NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462529488|ref|XP_054226835|]
View 

citron Rho-interacting kinase isoform X12 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1184-1480 4.78e-74

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


:

Pssm-ID: 214481  Cd Length: 302  Bit Score: 249.19  E-value: 4.78e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1184 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1256
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1257 LAQSHLPAQPDISPNiFEAVKGCHLFGAGKIENGLCICAAMPSKVVIL-RYNENLSKYCIR-----KEIETSEPCSCIHF 1330
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1331 TNY---SILIGTNKfYEIDMKQYTlEEFLDKNDHSLAPAVFAASSNSFPVSIVQvnsagqREEYLLCFHEFGVFVDSYG- 1406
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFH-ESLVSKEDLSLPFLSEETSLKPISVVQVP------RDEVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  1407 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAylDIPNPRYLGPaiSSGAIYLASSY 1480
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 935-990 3.84e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


:

Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.84e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-877 7.38e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 7.38e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   65 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 130
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  131 EEFKRKATECQHKLLKAKdqgkpevGEYAKLEKinaeqqlKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 210
Cdd:TIGR02168  277 SELEEEIEELQKELYALA-------NEISRLEQ-------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  211 QNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvsAQHLEVH 289
Cdd:TIGR02168  343 EEKLEELKEELESLEAElEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-------LERLEDR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  290 LKQKEQHYEEkikvldnqikkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaan 369
Cdd:TIGR02168  416 RERLQQEIEE-------------LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA------ 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  370 sslftqrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKNRLLEL-------ETRLrEVSLEHE 442
Cdd:TIGR02168  477 --------LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGGR 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  443 EQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 520
Cdd:TIGR02168  547 LQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  521 VITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  593 TTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkeh 672
Cdd:TIGR02168  705 KELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE--------- 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  673 kaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 752
Cdd:TIGR02168  769 --RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  753 LQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  830 VPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 877
Cdd:TIGR02168  927 LELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1020-1139 6.95e-08

PH domain; PH stands for pleckstrin homology.


:

Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 6.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1099
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462529488 1100 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1496-1585 4.09e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 4.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1496 ESGTEHHRGPSTSRSSPNKRGPPtyNEHITKRVASSPAP---------------PEGPSH---PREPSTPHRYREGRTEL 1557
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKP--GETKEGEVGKKPGPakehkpskiptlskkPEFPKDpkhPKDPEEPKKPKRPRSAQ 604

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462529488 1558 R--RDKSPGRP--LEREKSPGRMLSTRRERSP 1585
Cdd:PTZ00449   605 RptRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1184-1480 4.78e-74

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 249.19  E-value: 4.78e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1184 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1256
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1257 LAQSHLPAQPDISPNiFEAVKGCHLFGAGKIENGLCICAAMPSKVVIL-RYNENLSKYCIR-----KEIETSEPCSCIHF 1330
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1331 TNY---SILIGTNKfYEIDMKQYTlEEFLDKNDHSLAPAVFAASSNSFPVSIVQvnsagqREEYLLCFHEFGVFVDSYG- 1406
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFH-ESLVSKEDLSLPFLSEETSLKPISVVQVP------RDEVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  1407 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAylDIPNPRYLGPaiSSGAIYLASSY 1480
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1192-1444 8.76e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 229.44  E-value: 8.76e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1192 SDQVVLVGTEEGLYALNV-LKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDISP 1270
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1271 NIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1348
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1349 QYTLEEFLdkndhsLAPAVFAASSNSFPVSIVQVNsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1428
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 2462529488 1429 YLFVTHFNSLEVIEIQ 1444
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 935-990 3.84e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.84e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-877 7.38e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 7.38e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   65 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 130
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  131 EEFKRKATECQHKLLKAKdqgkpevGEYAKLEKinaeqqlKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 210
Cdd:TIGR02168  277 SELEEEIEELQKELYALA-------NEISRLEQ-------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  211 QNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvsAQHLEVH 289
Cdd:TIGR02168  343 EEKLEELKEELESLEAElEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-------LERLEDR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  290 LKQKEQHYEEkikvldnqikkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaan 369
Cdd:TIGR02168  416 RERLQQEIEE-------------LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA------ 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  370 sslftqrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKNRLLEL-------ETRLrEVSLEHE 442
Cdd:TIGR02168  477 --------LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGGR 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  443 EQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 520
Cdd:TIGR02168  547 LQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  521 VITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  593 TTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkeh 672
Cdd:TIGR02168  705 KELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE--------- 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  673 kaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 752
Cdd:TIGR02168  769 --RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  753 LQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  830 VPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 877
Cdd:TIGR02168  927 LELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 166-777 1.05e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 1.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  166 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEerrhslenkvKRLETME 245
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE----------AELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  246 RRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRH 325
Cdd:COG1196    274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE----ERLEELEEELAELEEELEELEEELEELEEELEEA 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  326 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ 405
Cdd:COG1196    350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  406 NRKLEEQLEKISHQDHSDKNRLLELETR---LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 482
Cdd:COG1196    430 LAELEEEEEEEEEALEEAAEEEAELEEEeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  483 AKTELEETTAEAEeeIQALTAHRDEIQRKFDALRnsctviTDLEEQLNQLTEDNAElnnqnfylskqldeasGANDEIVQ 562
Cdd:COG1196    510 VKAALLLAGLRGL--AGAVAVLIGVEAAYEAALE------AALAAALQNIVVEDDE----------------VAAAAIEY 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQR 642
Cdd:COG1196    566 LKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGR 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  643 MLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 722
Cdd:COG1196    646 LREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEA 725

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  723 ElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 777
Cdd:COG1196    726 L-EEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 15-874 6.16e-20

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.96  E-value: 6.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   15 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 94
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   95 VEEMRLMMNQLEEDLVSARRRSDLYESELRES----RLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQL 170
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLqellRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  171 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENR 250
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  251 LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAH 330
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  331 EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkLEAQNRKLE 410
Cdd:pfam02463  451 EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS--------------GLKVLLALI 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  411 EQLEKISHQDHSDKNRLLE--LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 488
Cdd:pfam02463  517 KDGVGGRIISAHGRLGDLGvaVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAV 596

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  489 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 568
Cdd:pfam02463  597 LEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL 676

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  569 HLRREITEREMQLTSQKQTMEALKTTCT-MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTE 647
Cdd:pfam02463  677 EIQELQEKAESELAKEEILRRQLEIKKKeQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSR 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  648 KQSRARADQRITESRQVVELAVKEHKAEILALQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQR 727
Cdd:pfam02463  757 LKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE-EKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEEL 835

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  728 LLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 807
Cdd:pfam02463  836 EELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLN 910

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  808 QPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 874
Cdd:pfam02463  911 LLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNL 977
PTZ00121 PTZ00121
MAEBL; Provisional
 5-771 1.38e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 92.90  E-value: 1.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    5 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLLHDIR--EQSRK 82
Cdd:PTZ00121  1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKKAEDARkaEEARK 1135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQEYQAQVEEMRlmmnqleeDLVSARRRSDLYESElrESRLAAE----EFKRKATECQ--HKLLKAKDQGKPEVG 156
Cdd:PTZ00121  1136 AEDARKAEEARKAEDAK--------RVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRkaEELRKAEDARKAEAA 1205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  157 EYAKLEKiNAEQQLKIQElqEKLEKAVKASTEATELLQNIRQA-KERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PTZ00121  1206 RKAEEER-KAEEARKAED--AKKAEAVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  236 nkVKRLETMERRENRLKDDIQTKSQQIQQMAD---KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKiKVLDNQIKKDL 312
Cdd:PTZ00121  1283 --LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEA 1359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 392
Cdd:PTZ00121  1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  393 FYLETQAGKLEA---QNRKLEEQLEKISHQDHSD--------KNRLLELETRLREVSLEHEE--QKLELKRQLTELQLSL 459
Cdd:PTZ00121  1440 AEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADeakkkaeeAKKADEAKKKAEEAKKKADEakKAAEAKKKADEAKKAE 1519

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  460 QERES-QLTALQAARAALE----SQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTE 534
Cdd:PTZ00121  1520 EAKKAdEAKKAEEAKKADEakkaEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEE 1591

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  535 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQTMEALKTTCTML---EEQVMDLEALNDE 611
Cdd:PTZ00121  1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE--ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeEENKIKAAEEAKK 1669

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  612 LLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAE 691
Cdd:PTZ00121  1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAE 1747

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  692 SLsdKLNDLEKK---HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS 768
Cdd:PTZ00121  1748 EA--KKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK 1825


                   ...
gi 2462529488  769 DLE 771
Cdd:PTZ00121  1826 EME 1828
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1192-1443 8.45e-11

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 67.22  E-value: 8.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1192 SDQVVLVGTEEGLYALNVLKNS--------LTHVPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1263
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1264 aqpDISPNIFEAVK-----GCHLFGAGKiENGLCICAAMPSKVVILRYN------ENLSKYCIRKEIETSEPCScIHFTN 1332
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNksgnlkKALTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1333 YSILIGTNKFYEI-DMKQYTLEEFLDKNDHSlaPAVFAASSNSFPVSIVQVNSagqreEYLLCFHEFGVFVDSYGRRSRT 1411
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462529488 1412 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1443
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 939-987 1.77e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 2462529488   939 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 987
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1020-1139 6.95e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 6.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1099
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462529488 1100 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1020-1139 2.67e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.67e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1099
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 2462529488  1100 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 934-989 1.91e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.91e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  934 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 989
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1496-1585 4.09e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 4.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1496 ESGTEHHRGPSTSRSSPNKRGPPtyNEHITKRVASSPAP---------------PEGPSH---PREPSTPHRYREGRTEL 1557
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKP--GETKEGEVGKKPGPakehkpskiptlskkPEFPKDpkhPKDPEEPKKPKRPRSAQ 604

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462529488 1558 R--RDKSPGRP--LEREKSPGRMLSTRRERSP 1585
Cdd:PTZ00449   605 RptRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1021-1066 6.53e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.88  E-value: 6.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2462529488 1021 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1066
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1184-1480 4.78e-74

