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Conserved domains on  [gi|2462625184|ref|XP_054219172|]
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nicotinamide riboside kinase 1 isoform X3 [Homo sapiens]

Protein Classification

nicotinamide riboside kinase( domain architecture ID 10113996)

nicotinamide riboside kinase catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 12-140 1.30e-65

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


:

Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 199.09  E-value: 1.30e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  12 ISCVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESA--RHSVVST- 88
Cdd:cd02024     4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfPKFLRSHg 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  89 --------------------DQESAEEIPILIIEGFLLFNYN------------------------TRVYQP------PD 118
Cdd:cd02024    84 nendpekefiedaqieetkaDLLGAEDLHILIVDGFLLYNYKplvdlfdiryflrvpyetckrrreARTGYVtlegfwPD 163

                         170       180
                  ....*....|....*....|..
gi 2462625184 119 SPGYFDGHVWPMYLKYRQEMQD 140
Cdd:cd02024   164 PPGYFDGHVWPMYLKHHAEMFE 185
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 12-140 1.30e-65

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 199.09  E-value: 1.30e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  12 ISCVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESA--RHSVVST- 88
Cdd:cd02024     4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfPKFLRSHg 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  89 --------------------DQESAEEIPILIIEGFLLFNYN------------------------TRVYQP------PD 118
Cdd:cd02024    84 nendpekefiedaqieetkaDLLGAEDLHILIVDGFLLYNYKplvdlfdiryflrvpyetckrrreARTGYVtlegfwPD 163

                         170       180
                  ....*....|....*....|..
gi 2462625184 119 SPGYFDGHVWPMYLKYRQEMQD 140
Cdd:cd02024   164 PPGYFDGHVWPMYLKHHAEMFE 185
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 18-109 2.14e-14

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 67.94  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  18 SGKTTLAKNLQKHLP--NCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWmeSARHSVV------STD 89
Cdd:COG0572    18 SGKTTFARRLAEQLGadKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPL--KAGESVElpvydfATG 95

                          90       100
                  ....*....|....*....|....*
gi 2462625184  90 QESAEEI-----PILIIEGFLLFNY 109
Cdd:COG0572    96 TRSGETVkvepaDVIIVEGIHALND 120
AAA_18 pfam13238
AAA domain;
18-113 7.25e-07

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 46.27  E-value: 7.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  18 SGKTTLAKNLQKHLpNCSVISQDDFFKPESEIETDKNgflqYDVLEALNMEKMMSAISCWMESArhsvvstdqeSAEEIP 97
Cdd:pfam13238   9 VGKTTLAKELSKRL-GFGDNVRDLALENGLVLGDDPE----TRESKRLDEDKLDRLLDLLEENA----------ALEEGG 73

                          90
                  ....*....|....*.
gi 2462625184  98 ILIIEGFLLFNYNTRV 113
Cdd:pfam13238  74 NLIIDGHLAELEPERA 89
PRK06762 PRK06762
hypothetical protein; Provisional
 8-40 5.17e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 38.80  E-value: 5.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462625184   8 RGNviscvTNSGKTTLAKNLQKHL-PNCSVISQD 40
Cdd:PRK06762    8 RGN-----SGSGKTTIAKQLQERLgRGTLLVSQD 36
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 12-140 1.30e-65

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 199.09  E-value: 1.30e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  12 ISCVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESA--RHSVVST- 88
Cdd:cd02024     4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfPKFLRSHg 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  89 --------------------DQESAEEIPILIIEGFLLFNYN------------------------TRVYQP------PD 118
Cdd:cd02024    84 nendpekefiedaqieetkaDLLGAEDLHILIVDGFLLYNYKplvdlfdiryflrvpyetckrrreARTGYVtlegfwPD 163

                         170       180
                  ....*....|....*....|..
gi 2462625184 119 SPGYFDGHVWPMYLKYRQEMQD 140
Cdd:cd02024   164 PPGYFDGHVWPMYLKHHAEMFE 185
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 18-109 2.14e-14

