|
Name |
Accession |
Description |
Interval |
E-value |
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1707-1916 |
2.22e-116 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
:
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 367.23 E-value: 2.22e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1707 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 1785
Cdd:pfam00147 1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1786 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 1857
Cdd:pfam00147 80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1858 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 1916
Cdd:pfam00147 160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
847-1241 |
6.37e-24 |
|
Fibronectin type 3 domain [General function prediction only];
:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 108.94 E-value: 6.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401 183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401 263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401 336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401 416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401 496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573
|
410
....*....|....*
gi 2462624518 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401 574 ITTLGGSLLTTTSTN 588
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1322-1686 |
3.32e-18 |
|
Fibronectin type 3 domain [General function prediction only];
:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 90.83 E-value: 3.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1322 YRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEI-IDSNRLLETVEYNISGAER 1400
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAvAAAPPTATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1401 TAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTaMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS 1480
Cdd:COG3401 104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATA-GTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVAT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1481 -MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VD 1554
Cdd:COG3401 183 tSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdAT 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1555 SYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQS 1627
Cdd:COG3401 263 GYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGS 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1628 ETALLTWRPPRAS-VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1686
Cdd:COG3401 341 SSITLSWTASSDAdVTGYN-VYrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
804-884 |
1.32e-12 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 65.13 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 2462624518 881 SSNP 884
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
713-793 |
7.15e-12 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 7.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....
gi 2462624518 790 TRGP 793
Cdd:pfam00041 80 GEGP 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1257-1336 |
1.92e-11 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1257 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1333
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 2462624518 1334 RTP 1336
Cdd:pfam00041 81 EGP 83
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
624-779 |
5.88e-10 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.25 E-value: 5.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-RELEPGVEYFIRVFAI----L 696
Cdd:COG3401 234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401 311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388
|
....*
gi 2462624518 775 PGQEY 779
Cdd:COG3401 389 PGTTY 393
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
408-435 |
2.22e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 45.75 E-value: 2.22e-06
10 20
....*....|....*....|....*...
gi 2462624518 408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
501-528 |
9.82e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 43.83 E-value: 9.82e-06
10 20
....*....|....*....|....*...
gi 2462624518 501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
190-217 |
1.51e-05 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 43.44 E-value: 1.51e-05
10 20
....*....|....*....|....*...
gi 2462624518 190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
594-621 |
2.81e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 39.97 E-value: 2.81e-04
10 20
....*....|....*....|....*...
gi 2462624518 594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
380-403 |
6.89e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 6.89e-04
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
439-466 |
7.30e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 38.82 E-value: 7.30e-04
10 20
....*....|....*....|....*...
gi 2462624518 439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
346-373 |
1.19e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 38.05 E-value: 1.19e-03
10 20
....*....|....*....|....*...
gi 2462624518 346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
470-496 |
1.20e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 38.05 E-value: 1.20e-03
10 20
....*....|....*....|....*..
gi 2462624518 470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
563-589 |
2.11e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 37.28 E-value: 2.11e-03
10 20
....*....|....*....|....*..
gi 2462624518 563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
535-558 |
3.73e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 3.73e-03
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
252-280 |
5.58e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 36.12 E-value: 5.58e-03
10 20
....*....|....*....|....*....
gi 2462624518 252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720 2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
221-248 |
5.86e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 36.12 E-value: 5.86e-03
10 20
....*....|....*....|....*...
gi 2462624518 221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| Nar1 super family |
cl34792 |
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
277-424 |
8.56e-03 |
|
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
The actual alignment was detected with superfamily member COG4624:
Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 40.78 E-value: 8.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 277 DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCeegftgedcgkptCPHACHTQGRC 356
Cdd:COG4624 3 LLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCC-------------CCCCRCCVAIS 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624518 357 EEGQCVCDEGFaGVDCSEKRCPADCHNRGRCVDgrcECDDGFTGADCGELKcpngcSGHGRCVN-GQCV 424
Cdd:COG4624 70 CIQVRGIIIID-KRGPSIIRDKEKCKNCYPCVR---ACPVKAIKVDDGKAE-----IDEEKCIScGQCV 129
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1707-1916 |
2.22e-116 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 367.23 E-value: 2.22e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1707 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 1785
Cdd:pfam00147 1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1786 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 1857
Cdd:pfam00147 80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1858 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 1916
Cdd:pfam00147 160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
|
|
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1706-1915 |
2.95e-107 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 340.76 E-value: 2.95e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1706 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 1785
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1786 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 1864
Cdd:cd00087 80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2462624518 1865 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1915
Cdd:cd00087 160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1707-1915 |
2.01e-106 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 338.48 E-value: 2.01e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1707 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 1786
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1787 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 1864
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1865 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1915
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
847-1241 |
6.37e-24 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 108.94 E-value: 6.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401 183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401 263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401 336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401 416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401 496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573
|
410
....*....|....*
gi 2462624518 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401 574 ITTLGGSLLTTTSTN 588
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1322-1686 |
3.32e-18 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 90.83 E-value: 3.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1322 YRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEI-IDSNRLLETVEYNISGAER 1400
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAvAAAPPTATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1401 TAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTaMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS 1480
Cdd:COG3401 104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATA-GTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVAT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1481 -MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VD 1554
Cdd:COG3401 183 tSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdAT 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1555 SYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQS 1627
Cdd:COG3401 263 GYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGS 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1628 ETALLTWRPPRAS-VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1686
Cdd:COG3401 341 SSITLSWTASSDAdVTGYN-VYrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1615-1687 |
2.88e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 72.45 E-value: 2.88e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624518 1615 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1687
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
894-976 |
2.53e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77
|
....*..
gi 2462624518 970 EDKESNP 976
Cdd:pfam00041 78 GGGEGPP 84
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1615-1687 |
1.85e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 67.64 E-value: 1.85e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624518 1615 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1687
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
894-978 |
5.41e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 66.37 E-value: 5.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79
|
....*...
gi 2462624518 971 DKESNPAT 978
Cdd:cd00063 80 GGESPPSE 87
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1438-1524 |
8.72e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.98 E-value: 8.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1438 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1513
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2462624518 1514 ESEPV-SGSFTT 1524
Cdd:cd00063 82 ESPPSeSVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
804-884 |
1.32e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 65.13 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 2462624518 881 SSNP 884
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
713-793 |
7.15e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 7.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....
gi 2462624518 790 TRGP 793
Cdd:pfam00041 80 GEGP 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
667-988 |
1.18e-11 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 69.65 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 667 QFRVPGDQTSTIIRELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401 264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401 341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401 418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497
|
330 340
....*....|....*....|....*..
gi 2462624518 962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401 498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
986-1062 |
1.83e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.86 E-value: 1.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2462624518 1061 KS 1062
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1257-1336 |
1.92e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1257 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1333
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 2462624518 1334 RTP 1336
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
624-779 |
5.88e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.25 E-value: 5.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-RELEPGVEYFIRVFAI----L 696
Cdd:COG3401 234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401 311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388
|
....*
gi 2462624518 775 PGQEY 779
Cdd:COG3401 389 PGTTY 393
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
804-882 |
2.14e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2462624518 881 SS 882
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
624-695 |
2.06e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 53.19 E-value: 2.06e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624518 624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
624-710 |
2.71e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.27 E-value: 2.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAILENK 699
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 2462624518 700 KSIPVSARVAT 710
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
713-801 |
1.76e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.96 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|..
gi 2462624518 790 TRGPGLKRVTTT 801
Cdd:cd00063 81 GESPPSESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
713-794 |
2.59e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.92 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79
|
....
gi 2462624518 791 RGPG 794
Cdd:smart00060 80 AGEG 83
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1717-1750 |
4.52e-07 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 47.94 E-value: 4.52e-07
10 20 30
....*....|....*....|....*....|....*
gi 2462624518 1717 NGDTTSGLYTIYLNGD-KAEALEVFCDMTSDGGGW 1750
Cdd:NF040941 9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
408-435 |
2.22e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 45.75 E-value: 2.22e-06
10 20
....*....|....*....|....*...
gi 2462624518 408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
501-528 |
9.82e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 43.83 E-value: 9.82e-06
10 20
....*....|....*....|....*...