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 249.19  E-value: 4.78e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1184 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1256
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1257 LAQSHLPAQPDISPNiFEAVKGCHLFGAGKIENGLCICAAMPSKVVIL-RYNENLSKYCIR-----KEIETSEPCSCIHF 1330
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1331 TNY---SILIGTNKfYEIDMKQYTlEEFLDKNDHSLAPAVFAASSNSFPVSIVQvnsagqREEYLLCFHEFGVFVDSYG- 1406
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFH-ESLVSKEDLSLPFLSEETSLKPISVVQVP------RDEVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  1407 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAylDIPNPRYLGPaiSSGAIYLASSY 1480
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1192-1444 8.76e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 229.44  E-value: 8.76e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1192 SDQVVLVGTEEGLYALNV-LKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDISP 1270
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1271 NIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1348
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1349 QYTLEEFLdkndhsLAPAVFAASSNSFPVSIVQVNsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1428
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 2462529488 1429 YLFVTHFNSLEVIEIQ 1444
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 935-990 3.84e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.84e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-877 7.38e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 7.38e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   65 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 130
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  131 EEFKRKATECQHKLLKAKdqgkpevGEYAKLEKinaeqqlKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 210
Cdd:TIGR02168  277 SELEEEIEELQKELYALA-------NEISRLEQ-------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  211 QNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvsAQHLEVH 289
Cdd:TIGR02168  343 EEKLEELKEELESLEAElEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-------LERLEDR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  290 LKQKEQHYEEkikvldnqikkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaan 369
Cdd:TIGR02168  416 RERLQQEIEE-------------LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA------ 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  370 sslftqrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKNRLLEL-------ETRLrEVSLEHE 442
Cdd:TIGR02168  477 --------LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGGR 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  443 EQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 520
Cdd:TIGR02168  547 LQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  521 VITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  593 TTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkeh 672
Cdd:TIGR02168  705 KELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE--------- 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  673 kaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 752
Cdd:TIGR02168  769 --RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  753 LQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  830 VPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 877
Cdd:TIGR02168  927 LELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-770 1.30e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.46  E-value: 1.30e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    2 MEQEMTRLHRRVSEVEAVL----SQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVsqedDKALQLLHDIR 77
Cdd:TIGR02168  184 TRENLDRLEDILNELERQLksleRQAEKAERYKELKAELRELELALLVLRLEELREELEELQEEL----KEAEEELEELT 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   78 EQSrklqeikeQEYQAQVEEMRLMMNQLEEDLVSARRR--------SDLyESELRE--SRLAAEEFKRKATECQHKLLKA 147
Cdd:TIGR02168  260 AEL--------QELEEKLEELRLEVSELEEEIEELQKElyalaneiSRL-EQQKQIlrERLANLERQLEELEAQLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  148 KDQGKPEvgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRKKLVEA 227
Cdd:TIGR02168  331 KLDELAE--ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAS---LNNEIERL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  228 EERRHSLENKVKRL-----ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIK 302
Cdd:TIGR02168  406 EARLERLEDRRERLqqeieELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  303 VLDNQIkkdladkETLENMMQRHEEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMK 379
Cdd:TIGR02168  486 QLQARL-------DSLERLQENLEGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLN 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  380 AQEEMISELRQQK-----FYLETQAGKLEAQNRKLEE------------QLEKISHQDHSDKNRLL-------------- 428
Cdd:TIGR02168  557 AAKKAIAFLKQNElgrvtFLPLDSIKGTEIQGNDREIlkniegflgvakDLVKFDPKLRKALSYLLggvlvvddldnale 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  429 ---ELETRLREVSLE-------------HEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 489
Cdd:TIGR02168  637 lakKLRPGYRIVTLDgdlvrpggvitggSAKTNssiLERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQ 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  490 TTAEAEEEIQALTAHRDEIQRkfdalrnsctvitdLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDH 569
Cdd:TIGR02168  717 LRKELEELSRQISALRKDLAR--------------LEAEVEQLEERIAQLSKE---LTELEAEIEELEERLEEAEEELAE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  570 LRREITEREMQLtsqKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEK 648
Cdd:TIGR02168  780 AEAEIEELEAQI---EQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELsEDIES 856

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  649 QSRARADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----EL 724
Cdd:TIGR02168  857 LAAEIEELEELIEEL--ESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrleGL 934

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462529488  725 KQRLLEEQAKL--QQQMDLQ--KNHIFRLTQGLQEALDRADLLKTERSDL 770
Cdd:TIGR02168  935 EVRIDNLQERLseEYSLTLEeaEALENKIEDDEEEARRRLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 5-778 4.31e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 107.45  E-value: 4.31e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    5 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVsqeddkaLQLLHDIREQSRKLQ 84
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL-------YALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   85 EIKEQEYQAQVEEMRLmmnqlEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLlkakdqgkpevgeyAKLEKI 164
Cdd:TIGR02168  306 ILRERLANLERQLEEL-----EAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL--------------EELEAE 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  165 NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ----NREDSSEGIRKKLVEAE---------ERR 231
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEdrreRLQQEIEELLKKLEEAElkelqaeleELE 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  232 HSLENKVKRLETMERRENRLKDDIQTKSQQIQQmadkileLEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD 311
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDA-------AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLS 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  312 -----LADKETLENMMQRHEEEAHEK--GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 384
Cdd:TIGR02168  520 gilgvLSELISVDEGYEAAIEAALGGrlQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEG 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  385 ISELRQQKFYLETQAGKL---------------EAQN--RKLEEQLEKISHQDHSDKNR-LLELETRLREVSLEHEEQKL 446
Cdd:TIGR02168  600 FLGVAKDLVKFDPKLRKAlsyllggvlvvddldNALElaKKLRPGYRIVTLDGDLVRPGgVITGGSAKTNSSILERRREI 679

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  447 -ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDL 525
Cdd:TIGR02168  680 eELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL 759

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  526 EEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL 605
Cdd:TIGR02168  760 EAEIEELEERLEEAEEE---LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAAT 836

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  606 EALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR---QVVELAVKEHKAEILALQQA 682
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRselEELSEELRELESKRSELRRE 916

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  683 LKEqklkaesLSDKLNDLEKKHAMLEMNARSLQQKLeteRELKQRLLEEQAKLQQQMDLQ----KNHIFRLTQGLQE--- 755
Cdd:TIGR02168  917 LEE-------LREKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDDeeeaRRRLKRLENKIKElgp 986

                          810       820       830
                   ....*....|....*....|....*....|....
gi 2462529488  756 ----ALD-------RADLLKTERSDLEYQLENIQ 778
Cdd:TIGR02168  987 vnlaAIEeyeelkeRYDFLTAQKEDLTEAKETLE 1020
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 166-777 1.05e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 1.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  166 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEerrhslenkvKRLETME 245
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE----------AELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  246 RRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRH 325
Cdd:COG1196    274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE----ERLEELEEELAELEEELEELEEELEELEEELEEA 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  326 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ 405
Cdd:COG1196    350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  406 NRKLEEQLEKISHQDHSDKNRLLELETR---LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 482
Cdd:COG1196    430 LAELEEEEEEEEEALEEAAEEEAELEEEeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  483 AKTELEETTAEAEeeIQALTAHRDEIQRKFDALRnsctviTDLEEQLNQLTEDNAElnnqnfylskqldeasGANDEIVQ 562
Cdd:COG1196    510 VKAALLLAGLRGL--AGAVAVLIGVEAAYEAALE------AALAAALQNIVVEDDE----------------VAAAAIEY 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQR 642
Cdd:COG1196    566 LKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGR 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  643 MLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 722
Cdd:COG1196    646 LREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEA 725

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  723 ElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 777
Cdd:COG1196    726 L-EEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 229-789 8.37e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 103.09  E-value: 8.37e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  229 ERRHSLENKvkrLETMERRENRLKDDIQTKSQQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 300
Cdd:COG1196    172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  301 IKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 380
Cdd:COG1196    248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  381 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVS----------LEHEEQKLELKR 450
Cdd:COG1196    321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  451 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 530
Cdd:COG1196    401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  531 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQ---------K 585
Cdd:COG1196    481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNivveddevaA 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  586 QTMEALKTT----CTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 661
Cdd:COG1196    561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  662 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 741
Cdd:COG1196    641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 2462529488  742 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 789
Cdd:COG1196    721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 124-771 2.57e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.55  E-value: 2.57e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  124 RESRLAAE--EFKRKATECQHKLLKAKDQGKpevgeYAKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKE 201
Cdd:COG1196    207 RQAEKAERyrELKEELKELEAELLLLKLREL-----EAELEELEAE----LEELEAELEELEAELAELEAELEELRLELE 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  202 RAERELEKLQNREdssEGIRKKLVEAEERRHSLENKVKRLetmERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQV 281
Cdd:COG1196    278 ELELELEEAQAEE---YELLAELARLEQDIARLEERRREL---EERLEELEEELAELEEELEELEEELEELEEELEEAEE 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  282 SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAhekgkilseqkaminamdSKIRSLEQRIvels 361
Cdd:COG1196    352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA------------------AQLEELEEAE---- 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  362 eanklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdkNRLLELETRLREVSLEH 441
Cdd:COG1196    410 -------------EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE--------AELEEEEEALLELLAEL 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  442 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSctv 521
Cdd:COG1196    469 LEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK--AALLLAGLRGLAGAVAVLIGVEAAYEAALEAA--- 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  522 itDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM-- 597
Cdd:COG1196    544 --LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGdt 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  598 LEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEIL 677
Cdd:COG1196    622 LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA-GGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALL 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  678 ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-- 755
Cdd:COG1196    701 AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAlg 780

                          650       660
                   ....*....|....*....|....*...
gi 2462529488  756 -----ALD-------RADLLKTERSDLE 771
Cdd:COG1196    781 pvnllAIEeyeeleeRYDFLSEQREDLE 808
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1-720 3.88e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.90  E-value: 3.88e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    1 MMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS 80
Cdd:TIGR02168  250 EAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELE 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   81 RKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQG 151
Cdd:TIGR02168  330 SKLDELAEelaeleeklEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARL 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  152 KPEVGEYAKLEKINAEQQ-----LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSegiRKKLVE 226
Cdd:TIGR02168  410 ERLEDRRERLQQEIEELLkkleeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAA---ERELAQ 486

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  227 AEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKIlELEEKHREA-----QVSAQHLEV-----------HL 290
Cdd:TIGR02168  487 LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELI-SVDEGYEAAieaalGGRLQAVVVenlnaakkaiaFL 565

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  291 KQKE----------QHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL-----EQ 355
Cdd:TIGR02168  566 KQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAkklrpGY 645

