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Conserved domains on  [gi|2462526305|ref|XP_054225294|]
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p53-induced death domain-containing protein 1 isoform X16 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-299 6.04e-39

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 148.54  E-value: 6.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGAL 193
Cdd:COG4886   125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 194 STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPaSLAGLRSLRLLVLHSNLLASVPaDLARLPLLTRLDLRDN 273
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNN 282

                         170       180
                  ....*....|....*....|....*.
gi 2462526305 274 QLRDLPPELLDAPFVRLQGNPLGEAS 299
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLL 308
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 421-453 1.81e-12

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


:

Pssm-ID: 463098  Cd Length: 34  Bit Score: 61.78  E-value: 1.81e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462526305 421 WGDLETYLEEEAPQRL-WAHCQVPHFSWFLVVSR 453
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
ZU5 super family cl02517
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 325-416 3.98e-08

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


The actual alignment was detected with superfamily member pfam00791:

Pssm-ID: 470600  Cd Length: 97  Bit Score: 51.37  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 325 SFPVTPRGCSVTLA-CGVRLQFPAGATATP--ITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFT 401
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGtrIECYLAVNRDESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEVPHC 81

                          90
                  ....*....|....*
gi 2462526305 402 PPQARRCREVVVRTR 416
Cdd:pfam00791  82 ASLRPEEWEIVLKRS 96
ZU5 super family cl02517
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 465-537 2.21e-06

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


The actual alignment was detected with superfamily member pfam00791:

Pssm-ID: 470600  Cd Length: 97  Bit Score: 46.37  E-value: 2.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462526305 465 GTLLCSsgHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLsqsGPP--SFLQPVTVQLP 537
Cdd:pfam00791  10 GRLVLP--NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-299 6.04e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 148.54  E-value: 6.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGAL 193
Cdd:COG4886   125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 194 STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPaSLAGLRSLRLLVLHSNLLASVPaDLARLPLLTRLDLRDN 273
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNN 282

                         170       180
                  ....*....|....*....|....*.
gi 2462526305 274 QLRDLPPELLDAPFVRLQGNPLGEAS 299
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLL 308
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-275 5.45e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 5.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 117 LPAGLSGLAHLAHLDLSFNSLE-TLPACVLQMRGLGAL-LLSHNCLSELPEALGALPALTFLTVTHNRLQ-TLPPALGAL 193
Cdd:PLN00113  276 IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 194 STLQRLDLSQN-LLDTLPPEIGGLGSLLELNLASNRLQS-LPASLAGLRSLRLLVLHSNLLA-SVPADLARLPLLTRLDL 270
Cdd:PLN00113  356 NNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDI 435


                  ....*
gi 2462526305 271 RDNQL 275
Cdd:PLN00113  436 SNNNL 440
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-273 2.47e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 114 LTNLPaGLSGLAHLAHLDLSFNSLETlpacvlqMRGLGALL------LSHNCLSELpEALGALPALTFLTVTHnrlQTLP 187
Cdd:cd21340    36 ITKIE-NLEFLTNLTHLYLQNNQIEK-------IENLENLVnlkklyLGGNRISVV-EGLENLTNLEELHIEN---QRLP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 188 PAlgalstlQRLDLSQNLLDTLppeiggLGSLLELNLASNRLQSLpASLAGLRSLRLLVLHSNLLASVPA---DLARLPL 264
Cdd:cd21340   104 PG-------EKLTFDPRSLAAL------SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldLLSSWPS 169


                  ....*....
gi 2462526305 265 LTRLDLRDN 273
Cdd:cd21340   170 LRELDLTGN 178
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 421-453 1.81e-12

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


Pssm-ID: 463098  Cd Length: 34  Bit Score: 61.78  E-value: 1.81e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462526305 421 WGDLETYLEEEAPQRL-WAHCQVPHFSWFLVVSR 453
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
LRR_8 pfam13855
Leucine rich repeat;
194-252 1.39e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.39e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462526305 194 STLQRLDLSQNLLDTLPPEI-GGLGSLLELNLASNRLQSL-PASLAGLRSLRLLVLHSNLL 252
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 325-416 3.98e-08

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 51.37  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 325 SFPVTPRGCSVTLA-CGVRLQFPAGATATP--ITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFT 401
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGtrIECYLAVNRDESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEVPHC 81

                          90
                  ....*....|....*
gi 2462526305 402 PPQARRCREVVVRTR 416
Cdd:pfam00791  82 ASLRPEEWEIVLKRS 96
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 465-537 2.21e-06

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 46.37  E-value: 2.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462526305 465 GTLLCSsgHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLsqsGPP--SFLQPVTVQLP 537
Cdd:pfam00791  10 GRLVLP--NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 475-537 7.21e-05

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 42.34  E-value: 7.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462526305  475 GVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGpPSFLQPVTVQLP 537
Cdd:smart00218  22 GVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHG-ALFLRPVILEVP 83
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 320-390 3.45e-03

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 37.33  E-value: 3.45e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462526305  320 TSDLDSFPVTPRGCSVTLA-CGVRLQFPAGATATP--ITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAF 390
Cdd:smart00218   1 PSFLVSGTFDARGGRLRGPrTGVRLIIPPGAIPQGtrYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHGALF 74
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-299 6.04e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 148.54  E-value: 6.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGAL 193
Cdd:COG4886   125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 194 STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPaSLAGLRSLRLLVLHSNLLASVPaDLARLPLLTRLDLRDN 273
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNN 282

                         170       180
                  ....*....|....*....|....*.
gi 2462526305 274 QLRDLPPELLDAPFVRLQGNPLGEAS 299
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-279 4.90e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.37  E-value: 4.90e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 104 DTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLetlpacVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLP 263
Cdd:COG4886   149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLT 228

                         170
                  ....*....|....*.
gi 2462526305 264 LLTRLDLRDNQLRDLP 279
Cdd:COG4886   229 NLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-303 7.41e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 7.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305  78 LEATLAQLPQslscLRSLVLKGGQrrdtlgaclrgaLTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSH 157
Cdd:COG4886   151 LPEPLGNLTN----LKSLDLSNNQ------------LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSG 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 158 NCLSELPEALGALPALTFLTVTHNRLQTLPpALGALSTLQRLDLSQNLLDTLPPEiGGLGSLLELNLASNRLQSLP---- 233
Cdd:COG4886   215 NQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKlkel 292

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAP 303
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-275 5.45e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 5.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 117 LPAGLSGLAHLAHLDLSFNSLE-TLPACVLQMRGLGAL-LLSHNCLSELPEALGALPALTFLTVTHNRLQ-TLPPALGAL 193
Cdd:PLN00113  276 IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 194 STLQRLDLSQN-LLDTLPPEIGGLGSLLELNLASNRLQS-LPASLAGLRSLRLLVLHSNLLA-SVPADLARLPLLTRLDL 270
Cdd:PLN00113  356 NNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDI 435


                  ....*
gi 2462526305 271 RDNQL 275
Cdd:PLN00113  436 SNNNL 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-275 3.72e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.59  E-value: 3.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 117 LPAGLSGLAHLAHLDLSFNSLE-TLPACVLQMRGLGALLLSHNCLS-ELPEALGALPALTFLTVTHNRLQ-TLPPALGAL 193
Cdd:PLN00113  180 IPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 194 STLQRLDLSQNLL-DTLPPEIGGLGSLLELNLASNRLQ-SLPASLAGLRSLRLLVLHSN-LLASVPADLARLPLLTRLDL 270
Cdd:PLN00113  260 KNLQYLFLYQNKLsGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNnFTGKIPVALTSLPRLQVLQL 339


                  ....*
gi 2462526305 271 RDNQL 275
Cdd:PLN00113  340 WSNKF 344
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
110-282 1.08e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 1.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT---- 185
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSllll 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 186 LPPALGALSTLQRLDLSQNlldtlpPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                         170
                  ....*....|....*..
gi 2462526305 266 TRLDLRDNQLRDLPPEL 282
Cdd:COG4886   162 KSLDLSNNQLTDLPEEL 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
49-262 6.34e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.12  E-value: 6.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305  49 QLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQS---LSCLRSLVLKGGQRRDTLgaclRGALTNLPAGLSglA 125
Cdd:PRK15370  231 QLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFhnkISCLPENLPEELRYLSVY----DNSIRTLPAHLP--S 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 126 HLAHLDLSFNSLETLPAcVLQMrGLGALLLSHNCLSELPEALGalPALTFLTVTHNRLQTLPPALGalSTLQRLDLSQNL 205
Cdd:PRK15370  305 GITHLNVQSNSLTALPE-TLPP-GLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNA 378

