NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462528961|ref|XP_054226580|]
View 

tesmin isoform X1 [Homo sapiens]

Protein Classification

TCR domain-containing protein( domain architecture ID 10508328)

TCR domain-containing protein similar to Homo sapiens tesmin, a testis-specific metallothionein-like protein, and to Arabidopsis thaliana TSO1, a novel protein that modulates cytokinesis and cell expansion in Arabidopsis

Gene Ontology:  GO:0003700|GO:0003677|GO:0046872

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TCR pfam03638
Tesmin/TSO1-like CXC domain, cysteine-rich domain; This family includes proteins that have two ...
 367-404 5.43e-17

Tesmin/TSO1-like CXC domain, cysteine-rich domain; This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin and TSO1. This family is called a CXC domain in.


:

Pssm-ID: 461001  Cd Length: 38  Bit Score: 74.56  E-value: 5.43e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462528961 367 NKGCNCRRSGCLKNYCECYEAQIMCSSICKCIGCKNYE 404
Cdd:pfam03638   1 KKGCNCKKSKCLKLYCECFAAGVFCSSNCKCEGCKNTE 38
 
Name Accession Description Interval E-value
TCR pfam03638
Tesmin/TSO1-like CXC domain, cysteine-rich domain; This family includes proteins that have two ...
 367-404 5.43e-17

Tesmin/TSO1-like CXC domain, cysteine-rich domain; This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin and TSO1. This family is called a CXC domain in.


Pssm-ID: 461001  Cd Length: 38  Bit Score: 74.56  E-value: 5.43e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462528961 367 NKGCNCRRSGCLKNYCECYEAQIMCSSICKCIGCKNYE 404
Cdd:pfam03638   1 KKGCNCKKSKCLKLYCECFAAGVFCSSNCKCEGCKNTE 38
MSL2_CXC cd13122
DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins; The CXC ...
 364-402 2.62e-03

DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins; The CXC domain of Drosophila melanogaster MSL2 forms a Zn(3)Cys(9) cluster and is involved in recruiting members of the dosage compensation complex (DCC) to sites on the X chromosome.


Pssm-ID: 240555  Cd Length: 50  Bit Score: 35.83  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462528961 364 PQHNKGCNCRRSG-------CLKNYCECYEAQIMCSSiCKCIGCKN 402
Cdd:cd13122     1 PPEKKGCRCGTATqspgvltCRGQRCPCYSNGKSCLD-CKCRGCKN 45
 
Name Accession Description Interval E-value
TCR pfam03638
Tesmin/TSO1-like CXC domain, cysteine-rich domain; This family includes proteins that have two ...
 367-404 5.43e-17

Tesmin/TSO1-like CXC domain, cysteine-rich domain; This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin and TSO1. This family is called a CXC domain in.


Pssm-ID: 461001  Cd Length: 38  Bit Score: 74.56  E-value: 5.43e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462528961 367 NKGCNCRRSGCLKNYCECYEAQIMCSSICKCIGCKNYE 404
Cdd:pfam03638   1 KKGCNCKKSKCLKLYCECFAAGVFCSSNCKCEGCKNTE 38
MSL2-CXC pfam16682
CXC domain of E3 ubiquitin-protein ligase MSL2; MSL2-CXC is an autonomously folded domain ...
 363-402 1.87e-04

CXC domain of E3 ubiquitin-protein ligase MSL2; MSL2-CXC is an autonomously folded domain containing that binds three zinc ions. It lies on the E3 ubiquitin-protein ligase MSL2 in eukaryotes. The CXC domain critically contributes to the DNA-binding activity of MSL2. It carries 9 invariant cysteines within about a 50 residue region.


Pssm-ID: 435512  Cd Length: 55  Bit Score: 39.34  E-value: 1.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462528961 363 KPQHNKGCNCRRSG-------CLKNYCECYEAQIMCSSiCKCIGCKN 402
Cdd:pfam16682   1 KPPEKKGCRCGTSTptppkltCRNQRCPCYSNGKSCTD-CKCRGCKN 46
MSL2_CXC cd13122
DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins; The CXC ...
 364-402 2.62e-03

DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins; The CXC domain of Drosophila melanogaster MSL2 forms a Zn(3)Cys(9) cluster and is involved in recruiting members of the dosage compensation complex (DCC) to sites on the X chromosome.


Pssm-ID: 240555  Cd Length: 50  Bit Score: 35.83  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462528961 364 PQHNKGCNCRRSG-------CLKNYCECYEAQIMCSSiCKCIGCKN 402
Cdd:cd13122     1 PPEKKGCRCGTATqspgvltCRGQRCPCYSNGKSCLD-CKCRGCKN 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH