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Conserved domains on  [gi|2462517138|ref|XP_054220837|]
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A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc super family cl00064
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 1-148 2.61e-62

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


The actual alignment was detected with superfamily member cd04273:

Pssm-ID: 469599  Cd Length: 207  Bit Score: 209.40  E-value: 2.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138   1 MVGYRQSLSLIeRGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF----GPSGMQGYAPVTGMCHPLRSCALN 76
Cdd:cd04273    55 VLEDEESGLLI-SGNAQKSLKSFCRWQKKLNPPNDSDPEHHDHAILLTRQDIcrsnGNCDTLGLAPVGGMCSPSRSCSIN 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517138  77 HEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLL 148
Cdd:cd04273   134 EDTGLSSAFTIAHELGHVLGMPHDGDGNSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGdgNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 406-520 2.08e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 110.36  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 406 TVKGTLGKAsKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNqVTGSFILNPKGK-EATSRTFTAMGLEWEDAV-EDA 483
Cdd:pfam05986   1 TVSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462517138 484 KESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 520
Cdd:pfam05986  79 LEELHAPGPTQEDLEIQVLRQYGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 163-232 8.10e-22

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 89.71  E-value: 8.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 163 PGINYSMDEQCRFDFGSGYQTCLAFrTFEPCKQLWCSHPDNPYfCKTKKGPPLDGTECAPGKWCFKGHCI 232
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 246-298 2.33e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 71.08  E-value: 2.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517138  246 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRPCLGPMFEYQVCNSEECP 298
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 542-597 1.82e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 1.82e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517138 542 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPkPIRRRCNQHPC 597
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 663-712 6.30e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 6.30e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517138 663 WRLGAWSQCSATCGEGIQQRQVVCR------TNANSLghCEGD-RPDTVQVCSLPAC 712
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsIVPDSE--CSAQkKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 300-404 7.71e-08

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 51.63  E-value: 7.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 300 TYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAqkCELICQSADTGDVVFMNQVVHDGTRCSYRDP----- 367
Cdd:pfam19236   1 TQLEFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgt 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462517138 368 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHC 404
Cdd:pfam19236  79 LSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 602-659 7.96e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 7.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517138 602 WVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkVMPAKACAGD-RPEARRPCLRVPC 659
Cdd:pfam19030   1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGS---IVPDSECSAQkKPPETQSCNLKPC 55
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 800-914 5.20e-04

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 800 TSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQ-HPFAPETPIPGASWSISPTTPGGL 878
Cdd:PRK07764  600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPkHVAVPDASDGGDGWPAKAGGAAPA 679

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462517138 879 PWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT 914
Cdd:PRK07764  680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 1-148 2.61e-62

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 209.40  E-value: 2.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138   1 MVGYRQSLSLIeRGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF----GPSGMQGYAPVTGMCHPLRSCALN 76
Cdd:cd04273    55 VLEDEESGLLI-SGNAQKSLKSFCRWQKKLNPPNDSDPEHHDHAILLTRQDIcrsnGNCDTLGLAPVGGMCSPSRSCSIN 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517138  77 HEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLL 148
Cdd:cd04273   134 EDTGLSSAFTIAHELGHVLGMPHDGDGNSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGdgNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 406-520 2.08e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 110.36  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 406 TVKGTLGKAsKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNqVTGSFILNPKGK-EATSRTFTAMGLEWEDAV-EDA 483
Cdd:pfam05986   1 TVSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462517138 484 KESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 520
Cdd:pfam05986  79 LEELHAPGPTQEDLEIQVLRQYGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 163-232 8.10e-22

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 89.71  E-value: 8.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 163 PGINYSMDEQCRFDFGSGYQTCLAFrTFEPCKQLWCSHPDNPYfCKTKKGPPLDGTECAPGKWCFKGHCI 232
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKCV 68
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 14-151 9.25e-20

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 88.13  E-value: 9.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  14 GNPSRSLEQVCRWahsQQRQDPSHAEHhDHVVFLTRQDFGpSGMQGYAPVTGMCHPLRSCALN---HEDGFSSAFVIAHE 90
Cdd:pfam01421  64 GDANDTLRNFLKW---RQEYLKKRKPH-DVAQLLSGVEFG-GTTVGAAYVGGMCSLEYSGGVNedhSKNLESFAVTMAHE 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517138  91 TGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRfHWSRCSKLELSRYLPSYD--CLLDDP 151
Cdd:pfam01421 139 LGHNLGMQHDDFNGGCKCPPGGGCIMNPSAGSSFPR-KFSNCSQEDFEQFLTKQKgaCLFNKP 200
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 246-298 2.33e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 71.08  E-value: 2.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517138  246 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRPCLGPMFEYQVCNSEECP 298
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 542-597 1.82e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 1.82e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517138 542 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPkPIRRRCNQHPC 597
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 663-712 6.30e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 6.30e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517138 663 WRLGAWSQCSATCGEGIQQRQVVCR------TNANSLghCEGD-RPDTVQVCSLPAC 712
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsIVPDSE--CSAQkKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 300-404 7.71e-08

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 51.63  E-value: 7.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 300 TYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAqkCELICQSADTGDVVFMNQVVHDGTRCSYRDP----- 367
Cdd:pfam19236   1 TQLEFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgt 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462517138 368 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHC 404
Cdd:pfam19236  79 LSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP_1 pfam00090
Thrombospondin type 1 domain;
247-297 7.75e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.34  E-value: 7.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462517138 247 SSWTKFGSCSRSCGGGVRSRSRSCNNPSPayGGRPCLGPMFEYQVCNSEEC 297
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 602-659 7.96e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 7.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517138 602 WVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkVMPAKACAGD-RPEARRPCLRVPC 659
Cdd:pfam19030   1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGS---IVPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 666-712 6.45e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.81  E-value: 6.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462517138  666 GAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTvQVCSLPAC 712
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGggPCTGEDVET-RACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 601-660 1.55e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  601 VWVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkvmPAKACAGDRPEaRRPCLRVPCP 660
Cdd:smart00209   1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQN-----GGGPCTGEDVE-TRACNEQPCP 53
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 800-914 5.20e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 800 TSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQ-HPFAPETPIPGASWSISPTTPGGL 878
Cdd:PRK07764  600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPkHVAVPDASDGGDGWPAKAGGAAPA 679

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462517138 879 PWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT 914
Cdd:PRK07764  680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 1-148 2.61e-62

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 209.40  E-value: 2.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138   1 MVGYRQSLSLIeRGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF----GPSGMQGYAPVTGMCHPLRSCALN 76
Cdd:cd04273    55 VLEDEESGLLI-SGNAQKSLKSFCRWQKKLNPPNDSDPEHHDHAILLTRQDIcrsnGNCDTLGLAPVGGMCSPSRSCSIN 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517138  77 HEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLL 148
Cdd:cd04273   134 EDTGLSSAFTIAHELGHVLGMPHDGDGNSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGdgNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 406-520 2.08e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 110.36  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 406 TVKGTLGKAsKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNqVTGSFILNPKGK-EATSRTFTAMGLEWEDAV-EDA 483
Cdd:pfam05986   1 TVSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462517138 484 KESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 520
Cdd:pfam05986  79 LEELHAPGPTQEDLEIQVLRQYGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 163-232 8.10e-22

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 89.71  E-value: 8.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 163 PGINYSMDEQCRFDFGSGYQTCLAFrTFEPCKQLWCSHPDNPYfCKTKKGPPLDGTECAPGKWCFKGHCI 232
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKCV 68
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 14-151 9.25e-20

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 88.13  E-value: 9.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  14 GNPSRSLEQVCRWahsQQRQDPSHAEHhDHVVFLTRQDFGpSGMQGYAPVTGMCHPLRSCALN---HEDGFSSAFVIAHE 90
Cdd:pfam01421  64 GDANDTLRNFLKW---RQEYLKKRKPH-DVAQLLSGVEFG-GTTVGAAYVGGMCSLEYSGGVNedhSKNLESFAVTMAHE 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517138  91 TGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRfHWSRCSKLELSRYLPSYD--CLLDDP 151
Cdd:pfam01421 139 LGHNLGMQHDDFNGGCKCPPGGGCIMNPSAGSSFPR-KFSNCSQEDFEQFLTKQKgaCLFNKP 200
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 17-134 7.09e-17

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 79.77  E-value: 7.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  17 SRSLEQVCRWAHSQqrqdpshAEHHDHVVFLTRQDFGPSGMQGYAPVTGMCHPLRSCAL--NHEDGFSSAFVIAHETGHV 94
Cdd:cd04267    72 SNTLNSFSFWRAEG-------PIRHDNAVLLTAQDFIEGDILGLAYVGSMCNPYSSVGVveDTGFTLLTALTMAHELGHN 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462517138  95 LGMEHDGQGNGCADETSLGS-VMAPLVQAAFHRfHWSRCSK 134
Cdd:cd04267   145 LGAEHDGGDELAFECDGGGNyIMAPVDSGLNSY-RFSQCSI 184
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 14-149 1.69e-16

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 78.81  E-value: 1.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  14 GNPSRSLEQVCRWahsqQRQDPSHAEHHDHVVFLTRQDFgPSGMQGYAPVTGMCHPLRSCALNHEDG---FSSAFVIAHE 90
Cdd:cd04269    64 GDAGETLNRFLDW----KRSNLLPRKPHDNAQLLTGRDF-DGNTVGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHE 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517138  91 TGHVLGMEHDG-----QGNGCadetslgsVMAPlvQAAFHRFHWSRCSKLELSRYLPSYD--CLLD 149
Cdd:cd04269   139 LGHNLGMEHDDggctcGRSTC--------IMAP--SPSSLTDAFSNCSYEDYQKFLSRGGgqCLLN 194
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 246-298 2.33e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 71.08  E-value: 2.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517138  246 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRPCLGPMFEYQVCNSEECP 298
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 40-141 9.32e-10

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 58.30  E-value: 9.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  40 HHDHVVFLTRQDFgPSGMQGYAPVTGMCHPLRSCAL---NHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADE------- 109
Cdd:cd00203    51 KADIAILVTRQDF-DGGTGGWAYLGRVCDSLRGVGVlqdNQSGTKEGAQTIAHELGHALGFYHDHDRKDRDDYptiddtl 129

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462517138 110 ----TSLGSVMAPLVQAAFH--RFHWSRCSKLELSRYL 141
Cdd:cd00203   130 naedDDYYSVMSYTKGSFSDgqRKDFSQCDIDQINKLY 167
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 542-597 1.82e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 1.82e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517138 542 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPkPIRRRCNQHPC 597
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 663-712 6.30e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 6.30e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517138 663 WRLGAWSQCSATCGEGIQQRQVVCR------TNANSLghCEGD-RPDTVQVCSLPAC 712
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsIVPDSE--CSAQkKPPETQSCNLKPC 55
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 41-147 1.94e-08

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 55.82  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  41 HDHVVFLTRQDFGP-------SGMQGYAPVTGMCHPLRsCALNHEDG--FSSAFVIAHETGHVLGMEHDGQG-------- 103
Cdd:cd04272    95 PDVVFLVTGLDMSTysggslqTGTGGYAYVGGACTENR-VAMGEDTPgsYYGVYTMTHELAHLLGAPHDGSPppswvkgh 173

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462517138 104 ---NGCADEtsLGSVMAPLVQAAFHrFHWSRCSKLELSRYL--PSYDCL 147
Cdd:cd04272   174 pgsLDCPWD--DGYIMSYVVNGERQ-YRFSQCSQRQIRNVFrrLGASCL 219
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 300-404 7.71e-08

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 51.63  E-value: 7.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 300 TYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAqkCELICQSADTGDVVFMNQVVHDGTRCSYRDP----- 367
Cdd:pfam19236   1 TQLEFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgt 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462517138 368 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHC 404
Cdd:pfam19236  79 LSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP_1 pfam00090
Thrombospondin type 1 domain;
247-297 7.75e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.34  E-value: 7.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462517138 247 SSWTKFGSCSRSCGGGVRSRSRSCNNPSPayGGRPCLGPMFEYQVCNSEEC 297
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 602-659 7.96e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 7.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517138 602 WVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkVMPAKACAGD-RPEARRPCLRVPC 659
Cdd:pfam19030   1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGS---IVPDSECSAQkKPPETQSCNLKPC 55
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 247-297 9.01e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 49.20  E-value: 9.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462517138 247 SSWTKFGSCSRSCGGGVRSRSRSCNNPsPAYGGRPClGPMFEYQVCNSEEC 297
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 666-712 6.45e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.81  E-value: 6.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462517138  666 GAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTvQVCSLPAC 712
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGggPCTGEDVET-RACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
666-712 1.32e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 45.87  E-value: 1.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462517138 666 GAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTvQVCSLPAC 712
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIET-QACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 601-660 1.55e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  601 VWVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkvmPAKACAGDRPEaRRPCLRVPCP 660
Cdd:smart00209   1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQN-----GGGPCTGEDVE-TRACNEQPCP 53
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 800-914 5.20e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138 800 TSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQ-HPFAPETPIPGASWSISPTTPGGL 878
Cdd:PRK07764  600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPkHVAVPDASDGGDGWPAKAGGAAPA 679

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462517138 879 PWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT 914
Cdd:PRK07764  680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715
PHA03247 PHA03247
large tegument protein UL36; Provisional
 808-914 8.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517138  808 PGSPLPGPQDPA---------DAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASwSISPTTPGGl 878
Cdd:PHA03247  2676 ASSPPQRPRRRAarptvgsltSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-PAGPATPGG- 2753

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462517138  879 pwgwtqtPTPVPEDKGQPGedlrhPGTSLPAASPVT 914
Cdd:PHA03247  2754 -------PARPARPPTTAG-----PPAPAPPAAPAA 2777
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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