gi 2462624518 501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
190-217 |
1.51e-05 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 43.44 E-value: 1.51e-05
10 20
....*....|....*....|....*...
gi 2462624518 190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
624-695 |
8.08e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 42.99 E-value: 8.08e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624518 624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1260-1344 |
2.39e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 41.71 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1260 GDLAVSEVGWDGLRLNWTAADNAY---EHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYR-T 1335
Cdd:cd00063 5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84
|
....*....
gi 2462624518 1336 PVLSAEAST 1344
Cdd:cd00063 85 PSESVTVTT 93
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
594-621 |
2.81e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 39.97 E-value: 2.81e-04
10 20
....*....|....*....|....*...
gi 2462624518 594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
380-403 |
6.89e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 6.89e-04
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
439-466 |
7.30e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.82 E-value: 7.30e-04
10 20
....*....|....*....|....*...
gi 2462624518 439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
346-373 |
1.19e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.05 E-value: 1.19e-03
10 20
....*....|....*....|....*...
gi 2462624518 346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
470-496 |
1.20e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.05 E-value: 1.20e-03
10 20
....*....|....*....|....*..
gi 2462624518 470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
563-589 |
2.11e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 2.11e-03
10 20
....*....|....*....|....*..
gi 2462624518 563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1261-1329 |
3.15e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 38.36 E-value: 3.15e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1261 DLAVSEVGWDGLRLNWTA-ADNAYEHFVIQVQEVNKVEAA--QNLTLPGSLRAVDIPGLEAATPYRVSIYGV 1329
Cdd:smart00060 6 NLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
535-558 |
3.73e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 3.73e-03
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
252-280 |
5.58e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.12 E-value: 5.58e-03
10 20
....*....|....*....|....*....
gi 2462624518 252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720 2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
409-434 |
5.74e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.08 E-value: 5.74e-03
10 20 30
....*....|....*....|....*....|
gi 2462624518 409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054 8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
221-248 |
5.86e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.12 E-value: 5.86e-03
10 20
....*....|....*....|....*...
gi 2462624518 221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| Nar1 |
COG4624 |
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
277-424 |
8.56e-03 |
|
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 40.78 E-value: 8.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 277 DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCeegftgedcgkptCPHACHTQGRC 356
Cdd:COG4624 3 LLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCC-------------CCCCRCCVAIS 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624518 357 EEGQCVCDEGFaGVDCSEKRCPADCHNRGRCVDgrcECDDGFTGADCGELKcpngcSGHGRCVN-GQCV 424
Cdd:COG4624 70 CIQVRGIIIID-KRGPSIIRDKEKCKNCYPCVR---ACPVKAIKVDDGKAE-----IDEEKCIScGQCV 129
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
284-311 |
9.04e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 35.74 E-value: 9.04e-03
10 20
....*....|....*....|....*...
gi 2462624518 284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
471-496 |
9.97e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 35.69 E-value: 9.97e-03
10 20 30
....*....|....*....|....*....|
gi 2462624518 471 PNDCHQHGRCVNGM----CVCDDGYTGEDC 496
Cdd:cd00054 8 GNPCQNGGTCVNTVgsyrCSCPPGYTGRNC 37
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1707-1916 |
2.22e-116 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 367.23 E-value: 2.22e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1707 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 1785
Cdd:pfam00147 1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1786 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 1857
Cdd:pfam00147 80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1858 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 1916
Cdd:pfam00147 160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
|
|
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1706-1915 |
2.95e-107 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 340.76 E-value: 2.95e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1706 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 1785
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1786 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 1864
Cdd:cd00087 80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2462624518 1865 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1915
Cdd:cd00087 160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1707-1915 |
2.01e-106 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 338.48 E-value: 2.01e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1707 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 1786
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1787 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 1864
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1865 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 1915
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
847-1241 |
6.37e-24 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 108.94 E-value: 6.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401 183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401 263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401 336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401 416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401 496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573
|
410
....*....|....*
gi 2462624518 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401 574 ITTLGGSLLTTTSTN 588
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1322-1686 |
3.32e-18 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 90.83 E-value: 3.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1322 YRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEI-IDSNRLLETVEYNISGAER 1400
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAvAAAPPTATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1401 TAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTaMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS 1480
Cdd:COG3401 104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATA-GTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVAT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1481 -MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VD 1554
Cdd:COG3401 183 tSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdAT 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1555 SYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQS 1627
Cdd:COG3401 263 GYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGS 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1628 ETALLTWRPPRAS-VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1686
Cdd:COG3401 341 SSITLSWTASSDAdVTGYN-VYrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1615-1687 |
2.88e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 72.45 E-value: 2.88e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624518 1615 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1687
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
894-976 |
2.53e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77
|
....*..
