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Conserved domains on  [gi|2462518397|ref|XP_054221454|]
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probable E3 ubiquitin-protein ligase HERC4 isoform X13 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-362 1.30e-82

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 263.38  E-value: 1.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184    21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPscfpkimcvdslVRICSGLSygrirnikslsd 160
Cdd:COG5184    97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTP------------VQVDAGLS------------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 161 iQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGR 240
Cdd:COG5184   150 -GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGS 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 241 NKFGQLGLNDENDRYVPNLLKSLrsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiV 320
Cdd:COG5184   226 NSSGQLGDGTTTDRATPVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--V 301

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2462518397 321 TEIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 362
Cdd:COG5184   302 VAVAAGSSHTCA-LLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-362 1.30e-82

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 263.38  E-value: 1.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184    21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPscfpkimcvdslVRICSGLSygrirnikslsd 160
Cdd:COG5184    97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTP------------VQVDAGLS------------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 161 iQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGR 240
Cdd:COG5184   150 -GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGS 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 241 NKFGQLGLNDENDRYVPNLLKSLrsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiV 320
Cdd:COG5184   226 NSSGQLGDGTTTDRATPVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--V 301

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2462518397 321 TEIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 362
Cdd:COG5184   302 VAVAAGSSHTCA-LLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
232-281 1.60e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 70.62  E-value: 1.60e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462518397 232 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 281
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-362 1.30e-82

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 263.38  E-value: 1.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184    21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPscfpkimcvdslVRICSGLSygrirnikslsd 160
Cdd:COG5184    97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTP------------VQVDAGLS------------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 161 iQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGR 240
Cdd:COG5184   150 -GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGS 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 241 NKFGQLGLNDENDRYVPNLLKSLrsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiV 320
Cdd:COG5184   226 NSSGQLGDGTTTDRATPVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--V 301

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2462518397 321 TEIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 362
Cdd:COG5184   302 VAVAAGSSHTCA-LLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 37-367 4.09e-76

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 246.43  E-value: 4.09e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397  37 RDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDG 114
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGdgTTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 115 QLGLvGSEECIRVPscfpkimcvdslVRIcSGLSYgrirnikslsdiqIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 194
Cdd:COG5184    79 QLGD-GTTTDRTTP------------VKV-PGLTG-------------VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 195 LGTDcKKQTSPQLLKSLLGiPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSqkIVYICCG 274
Cdd:COG5184   132 DGTT-TNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAG 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397 275 EDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTEIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTG 354
Cdd:COG5184   208 GDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTVWCWGDNSYGQLGDG 284

                         330
                  ....*....|...
gi 2462518397 355 STSNRKSPFTVKG 367
Cdd:COG5184   285 TTTDRSTPVKVPG 297
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 1-206 5.03e-37

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 141.27  E-value: 5.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397   1 MLCWGNASFGQLGLGGIDEEIVlePRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE--KSRKKPEQV 78
Cdd:COG5184   170 VWCWGANSYGQLGDGTTTDRPT--PVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGttTDRATPVQV 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518397  79 VALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPscfpkimcvdslVRIcSGLSygrirniksl 158
Cdd:COG5184   246 AGLT--GVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGD-GTTTDRSTP------------VKV-PGLS---------- 299

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462518397 159 sdiQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQ 206
Cdd:COG5184   300 ---GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTT-TDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
232-281 1.60e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 70.62  E-value: 1.60e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462518397 232 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 281
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-99 8.41e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.92  E-value: 8.41e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462518397  52 DGTVYTCGCNDLGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLAL 99
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLgtTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
181-229 1.25e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.53  E-value: 1.25e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518397 181 EVFCWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 229
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
284-332 5.38e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 5.38e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518397 284 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSA 332
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
102-176 3.57e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 55.60  E-value: 3.57e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518397 102 KGQVYAWGLDSDGQLGLvGSEECIRVPSCfpkimcvdslvricsglsygrirnIKSLSDIQIVQVACGYYHSLAL 176
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGL-GTTENVLVPQK------------------------VEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
163-192 3.44e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 52.43  E-value: 3.44e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462518397 163 IVQVACGYYHSLALSKASEVFCWGQNKYGQ 192
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
86-115 7.35e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.57  E-value: 7.35e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462518397  86 IVAVSCGEAHTLALNDKGQVYAWGLDSDGQ 115
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
36-65 2.31e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.03  E-value: 2.31e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462518397  36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQ 65
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
3-49 3.19e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.13  E-value: 3.19e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462518397   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFV 49
Cdd:pfam00415   6 TWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
218-245 3.22e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 3.22e-06
                          10        20
                  ....*....|....*....|....*...
gi 2462518397 218 QVAAGGAHSFVLTLSGAIFGWGRNKFGQ 245
Cdd:pfam13540   3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
337-367 2.39e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 41.73  E-value: 2.39e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462518397 337 SGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 367
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG 31
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
268-297 2.67e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.26  E-value: 2.67e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462518397 268 IVYICCGEDHTAALTKEGGVFTFGAGGYGQ 297
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
320-350 5.71e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 34.71  E-value: 5.71e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462518397 320 VTEIACGRQHTsAFVPSSGRIYSFGLGGNGQ 350
Cdd:pfam13540   1 VVSVAAGDNHT-LALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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