NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462528409|ref|XP_054226311|]
View 

centrosomal protein of 295 kDa isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PTZ00121 super family cl31754
MAEBL; Provisional
27-554 1.95e-07

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.07  E-value: 1.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   27 ERRRKLRLLQVREQERDIALQIREDI---KQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLAS--LRSMGEGHRQAK 101
Cdd:PTZ00121  1246 EEERNNEEIRKFEEARMAHFARRQAAikaEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAeeAKKADEAKKKAE 1325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  102 ENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEillkqktwhIKARKEALLVEKERSAKITSLPPPPPTlfeniEVK 181
Cdd:PTZ00121  1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA---------AEEKAEAAEKKKEEAKKKADAAKKKAE-----EKK 1391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  182 RISAVKTNSstyhhlhtfvnrETDTKQPDARLAAEEEAKRLEELQKQA-----AQERMERFEKAHvRGFQAMKKIHLAQN 256
Cdd:PTZ00121  1392 KADEAKKKA------------EEDKKKADELKKAAAAKKKADEAKKKAeekkkADEAKKKAEEAK-KADEAKKKAEEAKK 1458
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  257 QEKLMKELKQLQQEDLARRRQTVAQMPPQLvelpYKRSEMKEDWQRELEFAFEDMYNADRKVKGNlilhlepeplptvtn 336
Cdd:PTZ00121  1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEA----KKKAEEAKKKADEAKKAAEAKKKADEAKKAE--------------- 1519
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  337 qiQDEELDLSMEQENLGAAEDLPVTEAEICSSEtdvplVMKTQQIPSKVLFKKLLNKIRSQKSlwtiKSMSEDESEMITT 416
Cdd:PTZ00121  1520 --EAKKADEAKKAEEAKKADEAKKAEEKKKADE-----LKKAEELKKAEEKKKAEEAKKAEED----KNMALRKAEEAKK 1588
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  417 VSEieskAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
Cdd:PTZ00121  1589 AEE----ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAA 1664
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462528409  497 QEEAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETdcFRAQLEEEKRKKTQ 554
Cdd:PTZ00121  1665 EEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE--LKKKEAEEKKKAEE 1720
ALMS_motif super family cl21154
ALMS motif; This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), ...
2478-2589 5.42e-06

ALMS motif; This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), KIAA1731 and C10orf90.


The actual alignment was detected with superfamily member pfam15309:

Pssm-ID: 464634  Cd Length: 131  Bit Score: 48.14  E-value: 5.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409 2478 SLQEAFIKRKKSFMERSHQRQKeiRNKIHVSE-------NSQIKTVKEKPSISSSVSRLKGVNKVRASFPEDRKTTQALR 2550
Cdd:pfam15309    5 SLQEALEMHRPDFISRSRERLK--RLELLVEErklqevlQRERERLFNKPIPRTNKRQQTVPLPDNLFKPRRRAISKKEM 82
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462528409 2551 HQRGLRLYNQLAEVKQQKEEKTKQEAYAQNRARAKEFHK 2589
Cdd:pfam15309   83 IARSKRIYEQLPEVKKKKEEEKRKAEYKSNRLKAQLFKK 121
 