gi 2462624518 970 EDKESNP 976
Cdd:pfam00041 78 GGGEGPP 84
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1615-1687 |
1.85e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 67.64 E-value: 1.85e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624518 1615 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1687
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1075-1154 |
2.29e-13 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 67.05 E-value: 2.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1075 PELENLTVTEVGWDGLRLNWTAADQ---AYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGY 1151
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 2462624518 1152 RTP 1154
Cdd:pfam00041 81 EGP 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1438-1517 |
2.47e-13 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 67.05 E-value: 2.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1438 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1513
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 2462624518 1514 ESEP 1517
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
986-1064 |
2.67e-13 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 67.05 E-value: 2.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYSLPTGQ--WVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 2462624518 1061 KSKP 1064
Cdd:pfam00041 81 EGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
894-978 |
5.41e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 66.37 E-value: 5.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79
|
....*...
gi 2462624518 971 DKESNPAT 978
Cdd:cd00063 80 GGESPPSE 87
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1438-1524 |
8.72e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.98 E-value: 8.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1438 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1513
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2462624518 1514 ESEPV-SGSFTT 1524
Cdd:cd00063 82 ESPPSeSVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
804-884 |
1.32e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 65.13 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 2462624518 881 SSNP 884
Cdd:pfam00041 81 EGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
986-1065 |
3.10e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 3.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYS-LPTGQWVGVQLPR-NTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*
gi 2462624518 1061 KSKPA 1065
Cdd:cd00063 82 ESPPS 86
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1615-1700 |
3.25e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.05 E-value: 3.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1615 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYTAKIQALNGPL 1689
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2462624518 1690 RSNMIQTI-FTT 1700
Cdd:cd00063 82 ESPPSESVtVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
713-793 |
7.15e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 7.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....
gi 2462624518 790 TRGP 793
Cdd:pfam00041 80 GEGP 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
667-988 |
1.18e-11 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 69.65 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 667 QFRVPGDQTSTIIRELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401 264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401 341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401 418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497
|
330 340
....*....|....*....|....*..
gi 2462624518 962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401 498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1169-1241 |
1.32e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.05 E-value: 1.32e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624518 1169 GEVVVAEVGWDALKLNWTAPE---GAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQD 1241
Cdd:pfam00041 4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
986-1062 |
1.83e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.86 E-value: 1.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2462624518 1061 KS 1062
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1257-1336 |
1.92e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1257 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1333
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 2462624518 1334 RTP 1336
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
804-891 |
2.33e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.74 E-value: 2.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2462624518 881 SSNPAK-ETFTT 891
Cdd:cd00063 82 ESPPSEsVTVTT 93
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1416-1687 |
1.37e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 66.18 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1416 YLSGLAPSIRTKTISATATTAMGSPKEVIFSDITENSATVSW---RAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTR 1492
Cdd:COG3401 28 KAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTggrAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGAT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1493 LVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTV 1572
Cdd:COG3401 108 NTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1573 SGNTVEYALTDLEPATEYTLRIFA---EKGPQKSSTITA-KFTTDLDSPRDLTATEVQSETALLTWRP-PRASVTGYLLV 1647
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAAtdtGGESAPSNEVSVtTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVY 267
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462624518 1648 YESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1687
Cdd:COG3401 268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA 307
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1529-1599 |
2.28e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.58 E-value: 2.28e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624518 1529 PSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKG 1599
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
624-779 |
5.88e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.25 E-value: 5.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-RELEPGVEYFIRVFAI----L 696
Cdd:COG3401 234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401 311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388
|
....*
gi 2462624518 775 PGQEY 779
Cdd:COG3401 389 PGTTY 393
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
894-974 |
6.44e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.24 E-value: 6.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 894 DAPRNLRRVSQTDNSITLEWR-----NGKAAIDSYRIKYAPiSGGDHAEVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAV 968
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYRE-EGSEWKEVNVTPS---STSYTLTGLKPGTEYEFRVRAV 77
|
....*.