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462526305 206 LDTLPPEIGglGSLLELNLASNRLQSLPASLAGLRS-----LRLLVLHSNLLASVPADLARL 262
Cdd:PRK15370  379 LTNLPENLP--AALQIMQASRNNLVRLPESLPHFRGegpqpTRIIVEYNPFSERTIQNMQRL 438
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-282 1.75e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 1.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 117 LPAGLSGLAHLAHLDLSFNSLET-LPACVLQMRGLGALLLSHNCLS-ELPEALGALPALTFLTVTHNRLQ---------- 184
Cdd:PLN00113  372 IPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdm 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 185 ---------------TLPPALGAlSTLQRLDLSQNLLD-TLPPEIGGLGSLLELNLASNRLQS-LPASLAGLRSLRLLVL 247
Cdd:PLN00113  452 pslqmlslarnkffgGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2462526305 248 -HSNLLASVPADLARLPLLTRLDLRDNQLR-DLPPEL 282
Cdd:PLN00113  531 sHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-273 2.47e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 114 LTNLPaGLSGLAHLAHLDLSFNSLETlpacvlqMRGLGALL------LSHNCLSELpEALGALPALTFLTVTHnrlQTLP 187
Cdd:cd21340    36 ITKIE-NLEFLTNLTHLYLQNNQIEK-------IENLENLVnlkklyLGGNRISVV-EGLENLTNLEELHIEN---QRLP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 188 PAlgalstlQRLDLSQNLLDTLppeiggLGSLLELNLASNRLQSLpASLAGLRSLRLLVLHSNLLASVPA---DLARLPL 264
Cdd:cd21340   104 PG-------EKLTFDPRSLAAL------SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldLLSSWPS 169


                  ....*....
gi 2462526305 265 LTRLDLRDN 273
Cdd:cd21340   170 LRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
114-282 2.81e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.19  E-value: 2.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 114 LTNLPAGLSGlaHLAHLDLSFNSL----ETLPACVLQMRglgallLSHNCLSELPEALGAlpALTFLTVTHNRLQTLPPA 189
Cdd:PRK15370  211 LKSLPENLQG--NIKTLYANSNQLtsipATLPDTIQEME------LSINRITELPERLPS--ALQSLDLFHNKISCLPEN 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 190 LGalSTLQRLDLSQNLLDTLPPEIGGlgSLLELNLASNRLQSLPASLAglRSLRLLVLHSNLLASVPADLA--------- 260
Cdd:PRK15370  281 LP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLPpelqvldvs 354

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462526305 261 --RL--------PLLTRLDLRDNQLRDLPPEL 282
Cdd:PRK15370  355 knQItvlpetlpPTITTLDVSRNALTNLPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-295 1.70e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 1.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 126 HLAHLDLSFNSLETLPACvlqmRGLGALLLSHNCLSELpEALGALPALTFLTVTHNRLQTLPPaLGALSTLQRLDLSQNL 205
Cdd:cd21340     6 HLYLNDKNITKIDNLSLC----KNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 206 LDTLppE-IGGLGSLLELNLASNRL---QSL---PASLAGL-RSLRLLVLHSNLLASVpADLARLPLLTRLDLRDNQLRD 277
Cdd:cd21340    80 ISVV--EgLENLTNLEELHIENQRLppgEKLtfdPRSLAALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISD 156

                         170       180
                  ....*....|....*....|....*
gi 2462526305 278 LpPELLDA----PFVR---LQGNPL 295
Cdd:cd21340   157 L-EELLDLlsswPSLReldLTGNPV 180
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 421-453 1.81e-12

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


Pssm-ID: 463098  Cd Length: 34  Bit Score: 61.78  E-value: 1.81e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462526305 421 WGDLETYLEEEAPQRL-WAHCQVPHFSWFLVVSR 453
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-282 1.92e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 1.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 123 GLAHLAHLDLSFNSLE-TLPACVLQM-RGLGALLLSHNCLSElPEALGALPALTFLTVTHNRLQ-TLPPALGALSTLQRL 199
Cdd:PLN00113   91 RLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 200 DLSQN-LLDTLPPEIGGLGSLLELNLASNRLQ-SLPASLAGLRSLRLLVL-HSNLLASVPADLARLPLLTRLDLRDNQLR 276
Cdd:PLN00113  170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLT 249


                  ....*..
gi 2462526305 277 -DLPPEL 282
Cdd:PLN00113  250 gPIPSSL 256
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
114-302 3.00e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 63.26  E-value: 3.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPAcvlqmrGLGALLLSHNCLSELPealgALPA-LTFLTVTHNRLQTLPPalgA 192
Cdd:PRK15387  274 LTHLPALPSGLCKLWIFGNQLTSLPVLPP------GLQELSVSDNQLASLP----ALPSeLCKLWAYNNQLTSLPT---L 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 193 LSTLQRLDLSQNLLDTLPPEIGGLGSLLELNlasNRLQSLPASLAGLRSlrlLVLHSNLLASVPA-------------DL 259
Cdd:PRK15387  341 PSGLQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLPALPSGLKE---LIVSGNRLTSLPVlpselkelmvsgnRL 414

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462526305 260 ARLPLLT----RLDLRDNQLRDLPPELL---DAPFVRLQGNPLGEASPDA 302
Cdd:PRK15387  415 TSLPMLPsgllSLSVYRNQLTRLPESLIhlsSETTVNLEGNPLSERTLQA 464
LRR_8 pfam13855
Leucine rich repeat;
194-252 1.39e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.39e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462526305 194 STLQRLDLSQNLLDTLPPEI-GGLGSLLELNLASNRLQSL-PASLAGLRSLRLLVLHSNLL 252
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 116-239 1.20e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 116 NLPaGLSGLAHLAHLDLSFNSL-ETLPACVLQMRGLGALLLSHNCLS-ELPEALGALPALTFLTVTHNRLQ-TLPPALGA 192
Cdd:PLN00113  467 GLP-DSFGSKRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSE 545

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462526305 193 LSTLQRLDLSQNLLD-TLPPEIGGLGSLLELNLASNRLQ-SLPASLAGL 239
Cdd:PLN00113  546 MPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFL 594
LRR_8 pfam13855
Leucine rich repeat;
171-229 1.69e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.69e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462526305 171 PALTFLTVTHNRLQTLPP-ALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRL 229
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 325-416 3.98e-08

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 51.37  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 325 SFPVTPRGCSVTLA-CGVRLQFPAGATATP--ITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFT 401
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGtrIECYLAVNRDESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEVPHC 81

                          90
                  ....*....|....*
gi 2462526305 402 PPQARRCREVVVRTR 416
Cdd:pfam00791  82 ASLRPEEWEIVLKRS 96
PLN03150 PLN03150
hypothetical protein; Provisional
 186-273 6.91e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.59  E-value: 6.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 186 LPPALGALSTLQRLDLSQNLLD-TLPPEIGGLGSLLELNLASNRLQ-SLPASLAGLRSLRLLVLHSNLLAS-VPADLARL 262
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAALGGR 513

                          90
                  ....*....|..
gi 2462526305 263 PLL-TRLDLRDN 273
Cdd:PLN03150  514 LLHrASFNFTDN 525
LRR_8 pfam13855
Leucine rich repeat;
218-275 1.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 218 SLLELNLASNRLQSL-PASLAGLRSLRLLVLHSNLLASV-PADLARLPLLTRLDLRDNQL 275
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 163-239 1.75e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.97  E-value: 1.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 163 LPEALGALPALTFLTVTHNRLQ-TLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQS-LPASLAGL 239
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSLSGrVPAALGGR 513
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 465-537 2.21e-06

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 46.37  E-value: 2.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462526305 465 GTLLCSsgHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLsqsGPP--SFLQPVTVQLP 537
Cdd:pfam00791  10 GRLVLP--NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
PLN03150 PLN03150
hypothetical protein; Provisional
 110-216 3.15e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.20  E-value: 3.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 110 LRGALtnlPAGLSGLAHLAHLDLSFNSLEtlpacvlqmrglgalllshnclSELPEALGALPALTFLTVTHNRLQ-TLPP 188
Cdd:PLN03150  430 LRGFI---PNDISKLRHLQSINLSGNSIR----------------------GNIPPSLGSITSLEVLDLSYNSFNgSIPE 484

                          90       100
                  ....*....|....*....|....*....
gi 2462526305 189 ALGALSTLQRLDLSQNLLD-TLPPEIGGL 216
Cdd:PLN03150  485 SLGQLTSLRILNLNGNSLSgRVPAALGGR 513
LRR_8 pfam13855
Leucine rich repeat;
126-183 1.06e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 126 HLAHLDLSFNSLETLPACVLQ-MRGLGALLLSHNCLSEL-PEALGALPALTFLTVTHNRL 183
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
142-343 1.31e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.23  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 142 ACVLQMR-----GLGALLLSHNCLSELPEALGAlpALTFLTVTHNRLQTLPPALGALSTLQrldLSQNLLDTLPPEIGGL 216
Cdd:PRK15387  190 AVVQKMRaclnnGNAVLNVGESGLTTLPDCLPA--HITTLVIPDNNLTSLPALPPELRTLE---VSGNQLTSLPVLPPGL 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 217 gslLELNLASNRLQSLPASLAGLRSLRLLvlhSNLLASVPadlARLPLLTRLDLRDNQLRDLP--PELL------DAPFV 288
Cdd:PRK15387  265 ---LELSIFSNPLTHLPALPSGLCKLWIF---GNQLTSLP---VLPPGLQELSVSDNQLASLPalPSELcklwayNNQLT 335

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 289 RLQGNPLGEASPDAPSSPVAALiPEMP----RLFLTSD-LDSFPVTPRGCSVTLACGVRL 343
Cdd:PRK15387  336 SLPTLPSGLQELSVSDNQLASL-PTLPselyKLWAYNNrLTSLPALPSGLKELIVSGNRL 394
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 475-537 7.21e-05

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 42.34  E-value: 7.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462526305  475 GVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGpPSFLQPVTVQLP 537
Cdd:smart00218  22 GVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHG-ALFLRPVILEVP 83
PLN03150 PLN03150
hypothetical protein; Provisional
 203-275 2.13e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.13e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462526305 203 QNLLDTLPPEIGGLGSLLELNLASNRLQ-SLPASLAGLRSLRLLVL-HSNLLASVPADLARLPLLTRLDLRDNQL 275
Cdd:PLN03150  428 QGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLsYNSFNGSIPESLGQLTSLRILNLNGNSL 502
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 33-318 2.40e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305  33 LGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHE-DPQLLEATLAQLPQSLScLRSLVLKGGQRRDtlgaclR 111
Cdd:COG5238   151 LGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQiGDEGIEELAEALTQNTT-VTTLWLKRNPIGD------E 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 112 GAlTNLPAGLSGLAHLAHLDLSFNSLETlpacvlqmRGLGALLlshnclselpEALGALPALTFLTVTHNRL-----QTL 186
Cdd:COG5238   224 GA-EILAEALKGNKSLTTLDLSNNQIGD--------EGVIALA----------EALKNNTTVETLYLSGNQIgaegaIAL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 187 PPALGALSTLQRLDLSQNLLD-----TLPPEIGGLGSLLELNLASNRL-----QSLPASLAGLRSLRLLVLHSNLLASVP 256
Cdd:COG5238   285 AKALQGNTTLTSLDLSVNRIGdegaiALAEGLQGNKTLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIGDEG 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462526305 257 AD-----LARLPLLTRLDLRDNQLRDLPPE-LLDA------PFVRLQGNPLGEASPDApsspVAALIPEMPRLF 318
Cdd:COG5238   365 AIalakyLEGNTTLRELNLGKNNIGKQGAEaLIDAlqtnrlHTLILDGNLIGAEAQQR----LEQLLERIKSVY 434
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 117-279 7.71e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 7.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 117 LPAGLSGLAHLAHLDLSFNSL-----ETLPACvLQMRGLGALLLSHNCLSELPEAL--GAL----PALTFLTVTHNRLQT 185
Cdd:cd00116    73 LLQGLTKGCGLQELDLSDNALgpdgcGVLESL-LRSSSLQELKLNNNGLGDRGLRLlaKGLkdlpPALEKLVLGRNRLEG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 186 -----LPPALGALSTLQRLDLSQNlldtlppEIGGLGsllelnlasnrLQSLPASLAGLRSLRLLVLHSN--------LL 252
Cdd:cd00116   152 asceaLAKALRANRDLKELNLANN-------GIGDAG-----------IRALAEGLKANCNLEVLDLNNNgltdegasAL 213

                         170       180
                  ....*....|....*....|....*..
gi 2462526305 253 ASVPADLARLpllTRLDLRDNQLRDLP 279
Cdd:cd00116   214 AETLASLKSL---EVLNLGDNNLTDAG 237
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
145-282 2.07e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526305 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNL 224
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462526305 225 ASNRLQSLPASLAGLRSLRLLVLHSNllasvpADLARLPLLTRLDLRDNQLRDLPPEL 282
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEEL 132
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 320-390 3.45e-03

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 37.33  E-value: 3.45e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462526305  320 TSDLDSFPVTPRGCSVTLA-CGVRLQFPAGATATP--ITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAF 390
Cdd:smart00218   1 PSFLVSGTFDARGGRLRGPrTGVRLIIPPGAIPQGtrYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHGALF 74
LRR_8 pfam13855
Leucine rich repeat;
240-295 3.58e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462526305 240 RSLRLLVLHSNLLASVPAD-LARLPLLTRLDLRDNQLRDLPPELLDAP----FVRLQGNPL 295
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLpslrYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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