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  356 RIVEL-----------SEANKLAANSSLFTQRN-------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 417
Cdd:TIGR02168  646 RIVTLdgdlvrpggviTGGSAKTNSSILERRREieeleekIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELS 725

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  418 HQDHSDKNRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEA 494
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  495 EEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgandeivqLRSEV 567
Cdd:TIGR02168  806 DELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDIESLAAEIEELEELIEE----------LESEL 875

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  568 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRML--- 644
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTlee 955

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  645 -----DTEKQSRARADQRITESRQ------VVELAVKEHKAEILALQQALKEQKlkaESLSDKLNDLEKkhAMLEMNARS 713
Cdd:TIGR02168  956 aealeNKIEDDEEEARRRLKRLENkikelgPVNLAAIEEYEELKERYDFLTAQK---EDLTEAKETLEE--AIEEIDREA 1030


                   ....*..
gi 2462529488  714 LQQKLET 720
Cdd:TIGR02168 1031 RERFKDT 1037
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 167-870 7.26e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.13  E-value: 7.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  167 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEkLQNREDSSEG--IRKKLVEAEERRHSLENKVKRletM 244
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELalLVLRLEELREELEELQEELKE---A 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  245 ERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 321
Cdd:TIGR02168  252 EEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  322 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGK 401
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE--------------ELEEQLETLRSKVAQLELQIAS 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  402 LEAQNRKLEEQLEKISHQDHSDKNRLLELETRLrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 481
Cdd:TIGR02168  398 LNNEIERLEARLERLEDRRERLQQEIEELLKKL------EEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  482 QAKteleettaeaeeeiQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIV 561
Cdd:TIGR02168  472 EAE--------------QALDAAERELAQ----LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELI 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  562 QLRSEV---------DHLRREITERemqLTSQKQTMEALK----TTCTMLEEQVM---DLEALNDELLEKERQWEAWRSV 625
Cdd:TIGR02168  530 SVDEGYeaaieaalgGRLQAVVVEN---LNAAKKAIAFLKqnelGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKD 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  626 LGDEKSQFEcrvRELQRMLD-----------TEKQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQK 687
Cdd:TIGR02168  607 LVKFDPKLR---KALSYLLGgvlvvddldnaLELAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEELE 683

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  688 LKAESLSDKLNDLEKKHAMLemnaRSLQQKLETERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTER 767
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAEL----RKELEELEEELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKEL 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  768 SDLEYQLEniqvLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKAR 847
Cdd:TIGR02168  757 TELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832

                          730       740
                   ....*....|....*....|...
gi 2462529488  848 CAELEEALQKTRIELRSAREEAA 870
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIE 855
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 197-775 2.80e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.09  E-value: 2.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  197 RQAkERAER--ELEKlqnredssegiRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEE 274
Cdd:COG1196    207 RQA-EKAERyrELKE-----------ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRL 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  275 KHREAQVSAQhlevHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE 354
Cdd:COG1196    275 ELEELELELE----EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  355 QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishQDHSDKNRLLELETRL 434
Cdd:COG1196    351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE----ALLERLERLEEELEEL 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  435 REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAhrDEIQRKFDA 514
Cdd:COG1196    427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL--LLEAEADYE 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  515 LRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD------HLRREITEREMQLTSQKqtM 588
Cdd:COG1196    505 GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVaaaaieYLKAAKAGRATFLPLDK--I 582

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  589 EALKTTCTMLEEQVMDLEALndeLLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 668
Cdd:COG1196    583 RARAALAAALARGAIGAAVD---LVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAG 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  669 VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFR 748
Cdd:COG1196    660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLE 739

                          570       580
                   ....*....|....*....|....*..
gi 2462529488  749 LTQGLQEALDRADLLKTERSDLEYQLE 775
Cdd:COG1196    740 ELLEEEELLEEEALEELPEPPDLEELE 766
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 15-874 6.16e-20

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.96  E-value: 6.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   15 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 94
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   95 VEEMRLMMNQLEEDLVSARRRSDLYESELRES----RLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQL 170
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLqellRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  171 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENR 250
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  251 LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAH 330
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  331 EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkLEAQNRKLE 410
Cdd:pfam02463  451 EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS--------------GLKVLLALI 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  411 EQLEKISHQDHSDKNRLLE--LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 488
Cdd:pfam02463  517 KDGVGGRIISAHGRLGDLGvaVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAV 596

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  489 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 568
Cdd:pfam02463  597 LEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL 676

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  569 HLRREITEREMQLTSQKQTMEALKTTCT-MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTE 647
Cdd:pfam02463  677 EIQELQEKAESELAKEEILRRQLEIKKKeQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSR 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  648 KQSRARADQRITESRQVVELAVKEHKAEILALQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQR 727
Cdd:pfam02463  757 LKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE-EKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEEL 835

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  728 LLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 807
Cdd:pfam02463  836 EELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLN 910

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  808 QPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 874
Cdd:pfam02463  911 LLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNL 977
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 193-778 1.10e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 95.86  E-value: 1.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  193 LQNIRQAKERAERELEK--------LQNREDSSEGIRKKLVEAEERRHSLENKVKRLETmerRENRLKDDIQTKSQQIQQ 264
Cdd:TIGR04523   24 YKNIANKQDTEEKQLEKklktikneLKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQ---QIKDLNDKLKKNKDKINK 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  265 M-AD-KILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLAD--------------KETLENMMQRHEE 327
Cdd:TIGR04523  101 LnSDlSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLTEIKKKEKEleklnnkyndlkkqKEELENELNLLEK 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  328 EAHEKGKILSEQKAMINAMD---SKIRSLEQRIVEL-SEANKL-AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKL 402
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLElllSNLKKKIQKNKSLeSQISELkKQNNQLKDNIEKKQQE--INEKTTEISNTQTQLNQL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  403 EAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE------------HEEQKLELK---RQLTELQLSLQERESQLT 467
Cdd:TIGR04523  259 KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEisdlnnqkeqdwNKELKSELKnqeKKLEEIQNQISQNNKIIS 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  468 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ--NFY 545
Cdd:TIGR04523  339 QLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQikKLQ 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  546 LSKQLDEASGAN--DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV----MDLEALNDELLEKERQW 619
Cdd:TIGR04523  419 QEKELLEKEIERlkETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSInkikQNLEQKQKELKSKEKEL 498

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  620 EAwrsvLGDEKSQFECRVRELqrmldTEKQSraradqritesrqvvELAVKEHKAEILALQqalKEQKLKaeSLSDKLN- 698
Cdd:TIGR04523  499 KK----LNEEKKELEEKVKDL-----TKKIS---------------SLKEKIEKLESEKKE---KESKIS--DLEDELNk 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  699 -DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL-------DRADLLKTERSDL 770
Cdd:TIGR04523  550 dDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEkkissleKELEKAKKENEKL 629


                   ....*...
gi 2462529488  771 EYQLENIQ 778
Cdd:TIGR04523  630 SSIIKNIK 637
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 50-702 2.62e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 95.00  E-value: 2.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   50 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 129
Cdd:COG1196    204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  130 AEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK 209
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  210 LQNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEV 288
Cdd:COG1196    356 AEAELAEAEEALLEAEAElAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  289 HLKQKEQHYEEKIKvldnQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAA 368
Cdd:COG1196    436 EEEEEEEALEEAAE----EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  369 NSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRkleeqlekishqdhsdKNRLLELETRLREVSlehEEQKLEL 448
Cdd:COG1196    512 AALLLAGLRGLAGA--VAVLIGVEAAYEAALEAALAAAL----------------QNIVVEDDEVAAAAI---EYLKAAK 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  449 KRQLTELQLSLQERESQLTALQAARAALESQLRQAkTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQ 528
Cdd:COG1196    571 AGRATFLPLDKIRARAALAAALARGAIGAAVDLVA-SDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREV 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  529 LNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEAL 608
Cdd:COG1196    650 TLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQ 729

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  609 NDELLEKERQWEawrsvLGDEKSQFECRVRELQRMLDTEKQSR--ARADQRITESRQVVELAVKEHkaeilalqQALKEQ 686
Cdd:COG1196    730 LEAEREELLEEL-----LEEEELLEEEALEELPEPPDLEELERelERLEREIEALGPVNLLAIEEY--------EELEER 796

                          650
                   ....*....|....*.
gi 2462529488  687 KlkaESLSDKLNDLEK 702
Cdd:COG1196    797 Y---DFLSEQREDLEE 809
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-573 5.92e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 93.85  E-value: 5.92e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:COG1196    252 EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQ---------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQgkp 153
Cdd:COG1196    332 LEELEEEleeleeeleEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA--- 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  154 EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS 233
Cdd:COG1196    409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  234 LENKVKRLETMERRENRLKDDIQTKSQQIQQ---MADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKK 310
Cdd:COG1196    489 AAARLLLLLEAEADYEGFLEGVKAALLLAGLrglAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKA 568

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  311 DLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE---QRIVELSEANKLAANSSLFTQRNMKAQEEMISE 387
Cdd:COG1196    569 AKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADaryYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRE 648

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  388 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLT 467
Cdd:COG1196    649 VTLEGEGGSAGGSLTGGSRRELLAALLEAEAEL----EELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEE 724

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  468 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctvITDLEEQLNQL-------TEDNAELN 540
Cdd:COG1196    725 ALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE----------LERLEREIEALgpvnllaIEEYEELE 794

                          570       580       590
                   ....*....|....*....|....*....|...
gi 2462529488  541 NQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 573
Cdd:COG1196    795 ERYDFLSEQREDLEEARETLEEAIEEIDRETRE 827
PTZ00121 PTZ00121
MAEBL; Provisional
 5-771 1.38e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 92.90  E-value: 1.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    5 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLLHDIR--EQSRK 82
Cdd:PTZ00121  1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKKAEDARkaEEARK 1135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQEYQAQVEEMRlmmnqleeDLVSARRRSDLYESElrESRLAAE----EFKRKATECQ--HKLLKAKDQGKPEVG 156
Cdd:PTZ00121  1136 AEDARKAEEARKAEDAK--------RVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRkaEELRKAEDARKAEAA 1205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  157 EYAKLEKiNAEQQLKIQElqEKLEKAVKASTEATELLQNIRQA-KERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PTZ00121  1206 RKAEEER-KAEEARKAED--AKKAEAVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  236 nkVKRLETMERRENRLKDDIQTKSQQIQQMAD---KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKiKVLDNQIKKDL 312
Cdd:PTZ00121  1283 --LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEA 1359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 392
Cdd:PTZ00121  1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  393 FYLETQAGKLEA---QNRKLEEQLEKISHQDHSD--------KNRLLELETRLREVSLEHEE--QKLELKRQLTELQLSL 459
Cdd:PTZ00121  1440 AEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADeakkkaeeAKKADEAKKKAEEAKKKADEakKAAEAKKKADEAKKAE 1519