gi 2462624518 969 KEDKES 974
Cdd:smart00060 78 NGAGEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
804-882 |
2.14e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2462624518 881 SS 882
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1348-1417 |
2.73e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 55.50 E-value: 2.73e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624518 1348 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1417
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1438-1515 |
4.37e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 54.93 E-value: 4.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1438 GSPKEVIFSDITENSATVSWRAPT-AQVESFRITYVPITGGTPS---MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1513
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2462624518 1514 ES 1515
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
624-695 |
2.06e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 53.19 E-value: 2.06e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624518 624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
624-710 |
2.71e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.27 E-value: 2.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAILENK 699
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 2462624518 700 KSIPVSARVAT 710
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1527-1603 |
4.51e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 52.23 E-value: 4.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1527 DGPSGLVTANITDSEALARWQ-PAIATVDSYVISYTGEKVPEITR----TVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 1601
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEGSEwkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2462624518 1602 KS 1603
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1527-1612 |
1.30e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 51.34 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1527 DGPSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 1601
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2462624518 1602 KS-STITAKFTT 1612
Cdd:cd00063 82 ESpPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
713-801 |
1.76e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.96 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|..
gi 2462624518 790 TRGPGLKRVTTT 801
Cdd:cd00063 81 GESPPSESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
713-794 |
2.59e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.92 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79
|
....
gi 2462624518 791 RGPG 794
Cdd:smart00060 80 AGEG 83
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1717-1750 |
4.52e-07 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 47.94 E-value: 4.52e-07
10 20 30
....*....|....*....|....*....|....*
gi 2462624518 1717 NGDTTSGLYTIYLNGD-KAEALEVFCDMTSDGGGW 1750
Cdd:NF040941 9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
408-435 |
2.22e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 45.75 E-value: 2.22e-06
10 20
....*....|....*....|....*...
gi 2462624518 408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1111-1505 |
5.01e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 51.54 E-value: 5.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1111 ANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGV-IQGYRTPVLSAEASTGETPNL--GEVVVAEVGWDALKLNWTA 1187
Cdd:COG3401 176 ATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATdTGGESAPSNEVSVTTPTTPPSapTGLTATADTPGSVTLSWDP 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1188 PEGAY-EYFFIQVQEADTVEAAQnLTVPGGLRSTDlPGLKAATHYTITIRGVTQDFSTTPLSVEV-LTEDLPQLG---DL 1262
Cdd:COG3401 256 VTESDaTGYRVYRSNSGDGPFTK-VATVTTTSYTD-TGLTNGTTYYYRVTAVDAAGNESAPSNVVsVTTDLTPPAapsGL 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1263 AVSEVGWDGLRLNWTAADNAYE-HFVI--------QVQEVNKVEAAQNLT----LPG-----SLRAVDIPGLEAATPYRV 1324
Cdd:COG3401 334 TATAVGSSSITLSWTASSDADVtGYNVyrstsgggTYTKIAETVTTTSYTdtglTPGttyyyKVTAVDAAGNESAPSEEV 413
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1325 SIYGVIrGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSW-----MATDGIFETFTIEIIDSNRLLETVEYNISGAE 1399
Cdd:COG3401 414 SATTAS-AASGESLTASVDAVPLTDVAGATAAASAASNPGVSAavladGGDTGNAVPFTTTSSTVTATTTDTTTANLSVT 492
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1400 RTAHISGLPPSTDfivylsglapSIRTKTISATATTAMGSPKEVIFSDITENSATVSWRAPTAQvesfrITYVPITGGTP 1479
Cdd:COG3401 493 TGSLVGGSGASSV----------TNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVL-----ITDLVSLTTSA 557
|
410 420
....*....|....*....|....*.
