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Conserved domains on  [gi|2462518880|ref|XP_054221691|]
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alpha-2,8-sialyltransferase 8F isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-241 1.67e-170

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23991:

Pssm-ID: 480271  Cd Length: 273  Bit Score: 470.78  E-value: 1.67e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTN 80
Cdd:cd23991    33 LTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISKDVGSKTN 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  81 LVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23991   113 LVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFW 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 161 RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQ 240
Cdd:cd23991   193 RSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQ 272


                  .
gi 2462518880 241 F 241
Cdd:cd23991   273 F 273
 
Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 1-241 1.67e-170

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 470.78  E-value: 1.67e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTN 80
Cdd:cd23991    33 LTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISKDVGSKTN 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  81 LVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23991   113 LVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFW 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 161 RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQ 240
Cdd:cd23991   193 RSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQ 272


                  .
gi 2462518880 241 F 241
Cdd:cd23991   273 F 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 15-236 1.10e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 260.23  E-value: 1.10e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  15 KNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINP-SIITLKY 93
Cdd:pfam00777  26 EELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKG-YEKDVGSKTTLRTMNPeSAIDSKY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  94 GNLKEKKAL--FLEDIATY--GDAFFLLPAFSFRANTGTSFKVYYTLEESKARQ---KVLFFHPKYLKDLALFW-RTKGV 165
Cdd:pfam00777 105 GNLGFSHPRdpFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVdpdKVLFLHPDFLRYVANFWlRSHGL 184

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518880 166 TAYRLSTGLMITSVAVELCKNVKLYGFWPFSKtveDIPVSHHYYDNKLPK----HGFHQMPKEYSQILQLHMKGI 236
Cdd:pfam00777 185 KGRRPSTGLLMLSLALHLCDEVSLYGFGPFLD---SRGNSHHYYDNVLMKkggfYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 1-241 1.67e-170

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 470.78  E-value: 1.67e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTN 80
Cdd:cd23991    33 LTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISKDVGSKTN 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  81 LVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23991   113 LVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFW 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 161 RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQ 240
Cdd:cd23991   193 RSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQ 272


                  .
gi 2462518880 241 F 241
Cdd:cd23991   273 F 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 1-241 6.42e-153

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 426.29  E-value: 6.42e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdvSKDVGSKTN 80
Cdd:cd23971    33 IHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLND--SKDVGSKTN 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  81 LVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23971   111 LVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLRALYTLEDFGSPQKVLFFNPEYLRNLSRYW 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 161 RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQ 240
Cdd:cd23971   191 KSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLH 270


                  .
gi 2462518880 241 F 241
Cdd:cd23971   271 L 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 1-240 6.38e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 281.72  E-value: 6.38e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEIPIKKNIFHMFPVSQPFvDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTN 80
Cdd:cd23989    33 LWFDGEFLHSHTVDNETYSLFPQDTPL-QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSREYTDDVGTKTQ 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  81 LVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23989   112 LVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRNVGKFW 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 161 RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQ 240
Cdd:cd23989   192 KSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 3-240 2.28e-89

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 265.28  E-value: 2.28e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   3 YEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVsKDVGSKTNLV 82
Cdd:cd23963    34 YSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFE-KDVGRKTNLT 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  83 TINPSIITLKYGNLK--EKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23963   113 TLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFW 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 161 RTKGVTAyRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPK--HGFHQMPKEYSQILQLHMKGILK 238
Cdd:cd23963   193 KRRGLEK-RPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDDLSPStkNKVHNMPEEFKLLRELHKKGVLK 271


                  ..
gi 2462518880 239 LQ 240
Cdd:cd23963   272 LH 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 15-236 1.10e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 260.23  E-value: 1.10e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  15 KNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINP-SIITLKY 93
Cdd:pfam00777  26 EELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKG-YEKDVGSKTTLRTMNPeSAIDSKY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  94 GNLKEKKAL--FLEDIATY--GDAFFLLPAFSFRANTGTSFKVYYTLEESKARQ---KVLFFHPKYLKDLALFW-RTKGV 165
Cdd:pfam00777 105 GNLGFSHPRdpFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVdpdKVLFLHPDFLRYVANFWlRSHGL 184