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  460 QERES-QLTALQAARAALE----SQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTE 534
Cdd:PTZ00121  1520 EAKKAdEAKKAEEAKKADEakkaEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEE 1591

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  535 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQTMEALKTTCTML---EEQVMDLEALNDE 611
Cdd:PTZ00121  1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE--ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeEENKIKAAEEAKK 1669

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  612 LLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAE 691
Cdd:PTZ00121  1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAE 1747

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  692 SLsdKLNDLEKK---HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS 768
Cdd:PTZ00121  1748 EA--KKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK 1825


                   ...
gi 2462529488  769 DLE 771
Cdd:PTZ00121  1826 EME 1828
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 9-778 1.52e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 92.44  E-value: 1.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    9 LHRRVSEVEAVLSQKEVElkASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 88
Cdd:TIGR02169  216 LLKEKREYEGYELLKEKE--ALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   89 QEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELREsrlaAEEFKRKATECQHKLLKAKDQGKPEVGEYAK-LEKINAE 167
Cdd:TIGR02169  287 EEQLRVKEKIG----ELEAEIASLERSIAEKERELED----AEERLAKLEAEIDKLLAEIEELEREIEEERKrRDKLTEE 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  168 qqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS----LENKVKRLET 243
Cdd:TIGR02169  359 ----YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEeladLNAAIAGIEA 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  244 ----MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK-----------------IK 302
Cdd:TIGR02169  435 kineLEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAeaqaraseervrggravEE 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  303 VLDNQIKK-------------------DLADKETLENMMQRHEEEAHEKGKILSEQKAM------INAMDSKIRSLE--- 354
Cdd:TIGR02169  515 VLKASIQGvhgtvaqlgsvgeryataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratflpLNKMRDERRDLSils 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  355 -----QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeqLEKI-SHQDHSDKNRL 427
Cdd:TIGR02169  595 edgviGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMgKYRMVTLEGEL----------FEKSgAMTGGSRAPRG 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  428 LELETR-LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 506
Cdd:TIGR02169  665 GILFSRsEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEE 744

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  507 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLskqldEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQ 586
Cdd:TIGR02169  745 DLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDL-----EARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQ 819

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  587 TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ---RMLDTEKQSRARADQRITESRQ 663
Cdd:TIGR02169  820 KLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEaalRDLESRLGDLKKERDELEAQLR 899

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  664 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmnarSLQQKLETERELKQRLLEEQAKLQQQMDLQk 743
Cdd:TIGR02169  900 ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE----EIPEEELSLEDVQAELQRVEEEIRALEPVN- 974

                          810       820       830
                   ....*....|....*....|....*....|....*
gi 2462529488  744 nhiFRLTQGLQEALDRADLLKTERSDLEYQLENIQ 778
Cdd:TIGR02169  975 ---MLAIQEYEEVLKRLDELKEKRAKLEEERKAIL 1006
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-436 6.69e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.50  E-value: 6.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQEyqaqveemrlmmnqleedlvsarrrsDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 162
Cdd:TIGR02168  756 LTELEAEI--------------------------EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  163 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ-NREDSSEGIRKKLVEAEErrhslenKVKRL 241
Cdd:TIGR02168  810 AELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAaEIEELEELIEELESELEA-------LLNER 882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  242 ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLkqkeqhyeEKIKVLDNQIKKDLADKETLENM 321
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRL--------EGLEVRIDNLQERLSEEYSLTLE 954

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  322 MQrheeEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEANKLAansslftqrnmkaqEEMISELRQQKFYLETQAGK 401
Cdd:TIGR02168  955 EA----EALENKIEDDEEEA-----RRRLKRLENKIKELGPVNLAA--------------IEEYEELKERYDFLTAQKED 1011

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2462529488  402 LEAQNRKLEEQLEKIshqDHSDKNRLLELETRLRE 436
Cdd:TIGR02168 1012 LTEAKETLEEAIEEI---DREARERFKDTFDQVNE 1043
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 3-814 8.24e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 90.03  E-value: 8.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDI--REQS 80
Cdd:pfam02463  264 EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIeeLEKE 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   81 RKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAkdqgkpevgeyAK 160
Cdd:pfam02463  344 LKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKE-----------AQ 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  161 LEKINAEQQLKI-QELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegirKKLVEAEERRHSLENKVK 239
Cdd:pfam02463  409 LLLELARQLEDLlKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL---------KDELELKKSEDLLKETQL 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  240 RLETMERRENRLKDDIQTKSQQiqqmadkilelEEKHREAqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 319
Cdd:pfam02463  480 VKLQEQLELLLSRQKLEERSQK-----------ESKARSG------LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYK 542

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  320 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQA 399
Cdd:pfam02463  543 VAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRA 622

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  400 GKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaarAALESQ 479
Cdd:pfam02463  623 KVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESEL-------AKEEIL 695

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  480 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgande 559
Cdd:pfam02463  696 RRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSE------- 768

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  560 iVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfECRVRE 639
Cdd:pfam02463  769 -LSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELAL-ELKEEQ 846

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  640 LQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 719
Cdd:pfam02463  847 KLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEE 926

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  720 TERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKlI 799
Cdd:pfam02463  927 AEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEK-K 1005

                          810
                   ....*....|....*
gi 2462529488  800 DFLQAKMDQPAKKKK 814
Cdd:pfam02463 1006 KLIRAIIEETCQRLK 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 214-871 4.17e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.80  E-value: 4.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  214 EDSSEGIRKKLVEA------EERRHSLENKvkrLETMERRENRLKDDI-----QTKSQQIQ-QMADKILELEEKHREAQ- 280
Cdd:TIGR02168  151 EAKPEERRAIFEEAagiskyKERRKETERK---LERTRENLDRLEDILnelerQLKSLERQaEKAERYKELKAELRELEl 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  281 -VSAQHLEVHLKQKEQ------HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL 353
Cdd:TIGR02168  228 aLLVLRLEELREELEElqeelkEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  354 EQRIVELseanklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETR 433
Cdd:TIGR02168  308 RERLANL--------------ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESR 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  434 LREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALT 502
Cdd:TIGR02168  374 LEELEEQLETLRskvAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEEllkkleeaELKELQAELEELEEELEELQ 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  503 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE-------VDHLRREIT 575
Cdd:TIGR02168  454 EELERLEEALEELREE---LEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNqsglsgiLGVLSELIS 530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  576 ERE-------------MQ------LTSQKQTMEALK----TTCTMLEEQVM---DLEALNDELLEKERQWEAWRSVLGDE 629
Cdd:TIGR02168  531 VDEgyeaaieaalggrLQavvvenLNAAKKAIAFLKqnelGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKDLVKF 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  630 KSQFE---------CRV-------RELQRMLD------TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQK 687
Cdd:TIGR02168  611 DPKLRkalsyllggVLVvddldnaLELAKKLRpgyrivTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELE 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  688 LKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA 760
Cdd:TIGR02168  691 EKIAELEKALAELRKELEELEEELEQLRKELEElsrqisaLRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  761 DLLKTERSDLEYQLENIQVLYShekvKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLA 840
Cdd:TIGR02168  771 EEAEEELAEAEAEIEELEAQIE----QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750
                   ....*....|....*....|....*....|.
gi 2462529488  841 LEKEKARCAELEEALQKTRIELRSAREEAAH 871
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELESELEA 877
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
12-578 1.03e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 86.27  E-value: 1.03e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   12 RVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEqaRMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY 91
Cdd:PRK03918   187 RTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK--ELEELKEEIEELEKELESLEGSKRKLEEKIREL 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   92 QAQVEEMRLMMNQLEEdlvSARRRSDLYESELRESRLaaEEFKRKATECQHKLLKakdqgkpevgEYAKLEKINAEQQLK 171
Cdd:PRK03918   265 EERIEELKKEIEELEE---KVKELKELKEKAEEYIKL--SEFYEEYLDELREIEK----------RLSRLEEEINGIEER 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  172 IQELQEKLEKAVKASTEATELLQNIRQAKERAErELEKLQNREDSSEGIRKKL--VEAEERRHSLENKVKRLETMERREN 249
Cdd:PRK03918   330 IKELEEKEERLEELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLtgLTPEKLEKELEELEKAKEEIEEEIS 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  250 RLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkqkEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEA 329
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT------EEHRKELLEEYTAELKRIEKELKEIEEKERKLRKEL 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  330 HEKGKILSEQKAMI--NAMDSKIRSLEQRIVELsEANKLAANSSLFTqrnmKAQEEMIsELRQQKFYLETQAGKLEAQNR 407
Cdd:PRK03918   483 RELEKVLKKESELIklKELAEQLKELEEKLKKY-NLEELEKKAEEYE----KLKEKLI-KLKGEIKSLKKELEKLEELKK 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  408 KLEEQLEKIshqdHSDKNRLLELETRLREVSLEHEEqklELKRQLTELQ------LSLQERESQLTALQAARAALESQLR 481
Cdd:PRK03918   557 KLAELEKKL----DELEEELAELLKELEELGFESVE---ELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEELD 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  482 QAktelEETTAEAEEEIQALTAHRDEIQRKFDalrnsctvitdlEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIv 561
Cdd:PRK03918   630 KA----FEELAETEKRLEELRKELEELEKKYS------------EEEYEELREEYLELSRELAGLRAELEELEKRREEI- 692

                          570
                   ....*....|....*..
gi 2462529488  562 qlRSEVDHLRREITERE 578
Cdd:PRK03918   693 --KKTLEKLKEELEERE 707
PTZ00121 PTZ00121
MAEBL; Provisional
 3-445 3.30e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 85.19  E-value: 3.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQAR-----MEVSQEDDKALQLLHDIR 77
Cdd:PTZ00121  1259 EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKkadeaKKKAEEAKKKADAAKKKA 1338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   78 EQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV---SARRRSDLYESELRESRLA------AEEFKRKATECQHKLLKAK 148
Cdd:PTZ00121  1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKkkeEAKKKADAAKKKAEEKKKAdeakkkAEEDKKKADELKKAAAAKK 1418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  149 --DQGKPEVGEYAKLE--KINAEQQLKIQELQEKLEKAVKA----------------------STEATELLQNIRQAKER 202
Cdd:PTZ00121  1419 kaDEAKKKAEEKKKADeaKKKAEEAKKADEAKKKAEEAKKAeeakkkaeeakkadeakkkaeeAKKADEAKKKAEEAKKK 1498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  203 AErELEKLQNREDSSEGIRK--------KLVEAEERRHSLENK----------VKRLETMERRENRLKDDIQTKSQQIQQ 264
Cdd:PTZ00121  1499 AD-EAKKAAEAKKKADEAKKaeeakkadEAKKAEEAKKADEAKkaeekkkadeLKKAEELKKAEEKKKAEEAKKAEEDKN 1577

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  265 MADKILE----LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE---------AHE 331
Cdd:PTZ00121  1578 MALRKAEeakkAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEkkkaeelkkAEE 1657

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  332 KGKILSEQKAMINAMDSK----IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 407
Cdd:PTZ00121  1658 ENKIKAAEEAKKAEEDKKkaeeAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKK 1737

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2462529488  408 KLEEQLEKISH--QDHSDKNRLLELETRLREVSLEHEEQK 445
Cdd:PTZ00121  1738 EAEEDKKKAEEakKDEEEKKKIAHLKKEEEKKAEEIRKEK 1777
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 228-1018 4.62e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 84.40  E-value: 4.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  228 EERRHSLENKVKRL----ETMERRENRLKD---DIQTKSQQIQQMADKILELeeKHREAQvSAQHLEVHLkQKEQHYEEK 300
Cdd:pfam15921   81 EEYSHQVKDLQRRLnesnELHEKQKFYLRQsviDLQTKLQEMQMERDAMADI--RRRESQ-SQEDLRNQL-QNTVHELEA 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  301 IKVLDNQIKKDLADK-ETLENMMQRHEEEAHE-----------KGKILSEQKAM---------------INAMDSKIRSL 353
Cdd:pfam15921  157 AKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhfrslgsaiskiLRELDTEISYL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  354 EQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN--- 425
Cdd:pfam15921  237 KGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSmym 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  426 -RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 504
Cdd:pfam15921  317 rQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  505 RDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDEASGANDEI-------VQLRSE 566
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAAIQGKNESLekvssltAQLEST 473

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  567 VDHLRREITEremqLTSQKQTMEALKTTctmleeqVMDLEAlndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDT 646
Cdd:pfam15921  474 KEMLRKVVEE----LTAKKMTLESSERT-------VSDLTA---SLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNE 539

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  647 EKQSR-------------ARADQRITESRQVVEL-------------AVKEHKA----EILALQQALKEQKLKAESLSDK 696
Cdd:pfam15921  540 GDHLRnvqtecealklqmAEKDKVIEILRQQIENmtqlvgqhgrtagAMQVEKAqlekEINDRRLELQEFKILKDKKDAK 619

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  697 LNDLEKKHAMLEMNARSL----QQKLETERELKQrlleEQAKLQQQMDLQKNHIFRLTQGLqEALDR-----ADLLKTER 767
Cdd:pfam15921  620 IRELEARVSDLELEKVKLvnagSERLRAVKDIKQ----ERDQLLNEVKTSRNELNSLSEDY-EVLKRnfrnkSEEMETTT 694

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  768 SDLEYQLENIQ--------VLYSHE---------KVKMEGTISQQTKLIDFLQAKMD------QPAKKKKGLFSRRK--- 821
Cdd:pfam15921  695 NKLKMQLKSAQseleqtrnTLKSMEgsdghamkvAMGMQKQITAKRGQIDALQSKIQfleeamTNANKEKHFLKEEKnkl 774

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  822 --EDPALPTQVPLQYNELKLALEKE---KARCAELEEALQKT------------RIELRSAREEAAHR---KATDHP-HP 880
Cdd:pfam15921  775 sqELSTVATEKNKMAGELEVLRSQErrlKEKVANMEVALDKAslqfaecqdiiqRQEQESVRLKLQHTldvKELQGPgYT 854

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  881 STPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKERMHHnIPHRFNVGLNMRATKCAVCLDTV 959
Cdd:pfam15921  855 SNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQLLQE-LRSVINEEPTVQLSKAEDKGRAP 933

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  960 HFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYAThFTEAFCRDKMNSPGLQTKEPSS 1018
Cdd:pfam15921  934 SLGALDDRVRDCIIESSLRSDICHSSSNSLQTEGSK-SSETCSREPVLLHAGELEDPSS 991
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 62-857 1.07e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.19  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   62 VSQEDDKALQLLHDIREQSRKLQEIkeqeyQAQVEEMRLMMNQLEEDLVSARRRSDLyESELREsrlaaeefkRKATECQ 141
Cdd:TIGR02169  165 VAEFDRKKEKALEELEEVEENIERL-----DLIIDEKRQQLERLRREREKAERYQAL-LKEKRE---------YEGYELL 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  142 HKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ----------------------NIRQA 199
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKdlgeeeqlrvkekigeleaeiaSLERS 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  200 KERAERELEKLQNREDSSEG-IRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMA------------ 266
Cdd:TIGR02169  310 IAEKERELEDAEERLAKLEAeIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDkefaetrdelkd 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  267 --DKILELEEKHREAQVSAQHLEVHLKQKEQHYEE---KIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKA 341
Cdd:TIGR02169  390 yrEKLEKLKREINELKRELDRLQEELQRLSEELADlnaAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQ 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  342 MINAMDSKIRSLEQRIVELS---EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE-----QL 413
Cdd:TIGR02169  470 ELYDLKEEYDRVEKELSKLQrelAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEvaagnRL 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  414 EKISHQDHSDKNRLLELETR----------LREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaaRAALESQLRQA 483
Cdd:TIGR02169  550 NNVVVEDDAVAKEAIELLKRrkagratflpLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY------EPAFKYVFGDT 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  484 KTELEETTAEAEEEIQALTAHRDEIQRK-------FDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA 556
Cdd:TIGR02169  624 LVVEDIEAARRLMGKYRMVTLEGELFEKsgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENR 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  557 NDEivqLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqvmDLEALNDELLEKERQWEAWRSVLGD---EKSQF 633
Cdd:TIGR02169  704 LDE---LSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEE---DLSSLEQEIENVKSELKELEARIEEleeDLHKL 777

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  634 ECRVRELQRMLDTEKQsraradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARS 713
Cdd:TIGR02169  778 EEALNDLEARLSHSRI------PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKS 851

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  714 LQQKLETERELKQRLLEEQAKLQQQmdlqknhifrltqgLQEALDRADLLKTERSDLEYQLENIQvlyshekvKMEGTIS 793
Cdd:TIGR02169  852 IEKEIENLNGKKEELEEELEELEAA--------------LRDLESRLGDLKKERDELEAQLRELE--------RKIEELE 909

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  794 QQtklIDFLQAKMDQPAKKKKGLFSRRKE-DPALPTQVPlqYNELKLALEKEKARCAELEEALQK 857
Cdd:TIGR02169  910 AQ---IEKKRKRLSELKAKLEALEEELSEiEDPKGEDEE--IPEEELSLEDVQAELQRVEEEIRA 969
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 3-725 1.10e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.19  E-value: 1.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQ--KEVELKASETQRSLLEQdLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS 80
Cdd:TIGR02169  257 TEEISELEKRLEEIEQLLEElnKKIKDLGEEEQLRVKEK-IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLL 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   81 RKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK 160
Cdd:TIGR02169  336 AEIEELERE-----IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDR 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  161 LEKINAEQQLKIQELQEKL----EKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLEN 236
Cdd:TIGR02169  411 LQEELQRLSEELADLNAAIagieAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQR 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  237 KVKRLETMER------RENR-----LKDDIQTKSQQIQQMadkiLELEEKHREAQVSA--QHLEVHLKQKEQHYEEKIKV 303
Cdd:TIGR02169  491 ELAEAEAQARaseervRGGRaveevLKASIQGVHGTVAQL----GSVGERYATAIEVAagNRLNNVVVEDDAVAKEAIEL 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  304 LdnqiKKDLADKET---LENM--MQRHEEEAHEKGKI-----LSE-----QKA---------MINAMDS------KIR-- 351
Cdd:TIGR02169  567 L----KRRKAGRATflpLNKMrdERRDLSILSEDGVIgfavdLVEfdpkyEPAfkyvfgdtlVVEDIEAarrlmgKYRmv 642

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  352 SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyletqaGKLEAQNRKLEEQLEKISHQDHSDKNRLLELE 431
Cdd:TIGR02169  643 TLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERL-------EGLKRELSSLQSELRRIENRLDELSQELSDAS 715

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  432 TRLREVSLEHE--EQKLE-LKRQLTELQLSLQERESQLTALQAARAALESQLrQAKTELEETTAEAEEEIQALTAHR--D 506
Cdd:TIGR02169  716 RKIGEIEKEIEqlEQEEEkLKERLEELEEDLSSLEQEIENVKSELKELEARI-EELEEDLHKLEEALNDLEARLSHSriP 794

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  507 EIQRKFDALRnscTVITDLEEQLNQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQ 586
Cdd:TIGR02169  795 EIQAELSKLE---EEVSRIEARLREI---EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEE 868

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  587 TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVE 666
Cdd:TIGR02169  869 ELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPE 948