gi 2462624518 1480 SMVTVDGTKTQTRLVKLIPGVEYLVS 1505
Cdd:COG3401 558 SSSVSGAGLGSGNLYLITTLGGSLLT 583
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1078-1162 |
5.26e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.72 E-value: 5.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1078 ENLTVTEVGWDGLRLNWTAADQAY---EHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYR-T 1153
Cdd:cd00063 5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84
|
....*....
gi 2462624518 1154 PVLSAEAST 1162
Cdd:cd00063 85 PSESVTVTT 93
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
501-528 |
9.82e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 43.83 E-value: 9.82e-06
10 20
....*....|....*....|....*...
gi 2462624518 501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
190-217 |
1.51e-05 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 43.44 E-value: 1.51e-05
10 20
....*....|....*....|....*...
gi 2462624518 190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1171-1253 |
2.71e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.41 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1171 VVVAEVGWDALKLNWTAPE---GAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPL 1247
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86
|
....*.
gi 2462624518 1248 SVEVLT 1253
Cdd:cd00063 87 ESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1171-1240 |
4.91e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 43.37 E-value: 4.91e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624518 1171 VVVAEVGWDALKLNWTAPEGAYEYFFI---QVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQ 1240
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGITGYIvgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1078-1147 |
5.00e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 43.37 E-value: 5.00e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624518 1078 ENLTVTEVGWDGLRLNWTA-ADQAYEHFIIQVQEANKVEAAR--NLTVPGSLRAVDIPGLKAATPYTVSIYGV 1147
Cdd:smart00060 5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEwkEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
624-695 |
8.08e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 42.99 E-value: 8.08e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624518 624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1260-1344 |
2.39e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 41.71 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1260 GDLAVSEVGWDGLRLNWTAADNAY---EHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYR-T 1335
Cdd:cd00063 5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84
|
....*....
gi 2462624518 1336 PVLSAEAST 1344
Cdd:cd00063 85 PSESVTVTT 93
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
868-1239 |
2.80e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 46.09 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 868 EYEVSL--ISRRGDMSSNPAKETFTTGLD-----APRNLRrVSQTDNSITLEWRNGK-AAIDSYRIKYAPisGGDHAEVD 939
Cdd:COG4733 598 DYEVRVraINALGVSSAWAASSETTVTGKtapppAPTGLT-ATGGLGGITLSWSFPVdADTLRTEIRYST--TGDWASAT 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 940 VPKSQQATTKTTLTGLRPGTEYGIGVSAVkeDKESN--PATINAATELDTPKDLQVSETAETsltllwKTPLAKfdryRL 1017
Cdd:COG4733 675 VAQALYPGNTYTLAGLKAGQTYYYRARAV--DRSGNvsAWWVSGQASADAAGILDAITGQIL------ETELGQ----EL 742
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1018 NYSLPTGQWVGVQLPRNTTsyvlrglepgqeynvlLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAA 1097
Cdd:COG4733 743 DAIIQNATVAEVVAATVTD----------------VTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAAD 806
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1098 DQAYEH-FIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEV 1176
Cdd:COG4733 807 AAGDASgGVTAGTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADV 886
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462624518 1177 GWDALKLNWTAPEGAYEY--FFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVT 1239
Cdd:COG4733 887 SAVADSTAASLTAIVIAAttIIDAIGDGTTREPAGDIGASGGAQGFAVTIVGSFDGAGAVATVDA 951
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
594-621 |
2.81e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 39.97 E-value: 2.81e-04
10 20
....*....|....*....|....*...
gi 2462624518 594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| fn3_2 |
pfam16893 |
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ... |
713-783 |
4.26e-04 |
|
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.