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518880 166 TAYRLSTGLMITSVAVELCKNVKLYGFWPFSKtveDIPVSHHYYDNKLPK----HGFHQMPKEYSQILQLHMKGI 236
Cdd:pfam00777 185 KGRRPSTGLLMLSLALHLCDEVSLYGFGPFLD---SRGNSHHYYDNVLMKkggfYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 1-239 1.38e-85

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 255.53  E-value: 1.38e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTN 80
Cdd:cd23990    33 LKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEKYVRDVGVKTD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  81 LVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23990   113 VVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFW 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462518880 161 RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKL 239
Cdd:cd23990   193 LRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPRPGFHAMPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 1-239 1.41e-68

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 212.64  E-value: 1.41e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEI-PIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKT 79
Cdd:cd23970    36 MHFDYSSHKYVfSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  80 NLVTINPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKV-LFFHPKYLKDL 156
Cdd:cd23970   115 NLTTFNPSILEKYYNNLLTIqdRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVqLAWPGNIMQHV 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 157 ALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHG-----FHQMPKEYSQILQL 231
Cdd:cd23970   195 NRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDKKGTKFTtkwqeSHQLPAEFVLLYKM 274


                  ....*...
gi 2462518880 232 HMKGILKL 239
Cdd:cd23970   275 HGAGVLKL 282
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 1-240 1.77e-65

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 204.57  E-value: 1.77e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVsKDVGSKTN 80
Cdd:cd23969    33 MHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYE-KDVGTKSN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  81 LVTINPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFsfrANTGTSFKVYYTLE---ESKARQKVLFFHPKYLKD 155
Cdd:cd23969   112 LTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAF---VSKGGEEHVQWTNEiilKHKLNVKTAYPPLRLNHA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 156 LALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNK--LPKHGFHQMPKEYSQILQLHM 233
Cdd:cd23969   189 IRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRkyLTTARPHKMPEEFRALRSLHQ 268


                  ....*..
gi 2462518880 234 KGILKLQ 240
Cdd:cd23969   269 RGALRLH 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 3-239 5.50e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 165.13  E-value: 5.50e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   3 YEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLV 82
Cdd:cd23988    35 YVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGTKSDFI 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  83 TINPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFW 160
Cdd:cd23988   114 TMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYW 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 161 RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKH----GFHQMPKEYSQILQLHMKGI 236
Cdd:cd23988   194 LTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRYfsnaGPHRMPLEFKTLNVLHNRGA 273


                  ...
gi 2462518880 237 LKL 239
Cdd:cd23988   274 LKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 13-239 1.08e-46

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 156.64  E-value: 1.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  13 IKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTgDVSKDVGSKTNLVTINPSIITLK 92
Cdd:cd23987    45 ISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVE-EYAKDVGTKTDLVTMNPSVVQRA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  93 YGNL--KEKKALFLEDIATYGDAFFLLPAFSFRantGTSFKVYYTLEES-KARQKVLFFHP--KYLKDLALFWRTKGVTA 167
Cdd:cd23987   124 FEDLvnETWKEKFLQRLQSLNGSILWIPAFMAK---GGEERVEWVNDLIlKHHINVRTAYPslRLLHAVRGYWLTNKVHI 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462518880 168 YRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKlpKHGF------HQMPKEYSQILQLHMKGILKL 239
Cdd:cd23987   201 KRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSL--KYGYtsqaspHTMPLEFKALKNLHQQGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 35-225 2.95e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 106.29  E-value: 2.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  35 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiITLKYGNLKEKKALFLEDiaTYGDAF 114
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKG-FEKDVGSKTTFRVLNSK-WAGFYLRGPRCGCHPLPL--EEEVVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 115 FLlpafsFRANTGTSFKVYYTLEESKArqKVLFFHPKYLKDLALFWRT-------KGVTAYRLSTGLMITSVAVELCKNV 187
Cdd:cd19952    77 IL-----SRAAAADFKRLKRRKKRHDN--AVLLLTDPAPDLLSYVRKRleklglkSFFGGNAPSSGLLAVLLALQLCDSV 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462518880 188 KLYGFWPFSKTVEDIPvsHHYYDNKLP--KHGFHQMPKEY 225
Cdd:cd19952   150 DLYGFGVDSGHAPKVP--YHYYDLVEAeeGTAVHSFDLEA 187
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 35-239 8.03e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 89.04  E-value: 8.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  35 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTInpSIITLK-----YGNL--------KEKKA 101
Cdd:cd23974    87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKG-FEKDVGRRTSFYTF--STNTLMnslraYAGVgfngppqsKETRY 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 102 LFLEDiatYGDAFFLLPAfsfrANTGT--------SFKVYYTLEESKARQKVLFFHP---KYLKDLALFWR---TKGVTA 167
Cdd:cd23974   164 IFLPD---HDRDYLLVKA----ALTHTpidrgrdkSKRPSKYFGKDVTAEKFKIYHPdfiRYLRNRFLWSPilnTKQRDI 236

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518880 168 YRLSTGLMITSVAVELCKNVKLYGFwpfsKTVEDIPVSHHYYDNKLPKHGF---HQMPKEYSQILQLHMKGILKL 239
Cdd:cd23974   237 YRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKL 307
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 35-239 4.15e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 86.93  E-value: 4.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  35 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKT------------NLVTINPSIITLKYGNL--KEKK 100
Cdd:cd23964    85 CAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKG-FEKDVGTKTsfytffpeslhnSLLKHVPQDKDTKYLFIpfKIRD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 101 ALFLEDIATYGDafflLPAFsfrantGTSFKVYYTLEESKAR-QKVLFFHPKYLKDLALFW-RTKgvTAYRLSTGLMITS 178
Cdd:cd23964   164 YDYLDAVLSGKP----VPDG------CDKGKRPPPLFGPKLNaTNVRLLHPDFIRYLFNRWlNSS--TSYRPTTGALMLL 231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462518880 179 VAVELCKNVKLYGF---WPFSKtvedipvshHYYDNK----LPKHGFHQMPKEYSQILQLHMKGILKL 239
Cdd:cd23964   232 TALHTCDQVSVYGFgydPRFSL---------HYYDKTfvkfTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 1-239 2.48e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 84.25  E-value: 2.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880   1 MSYEV-------ESKKEIPIKKNIFHMFPVSQPFVDYPYN------QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPT 67
Cdd:cd23966    33 LPPDVlkwwlslQSSKNSDLREVLEKLFQVVPGENPYRTRdpnrcrRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  68 TGdVSKDVGSKTNLVTINP-SIITLKYGN---LKEKKALFLEdiatygdafFLLPAFSfranTGTSFKVYYTLEES-KA- 141
Cdd:cd23966   113 KG-FEKDVGSKTTHHFMYPeSAVDLDPGVhlvLVPFKVLDLQ---------WLISALT----TGEITRTYTPVKRFiKAd 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 142 RQKVLFFHPKYLKDLALFWrTKGVTAYRlSTGLMITSVAVELCKNVKLYGF-------WpfsktvedipvsHHYYDNKLP 214
Cdd:cd23966   179 KDKVLVINPAFIKYVHDNW-TEHHGRYP-STGFLALIFALHICDEVSVFGFgadskgnW------------HHYWEKNRS 244

                         250       260       270
                  ....*....|....*....|....*....|
gi 2462518880 215 KHGF-----HQMPKEYSQILQLHMKGILKL 239
Cdd:cd23966   245 AGAFrktgvHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 35-239 6.12e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 75.56  E-value: 6.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  35 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLKE------------KKAL 102
Cdd:cd23973    86 CAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKG-YEEDVGTRTSFYVHTAHSITSSLMILQKrgfknipqdkdiKYIL 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 103 FLEDIATYG--DAFFLLPAFSFRANTGTSFKVYYTleESKARQKVLFFHPKYLKDLA-LFWRTKGVTA-----YRLSTGL 174
Cdd:cd23973   165 FPEGPRDYQwlEALLKNKTIPSGAYYGRRPRSYFS--GDFTEDKYLVLHPDFLRYVKnRFLRSKTLKGkywaiYRPTTGA 242

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462518880 175 MITSVAVELCKNVKLYGFWpfskTVEDIPVSHHYYDNKLPKHGF---HQMPKEYSQILQLHMKGILKL 239
Cdd:cd23973   243 FLLLTALHLCDTVSAYGFI----TEDYRKYPDHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 34-220 4.89e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 72.61  E-value: 4.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  34 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiitlKYGNLKEKKALFLEDIATYgDA 113
Cdd:cd23980    83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEG-FEADVGSKTTHHFVYPE----SFRELAQNVSMILVPFKTL-DL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 114 FFLLPAFSfranTGTSFKVYYTLEES-KARQ-KVLFFHPKYLKDLALFWrTKGVTAYRlSTGLMITSVAVELCKNVKLYG 191
Cdd:cd23980   157 EWVISATT----TGTISHTYVPVPRKiKVKKeKILIYHPAFIKYVFDRW-LQGHGRYP-STGILSVIFSLHVCDEVDLYG 230

                         170       180
                  ....*....|....*....|....*....
gi 2462518880 192 FWPFSKTvedipVSHHYYDNKLPKHGFHQ 220
Cdd:cd23980   231 FGADSKG-----NWHHYWENNPSAGAFRK 254
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 34-239 1.10e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 71.78  E-value: 1.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  34 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLV-----TINPSIITlkYGNL--------KEKK 100
Cdd:cd23972    84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKG-FEEDVGTKTSFYgftvnTMKNSLIS--YWNLgftrtpqgQDLQ 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 101 ALFL-EDIATY---GDAFFLLPAFSfRANTGTSFKVYYTLEESKARQKVLffHP---KYLKDLAL---FWRTKGVTAYRL 170
Cdd:cd23972   161 YIFIpSDIRDYvmlRSAILGVPVPE-GLDKGDRPHKYFGPEASAKKFKLL--HPdfiSYLTDRFLkskLLNTHYGHLYMP 237

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462518880 171 STGLMITSVAVELCKNVKLYGF-----WPFSKtvedipvshHYYDNK---LPKHGFHQMPKEYSQILQLHMKGILKL 239
Cdd:cd23972   238 STGALMLLTALHTCDQVSAYGFitsnyWKFSD---------HYYERKkkpLVFYANHDMLLEAALWRRLHKAGILQL 305
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 33-215 2.35e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 66.88  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  33 NQCAVVGNGG-ILNKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNL-VTINPSIitlkyGNLKEKKALFLEDIATY 110
Cdd:cd23965     2 DTCALVSSSGqLLGSGA-GKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSL-----PRLLRNAILLLAGTRAP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 111 GDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHP-KYLKDLALFWRTKGVTAYR----LSTGLMITSVAVELCK 185
Cdd:cd23965    75 TVVVFWGPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPeKMDYADELFEKETGKSRIKsgtwLSTGWFTMLLALDVCD 154

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462518880 186 NVKLYGFWP--FSKTVEDIPVSHHYYDNKLPK 215
Cdd:cd23965   155 EIKVYGMVPenYCREHPNSKVPYHYYEPGGLK 186
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 17-233 3.84e-13

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 66.91  E-value: 3.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  17 IFHMFPVSQPFVDyPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITL-KYGN 95
Cdd:cd23968    31 RYPFPESSLENTK-RYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKG-FEKDVGSKTTLRLINSQILSKpEFNF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  96 LKEKK----ALFLEDIATYG---DAFFLLPAFSFrantgtsFKVYYTLEESKARQKVLFFHPKYLKDL------ALFWRT 162
Cdd:cd23968   109 LTDPLyrnvTLLVWDPSSYNvnlEKWYKKPDFDF-------FPNYIKYRRRHPEEPFYLIDPRFLWRLwdilqeYTPEKI 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518880 163 KGVTAyrlSTGLMITSVAVELCKNVKLYGFWPfskTVEDIPVShHYYD---NKLPKHG-FHqmPKEYSQILQLHM 233
Cdd:cd23968   182 KPNPP---SSGFIGIVLMLHLCDWVDVYEYVP---SVRQTDRC-HYYDvekDLACTLGaWH--PLAAEKLLVRHL 247
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 35-210 4.44e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 61.04  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  35 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLKEkkalfLEDIaTYGDAF 114
Cdd:cd23976    18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRG-YGKDVGNKTSLRVIAHSSIQRILRNRNE-----LLNV-SQGTVF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 115 FLLPAFSFRANTGTSFkVYYTLEESK-----------ARQKVLFFHPKYLKDLAlfwRTKGVTAYRLSTGLMITSVAVEL 183
Cdd:cd23976    91 IFWGPSNYMRRDGKGL-VYNNLQLMNqilpklkvytiTRHKMLQFDELFKRETG---KDRKISNTWLSTGWFTMIIALEL 166

                         170       180
                  ....*....|....*....|....*....
gi 2462518880 184 CKNVKLYGFWP--FSKTVEDIPVSHHYYD 210
Cdd:cd23976   167 CDRINVYGMVPpdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 33-214 8.01e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 60.25  E-value: 8.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  33 NQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNL------------------VTINPSIITLKYG 94
Cdd:cd23978     2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrvvahssvyrvlrrpqefLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  95 N----LKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKvlffhpkylkdlALFWrtkgvtayrL 170
Cdd:cd23978    81 PpnkmQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKK------------SHSW---------L 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462518880 171 STGLMITSVAVELCKNVKLYGFWPF---SKTVEDIPVSHHYYDNKLP 214
Cdd:cd23978   140 STGWFTMVIAVELCDNVHVYGMVPPnycSKRPTPKKMPYHYYEPKGP 186
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 31-209 2.12e-10

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 59.34  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  31 PYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITL-KYGNLKEkkALFLE---- 105
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTTIRLINSQLVTTeKHKFLKD--SLYNEgili 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 106 --DIATY-GDA--FFLLPAFSFrantgtsFKVYYTLEESKARQKVLFFHPKYLKDLalfW-RTKGVTAYRL-----STGL 174
Cdd:cd23985   121 vwDPAPYhSDIpeWYKNPDYNF-------FENYKTYRRLNPNQPFYILHPQMQWEL---WdIIQENSPEEIqpnppSSGM 190

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2462518880 175 MITSVAVELCKNVKLYGFWPfSKTVEDIPvshHYY 209
Cdd:cd23985   191 LGIILMMTLCDQVDVYEFLP-SKRKTDVC---HYY 221
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 29-211 3.59e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 58.73  E-value: 3.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  29 DYPYNQ--------CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiitlKYGNLKEKK 100
Cdd:cd23979    69 ENPYRSwdpsrcrrCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVG-FEADVGSRTTHHFMYPE----SAKNLPANV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 101 ALFLEDIATYgDAFFLLPAFSfranTGtsfKVYYTLEESKA-----RQKVLFFHPKYLKDLALFWrTKGVTAYRlSTGLM 175
Cdd:cd23979   144 SFVLVPFKTL-DLLWITSALS----TG---QIRFTYAPVKQflrvdKDKVQIYNPAFFKYIHDRW-TEHHGRYP-STGML 213

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462518880 176 ITSVAVELCKNVKLYGFWPFSKTvedipVSHHYYDN 211
Cdd:cd23979   214 VLFFALHVCDEVNVYGFGADSRG-----NWHHYWEN 244
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 35-215 3.70e-10

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 57.69  E-value: 3.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  35 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPsiitlkygnlkekKALFLEDIATYGDAF 114
Cdd:cd23967     5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYP-------------ESAFRDPEEYDSDWL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 115 FLLPAFSF-------------RANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLAL----FWRTKGVTAYRLSTGLMIT 177
Cdd:cd23967    71 LVLVPFKSmdllwlqavikgkKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFdligLPMNGKQGKNVPTTGIIAI 150

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462518880 178 SVAVELCKNVKLYGF-WPFSKtvEDIPVshHYYDNKLPK 215
Cdd:cd23967   151 VMALHYCDEVDIAGFgYDPSD--PNAPL--HYYDSLTMK 185
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 34-231 3.16e-09