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 67.94  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  18 SGKTTLAKNLQKHLP--NCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWmeSARHSVV------STD 89
Cdd:COG0572    18 SGKTTFARRLAEQLGadKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPL--KAGESVElpvydfATG 95

                          90       100
                  ....*....|....*....|....*
gi 2462625184  90 QESAEEI-----PILIIEGFLLFNY 109
Cdd:COG0572    96 TRSGETVkvepaDVIIVEGIHALND 120
AAA_18 pfam13238
AAA domain;
18-113 7.25e-07

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 46.27  E-value: 7.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  18 SGKTTLAKNLQKHLpNCSVISQDDFFKPESEIETDKNgflqYDVLEALNMEKMMSAISCWMESArhsvvstdqeSAEEIP 97
Cdd:pfam13238   9 VGKTTLAKELSKRL-GFGDNVRDLALENGLVLGDDPE----TRESKRLDEDKLDRLLDLLEENA----------ALEEGG 73

                          90
                  ....*....|....*.
gi 2462625184  98 ILIIEGFLLFNYNTRV 113
Cdd:pfam13238  74 NLIIDGHLAELEPERA 89
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 16-113 2.56e-05

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 42.93  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  16 TNSGKTTLAKNLQKHLPN--CSVISQDDFFKPES--EIETDKNGF----------LQYDVLEALnmeKMMSAISCWMESA 81
Cdd:cd02023     8 SGSGKTTVAEEIIEQLGNpkVVIISQDSYYKDLSheELEERKNNNydhpdafdfdLLISHLQDL---KNGKSVEIPVYDF 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462625184  82 RHSVVSTDQESAEEIPILIIEGFLLFnYNTRV 113
Cdd:cd02023    85 KTHSRLKETVTVYPADVIILEGILAL-YDKEL 115
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 18-66 2.21e-04

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 39.98  E-value: 2.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462625184  18 SGKTTLAKNLQKHL----PNCSVISQDDFFKPEsEIETDKNGFlqYDV-----LEALN 66
Cdd:cd02028    10 SGKTTFAKKLSNQLrvngIGPVVISLDDYYVPR-KTPRDEDGN--YDFesildLDLLN 64
PRK06762 PRK06762
hypothetical protein; Provisional
 8-40 5.17e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 38.80  E-value: 5.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462625184   8 RGNviscvTNSGKTTLAKNLQKHL-PNCSVISQD 40
Cdd:PRK06762    8 RGN-----SGSGKTTIAKQLQERLgRGTLLVSQD 36
Cas10d_I-D cd09712
CRISPR/Cas system-associated protein Cas10d; CRISPR (Clustered Regularly Interspaced Short ...
 81-174 3.92e-03

CRISPR/Cas system-associated protein Cas10d; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain. Fused to N-terminal HD domain; signature gene for I-D subtype; also known as Csc3 family


Pssm-ID: 187843  Cd Length: 900  Bit Score: 37.19  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625184  81 ARHSVVSTDQESAEEIpiliIEGFllfnyNTRVYQPPDSPGYFDGHVWPmylkYRQEMQDITWEVVYLDGTKSEEDLFLQ 160
Cdd:cd09712   379 DRHPGATSVLEEIQEF----LQYF-----GDRLATWAEEEGYESEIQSP----TRQIFEDYLDEYLSIQGWESDHQAFYQ 445

                          90
                  ....*....|....
gi 2462625184 161 VYEDLIQelAKQKC 174
Cdd:cd09712   446 ELENYNN--AKTKK 457
PanK cd02025
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4 ...
 18-72 7.54e-03

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in CoA biosynthesis.


Pssm-ID: 238983  Cd Length: 220  Bit Score: 35.75  E-value: 7.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462625184  18 SGKTTLAKNLQKHL------PNCSVISQDDFFKPESEIET----DKNGFlqydvLEALNMEKMMS 72
Cdd:cd02025    10 VGKSTTARVLQALLsrwpdhPNVELITTDGFLYPNKELIErglmDRKGF-----PESYDMEALLK 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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