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Conserved domains on  [gi|2462527300|ref|XP_054225787|]
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tubby protein homolog isoform X6 [Homo sapiens]

Protein Classification

tubby family protein( domain architecture ID 11070239)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors; tubby family protein plays an important role in maintenance and function of neuronal cells during post differentiation and development in mammals, and may participate in the abscisic acid (ABA) signaling pathway in plants

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
242-449 1.27e-104

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 311.05  E-value: 1.27e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 242 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 320
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 321 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 393
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462527300 394 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDH 449
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQ 213
Tub_N super family cl24783
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 71-223 7.45e-32

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


The actual alignment was detected with superfamily member pfam16322:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 120.30  E-value: 7.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300  71 RQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQE----------ADSLASVQLGA 140
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEaaprsakrsgAHAALGTQGGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 141 TR----PTAP------------------ASAKRTKAAATAGGQGGAARKEKKGKH-------KGISSSMS-FDEDEEDEE 190
Cdd:pfam16322  81 GKgidgPAAFlteepqdsgselqilsvgDSPTSPPPDEELQEPGASGEEESSKQDlgdemqkKGISSSMNfDEEEEDEEE 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462527300 191 ENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 223
Cdd:pfam16322 161 ESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
242-449 1.27e-104

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 311.05  E-value: 1.27e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 242 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 320
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 321 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 393
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462527300 394 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDH 449
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQ 213
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 71-223 7.45e-32

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 120.30  E-value: 7.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300  71 RQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQE----------ADSLASVQLGA 140
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEaaprsakrsgAHAALGTQGGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 141 TR----PTAP------------------ASAKRTKAAATAGGQGGAARKEKKGKH-------KGISSSMS-FDEDEEDEE 190
Cdd:pfam16322  81 GKgidgPAAFlteepqdsgselqilsvgDSPTSPPPDEELQEPGASGEEESSKQDlgdemqkKGISSSMNfDEEEEDEEE 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462527300 191 ENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 223
Cdd:pfam16322 161 ESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
242-449 1.27e-104

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 311.05  E-value: 1.27e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 242 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 320
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 321 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 393
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462527300 394 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDH 449
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQ 213
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 71-223 7.45e-32

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 120.30  E-value: 7.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300  71 RQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQE----------ADSLASVQLGA 140
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEaaprsakrsgAHAALGTQGGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527300 141 TR----PTAP------------------ASAKRTKAAATAGGQGGAARKEKKGKH-------KGISSSMS-FDEDEEDEE 190
Cdd:pfam16322  81 GKgidgPAAFlteepqdsgselqilsvgDSPTSPPPDEELQEPGASGEEESSKQDlgdemqkKGISSSMNfDEEEEDEEE 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462527300 191 ENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 223
Cdd:pfam16322 161 ESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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