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Conserved domains on  [gi|2462622286|ref|XP_054217781|]
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endosome-associated-trafficking regulator 1 isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 211-374 4.10e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 4.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  211 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLEQKLEakMIKEESDYHDLESVVQQKRAVKAENHVVKLK 290
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRERLANLERQLEELEAQLEELESKLDELA 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  291 QEISLLQAQVSNFQRENEALRcGQGASLTMVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILKSIDRISEVK 370
Cdd:TIGR02168  337 EELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIERLEARLERLE 413


                   ....
gi 2462622286  371 DEEE 374
Cdd:TIGR02168  414 DRRE 417
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 211-374 4.10e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 4.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  211 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLEQKLEakMIKEESDYHDLESVVQQKRAVKAENHVVKLK 290
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRERLANLERQLEELEAQLEELESKLDELA 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  291 QEISLLQAQVSNFQRENEALRcGQGASLTMVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILKSIDRISEVK 370
Cdd:TIGR02168  337 EELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIERLEARLERLE 413


                   ....
gi 2462622286  371 DEEE 374
Cdd:TIGR02168  414 DRRE 417
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 211-371 4.55e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 4.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 211 DRHLRTLQISYDALKDENSKLRRKLNEVqsfsEAQTEMVRTLEQKLEAKM--IKEESDYHDLESVV--QQKRAVKAENHV 286
Cdd:COG1579    37 EDELAALEARLEAAKTELEDLEKEIKRL----ELEIEEVEARIKKYEEQLgnVRNNKEYEALQKEIesLKRRISDLEDEI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 287 VKLKQEISLLQAQVSNFQRENEALRcgqgASLTMVKQNADVALQNLRVVMNSAQASIKQLVSGAEtlnlvAEILKSIDRI 366
Cdd:COG1579   113 LELMERIEELEEELAELEAELAELE----AELEEKKAELDEELAELEAELEELEAEREELAAKIP-----PELLALYERI 183


                  ....*
gi 2462622286 367 SEVKD 371
Cdd:COG1579   184 RKRKN 188
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 197-309 8.96e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 37.95  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 197 SPSADFAVHGESLGDRHLRTLQisydaLKDENSKLRRKLNEVQSF---SEAQTEMVRTLEQKLEAKMIKEESDYHDLESV 273
Cdd:pfam07888 189 SLSKEFQELRNSLAQRDTQVLQ-----LQDTITTLTQKLTTAHRKeaeNEALLEELRSLQERLNASERKVEGLGEELSSM 263

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462622286 274 VQQKRAVKAENHVVKLK-QEISLLQAQVSNFQRENEA 309
Cdd:pfam07888 264 AAQRDRTQAELHQARLQaAQLTLQLADASLALREGRA 300
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 211-374 4.10e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 4.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  211 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLEQKLEakMIKEESDYHDLESVVQQKRAVKAENHVVKLK 290
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRERLANLERQLEELEAQLEELESKLDELA 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  291 QEISLLQAQVSNFQRENEALRcGQGASLTMVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILKSIDRISEVK 370
Cdd:TIGR02168  337 EELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIERLEARLERLE 413


                   ....
gi 2462622286  371 DEEE 374
Cdd:TIGR02168  414 DRRE 417
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 211-371 4.55e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 4.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 211 DRHLRTLQISYDALKDENSKLRRKLNEVqsfsEAQTEMVRTLEQKLEAKM--IKEESDYHDLESVV--QQKRAVKAENHV 286
Cdd:COG1579    37 EDELAALEARLEAAKTELEDLEKEIKRL----ELEIEEVEARIKKYEEQLgnVRNNKEYEALQKEIesLKRRISDLEDEI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 287 VKLKQEISLLQAQVSNFQRENEALRcgqgASLTMVKQNADVALQNLRVVMNSAQASIKQLVSGAEtlnlvAEILKSIDRI 366
Cdd:COG1579   113 LELMERIEELEEELAELEAELAELE----AELEEKKAELDEELAELEAELEELEAEREELAAKIP-----PELLALYERI 183


                  ....*
gi 2462622286 367 SEVKD 371
Cdd:COG1579   184 RKRKN 188
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 214-375 7.34e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 7.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  214 LRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLEQKLEAKMIKEESDYHDLESVVQQKRAV-----KAENHVVK 288
Cdd:TIGR02168  700 LAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELeerleEAEEELAE 779

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286  289 LKQEISLLQAQVSNFQRENEALRcGQGASLTMVKQNADVALQNLRVVMNSAQA-------SIKQLVSGAETLNLVAEIL- 360
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALR-EALDELRAELTLLNEEAANLRERLESLERriaaterRLEDLEEQIEELSEDIESLa 858

                          170
                   ....*....|....*
gi 2462622286  361 KSIDRISEVKDEEED 375
Cdd:TIGR02168  859 AEIEELEELIEELES 873
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
207-375 1.65e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 207 ESLGDRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEmVRTLEQKLEAKMIKEESDYHDLESVVQQKRAVKAENHV 286
Cdd:COG4717    56 DELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEE-LEELEEELEELEAELEELREELEKLEKLLQLLPLYQEL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 287 VKLKQEISLLQAQVSNFQRENEALRcgqgasltmvkqNADVALQNLRVVMNSAQASIKQL--VSGAETLNLVAEILKSID 364
Cdd:COG4717   135 EALEAELAELPERLEELEERLEELR------------ELEEELEELEAELAELQEELEELleQLSLATEEELQDLAEELE 202

                         170
                  ....*....|.
gi 2462622286 365 RISEVKDEEED 375
Cdd:COG4717   203 ELQQRLAELEE 213
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 197-309 8.96e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 37.95  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622286 197 SPSADFAVHGESLGDRHLRTLQisydaLKDENSKLRRKLNEVQSF---SEAQTEMVRTLEQKLEAKMIKEESDYHDLESV 273
Cdd:pfam07888 189 SLSKEFQELRNSLAQRDTQVLQ-----LQDTITTLTQKLTTAHRKeaeNEALLEELRSLQERLNASERKVEGLGEELSSM 263

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462622286 274 VQQKRAVKAENHVVKLK-QEISLLQAQVSNFQRENEA 309
Cdd:pfam07888 264 AAQRDRTQAELHQARLQaAQLTLQLADASLALREGRA 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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