Name Accession Description Interval E-value
PTZ00121 PTZ00121
MAEBL; Provisional
27-554 1.95e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.07  E-value: 1.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   27 ERRRKLRLLQVREQERDIALQIREDI---KQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLAS--LRSMGEGHRQAK 101
Cdd:PTZ00121  1246 EEERNNEEIRKFEEARMAHFARRQAAikaEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAeeAKKADEAKKKAE 1325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  102 ENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEillkqktwhIKARKEALLVEKERSAKITSLPPPPPTlfeniEVK 181
Cdd:PTZ00121  1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA---------AEEKAEAAEKKKEEAKKKADAAKKKAE-----EKK 1391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  182 RISAVKTNSstyhhlhtfvnrETDTKQPDARLAAEEEAKRLEELQKQA-----AQERMERFEKAHvRGFQAMKKIHLAQN 256
Cdd:PTZ00121  1392 KADEAKKKA------------EEDKKKADELKKAAAAKKKADEAKKKAeekkkADEAKKKAEEAK-KADEAKKKAEEAKK 1458
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  257 QEKLMKELKQLQQEDLARRRQTVAQMPPQLvelpYKRSEMKEDWQRELEFAFEDMYNADRKVKGNlilhlepeplptvtn 336
Cdd:PTZ00121  1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEA----KKKAEEAKKKADEAKKAAEAKKKADEAKKAE--------------- 1519
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  337 qiQDEELDLSMEQENLGAAEDLPVTEAEICSSEtdvplVMKTQQIPSKVLFKKLLNKIRSQKSlwtiKSMSEDESEMITT 416
Cdd:PTZ00121  1520 --EAKKADEAKKAEEAKKADEAKKAEEKKKADE-----LKKAEELKKAEEKKKAEEAKKAEED----KNMALRKAEEAKK 1588
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  417 VSEieskAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
Cdd:PTZ00121  1589 AEE----ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAA 1664
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462528409  497 QEEAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETdcFRAQLEEEKRKKTQ 554
Cdd:PTZ00121  1665 EEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE--LKKKEAEEKKKAEE 1720
ALMS_motif pfam15309
ALMS motif; This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), ...
2478-2589 5.42e-06

ALMS motif; This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), KIAA1731 and C10orf90.


Pssm-ID: 464634  Cd Length: 131  Bit Score: 48.14  E-value: 5.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409 2478 SLQEAFIKRKKSFMERSHQRQKeiRNKIHVSE-------NSQIKTVKEKPSISSSVSRLKGVNKVRASFPEDRKTTQALR 2550
Cdd:pfam15309    5 SLQEALEMHRPDFISRSRERLK--RLELLVEErklqevlQRERERLFNKPIPRTNKRQQTVPLPDNLFKPRRRAISKKEM 82
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462528409 2551 HQRGLRLYNQLAEVKQQKEEKTKQEAYAQNRARAKEFHK 2589
Cdd:pfam15309   83 IARSKRIYEQLPEVKKKKEEEKRKAEYKSNRLKAQLFKK 121
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
22-278 7.05e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 7.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   22 LKEDYERRRKLRLLQVREQERDIALQIRE-DIKQRRNQQFTRLAEELRAEWEESQTQ-------------KIQNLEKLYL 87
Cdd:COG1196    205 LERQAEKAERYRELKEELKELEAELLLLKlRELEAELEELEAELEELEAELEELEAElaeleaeleelrlELEELELELE 284
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   88 ASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALkvQKNQKEILLKQKTwhIKARKEALLVEKERSAKITSL 167
Cdd:COG1196    285 EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA--ELEEELEELEEEL--EELEEELEEAEEELEEAEAEL 360
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  168 PPPPPTLfENIEVKRISAVKTNSSTYHHLHTFVNRETDTKQPDARLAAEEEA--KRLEELQKQAAQERMERFEKAHVRGF 245
Cdd:COG1196    361 AEAEEAL-LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEAllERLERLEEELEELEEALAELEEEEEE 439
                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462528409  246 QAMKKIHLAQNQEKLMKELKQLQQEDLARRRQT 278
Cdd:COG1196    440 EEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
27-259 7.13e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.20  E-value: 7.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   27 ERRRKLRLLQVREQERDIAL----------QIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKlylASLRSMGEG 96
Cdd:pfam17380  375 SRMRELERLQMERQQKNERVrqeleaarkvKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEE---ERAREMERV 451
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   97 HRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQ--KNQKEILLKQKtwhIKARKEALLVEKERSAKITSLPPPPPTL 174
Cdd:pfam17380  452 RLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKraEEQRRKILEKE---LEERKQAMIEEERKRKLLEKEMEERQKA 528
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  175 FENIEVKRISavktnsstyhhlhtfvnRETDTKQPDArlaaeEEAKRLEELQKQAAQERmERFEkAHVRGFQAMKKIHLA 254
Cdd:pfam17380  529 IYEEERRREA-----------------EEERRKQQEM-----EERRRIQEQMRKATEER-SRLE-AMEREREMMRQIVES 584