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529488  667 LA-----VKEHKAEILALQQALKEQKLKA----ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELK 725
Cdd:TIGR02169  949 EElsledVQAELQRVEEEIRALEPVNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
107-620 1.57e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.42  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  107 EDLVSARRRSDLYESELRESRLAAEEFKrKATECQHKLLKAKDQGKPEVgeyakLEKINaEQQLKIQELQEKLEKAVKAS 186
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFI-KRTENIEELIKEKEKELEEV-----LREIN-EISSELPELREELEKLEKEV 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  187 TEATELLQNIRQAKERAEREL-------EKLQNREDSSEGIRKKLVEAEERR---HSLENKVKRLETMER-------REN 249
Cdd:PRK03918   231 KELEELKEEIEELEKELESLEgskrkleEKIRELEERIEELKKEIEELEEKVkelKELKEKAEEYIKLSEfyeeyldELR 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  250 RLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE------VHLKQKEQHYEEKIKVLDN--QIKKDLADK--ETLE 319
Cdd:PRK03918   311 EIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKelekrlEELEERHELYEEAKAKKEEleRLKKRLTGLtpEKLE 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  320 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMISELRQQKFY 394
Cdd:PRK03918   391 KELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELKRIEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  395 LETQAGKLEAQNRKLEEQLEKISH--QDHSDKNRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QLSLQERESQ 465
Cdd:PRK03918   471 IEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIKSLKKELEK 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  466 LTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLEEQLNQLTE 534
Cdd:PRK03918   551 LEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREEKELKKLEE 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  535 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDH--LRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDEL 612
Cdd:PRK03918   627 ELDKAFEELAETEKRLEELRKELEELEKKYSEEEYeeLREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER 706


                   ....*...
gi 2462529488  613 LEKERQWE 620
Cdd:PRK03918   707 EKAKKELE 714
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
197-789 2.11e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.03  E-value: 2.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  197 RQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH 276
Cdd:PRK03918   144 DESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEL 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  277 REAQVSAQHLEVHlkqkeqhyEEKIKVLDNQIKKDLADKETLENMMQRHEEeahekgkilseqkaMINAMDSKIRSLEQR 356
Cdd:PRK03918   224 EKLEKEVKELEEL--------KEEIEELEKELESLEGSKRKLEEKIRELEE--------------RIEELKKEIEELEEK 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  357 IVELSEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKNRLLELETRLRE 436
Cdd:PRK03918   282 VKELKELKEKA--------EEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKE 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  437 V-----SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 511
Cdd:PRK03918   350 LekrleELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKA 427

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  512 FDALRNS------CTVITDLEEQLNQLTEDNAELNNqnfyLSKQLDEASganDEIVQLRSEVDHLRREItEREMQLTSQK 585
Cdd:PRK03918   428 IEELKKAkgkcpvCGRELTEEHRKELLEEYTAELKR----IEKELKEIE---EKERKLRKELRELEKVL-KKESELIKLK 499

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  586 QTMEALKTTCTMLEE-QVMDLEALNDE---LLEKERQWEAWRSVLGDE---KSQFECRVRELQRMLDTEKQSRARADQRI 658
Cdd:PRK03918   500 ELAEQLKELEEKLKKyNLEELEKKAEEyekLKEKLIKLKGEIKSLKKElekLEELKKKLAELEKKLDELEEELAELLKEL 579

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  659 TE----SRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEE 731
Cdd:PRK03918   580 EElgfeSVEELEERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEE 659

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  732 Q-AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 789
Cdd:PRK03918   660 EyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 26-614 4.81e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.83  E-value: 4.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   26 ELKASETQRSLLEqdlatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQL 105
Cdd:TIGR04523  111 EIKNDKEQKNKLE-------VELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQ-----KEELENELNLL 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  106 EEDLvsARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAkdqgkpevgEYAKLEKINAEQQLKIQELQEKLEKAVKA 185
Cdd:TIGR04523  179 EKEK--LNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLES---------QISELKKQNNQLKDNIEKKQQEINEKTTE 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  186 STEATellQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRE--NRLKDDIQTKSQQIQ 263
Cdd:TIGR04523  248 ISNTQ---TQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDwnKELKSELKNQEKKLE 324

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  264 QMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvlDNQIKKDLADKETLENMMQRHEEEahekgkilseqkamI 343
Cdd:TIGR04523  325 EIQNQISQNNKIISQLNEQISQLKKELTNSESENSEK----QRELEEKQNEIEKLKKENQSYKQE--------------I 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  344 NAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 423
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQ--------------KDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVK 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  424 KNRLLELETrlrevSLEHEEQKLE--------LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleETTAEAE 495
Cdd:TIGR04523  453 ELIIKNLDN-----TRESLETQLKvlsrsinkIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLT----KKISSLK 523

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  496 EEIQALTAHRDEIQRKFDALRNSC-------------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQ 562
Cdd:TIGR04523  524 EKIEKLESEKKEKESKISDLEDELnkddfelkkenleKEIDEKNKEIEELKQTQKSLKKKQEEKQELID----------Q 593

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLE 614
Cdd:TIGR04523  594 KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQ 645
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 50-812 5.75e-14

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 77.69  E-value: 5.75e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   50 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 127
Cdd:COG3096    289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  128 LAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQ---LKIQELQEKLEKAvKASTEATELlqNIRQAKERAE 204
Cdd:COG3096    368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQtraIQYQQAVQALEKA-RALCGLPDL--TPENAEDYLA 444

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  205 RELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRlkddiqtksqqiQQMADKILELEEKHREAQVSAQ 284
Cdd:COG3096    445 AFRAKEQQATEEVLELEQKLSVADAARRQFEKAYELVCKIAGEVER------------SQAWQTARELLRRYRSQQALAQ 512

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  285 ---HLEVHLKQKEQHY------EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 355
Cdd:COG3096    513 rlqQLRAQLAELEQRLrqqqnaERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRA 592

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  356 RIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKN 425
Cdd:COG3096    593 RIKELAarAPAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQPGGAEDP 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  426 RLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ESQLTAL 469
Cdd:COG3096    673 RLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfdDSVFDAE 752

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  470 QAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtednaelnnqn 543
Cdd:COG3096    753 ELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF----------- 821

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  544 fyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTML---------------EEQVMDLE 606
Cdd:COG3096    822 --VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLnkllpqanlladetlADRLEELR 899

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  607 ALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHK 673
Cdd:COG3096    900 EELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSYEDA 975

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  674 AEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHifrl 749
Cdd:COG3096    976 VGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADA---- 1051

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  750 tqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 812
Cdd:COG3096   1052 -----EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 255-875 1.22e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 76.31  E-value: 1.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  255 IQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQR--HEEEAHE- 331
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNtvHELEAAKc 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  332 -KGKILSEQKAMINAMDSKIRSLE---QRI----VELSEAN--KLAANSSLFTQ--RNM-KAQEEMISELRQQKFYLETQ 398
Cdd:pfam15921  160 lKEDMLEDSNTQIEQLRKMMLSHEgvlQEIrsilVDFEEASgkKIYEHDSMSTMhfRSLgSAISKILRELDTEISYLKGR 239

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  399 AGKLEAQNRKLEEQLE---KISHQDHSDKNRLL----ELE-TRLREVSLEHEEQKLELKRQLTELQLSLQERES----QL 466
Cdd:pfam15921  240 IFPVEDQLEALKSESQnkiELLLQQHQDRIEQLisehEVEiTGLTEKASSARSQANSIQSQLEIIQEQARNQNSmymrQL 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  467 TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtviTDLEEQLNQLTednAELNNQNFYL 546
Cdd:pfam15921  320 SDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQES---GNLDDQLQKLL---ADLHKREKEL 393

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  547 SKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWrsvL 626
Cdd:pfam15921  394 SLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQ---L 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  627 GDEKSQFECRVRELQ-RMLDTEKQSRARADqrITESRQVVELAVKEHKAEILALQQALkeqKLKAESLSDKLNDLEK-KH 704
Cdd:pfam15921  471 ESTKEMLRKVVEELTaKKMTLESSERTVSD--LTASLQEKERAIEATNAEITKLRSRV---DLKLQELQHLKNEGDHlRN 545

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  705 AMLEMNARSLQ--------QKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS----DLEY 772
Cdd:pfam15921  546 VQTECEALKLQmaekdkviEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDakirELEA 625

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  773 QLENIQVlyshEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKglfSRRKEDPALPTqvplQYNELKLALekeKARCAELE 852
Cdd:pfam15921  626 RVSDLEL----EKVKLVNAGSERLRAVKDIKQERDQLLNEVK---TSRNELNSLSE----DYEVLKRNF---RNKSEEME 691

                          650       660
                   ....*....|....*....|...
gi 2462529488  853 EALQKTRIELRSAREEAAHRKAT 875
Cdd:pfam15921  692 TTTNKLKMQLKSAQSELEQTRNT 714
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 167-790 1.30e-13

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 76.37  E-value: 1.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  167 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegirkkLVEAEERRHSLENKVKRLET--- 243
Cdd:pfam01576    6 EMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETEL-------CAEAEEMRARLAARKQELEEilh 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  244 -MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 319
Cdd:pfam01576   79 eLESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQlekVTTEAKIKKLEEDILLLEDQNSKLSKERKLLE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  320 ---NMMQRHEEEAHEKGKILSEQKAMINAMdskirsleqrIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 396
Cdd:pfam01576  159 eriSEFTSNLAEEEEKAKSLSKLKNKHEAM----------ISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  397 TQAGKLEAQNRKLEEQLEkishqdhsdknrllELETRLREVSLeheeQKLELKRQLTELQLSLQERESQLTALQAARAAL 476
Cdd:pfam01576  229 AQIAELRAQLAKKEEELQ--------------AALARLEEETA----QKNNALKKIRELEAQISELQEDLESERAARNKA 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  477 ESQLRqakteleettaeaeeeiqaltahrdeiqrkfdalrnsctvitDLEEQLNQLTEDnaelnnqnfyLSKQLDEASGA 556
Cdd:pfam01576  291 EKQRR------------------------------------------DLGEELEALKTE----------LEDTLDTTAAQ 318

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  557 NDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCtmleeqvmdLEALNDELLEKER---QWEAWRSVLGDEKSQF 633
Cdd:pfam01576  319 QELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQA---------LEELTEQLEQAKRnkaNLEKAKQALESENAEL 389

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  634 ECRVRELQRMLDTEKQSRARADQritesrQVVELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNA 711
Cdd:pfam01576  390 QAELRTLQQAKQDSEHKRKKLEG------QLQELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDV 463

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  712 RSLQQKLETERELKQRllEEQAKLQ-----QQMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKV 786
Cdd:pfam01576  464 SSLESQLQDTQELLQE--ETRQKLNlstrlRQLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKK 531


                   ....
gi 2462529488  787 KMEG 790
Cdd:pfam01576  532 KLEE 535
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
3-566 1.33e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 76.23  E-value: 1.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:PRK02224   198 EKEEKDLHERLNGLESELAELDEEIERYEEQREQARETR----DEADEVLEEHEERREELETLEAEIEDLRETIAETERE 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQhkllkakdqgkpevgeyakle 162
Cdd:PRK02224   274 REELAEE-----VRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELR--------------------- 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  163 kinaeqqlkiQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLEnkvKRLE 242
Cdd:PRK02224   328 ----------DRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELE---EEIE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  243 TMERRENRLKDDIQtksqqiqQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADK 315
Cdd:PRK02224   395 ELRERFGDAPVDLG-------NAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHV 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  316 ETLENMMQRHEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELR 389
Cdd:PRK02224   468 ETIEEDRERVEELEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELR 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  390 QQKFYLETQAGKLEAQNRKLEEQ----------LEKISHQDHSDKNRLLELETRLREVSlEHEEQKLELKRQLTELQLSL 459
Cdd:PRK02224   544 ERAAELEAEAEEKREAAAEAEEEaeeareevaeLNSKLAELKERIESLERIRTLLAAIA-DAEDEIERLREKREALAELN 622

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  460 QERESQLTALQAARAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQ 531
Cdd:PRK02224   623 DERRERLAEKRERKRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEE 695

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 2462529488  532 LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE 566
Cdd:PRK02224   696 LRERREALENRVEALEALYDEAEELESMYGDLRAE 730
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
125-736 2.24e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 75.46  E-value: 2.24e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  125 ESRLAAEEFKRKATECQHKLlKAKDQGKPEVGEYAKL---EKINAEQQLKIQELQEKLEKAVKASTEATELLqnirqakE 201
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQL-KAQIEEKEEKDLHERLnglESELAELDEEIERYEEQREQARETRDEADEVL-------E 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  202 RAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVK-----RLETMERRENRLKD------DIQTKSQQIQQMADKIL 270
Cdd:PRK02224   245 EHEERREELETLEAEIEDLRETIAETEREREELAEEVRdlrerLEELEEERDDLLAEaglddaDAEAVEARREELEDRDE 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  271 ELEEKHREAQVSAQHlevHLKQKEQhYEEKIKVLDNQIKKDLADKETLENMMQRHEEEahekgkiLSEQKAMINAMDSKI 350
Cdd:PRK02224   325 ELRDRLEECRVAAQA---HNEEAES-LREDADDLEERAEELREEAAELESELEEAREA-------VEDRREEIEELEEEI 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  351 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLEL 430
Cdd:PRK02224   394 EELRERFGDAPVDLGNAEDFLEELREERDELREREAELEAT---LRTARERVEEAEALLEAGKCPECGQPVEGSPHVETI 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  431 EtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAlESQLRQAKTELEETTaeaeeeiQALTAHRDEIQR 510
Cdd:PRK02224   471 E--------EDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA-EDRIERLEERREDLE-------ELIAERRETIEE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  511 KfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 590
Cdd:PRK02224   535 K--------------RERAEELRERAAELE----------AEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIES 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  591 LKTTCTMLEEqVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavk 670
Cdd:PRK02224   591 LERIRTLLAA-IADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEYL------- 662

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  671 ehkaeilalqqalkeqklkaESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ 736
Cdd:PRK02224   663 --------------------EQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVE 708
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
157-601 2.29e-13

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 75.19  E-value: 2.29e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKL----------VE 226
Cdd:COG4717     54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekllqllplyQE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  227 AEERRHSLENKVKRLETMERRENRLKD---DIQTKSQQIQQMADKILELEE-----KHREAQVSAQHLEvHLKQKEQHYE 298
Cdd:COG4717    134 LEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELEELLEqlslaTEEELQDLAEELE-ELQQRLAELE 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  299 EKIKVLDNQIKKDLADKETLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFTQR 376
Cdd:COG4717    213 EELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLvLGLLALLFLL 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  377 NMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREV-----SLEHEEQKLELKRQ 451
Cdd:COG4717    293 LAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELqellrEAEELEEELQLEEL 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  452 LTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiQALTAHRDEIQRKFDALRN 517
Cdd:COG4717    369 EQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE---------LLEALDEEELEEELEELEE 439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  518 SctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 597
Cdd:COG4717    440 E---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAELRELAEEWAALKLALELLEEAREE 508


                   ....
gi 2462529488  598 LEEQ 601
Cdd:COG4717    509 YREE 512
PRK01156 PRK01156
chromosome segregation protein; Provisional
 23-593 2.50e-13

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 75.32  E-value: 2.50e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   23 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 100
Cdd:PRK01156   172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  101 MMNQLEEdlvSARRRSDLYESELRESRLAAEEFKRKATECQHKLL--KAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 178
Cdd:PRK01156   244 LSSLEDM---KNRYESEIKTAESDLSMELEKNNYYKELEERHMKIinDPVYKNRNYINDYFKYKNDIENKKQILSNIDAE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  179 LEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEErrhSLENKVKRLETMERRENRLKDDIQTK 258
Cdd:PRK01156   321 INKYHAIIKKLSVL-QKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLK---SIESLKKKIEEYSKNIERMSAFISEI 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  259 SQQIQQMADKIL-ELEEKHREAQ------VSAQHLEVHLKQKEQHYEEKIKVLDNQIK-----KDLADkETLENMMQRHE 326
Cdd:PRK01156   397 LKIQEIDPDAIKkELNEINVKLQdisskvSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgTTLGE-EKSNHIINHYN 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  327 EEAHEKGKILSEQKAMINAMDSKIRSLEQRI--VELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA 404
Cdd:PRK01156   476 EKKSRLEEKIREIEIEVKDIDEKIVDLKKRKeyLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  405 QNRKLEeqlekISHQDHSDKNRLLELETRLREVSLEheEQKLELKRQLTELQLSLQERESQLTALQAAraaLESQLRQAK 484
Cdd:PRK01156   556 KSLKLE-----DLDSKRTSWLNALAVISLIDIETNR--SRSNEIKKQLNDLESRLQEIEIGFPDDKSY---IDKSIREIE 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  485 TELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLR 564
Cdd:PRK01156   626 NEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDD---AKANRARLE 701

                          570       580
                   ....*....|....*....|....*....
gi 2462529488  565 SEVDHLRREITEREMQLTSQKQTMEALKT 593
Cdd:PRK01156   702 STIEILRTRINELSDRINDINETLESMKK 730
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 120-829 8.74e-13

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 73.60  E-value: 8.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  120 ESELRESRLAAEEfKRKATECQHKLLKAKDQGKpevgeyaklEKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--R 197
Cdd:pfam05483   98 EAELKQKENKLQE-NRKIIEAQRKAIQELQFEN---------EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaR 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  198 QAKERAERELEKLQNRE---DSSEGIRKKLVEAEERRHSLEN-------KVKR-LETMERRENRLKDDIQTKSQQIQQMA 266
Cdd:pfam05483  167 SAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELRVQAENarlemhfKLKEdHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  267 DKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMqrhEEEAHEKGKILSEQKAMINAM 346
Cdd:pfam05483  247 IQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKEL---EDIKMSLQRSMSTQKALEEDL 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  347 DSKIRSL----EQRIVELSEANKLAANSSLFT---QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ 419
Cdd:pfam05483  320 QIATKTIcqltEEKEAQMEELNKAKAAHSFVVtefEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  420 DHSDKNRLLELETRLREVSLEHEEQKL------ELKRQLTELQLSLQERES-------QLTALQAARAALESQLRQAKTE 486
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQELIFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  487 LEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQLNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSE 566
Cdd:pfam05483  480 LEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLELKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDE 549

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  567 VDHLRREIteremqltsqKQTMEALKTTCTMLEEQVMDLEAlndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMldt 646
Cdd:pfam05483  550 LESVREEF----------IQKGDEVKCKLDKSEENARSIEY---EVLKKEKQMKILENKCNNLKKQIENKNKNIEEL--- 613

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  647 EKQSRARADQRITESRQvveLAVKEHKAEILALQQALKEQKLKaESLSDKLNDLEKKhamlemnaRSLQQKLETERELKQ 726
Cdd:pfam05483  614 HQENKALKKKGSAENKQ---LNAYEIKVNKLELELASAKQKFE-EIIDNYQKEIEDK--------KISEEKLLEEVEKAK 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  727 RLLEEQAKLQQQMDLQKNH-IFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAK 805
Cdd:pfam05483  682 AIADEAVKLQKEIDKRCQHkIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQ 761

                          730       740
                   ....*....|....*....|....
gi 2462529488  806 MDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:pfam05483  762 LEIEKEEKEKLKMEAKENTAILKD 785
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 67-771 9.25e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 73.46  E-value: 9.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   67 DKALQLLHDIREQSRKLqEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEcQHKLLK 146
Cdd:TIGR00618  176 DQYTQLALMEFAKKKSL-HGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQ-KREAQE 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  147 AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKKLVE 226
Cdd:TIGR00618  254 EQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHI-KAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAA 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  227 AEERRHSLENKVKRLETMERRENRLKDDIQtKSQQIQQMADKILELEEKHREAQvsaQHLEvHLKQKEQHYEEKIKVLDN 306
Cdd:TIGR00618  333 HVKQQSSIEEQRRLLQTLHSQEIHIRDAHE-VATSIREISCQQHTLTQHIHTLQ---QQKT-TLTQKLQSLCKELDILQR 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  307 QIKKDLAdketlenmmqRHEEEAHEKGKILSEQKAMInamdskirsLEQRIVELSEAnklaansslFTQRnmKAQEEMIS 386
Cdd:TIGR00618  408 EQATIDT----------RTSAFRDLQGQLAHAKKQQE---------LQQRYAELCAA---------AITC--TAQCEKLE 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  387 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQL 466
Cdd:TIGR00618  458 KIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTY 537

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  467 TALQAARAALESQLrqakteleettAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYL 546
Cdd:TIGR00618  538 AQLETSEEDVYHQL-----------TSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEA 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  547 SKQLDEASGAndEIVQLRSEVDHLRREITERemqltsQKQTMEALKTTCtmleeqvmdLEALNDELLeKERQWEAWRSVL 626
Cdd:TIGR00618  607 EDMLACEQHA--LLRKLQPEQDLQDVRLHLQ------QCSQELALKLTA---------LHALQLTLT-QERVREHALSIR 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  627 GDEKSQFECRVRELQRMldtekQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAM 706
Cdd:TIGR00618  669 VLPKELLASRQLALQKM-----QSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQ 743

