain; This domain is found in eukaryotes and predominantly in ...
 115-280 1.51e-83

ELMO, armadillo-like helical domain; This domain is found in eukaryotes and predominantly in ELMO (Elongation and Cell motility) proteins and corresponds to the armadillo repeats domain (ARR). It may play an important role in defining the functions of the ELMO family members and may be functionally linked to the ELMO domain in these proteins, being involved in protein-protein interactions.


Pssm-ID: 463369  Cd Length: 154  Bit Score: 254.81  E-value: 1.51e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 115 TFAQEFINLDGISLLTQMVESGTeryqklqkimkpCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAID 194
Cdd:pfam11841   1 TFALEFISRNGLKLLISMVEGGT------------ESGEILAYALTAFVELMDHGIVSWDTLSPSFIKKIASYVNKSAQD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 195 ISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSI 274
Cdd:pfam11841  69 ASILQRSLAILESIVLNSSALYQLVEQEVTLESLITHLQSSNQEIQTNAIALINALFLKADDSKRKEIADTLSSKQLRNV 148


                  ....*.
gi 2462616998 275 ILTHVI 280
Cdd:pfam11841 149 ILKNII 154
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 303-481 7.65e-56

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


Pssm-ID: 461411  Cd Length: 161  Bit Score: 183.58  E-value: 7.65e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 303 NLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNssgsmekrksmYTRDYKKLGFINHvNPAMDFTqtPPGMLALD 382
Cdd:pfam04727   1 NLLRKRRKTPFDSENPEHERLLKELWKALFPDEPLESR-----------ISEKWKRLGFQGE-DPATDFR--GMGLLGLE 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998 383 NMLYFAKHHQDAYIRIVLENSSREDkhECPFGRSSIELTKMLCEILKVGELPSETCNDFhpMFFTHDRSFEEFFCICIQL 462
Cdd:pfam04727  67 NLLYFARNHPDSFQKILLEQSHRPQ--RYPFAVASINLTSLLYELLKIGKLDPEENKSY--LFFPLLLAFEELYCAAFQL 142

                         170
                  ....*....|....*....
gi 2462616998 463 LNKTWKEMRATSEDFNKVM 481
Cdd:pfam04727 143 FDRTWKEMGATIMDFNKVL 161
FERM_F1_TLN cd17090
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin and ...
 20-105 3.49e-03

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin and similar proteins; Talin is a cytoskeletal protein that activates integrins and couples them to cytoskeletal actin. Talin consists of an N-terminal head and a C-terminal rod. The talin head harbors a FERM (Band 4.1, ezrin, radixin, moesin) domain made up of F1, F2 and F3 domains, as well as an N-terminal region that precedes the FERM domain and has been referred to as the F0 domain. Both F0 and F1 domains have similar ubiquitin-like folds. This family corresponds to the F0 domain that is joined to the F1 domain in a novel fixed orientation by an extensive charged interface. It is required for maximal integrin-activation, by interacting with other FA components; no binding partner has yet been found for it.


Pssm-ID: 340610  Cd Length: 111  Bit Score: 37.32  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462616998  20 KLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQhadssnfyiTEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDA 99
Cdd:cd17090    13 KTVLVDDSQTVSQLVETICTKIGITNPEEFSLV---------REEEEEEKENKATLRKSTSRLRDDKKMESLKKKLHTDD 83


                  ....*.
gi 2462616998 100 KLEALK 105
Cdd:cd17090    84 ELNWLD 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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