                   ....*
gi 2462528409  255 QNQEK 259
Cdd:pfam17380  585 EKARA 589
 
Name Accession Description Interval E-value
PTZ00121 PTZ00121
MAEBL; Provisional
27-554 1.95e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.07  E-value: 1.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   27 ERRRKLRLLQVREQERDIALQIREDI---KQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLAS--LRSMGEGHRQAK 101
Cdd:PTZ00121  1246 EEERNNEEIRKFEEARMAHFARRQAAikaEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAeeAKKADEAKKKAE 1325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  102 ENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEillkqktwhIKARKEALLVEKERSAKITSLPPPPPTlfeniEVK 181
Cdd:PTZ00121  1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA---------AEEKAEAAEKKKEEAKKKADAAKKKAE-----EKK 1391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  182 RISAVKTNSstyhhlhtfvnrETDTKQPDARLAAEEEAKRLEELQKQA-----AQERMERFEKAHvRGFQAMKKIHLAQN 256
Cdd:PTZ00121  1392 KADEAKKKA------------EEDKKKADELKKAAAAKKKADEAKKKAeekkkADEAKKKAEEAK-KADEAKKKAEEAKK 1458
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  257 QEKLMKELKQLQQEDLARRRQTVAQMPPQLvelpYKRSEMKEDWQRELEFAFEDMYNADRKVKGNlilhlepeplptvtn 336
Cdd:PTZ00121  1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEA----KKKAEEAKKKADEAKKAAEAKKKADEAKKAE--------------- 1519
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  337 qiQDEELDLSMEQENLGAAEDLPVTEAEICSSEtdvplVMKTQQIPSKVLFKKLLNKIRSQKSlwtiKSMSEDESEMITT 416
Cdd:PTZ00121  1520 --EAKKADEAKKAEEAKKADEAKKAEEKKKADE-----LKKAEELKKAEEKKKAEEAKKAEED----KNMALRKAEEAKK 1588
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  417 VSEieskAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHP 496
Cdd:PTZ00121  1589 AEE----ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAA 1664
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462528409  497 QEEAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETdcFRAQLEEEKRKKTQ 554
Cdd:PTZ00121  1665 EEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE--LKKKEAEEKKKAEE 1720
ALMS_motif pfam15309
ALMS motif; This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), ...
2478-2589 5.42e-06

ALMS motif; This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), KIAA1731 and C10orf90.


Pssm-ID: 464634  Cd Length: 131  Bit Score: 48.14  E-value: 5.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409 2478 SLQEAFIKRKKSFMERSHQRQKeiRNKIHVSE-------NSQIKTVKEKPSISSSVSRLKGVNKVRASFPEDRKTTQALR 2550
Cdd:pfam15309    5 SLQEALEMHRPDFISRSRERLK--RLELLVEErklqevlQRERERLFNKPIPRTNKRQQTVPLPDNLFKPRRRAISKKEM 82
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462528409 2551 HQRGLRLYNQLAEVKQQKEEKTKQEAYAQNRARAKEFHK 2589
Cdd:pfam15309   83 IARSKRIYEQLPEVKKKKEEEKRKAEYKSNRLKAQLFKK 121
PTZ00121 PTZ00121
MAEBL; Provisional
23-317 1.46e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   23 KEDYERRRKLRLLQVREQERDIALQIREDIKQ---------RRNQQFTRLAEELRAEWEE------------SQTQKIQN 81
Cdd:PTZ00121  1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEEnkikaaeeaKKAEEDKKKAEEAKKAEEDekkaaealkkeaEEAKKAEE 1706
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   82 LEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKA-DLRHKEALKVQKNQKEILLKQKTWHIKARKEALL---VE 157
Cdd:PTZ00121  1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAeEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIeeeLD 1786
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  158 KERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVnreTDTKQ-PDARLAAEEEAKrleELQKQAAQERMER 236
Cdd:PTZ00121  1787 EEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMED---SAIKEvADSKNMQLEEAD---AFEKHKFNKNNEN 1860
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  237 FEKAHVRGFQAMKKIHLAQNQEKLM--KELKQLQQEDLARRRQTvAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNA 314
Cdd:PTZ00121  1861 GEDGNKEADFNKEKDLKEDDEEEIEeaDEIEKIDKDDIEREIPN-NNMAGKNNDIIDDKLDKDEYIKRDAEETREEIIKI 1939

