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Conserved domains on  [gi|2462519793|ref|XP_054222136|]
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non-structural maintenance of chromosomes element 4 homolog A isoform X1 [Homo sapiens]

Protein Classification

non-structural maintenance of chromosomes element 4( domain architecture ID 13867608)

non-structural maintenance of chromosomes element 4 is a component of the SMC5-SMC6 complex, which promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 285-331 1.52e-20

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


:

Pssm-ID: 462585  Cd Length: 89  Bit Score: 84.50  E-value: 1.52e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462519793 285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIDT 331
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEP 47
COG5125 super family cl34915
Uncharacterized conserved protein [Function unknown];
231-332 2.34e-11

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG5125:

Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 63.10  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519793 231 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 310
Cdd:COG5125   130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203

                          90       100
                  ....*....|....*....|..
gi 2462519793 311 IIRDGFARIRLDQDRLPVIDTE 332
Cdd:COG5125   204 LLKEGKAFLEFDEDGTLYVVSE 225
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
 133-187 5.30e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


:

Pssm-ID: 464708  Cd Length: 56  Bit Score: 57.22  E-value: 5.30e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462519793 133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 285-331 1.52e-20

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 84.50  E-value: 1.52e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462519793 285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIDT 331
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEP 47
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
231-332 2.34e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 63.10  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519793 231 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 310
Cdd:COG5125   130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203

                          90       100
                  ....*....|....*....|..
gi 2462519793 311 IIRDGFARIRLDQDRLPVIDTE 332
Cdd:COG5125   204 LLKEGKAFLEFDEDGTLYVVSE 225
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
 133-187 5.30e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


Pssm-ID: 464708  Cd Length: 56  Bit Score: 57.22  E-value: 5.30e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462519793 133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 285-331 1.52e-20

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 84.50  E-value: 1.52e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462519793 285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIDT 331
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEP 47
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
231-332 2.34e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 63.10  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519793 231 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 310
Cdd:COG5125   130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203

                          90       100
                  ....*....|....*....|..
gi 2462519793 311 IIRDGFARIRLDQDRLPVIDTE 332
Cdd:COG5125   204 LLKEGKAFLEFDEDGTLYVVSE 225
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
 133-187 5.30e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


Pssm-ID: 464708  Cd Length: 56  Bit Score: 57.22  E-value: 5.30e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462519793 133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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