Pssm-ID: 435634 Cd Length: 89 Bit Score: 41.03 E-value: 4.26e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624518 713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWE--IIFRNMNKedEGEITKSLRRpeTSYRQTGLAPGQEYEISL 783
Cdd:pfam16893 3 PKAPVLKVRNVTQTSVVLEWDPLELGTAKLKslDLYRNGQR--LGVIPNPLTN--TSTKLSGLSVDTEYTFQL 71
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
380-403 |
6.89e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 6.89e-04
|
| YjdB |
COG5492 |
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
1081-1668 |
7.26e-04 |
|
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only];
Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 44.68 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1081 TVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEA 1160
Cdd:COG5492 34 SSVTANLSVLASNDTSTTSSVASVVSTAGSGGTANTSSTVAVSGAALAAGAVSTVGVDATTVAQTVATASLEAGGVSSTG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1161 STGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQ 1240
Cdd:COG5492 114 TGTATTETVGTAATADAQIVKAASTGSGSVTAAVAVGSVGVASAGTSVTTTVATATSASLVSTLVVTSVGLTTASGSLNT 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1241 ----DFSTTPLSVEVLTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGL 1316
Cdd:COG5492 194 vvvtSVVGNGATDASTASAVVAAVTAVTSAGSLTSAASVTTAGDDGTGVVATTVTTTISTSSSTTLTVTGATSSASTLGS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1317 EAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEiidsnrlleTVEYNIS 1396
Cdd:COG5492 274 GSTTSTNTVTAGVGDTGVSVAVASSSAATTSAVVGTLSSSGGGGGVVTAAATTGVTVVTASSVA---------TTVDVVP 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1397 gaerTAHISGLPPSTDFIVylsGlapsiRTKTISATATTAMGSPKEVIFSDITENSATVSwraPTAQVE-----SFRITY 1471
Cdd:COG5492 345 ----VTGVTLNPTSVTLAV---G-----QTLTLTATVTPANATNKNVTWSSSDPSVATVD---SNGLVTavaagTATITA 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1472 vpitggtpsmVTVDGTKTQT---RLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQP 1548
Cdd:COG5492 410 ----------TTKDGGKTATctvTVTAAGSTGTVVVVSLAATSAVSASVVLTPAGTVNAGASTASLNVNATDGVSTTVGV 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1549 AIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSE 1628
Cdd:COG5492 480 ANVVSAVTVTASVAEVATSVGGGATVTVTVSTAATVTVTVGVKSTGIAVAGSTGILAGIVLSGSAKGDVAGGATLVDAGT 559
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 2462624518 1629 TALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYS 1668
Cdd:COG5492 560 ADVGGTTSTTTSVTDASVVSLTGSTSSTGVGVGGTTATGT 599
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
439-466 |
7.30e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.82 E-value: 7.30e-04
10 20
....*....|....*....|....*...
gi 2462624518 439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
377-403 |
7.44e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.43 E-value: 7.44e-04
10 20
....*....|....*....|....*..
gi 2462624518 377 CPADCHNRGRCVDGRCECDDGFTGADC 403
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
412-434 |
9.06e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 9.06e-04
|
| COG3979 |
COG3979 |
Chitodextrinase [Carbohydrate transport and metabolism]; |
1529-1899 |
1.12e-03 |
|
Chitodextrinase [Carbohydrate transport and metabolism];
Pssm-ID: 443178 [Multi-domain] Cd Length: 369 Bit Score: 43.61 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1529 PSGLVTANITDSEALARWQPAIAT--VDSYVISYTGEKVpeitRTVSGNTvEYALTDLEPATEYTLrifaekgpqkssTI 1606
Cdd:COG3979 6 PTGLTASNVTSSSVSLSWDASTDNvgVTGYDVYRGGDQV----ATVTGLT-AWTVTGLTPGTEYTF------------TV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1607 TAKFTTDLDSPR--DLTATEVQSETALLTWRPPRASVTGYllvyeSVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQA 1684
Cdd:COG3979 69 GACDAAGNVSAAsgTSTAMFGGSSTTLGSAEGVADTSGNL-----AASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1685 LNGplRSNMIQTIFTTIGLLYPFPKDcsQAMLNGDTTSGLYTIYLNGDKAEALEVFC------DMTSDGGGWIVFLRRKN 1758
Cdd:COG3979 144 GTG--GSGGTTTIITTGVEGGGGSKT--AQSLNAITAAGTAALNGGVVGGADEVLTCsavkddGSGGAGAGNTYWALNTL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1759 G------RENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEG 1832
Cdd:COG3979 220 GvsdtpsGTTATGGTVGITSAYGAGVSGNAAVNVNAGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAAN 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462624518 1833 YSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHW 1899
Cdd:COG3979 300 GPTGGYGATGTTVAGAAGVGGTKSGTGALGLSGAGGAGAAVSGTATGDDDAGADDSTAGVSGAGSTT 366
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
346-373 |
1.19e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.05 E-value: 1.19e-03
10 20
....*....|....*....|....*...