                   ...
gi 2462528409  315 DRK 317
Cdd:PTZ00121  1940 SKK 1942
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
22-278 7.05e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 7.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   22 LKEDYERRRKLRLLQVREQERDIALQIRE-DIKQRRNQQFTRLAEELRAEWEESQTQ-------------KIQNLEKLYL 87
Cdd:COG1196    205 LERQAEKAERYRELKEELKELEAELLLLKlRELEAELEELEAELEELEAELEELEAElaeleaeleelrlELEELELELE 284
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   88 ASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALkvQKNQKEILLKQKTwhIKARKEALLVEKERSAKITSL 167
Cdd:COG1196    285 EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA--ELEEELEELEEEL--EELEEELEEAEEELEEAEAEL 360
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  168 PPPPPTLfENIEVKRISAVKTNSSTYHHLHTFVNRETDTKQPDARLAAEEEA--KRLEELQKQAAQERMERFEKAHVRGF 245
Cdd:COG1196    361 AEAEEAL-LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEAllERLERLEEELEELEEALAELEEEEEE 439
                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462528409  246 QAMKKIHLAQNQEKLMKELKQLQQEDLARRRQT 278
Cdd:COG1196    440 EEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
27-259 7.13e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.20  E-value: 7.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   27 ERRRKLRLLQVREQERDIAL----------QIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKlylASLRSMGEG 96
Cdd:pfam17380  375 SRMRELERLQMERQQKNERVrqeleaarkvKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEE---ERAREMERV 451
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   97 HRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQ--KNQKEILLKQKtwhIKARKEALLVEKERSAKITSLPPPPPTL 174
Cdd:pfam17380  452 RLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKraEEQRRKILEKE---LEERKQAMIEEERKRKLLEKEMEERQKA 528
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  175 FENIEVKRISavktnsstyhhlhtfvnRETDTKQPDArlaaeEEAKRLEELQKQAAQERmERFEkAHVRGFQAMKKIHLA 254
Cdd:pfam17380  529 IYEEERRREA-----------------EEERRKQQEM-----EERRRIQEQMRKATEER-SRLE-AMEREREMMRQIVES 584

                   ....*
gi 2462528409  255 QNQEK 259
Cdd:pfam17380  585 EKARA 589
PTZ00121 PTZ00121
MAEBL; Provisional
12-277 7.39e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 7.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   12 RLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRaeweesqtQKIQNLEKLYLASLR 91
Cdd:PTZ00121  1576 KNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEK--------KKVEQLKKKEAEEKK 1647
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   92 SMGEGHRQAKENEPDLDALAQRAAERKRKADlrhkEALKVQKNQKEillkqktwhikaRKEALLVEKERSAKITSLPPPp 171
Cdd:PTZ00121  1648 KAEELKKAEEENKIKAAEEAKKAEEDKKKAE----EAKKAEEDEKK------------AAEALKKEAEEAKKAEELKKK- 1710
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  172 ptlfENIEVKRISAVKTNSstyhhlhtfvnRETDTKQPDARLAAEEEAKRLEELQKqaaqERMERFEKAHVRGFQAMKKI 251
Cdd:PTZ00121  1711 ----EAEEKKKAEELKKAE-----------EENKIKAEEAKKEAEEDKKKAEEAKK----DEEEKKKIAHLKKEEEKKAE 1771
                          250       260
                   ....*....|....*....|....*.
gi 2462528409  252 HLAQNQEKLMKElkQLQQEDLARRRQ 277
Cdd:PTZ00121  1772 EIRKEKEAVIEE--ELDEEDEKRRME 1795
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
17-276 1.47e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   17 EEAFILKEDYERRRKLRLLQVREQERDIA---LQIREDIKQRRNQQFTRLAEELRAEWEESQTQK-IQNLEKLYLASLRS 92
Cdd:COG1196    343 EEELEEAEEELEEAEAELAEAEEALLEAEaelAEAEEELEELAEELLEALRAAAELAAQLEELEEaEEALLERLERLEEE 422
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   93 MGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPP 172
Cdd:COG1196    423 LEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  173 TLFENIEVKRISAVKTNSSTYHHLHtfVNRETDTKQPDARLAA------------EEEAKRLEELQKQAAQERMERFEKA 240
Cdd:COG1196    503 YEGFLEGVKAALLLAGLRGLAGAVA--VLIGVEAAYEAALEAAlaaalqnivvedDEVAAAAIEYLKAAKAGRATFLPLD 580
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 2462528409  241 HVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRR 276
Cdd:COG1196    581 KIRARAALAAALARGAIGAAVDLVASDLREADARYY 616
PRK12704 PRK12704
phosphodiesterase; Provisional
3-141 1.91e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 1.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409    3 RKVVNTHKLRLSPNEEAFILKE---DYERRRKLRLLQVREQERDIALQIREDIKQRRNqQFTRLAEELRAEwEESQTQKI 79
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILEEakkEAEAIKKEALLEAKEEIHKLRNEFEKELRERRN-ELQKLEKRLLQK-EENLDRKL 102
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462528409   80 QNLEKlylaslrsmgeghrqaKENEpdLDALAQRAAERKRKADLRHKEALKVQKNQKEILLK 141
Cdd:PRK12704   103 ELLEK----------------REEE--LEKKEKELEQKQQELEKKEEELEELIEEQLQELER 146
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
38-281 2.59e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.19  E-value: 2.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   38 REQERDIALQIREDIKQRRNQQFTRLaeELRAEWEESQTQKIQNLEKlylaSLRSMGEGHRQAKENEPDLDALAQ----R 113
Cdd:pfam17380  287 RQQQEKFEKMEQERLRQEKEEKAREV--ERRRKLEEAEKARQAEMDR----QAAIYAEQERMAMERERELERIRQeerkR 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  114 AAERKRKADL-------RHKEALKVQKNQKEILLKQKtwhIKARKEALLVEKERSAKITSlppppptlfENIEVKRISAV 186
Cdd:pfam17380  361 ELERIRQEEIameisrmRELERLQMERQQKNERVRQE---LEAARKVKILEEERQRKIQQ---------QKVEMEQIRAE 428
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  187 KTNSstyhhlhtfvnRETDTKQPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKihlAQNQEKLMKELKQ 266
Cdd:pfam17380  429 QEEA-----------RQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEK---EKRDRKRAEEQRR 494
                          250
                   ....*....|....*..
gi 2462528409  267 --LQQEDLARRRQTVAQ 281
Cdd:pfam17380  495 kiLEKELEERKQAMIEE 511
PTZ00121 PTZ00121
MAEBL; Provisional
22-307 2.88e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409   22 LKEDYERRRKLRLLQVR-EQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQA 100
Cdd:PTZ00121  1307 AKKKAEEAKKADEAKKKaEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK 1386
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  101 KENEPDLDALAQRAAERKRKAD-LRHKEALKVQKNQKEILLKQKTWHIKARKEAllvEKERSAKITSLPPPPPTLFENIE 179
Cdd:PTZ00121  1387 AEEKKKADEAKKKAEEDKKKADeLKKAAAAKKKADEAKKKAEEKKKADEAKKKA---EEAKKADEAKKKAEEAKKAEEAK 1463
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462528409  180 VKRISAVKTNSSTYhhlhtfvNRETDTKQPDARLAAEEEAKRLEELQKQA-AQERMERFEKA-HVRGFQAMKKIHLAQNQ 257
Cdd:PTZ00121  1464 KKAEEAKKADEAKK-------KAEEAKKADEAKKKAEEAKKKADEAKKAAeAKKKADEAKKAeEAKKADEAKKAEEAKKA 1536
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462528409  258 EKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFA 307
Cdd:PTZ00121  1537 DEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEA 1586
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH