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Conserved domains on  [gi|2462529435|ref|XP_054226810|]
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tetraspanin-9 isoform X2 [Homo sapiens]

Protein Classification

tetraspanin-9 family protein( domain architecture ID 13626525)

tetraspanin-9 family protein is a transmembrane (TM) protein with four TM segments which may act as a molecular facilitator in diverse processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 105-202 7.05e-58

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


:

Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 178.71  E-value: 7.05e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNATTP 184
Cdd:cd03165     1 FVFREKVDLTAKDDLKEGLELYGTRNNRGLTNAWDITQTEFRCCGVTNYTDWYEVLGENRVPDSCCQEDSQDCGRNPTEL 80

                          90
                  ....*....|....*...
gi 2462529435 185 LWRTGCYEKVKMWFDDNK 202
Cdd:cd03165    81 WWKTGCYEKVQQWLVDNL 98
Tetraspanin pfam00335
Tetraspanin family;
9-228 2.90e-32

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 115.88  E-value: 2.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435   9 LKYMMFLFNLIFWLCGCGLLGVGIWLsVSQGNFATFSPSFPSLSAANLVIAIGTIVMVTGFLGCLGAIKENKCLLLSFFI 88
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL-LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435  89 VLLVILLAELILLILFFVYMDKVNENAKKDLKEGLLLYHTENNVG---LKNAWNIIQAEMRCCGvtdytdwypvlgentv 165
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLyscLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529435 166 pdrccmensqgcgrnattplwrtGCYEKVKMWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQ 228
Cdd:pfam00335 144 -----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 105-202 7.05e-58

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 178.71  E-value: 7.05e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNATTP 184
Cdd:cd03165     1 FVFREKVDLTAKDDLKEGLELYGTRNNRGLTNAWDITQTEFRCCGVTNYTDWYEVLGENRVPDSCCQEDSQDCGRNPTEL 80

                          90
                  ....*....|....*...
gi 2462529435 185 LWRTGCYEKVKMWFDDNK 202
Cdd:cd03165    81 WWKTGCYEKVQQWLVDNL 98
Tetraspanin pfam00335
Tetraspanin family;
9-228 2.90e-32

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 115.88  E-value: 2.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435   9 LKYMMFLFNLIFWLCGCGLLGVGIWLsVSQGNFATFSPSFPSLSAANLVIAIGTIVMVTGFLGCLGAIKENKCLLLSFFI 88
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL-LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435  89 VLLVILLAELILLILFFVYMDKVNENAKKDLKEGLLLYHTENNVG---LKNAWNIIQAEMRCCGvtdytdwypvlgentv 165
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLyscLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529435 166 pdrccmensqgcgrnattplwrtGCYEKVKMWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQ 228
Cdd:pfam00335 144 -----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 105-202 7.05e-58

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 178.71  E-value: 7.05e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNATTP 184
Cdd:cd03165     1 FVFREKVDLTAKDDLKEGLELYGTRNNRGLTNAWDITQTEFRCCGVTNYTDWYEVLGENRVPDSCCQEDSQDCGRNPTEL 80

                          90
                  ....*....|....*...
gi 2462529435 185 LWRTGCYEKVKMWFDDNK 202
Cdd:cd03165    81 WWKTGCYEKVQQWLVDNL 98
Tetraspanin pfam00335
Tetraspanin family;
9-228 2.90e-32

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 115.88  E-value: 2.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435   9 LKYMMFLFNLIFWLCGCGLLGVGIWLsVSQGNFATFSPSFPSLSAANLVIAIGTIVMVTGFLGCLGAIKENKCLLLSFFI 88
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL-LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435  89 VLLVILLAELILLILFFVYMDKVNENAKKDLKEGLLLYHTENNVG---LKNAWNIIQAEMRCCGvtdytdwypvlgentv 165
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLyscLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529435 166 pdrccmensqgcgrnattplwrtGCYEKVKMWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQ 228
Cdd:pfam00335 144 -----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 105-201 8.47e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 72.90  E-value: 8.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHTENNVglKNAWNIIQAEMRCCGVTDYTDWypvlgENTVPDRCCMENsqgcgrnatTP 184
Cdd:cd03164     1 FVYEKKLNNYVKEGLTDSLEQYHKDNNT--SEAWDMIQSNLQCCGINGTTDW-----GSGVPSSCCSSD---------TE 64

                          90
                  ....*....|....*..
gi 2462529435 185 LWRTGCYEKVKMWFDDN 201
Cdd:cd03164    65 YKVEGCYKKLKNWFESN 81
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 105-201 1.60e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 72.15  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHteNNVGLKNAWNIIQAEMRCCGVTDYTDWypVLGENTVPDRCCmensQGCGRNATTP 184
Cdd:cd03127     1 FVYRDQLESLVSDTLNDAWDEYY--VDDDFQEAMDALQSTFECCGVNGPTDY--LDLRLLVPSSCC----KGTDGNCGLN 72

                          90
                  ....*....|....*..
gi 2462529435 185 LWRTGCYEKVKMWFDDN 201
Cdd:cd03127    73 LYTEGCLEKLVDFLRSN 89
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 105-201 5.68e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 70.97  E-value: 5.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHTENNvgLKNAWNIIQAEMRCCGVTDYTDW--YPVLGENTVPDRCCMENSQGCGRNAT 182
Cdd:cd03166     1 YVFRDKVMSEFNDSFNQMISNYNKTND--FRKILDRMQKDLKCCGANNYTDWenIPSLDTDSVPDSCCINVTKGCGINFD 78

                          90       100
                  ....*....|....*....|
gi 2462529435 183 -TPLWRTGCYEKVKMWFDDN 201
Cdd:cd03166    79 eKVIHLEGCVTKIEGWLKKN 98
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 105-195 1.81e-13

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 64.37  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEgllLYHTENNVGLKN-AWNIIQAEMRCCGVTDYTDW-----YPVLGENTVPDRCCMENSQGCG 178
Cdd:cd03163     2 YVYRAKVEDELNPSIDK---VFNKYNGTNAESrAVDYLQRQLQCCGIHNYTDWentpwFKESKNNSVPLSCCKETFTSCT 78

                          90
                  ....*....|....*....
gi 2462529435 179 RNATTP--LWRTGCYEKVK 195
Cdd:cd03163    79 GSLTQPkdLYQEGCEAKLV 97
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 105-201 3.03e-13

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 63.91  E-value: 3.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLL-YHTENNVGLKNAWNIIQAEMRCCGVTDYTDW----YPVLGENT---VPDRCCMENSQG 176
Cdd:cd03155     1 YTYYQQLEDELKESLKRTMQEnYGQSGEEALTLTVDELQQEFKCCGSNNYTDWqdseWINSNEANgrlVPDSCCKTVVDR 80

                          90       100
                  ....*....|....*....|....*....
gi 2462529435 177 CGRNATTP----LWRTGCYEKVKMWFDDN 201
Cdd:cd03155    81 CGCLRDHPsniyKVEGGCIPKLEDFLYDH 109
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 126-201 1.07e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 51.76  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 126 YHTENNVG--LKNAWNIIQAEMRCCGVTDYTDW--------YPVLGENTVPDRCCMENSQG-----CGRNATTPLWR--T 188
Cdd:cd03156    21 YGNYNSTGdaITSTWNRVMIELKCCGVNGPTDFvdstsffrQKNEPNSPYPESCCKRNSNSqivdlDCPKLGSPNSYnkK 100

                          90
                  ....*....|...
gi 2462529435 189 GCYEKVKMWFDDN 201
Cdd:cd03156   101 GCYEKLSNPIERY 113
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 119-194 1.34e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


Pssm-ID: 239410  Cd Length: 103  Bit Score: 51.08  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 119 LKEGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNA----TTPLWRTGCYEKV 194
Cdd:cd03157    16 LKSRMSNFGLQRYQWLTHAWNSFQTEFKCCGVIYFTDWLEMTEMEWPPDSCCSNQYPGCARQAhyndLSDLYQEGCGPKI 95
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 126-201 7.51e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 49.30  E-value: 7.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 126 YHTE-NNVGLKNAWNIIQAEMRCCGVTDYTDWY--PVLG---ENTVPDRCCMENSQG---------CGRNATT--PLWRT 188
Cdd:cd03160    23 YGGNpENKTAEEAWDYVQFQLQCCGWTGPQDWTdnSLIKnssEPLYPCSCCNSSATAdsprpskgfCEAPASLdwPVYQE 102

                          90
                  ....*....|...
gi 2462529435 189 GCYEKVKMWFDDN 201
Cdd:cd03160   103 GCMEKLQSWLNEN 115
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 105-194 8.31e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 48.90  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHTenNVGLKNAWNIIQAEMRCCGVTDYTDW----YPVlgENTVPDRCCMeNSQGC--- 177
Cdd:cd03161     1 FVFRHEIKGTFLRTYNEAVSNYNG--DDERSDAVDTVQRTLHCCGVENYTDWlnspYFL--EKGIPLSCCK-NRSDCspq 75

                          90       100
                  ....*....|....*....|.
gi 2462529435 178 ----GRNATTPLWRTGCYEKV 194
Cdd:cd03161    76 dlknLTKAATKVYQQGCFTLV 96
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 105-201 3.44e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 44.99  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 105 FVYMDKVNENAKKDLKEGLLLYHTENNvgLKNAWNIIQAEMRCCGVTDYTDW-----YPVLGENT----VPDRCCMENSQ 175
Cdd:cd03158     1 FIFSNQTIDLLEENIRKAIVHYYDDLD--LQNIIDFVQKEFKCCGGDDYRDWsknmyFNCSSPNPeacgVPYSCCIRAKD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462529435 176 G------CGRN--------ATTPLWRTGCYEKVKMWFDDN 201
Cdd:cd03158    79 QevintmCGYGvqnlerleASKLIYTRGCIDAVVLWIEDN 118
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 104-201 1.14e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 42.80  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529435 104 FFVYMDKVnENAKKDLKEGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPvlgeNTVPDRC-C--MENSQGCGRN 180
Cdd:cd03154     4 GAVYKPKI-ENELKEKNTKLLSLLGQNAKSVKKSLEKFQKELKCCGLVNGADDWG----NDIPASCnCttTQSDCVVAYY 78

                          90       100
                  ....*....|....*....|.
gi 2462529435 181 ATTPLWRTGCYEKVKMWFDDN 201
Cdd:cd03154    79 GGSNVYKEPCISKIKDFLKKN 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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