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tyrosine-protein phosphatase non-receptor type 20 isoform X23 [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
PTP_DSP_cys super family | cl28904 | cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This ... |
78-105 | 1.13e-08 | ||
cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This superfamily is composed of cys-based phosphatases, which includes classical protein tyrosine phosphatases (PTPs) as well as dual-specificity phosphatases (DUSPs or DSPs). They are characterized by a CxxxxxR conserved catalytic loop (where C is the catalytic cysteine, x is any amino acid, and R is an arginine). PTPs are part of the tyrosine phosphorylation/dephosphorylation regulatory mechanism, and are important in the response of the cells to physiologic and pathologic changes in their environment. DUSPs show more substrate diversity (including RNA and lipids) and include pTyr, pSer, and pThr phosphatases. The actual alignment was detected with superfamily member cd14596: Pssm-ID: 475123 [Multi-domain] Cd Length: 207 Bit Score: 50.52 E-value: 1.13e-08
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Name | Accession | Description | Interval | E-value | ||
PTPc-N20 | cd14596 | catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein ... |
78-105 | 1.13e-08 | ||
catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization. Pssm-ID: 350444 [Multi-domain] Cd Length: 207 Bit Score: 50.52 E-value: 1.13e-08
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PTPc | smart00194 | Protein tyrosine phosphatase, catalytic domain; |
78-105 | 4.04e-06 | ||
Protein tyrosine phosphatase, catalytic domain; Pssm-ID: 214550 [Multi-domain] Cd Length: 259 Bit Score: 43.80 E-value: 4.04e-06
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Y_phosphatase | pfam00102 | Protein-tyrosine phosphatase; |
73-105 | 3.03e-05 | ||
Protein-tyrosine phosphatase; Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 41.07 E-value: 3.03e-05
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Name | Accession | Description | Interval | E-value | ||
PTPc-N20 | cd14596 | catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein ... |
78-105 | 1.13e-08 | ||
catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization. Pssm-ID: 350444 [Multi-domain] Cd Length: 207 Bit Score: 50.52 E-value: 1.13e-08
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PTPc-N20_13 | cd14538 | catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13; ... |
78-105 | 1.54e-08 | ||
catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13; Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) and type 13 (PTPN13, also known as PTPL1) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization. Human PTPN13 is an important regulator of tumor aggressiveness. Pssm-ID: 350386 [Multi-domain] Cd Length: 207 Bit Score: 50.07 E-value: 1.54e-08
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PTPc | smart00194 | Protein tyrosine phosphatase, catalytic domain; |
78-105 | 4.04e-06 | ||
Protein tyrosine phosphatase, catalytic domain; Pssm-ID: 214550 [Multi-domain] Cd Length: 259 Bit Score: 43.80 E-value: 4.04e-06
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Y_phosphatase | pfam00102 | Protein-tyrosine phosphatase; |
73-105 | 3.03e-05 | ||
Protein-tyrosine phosphatase; Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 41.07 E-value: 3.03e-05
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PTPc | cd00047 | catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1. ... |
78-105 | 1.02e-04 | ||
catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr. This family has a distinctive active site signature motif, HCSAGxGRxG, and are characterized as either transmembrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the cytoplasmic region of the transmembrane proteins, only one copy may be active. Pssm-ID: 350343 [Multi-domain] Cd Length: 200 Bit Score: 39.58 E-value: 1.02e-04
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PTPc_motif | smart00404 | Protein tyrosine phosphatase, catalytic domain motif; |
84-105 | 2.97e-04 | ||
Protein tyrosine phosphatase, catalytic domain motif; Pssm-ID: 214649 [Multi-domain] Cd Length: 105 Bit Score: 37.34 E-value: 2.97e-04
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PTPc_DSPc | smart00012 | Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine ... |
84-105 | 2.97e-04 | ||
Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine phosphatases. Homologues detected by this profile and not by those of "PTPc" or "DSPc" are predicted to be protein phosphatases with a similar fold to DSPs and PTPs, yet with unpredicted specificities. Pssm-ID: 214469 [Multi-domain] Cd Length: 105 Bit Score: 37.34 E-value: 2.97e-04
