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Conserved domains on  [gi|2462525865|ref|XP_054225081|]
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trafficking protein particle complex subunit 4 isoform X1 [Homo sapiens]

Protein Classification

trafficking protein particle complex subunit 4( domain architecture ID 13000952)

trafficking protein particle complex subunit 4 is a core component of the transport protein particle (TRAPP) complexes and one of the essential subunits for guanine nucleotide exchange factor (GEF) activity for Rab1 GTPase

CATH:  3.30.450.70
Gene Ontology:  GO:0016192|GO:0030008|GO:0006901|GO:0099022

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 13-100 3.07e-60

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341446  Cd Length: 127  Bit Score: 180.41  E-value: 3.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  13 LFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCEL 92
Cdd:cd14856    40 LHAIAAQLSPVPGSSGIELLETDTFRLHCFQTLTGIKFVLVADPKQPGLDALLRRVYELYADYVLKNPFYELEMPIRCEL 119


                  ....*...
gi 2462525865  93 FDQNLKLA 100
Cdd:cd14856   120 FDENLQKL 127
 
Name Accession Description Interval E-value
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 13-100 3.07e-60

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 180.41  E-value: 3.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  13 LFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCEL 92
Cdd:cd14856    40 LHAIAAQLSPVPGSSGIELLETDTFRLHCFQTLTGIKFVLVADPKQPGLDALLRRVYELYADYVLKNPFYELEMPIRCEL 119


                  ....*...
gi 2462525865  93 FDQNLKLA 100
Cdd:cd14856   120 FDENLQKL 127
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 11-104 6.20e-52

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 159.79  E-value: 6.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  11 FRLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQ-AGIDSLLRKIYEIYSDFALKNPFYSLEMPIR 89
Cdd:pfam04099  40 HSLHSISSKISPLPGSSGIESLETDTFKLHCLETLTGIKFVLVTDPGTgINRDSLLRKYYELYSDYVLKNPFYSLGMPIR 119

                          90
                  ....*....|....*
gi 2462525865  90 CELFDQNLKLALEVA 104
Cdd:pfam04099 120 CELFDEKLDQYVRSL 134
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
13-102 5.24e-31

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 106.91  E-value: 5.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  13 LFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCEL 92
Cdd:COG5122    43 VSAILTQTIPLPGSSGRLVLYFRNFVMTIFQTTTGTKFVFVAEKRTVNALFQLQKIYSLYSDYVTKNPFYSPEMPIQCSL 122

                          90
                  ....*....|
gi 2462525865  93 FDQNLKLALE 102
Cdd:COG5122   123 FDEHLKRMFE 132
 
Name Accession Description Interval E-value
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 13-100 3.07e-60

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 180.41  E-value: 3.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  13 LFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCEL 92
Cdd:cd14856    40 LHAIAAQLSPVPGSSGIELLETDTFRLHCFQTLTGIKFVLVADPKQPGLDALLRRVYELYADYVLKNPFYELEMPIRCEL 119


                  ....*...
gi 2462525865  93 FDQNLKLA 100
Cdd:cd14856   120 FDENLQKL 127
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 11-104 6.20e-52

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 159.79  E-value: 6.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  11 FRLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQ-AGIDSLLRKIYEIYSDFALKNPFYSLEMPIR 89
Cdd:pfam04099  40 HSLHSISSKISPLPGSSGIESLETDTFKLHCLETLTGIKFVLVTDPGTgINRDSLLRKYYELYSDYVLKNPFYSLGMPIR 119

                          90
                  ....*....|....*
gi 2462525865  90 CELFDQNLKLALEVA 104
Cdd:pfam04099 120 CELFDEKLDQYVRSL 134
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
13-102 5.24e-31

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 106.91  E-value: 5.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  13 LFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCEL 92
Cdd:COG5122    43 VSAILTQTIPLPGSSGRLVLYFRNFVMTIFQTTTGTKFVFVAEKRTVNALFQLQKIYSLYSDYVTKNPFYSPEMPIQCSL 122

                          90
                  ....*....|
gi 2462525865  93 FDQNLKLALE 102
Cdd:COG5122   123 FDEHLKRMFE 132
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 13-97 2.89e-23

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 86.83  E-value: 2.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  13 LFAIGS---QLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIY-EIYSDFALKNPFYSLEMPI 88
Cdd:cd14855    41 LFSLKSfvrKISPTDDTCGFHSYTTNKYKLHYYETPTGLKFVLLTDPNVGDLRDVLQQIYsNIYVEYVVKNPLYPPGEPI 120


                  ....*....
gi 2462525865  89 RCELFDQNL 97
Cdd:cd14855   121 TSELFRSKL 129
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 11-98 3.96e-18

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 73.67  E-value: 3.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  11 FRLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGI-DSLLRKIYEIYSDFALKNPFYSLEM--P 87
Cdd:cd14853    40 HSVRSINSKLSPNVEKYLKLSDKTNEYKVHAYVTATGLKFVMLTDVLMDRIeDVLKNFFSDLYVLYVKKNPNPFYEPnsP 119

                          90
                  ....*....|.
gi 2462525865  88 IRCELFDQNLK 98
Cdd:cd14853   120 IRSRLFDSKVQ 130
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 35-100 4.17e-09

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 50.61  E-value: 4.17e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525865  35 DTFK---LHCYQTLTGIKFVVLADPRQ-AGIDSLLRKIYEIYSDFALkNPFYSLEMPIRCELFDQNLKLA 100
Cdd:cd14825    62 DRFNewsVSAFVTAGNIRFLLLHDNKNdDGIKNFFQEVYELYVKILM-NPFYEPNTPIRSPAFDRRVRAL 130
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 42-100 2.20e-08

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 48.41  E-value: 2.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462525865  42 YQTLTGIKFVVLADPRQ---AGIDSLLRKIYEIYSDFALkNPFYSLEMPIRCELFDQNLKLA 100
Cdd:pfam04628  66 YVTNSHIKFILVHESSTksdENIKQFFQEVHELYVKTLM-NPFYKPNDPIRSPAFDKKVRKL 126
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 32-98 7.19e-08

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 47.20  E-value: 7.19e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462525865  32 LETDTFKLHCYQTLTGIKFVVL-----ADPRQAGIDSLLRKIYEIYSDfALKNPFYSLEMPIRCELFDQNLK 98
Cdd:cd14854    61 YPTEDYKVYGYVTNTKVKFILVledtnTPLRDNDVRTLFRRLHNAYVD-AVSNPFYPPGTPITSKKFDRRVD 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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