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Conserved domains on  [gi|2462521403|ref|XP_054222904|]
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peroxiredoxin-like 2A isoform X2 [Homo sapiens]

Protein Classification

peroxiredoxin-like family protein( domain architecture ID 10121943)

peroxiredoxin (PRX)-like family protein containing a CXXC motif, with the second cysteine in the motif corresponding to the peroxidatic cysteine of PRX, however, it does not contain the other two residues of the catalytic triad of PRXs; similar to vertebrate peroxiredoxin-like 2A, 2B (prostamide/prostaglandin F synthase) and 2C

CATH:  3.40.30.10
PubMed:  15518547|12517450|10049365
SCOP:  3000031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRX_like2 cd02970
Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. ...
 48-201 2.08e-37

Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.


:

Pssm-ID: 239268 [Multi-domain]  Cd Length: 149  Bit Score: 127.86  E-value: 2.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521403  48 YLEDIDLKTLEKEPRTFKAkeLWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHI-RTEVKDFQP 126
Cdd:cd02970     1 TAPDFELPDAGGETVTLSA--LLGEGPVVVVFYRGFGCPFCREYLRALSKLLPELDALGVELVAVGPESPeKLEAFDKGK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462521403 127 YFKGEIFLDekkkfygPQRRKMMFMGFIRLGVWYNFFRAWN----GGFSGNLEGEGFILGGVFVVGSGkQGILLEHREK 201
Cdd:cd02970    79 FLPFPVYAD-------PDRKLYRALGLVRSLPWSNTPRALWknaaIGFRGNDEGDGLQLPGVFVIGPD-GTILFAHVDR 149
 
Name Accession Description Interval E-value
PRX_like2 cd02970
Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. ...
 48-201 2.08e-37

Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.


Pssm-ID: 239268 [Multi-domain]  Cd Length: 149  Bit Score: 127.86  E-value: 2.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521403  48 YLEDIDLKTLEKEPRTFKAkeLWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHI-RTEVKDFQP 126
Cdd:cd02970     1 TAPDFELPDAGGETVTLSA--LLGEGPVVVVFYRGFGCPFCREYLRALSKLLPELDALGVELVAVGPESPeKLEAFDKGK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462521403 127 YFKGEIFLDekkkfygPQRRKMMFMGFIRLGVWYNFFRAWN----GGFSGNLEGEGFILGGVFVVGSGkQGILLEHREK 201
Cdd:cd02970    79 FLPFPVYAD-------PDRKLYRALGLVRSLPWSNTPRALWknaaIGFRGNDEGDGLQLPGVFVIGPD-GTILFAHVDR 149
AhpC-TSA_2 pfam13911
AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide ...
 94-202 8.06e-30

AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 433575  Cd Length: 114  Bit Score: 107.39  E-value: 8.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521403  94 DLSSLKSMLDQLGVPLYAVVKEHIRtEVKDFQ--PYFKGEIFLDEKKKFYGPQRRKM-----MFMGFIRLGVWYNFFRAW 166
Cdd:pfam13911   1 RLSSLKPELDAAGIRLVAIGCGTPG-RIEEFIklTGFPFPVYVDPSRKLYRALGLKRglsggLLPGFLGKGLRNMTRRAK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462521403 167 NGGFSGNLEGEGFILGGVFVVGSGKqGILLEHREKE 202
Cdd:pfam13911  80 AIGIPGNLGGDGTQLGGTFVFDKGG-EILYEHRDRG 114
 
Name Accession Description Interval E-value
PRX_like2 cd02970
Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. ...
 48-201 2.08e-37

Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.


Pssm-ID: 239268 [Multi-domain]  Cd Length: 149  Bit Score: 127.86  E-value: 2.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521403  48 YLEDIDLKTLEKEPRTFKAkeLWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHI-RTEVKDFQP 126
Cdd:cd02970     1 TAPDFELPDAGGETVTLSA--LLGEGPVVVVFYRGFGCPFCREYLRALSKLLPELDALGVELVAVGPESPeKLEAFDKGK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462521403 127 YFKGEIFLDekkkfygPQRRKMMFMGFIRLGVWYNFFRAWN----GGFSGNLEGEGFILGGVFVVGSGkQGILLEHREK 201
Cdd:cd02970    79 FLPFPVYAD-------PDRKLYRALGLVRSLPWSNTPRALWknaaIGFRGNDEGDGLQLPGVFVIGPD-GTILFAHVDR 149
AhpC-TSA_2 pfam13911
AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide ...
 94-202 8.06e-30

AhpC/TSA antioxidant enzyme; This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 433575  Cd Length: 114  Bit Score: 107.39  E-value: 8.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521403  94 DLSSLKSMLDQLGVPLYAVVKEHIRtEVKDFQ--PYFKGEIFLDEKKKFYGPQRRKM-----MFMGFIRLGVWYNFFRAW 166
Cdd:pfam13911   1 RLSSLKPELDAAGIRLVAIGCGTPG-RIEEFIklTGFPFPVYVDPSRKLYRALGLKRglsggLLPGFLGKGLRNMTRRAK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462521403 167 NGGFSGNLEGEGFILGGVFVVGSGKqGILLEHREKE 202
Cdd:pfam13911  80 AIGIPGNLGGDGTQLGGTFVFDKGG-EILYEHRDRG 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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