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PTPc-N22_18_12 | cd14542 | catalytic domain of tyrosine-protein phosphatase non-receptor type 22, type 18 and type 12; ... |
84-105 | 3.34e-04 | ||
catalytic domain of tyrosine-protein phosphatase non-receptor type 22, type 18 and type 12; Tyrosine-protein phosphatase non-receptor type 22 (PTPN22), type 18 (PTPN18) and type 12 (PTPN12) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN22 is expressed in hematopoietic cells and it functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signaling through the direct dephosphorylation of Src family kinases (Lck and Fyn), ITAMs of the TCRz/CD3 complex, and other signaling molecules. TPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination states. PTPN12 is characterized as a tumor suppressor and a pivotal regulator of EGFR/HER2 signaling. Pssm-ID: 350390 [Multi-domain] Cd Length: 202 Bit Score: 38.17 E-value: 3.34e-04
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PTPc-N13 | cd14597 | catalytic domain of tyrosine-protein phosphatase non-receptor type 13; Tyrosine-protein ... |
78-105 | 7.66e-04 | ||
catalytic domain of tyrosine-protein phosphatase non-receptor type 13; Tyrosine-protein phosphatase non-receptor type 13 (PTPN13, also known as PTPL1) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN13 is an important regulator of tumor aggressiveness. It regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. In hepatocellular carcinoma, PTPN13 is a tumor suppressor. PTPN13 contains a FERM domain, five PDZ domains, and a C-terminal catalytic PTP domain. With its PDZ domains, PTPN13 has numerous interacting partners that can actively participate in the regulation of its phosphatase activity or can permit direct or indirect recruitment of tyrosine phosphorylated substrates. Its FERM domain is necessary for localization to the membrane. Pssm-ID: 350445 [Multi-domain] Cd Length: 234 Bit Score: 37.12 E-value: 7.66e-04
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PTP_fungal | cd18533 | fungal protein tyrosine phosphatases; This subfamily contains Saccharomyces cerevisiae ... |
86-103 | 2.31e-03 | ||
fungal protein tyrosine phosphatases; This subfamily contains Saccharomyces cerevisiae protein-tyrosine phosphatases 1 (PTP1) and 2 (PTP2), Schizosaccharomyces pombe PTP1, PTP2, and PTP3, and similar fungal proteins. PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. PTP2, together with PTP3, is the major phosphatase that dephosphorylates and inactivates the MAP kinase HOG1 and also modulates its subcellular localization. Pssm-ID: 350509 [Multi-domain] Cd Length: 212 Bit Score: 35.69 E-value: 2.31e-03
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PTPc-KIM | cd14547 | catalytic domain of the kinase interaction motif (KIM) family of protein-tyrosine phosphatases; ... |
80-105 | 3.42e-03 | ||
catalytic domain of the kinase interaction motif (KIM) family of protein-tyrosine phosphatases; The kinase interaction motif (KIM) family of protein-tyrosine phosphatases (PTPs) includes tyrosine-protein phosphatases non-receptor type 7 (PTPN7) and non-receptor type 5 (PTPN5), and protein-tyrosine phosphatase receptor type R (PTPRR). PTPN7 is also called hematopoietic protein-tyrosine phosphatase (HePTP) while PTPN5 is also called striatal-enriched protein-tyrosine phosphatase (STEP). They belong to the family of classical tyrosine-specific PTPs (EC 3.1.3.48) that catalyze the dephosphorylation of phosphotyrosine peptides. KIM-PTPs are characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. They are highly specific to the MAPKs ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38, over JNK (c-Jun N-terminal kinase); they dephosphorylate these kinases and thereby critically modulate cell proliferation and differentiation. Pssm-ID: 350395 [Multi-domain] Cd Length: 224 Bit Score: 35.45 E-value: 3.42e-03
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PTPc-N18 | cd14603 | catalytic domain of tyrosine-protein phosphatase non-receptor type 18; Tyrosine-protein ... |
84-105 | 4.21e-03 | ||
catalytic domain of tyrosine-protein phosphatase non-receptor type 18; Tyrosine-protein phosphatase non-receptor type 18 (PTPN18), also called brain-derived phosphatase, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination states. The N-terminal catalytic PTP domain of PTPN18 blocks lysosomal routing and delays the degradation of HER2 by dephosphorylation, and its C-terminal PEST domain promotes K48-linked HER2 ubiquitination and its destruction via the proteasome pathway. Pssm-ID: 350451 [Multi-domain] Cd Length: 266 Bit Score: 35.19 E-value: 4.21e-03
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Blast search parameters | ||||
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