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 55.05  E-value: 3.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  34 QCAVVGNG-GILNKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiiTLKYGNLKE--KKALFLEDIATY 110
Cdd:cd23982     4 RCVVVGNGhNLKNSSL-GDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTIRLFYPE--SAQFDPGIEndPDTLLVLVPFKP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 111 GDAFFLLPAFSFRANTGTSF--KVYYTLEESKARQKVLffHPKYLKDLALfwRTKGVTAYRL-----STGLMITSVAVEL 183
Cdd:cd23982    80 LDFYWLYEILSNEKRVRKGFwkQPPRIWDANPKQIRIL--NPYYTYVAAT--KLLQVPGQRKkkqkpTTGLLAITLALHL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518880 184 CKNVKLYGF-WPFSkTVEDIPVshHYYDNKLPKH---GFHQMPKEYSQILQL 231
Cdd:cd23982   156 CDEVHIAGFgYPDN-GNSNQPI--HYYNQITLKSmanSGHNLNAEAQAIQRL 204
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 32-90 7.55e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 54.84  E-value: 7.55e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  32 YNQCAVVGN-GGILNKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIIT 90
Cdd:cd23986    49 FRSCAVVTSaGAILNSSL-GKEIDSHDAVLRFNSAPTRG-YEKDVGNKTTIRIINSQILT 106
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 34-104 2.88e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 52.62  E-value: 2.88e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462518880  34 QCAVVGNGGIL-NKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLkEKKALFL 104
Cdd:cd23981     4 RCIIVGNGGVLaNKSL-GSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQY-EKDSLFV 72
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 31-211 1.06e-06

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 47.82  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  31 PYNQCAVVGNGGIL-NKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNL-------VTINPS---------IITLKY 93
Cdd:cd23984     1 SCKKCVVVGNGGVLrNKSL-GKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFrlcypesIFSDPShydpnttvvLIPFKP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  94 GNLKEKKALFLED-IATYGdaFFLLPAFS--FRANTGTSFKVYYTleeSKARQKVLFFHPKYLKDLALFWRTkgvtayrl 170
Cdd:cd23984    79 HDLRWLLDLLMGKkVSAKG--FWKKPALNliYKPNQIRILNPFIL---RIAAYELLHFPKRFPKEKKPKHPT-------- 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2462518880 171 sTGLMITSVAVELCKNVKLYGF-WPFSktveDIPVSHHYYDN 211
Cdd:cd23984   146 -TGIIAITLALHICNEVHIAGFkYDFS----NLNSTLHYYGN 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 34-210 1.78e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 47.55  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  34 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLkygnLKEKKALFLEDIAtygDA 113
Cdd:cd23977     3 RCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAG-YEADVGNRSSLRVVSHTSVPL----LLRNQGYFFQQSR---DT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 114 FFLL--PAFSF-RANTGTSFKVY------------YTLEESKARQKVLFFHPKYLKDlalfwRTKGVTAyrLSTGLMITS 178
Cdd:cd23977    75 KYVIwgPERNMdRDGGGKTYRALltlakmyphlqvYTLTEEKMAYCDGVFQNETGKN-----RMKSGSF--LSTGWFTMI 147

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462518880 179 VAVELCKNVKLYGFW--PFSKTVEDIPVSHHYYD 210
Cdd:cd23977   148 LALELCEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 34-86 4.30e-06

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 46.27  E-value: 4.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462518880  34 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINP 86
Cdd:cd23983     4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYP 55
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 35-210 1.92e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 44.54  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880  35 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKygnLKEKKALFLEDIATygdAF 114
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKG-YEEDVGKRTTIRVVSHTSVPLL---LKNPDYFFKETNET---IY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518880 115 FLLPAFSFRANTGTSFkVYYTLE---ESKARQKVLFFHPKYLKDL-ALFWRTKG----VTAYRLSTGLMITSVAVELCKN 186
Cdd:cd23975    77 VIWGPFRNMRKDGKGI-VYNMLKkavESYPQAKIYVTTEKRMSYCdTVFKKETGkdrvQSGSYLSTGWFTLILAMDACYG 155

                         170       180
                  ....*....|....*....|....*.
gi 2462518880 187 VKLYGFW--PFSKTVEDIPVSHHYYD 210
Cdd:cd23975   156 IHVYGMIndTYCKTEGYRKVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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