gi 2462624518 346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
470-496 |
1.20e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.05 E-value: 1.20e-03
10 20
....*....|....*....|....*..
gi 2462624518 470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
473-496 |
1.34e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.34e-03
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
563-589 |
2.11e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 2.11e-03
10 20
....*....|....*....|....*..
gi 2462624518 563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1261-1329 |
3.15e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 38.36 E-value: 3.15e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624518 1261 DLAVSEVGWDGLRLNWTA-ADNAYEHFVIQVQEVNKVEAA--QNLTLPGSLRAVDIPGLEAATPYRVSIYGV 1329
Cdd:smart00060 6 NLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
535-558 |
3.73e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 3.73e-03
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
504-527 |
3.76e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 3.76e-03
|
| COG3979 |
COG3979 |
Chitodextrinase [Carbohydrate transport and metabolism]; |
895-1242 |
4.28e-03 |
|
Chitodextrinase [Carbohydrate transport and metabolism];
Pssm-ID: 443178 [Multi-domain] Cd Length: 369 Bit Score: 41.68 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 895 APRNLRRVSQTDNSITLEWRngkAAIDSYRIKYAPI-SGGDhaEVDVPKSQqatTKTTLTGLRPGTEYGIGVSAVkeDKE 973
Cdd:COG3979 5 APTGLTASNVTSSSVSLSWD---ASTDNVGVTGYDVyRGGD--QVATVTGL---TAWTVTGLTPGTEYTFTVGAC--DAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 974 SN----PATINAATELDTPKDLQVSETAETSLTllWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEY 1049
Cdd:COG3979 75 GNvsaaSGTSTAMFGGSSTTLGSAEGVADTSGN--LAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSGGTT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1050 NVLLTAEKGRHKSKPARVKASTEQAPelenlTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAV 1129
Cdd:COG3979 153 TIITTGVEGGGGSKTAQSLNAITAAG-----TAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 1130 DIPGLKAATPYTVSIYGVIQGYRTPV--LSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEA 1207
Cdd:COG3979 228 TTATGGTVGITSAYGAGVSGNAAVNVnaGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAANGPTGGYGA 307
|
330 340 350
....*....|....*....|....*....|....*
gi 2462624518 1208 AQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDF 1242
Cdd:COG3979 308 TGTTVAGAAGVGGTKSGTGALGLSGAGGAGAAVSG 342
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
252-280 |
5.58e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.12 E-value: 5.58e-03
10 20
....*....|....*....|....*....
gi 2462624518 252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720 2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
409-434 |
5.74e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.08 E-value: 5.74e-03
10 20 30
....*....|....*....|....*....|
gi 2462624518 409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054 8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
221-248 |
5.86e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.12 E-value: 5.86e-03
10 20
....*....|....*....|....*...
gi 2462624518 221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| Nar1 |
COG4624 |
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
277-424 |
8.56e-03 |
|
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 40.78 E-value: 8.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624518 277 DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCeegftgedcgkptCPHACHTQGRC 356
Cdd:COG4624 3 LLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCC-------------CCCCRCCVAIS 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624518 357 EEGQCVCDEGFaGVDCSEKRCPADCHNRGRCVDgrcECDDGFTGADCGELKcpngcSGHGRCVN-GQCV 424
Cdd:COG4624 70 CIQVRGIIIID-KRGPSIIRDKEKCKNCYPCVR---ACPVKAIKVDDGKAE-----IDEEKCIScGQCV 129
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
284-311 |
9.04e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 35.74 E-value: 9.04e-03
10 20
....*....|....*....|....*...
gi 2462624518 284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
471-496 |
9.97e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 35.69 E-value: 9.97e-03
10 20 30
....*....|....*....|....*....|
gi 2462624518 471 PNDCHQHGRCVNGM----CVCDDGYTGEDC 496
Cdd:cd00054 8 GNPCQNGGTCVNTVgsyrCSCPPGYTGRNC 37
|
|
| |