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  707 LEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLE 771
Cdd:TIGR00618  744 SLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREeDTHLLKTLEAEIG 809
C1_MgcRacGAP cd20821
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ...
 937-991 2.29e-12

protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410371  Cd Length: 55  Bit Score: 63.19  E-value: 2.29e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  937 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 991
Cdd:cd20821      1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
mukB PRK04863
chromosome partition protein MukB;
74-778 2.72e-12

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 72.30  E-value: 2.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   74 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLAAEEFKRKATECQHKLL 145
Cdd:PRK04863   307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALRQQEKIERYQADLEELEERleEQNEVVEEADEQQEENEARAE 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  146 KAKDqgkpevgEYAKLEKINAEQQLKIQELQEK---LEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRK 222
Cdd:PRK04863   387 AAEE-------EVDELKSQLADYQQALDVQQTRaiqYQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQE---ATE 456

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  223 KLVEAEERRHSLENKVKRLETMERRENRLKDDIqTKSQQIQQMADKILELEEKHREAQvSAQHLEVHLKQKEQHYEEKIK 302
Cdd:PRK04863   457 ELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEV-SRSEAWDVARELLRRLREQRHLAE-QLQQLRMRLSELEQRLRQQQR 534

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  303 V--LDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIR----SLEQRIVELS--EANKLAANSSLFT 374
Cdd:PRK04863   535 AerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRqqleQLQARIQRLAarAPAWLAAQDALAR 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  375 QRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE--HEEQ 444
Cdd:PRK04863   615 LREQSGEEfedsQDVTEYMQQLLERERELtverDELAARKQALDEEIERLSQPGGSEDPRLNALAERFGGVLLSeiYDDV 694

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  445 KLE-----------------------LKRQLTELQ-----LSLQE------RESQLTALQAARAAL----ESQLRQAKTE 486
Cdd:PRK04863   695 SLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcpedLYLIEgdpdsfDDSVFSVEELEKAVVvkiaDRQWRYSRFP 774

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  487 LEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLR 564
Cdd:PRK04863   775 EVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFI-------GSHLAVAFEADP----EAELRQLN 843

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  565 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE---------------EQVMDLEALNDELLEKER----------QW 619
Cdd:PRK04863   844 RRRVELERALADHESQEQQQRSQLEQAKEGLSALNrllprlnlladetlaDRVEEIREQLDEAEEAKRfvqqhgnalaQL 923

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  620 EAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILA----LQQALKEQKLKAES 692
Cdd:PRK04863   924 EPIVSVLQSDPEQFE----QLKQDYQQAQQTQRDAKQQAfalTEVVQRRAHFSYEDAAEMLAknsdLNEKLRQRLEQAEQ 999

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  693 LSDKLNDLEKKHA--MLEMNAR------SLQQKLETERELKQRL----------LEEQAKLQQQmdlqknhifRLTQGLQ 754
Cdd:PRK04863  1000 ERTRAREQLRQAQaqLAQYNQVlaslksSYDAKRQMLQELKQELqdlgvpadsgAEERARARRD---------ELHARLS 1070

                          810       820
                   ....*....|....*....|....
gi 2462529488  755 EALDRADLLKTERSDLEYQLENIQ 778
Cdd:PRK04863  1071 ANRSRRNQLEKQLTFCEAEMDNLT 1094
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 11-581 3.02e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.07  E-value: 3.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   11 RRVSEVEAVLSQKEVELKAS----ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEI 86
Cdd:pfam15921  317 RQLSDLESTVSQLRSELREAkrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   87 KEQeyqaqveEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAeEFKRKATECQHKLLK--AKDQGKPEvgeyaKLEKI 164
Cdd:pfam15921  397 KEQ-------NKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA-LLKAMKSECQGQMERqmAAIQGKNE-----SLEKV 463

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  165 NAeQQLKIQELQEKLEKAVKASTEATELLQNirqaKERAEREL-EKLQNREDSSEGIRKKLVEAEERrhsLENKVKRLET 243
Cdd:pfam15921  464 SS-LTAQLESTKEMLRKVVEELTAKKMTLES----SERTVSDLtASLQEKERAIEATNAEITKLRSR---VDLKLQELQH 535

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  244 MERRENRLKdDIQTKSQQIQqmadkiLELEEKHREAQVSAQHLEVHLKQKEQHYEE--KIKVLDNQIKKDLADKEtLEnm 321
Cdd:pfam15921  536 LKNEGDHLR-NVQTECEALK------LQMAEKDKVIEILRQQIENMTQLVGQHGRTagAMQVEKAQLEKEINDRR-LE-- 605

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  322 mqrheeeahekgkiLSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQQKFYLETQAG 400
Cdd:pfam15921  606 --------------LQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQERDQLLNEVK 663

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  401 KLEAQNRKLEEQLEKishqdhsdknrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA-ALESQ 479
Cdd:pfam15921  664 TSRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGhAMKVA 729

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  480 LRQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLD----EASG 555
Cdd:pfam15921  730 MGMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQELStvatEKNK 787

                          570       580
                   ....*....|....*....|....*.
gi 2462529488  556 ANDEIVQLRSEVDHLRREITEREMQL 581
Cdd:pfam15921  788 MAGELEVLRSQERRLKEKVANMEVAL 813
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
409-869 3.06e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 71.61  E-value: 3.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  409 LEEQLEKISHQDHSDknRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 485
Cdd:PRK02224   192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  486 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 557
Cdd:PRK02224   269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  558 DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRV 637
Cdd:PRK02224   349 EDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRERE 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  638 RELQRMLDTEKQSRARAD------------QRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN------D 699
Cdd:PRK02224   429 AELEATLRTARERVEEAEalleagkcpecgQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraedlvE 506

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  700 LEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 772
Cdd:PRK02224   507 AEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKE 586

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  773 QLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCAELE 852
Cdd:PRK02224   587 RIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKRELE 640

                          490
                   ....*....|....*...
gi 2462529488  853 EALQKTRIE-LRSAREEA 869
Cdd:PRK02224   641 AEFDEARIEeAREDKERA 658
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 67-753 5.34e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 71.15  E-value: 5.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   67 DKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKR--------KAT 138
Cdd:TIGR00618  200 TLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARieelraqeAVL 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  139 ECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNiRQAKERAERELEKLQNREDSSE 218
Cdd:TIGR00618  280 EETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ-QSSIEEQRRLLQTLHSQEIHIR 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  219 -------GIRKKLVEAEERRHSLENKVKRLETMERRENRLKddiqTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLK 291
Cdd:TIGR00618  359 dahevatSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLC----KELDILQREQATIDTRTSAFRDLQGQLAHAKKQQE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  292 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKG--KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAN 369
Cdd:TIGR00618  435 LQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQtkEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  370 SSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELK 449
Cdd:TIGR00618  515 PARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITV 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  450 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 529
Cdd:TIGR00618  595 RLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKEL 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  530 NQLTEDN-AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL--E 606
Cdd:TIGR00618  675 LASRQLAlQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQarT 754

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  607 ALNDELLEKERQWEAWRSVL--GDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKehkAEILALQQALK 684
Cdd:TIGR00618  755 VLKARTEAHFNNNEEVTAALqtGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILN---LQCETLVQEEE 831

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  685 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 753
Cdd:TIGR00618  832 QFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHEI 900
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 521-873 8.34e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.47  E-value: 8.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  521 VITDLEEQLNQLtEDNAELNNQNFYLSKQLDEAsgandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE 600
Cdd:TIGR02168  194 ILNELERQLKSL-ERQAEKAERYKELKAELREL-----ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEE 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  601 QvmdLEALNDELLEKERQWEAWRSVLGD---EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavKEHKAEIL 677
Cdd:TIGR02168  268 K---LEELRLEVSELEEEIEELQKELYAlanEISRLEQQKQILRERLANLERQLEELEAQLEELESK-----LDELAEEL 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  678 A-LQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERElkqrlleEQAKLQQQMDLQKNHIFRLTQGLQEA 756
Cdd:TIGR02168  340 AeLEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRS-------KVAQLELQIASLNNEIERLEARLERL 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  757 LDRADLLKTERSDLEYQLENiqvlysHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqVPLQYNE 836
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDA 479

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 2462529488  837 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 873
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 102-777 3.30e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 68.66  E-value: 3.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  102 MNQLEEDLVSARRRSDLYESELresrlaaEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEK 181
Cdd:pfam01576    7 MQAKEEELQKVKERQQKAESEL-------KELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  182 AVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLveaEERRHSLENKVKRLE----TMERRENRLKDDIQT 257
Cdd:pfam01576   80 LESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKL---QLEKVTTEAKIKKLEedilLLEDQNSKLSKERKL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  258 KSQQIQQMADKILELEEKHR---------EAQVSaqHLEVHLKQKEQHYEEKIKV----------LDNQIKKDLADKETL 318
Cdd:pfam01576  157 LEERISEFTSNLAEEEEKAKslsklknkhEAMIS--DLEERLKKEEKGRQELEKAkrklegestdLQEQIAELQAQIAEL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  319 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEanklaansSLFTQRNMKAQEEmiselrQQKFYLETQ 398
Cdd:pfam01576  235 RAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQE--------DLESERAARNKAE------KQRRDLGEE 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  399 agkLEAQNRKLEEQLEKISHQDHSDKNR---LLELETRLREVSLEHEEQKLELKR----QLTELQLSLQERESQLTALQA 471
Cdd:pfam01576  301 ---LEALKTELEDTLDTTAAQQELRSKReqeVTELKKALEEETRSHEAQLQEMRQkhtqALEELTEQLEQAKRNKANLEK 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  472 ARAALESQ----------LRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdalrnsctVITDLEEQLNQLTednAELNN 541
Cdd:pfam01576  378 AKQALESEnaelqaelrtLQQAKQDSEHKRKKLEGQLQELQARLSESER----------QRAELAEKLSKLQ---SELES 444

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  542 QNFYLSKQLDEASGANDEIVQLRSE---VDHLRREITEREMQLTSQKQTMEALKTTctmLEEQVmdlealnDELLEKERQ 618
Cdd:pfam01576  445 VSSLLNEAEGKNIKLSKDVSSLESQlqdTQELLQEETRQKLNLSTRLRQLEDERNS---LQEQL-------EEEEEAKRN 514

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  619 WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQvvELAVKEHKAEILA-----LQQALKEQKLKAESL 693
Cdd:pfam01576  515 VERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQ--QLEEKAAAYDKLEktknrLQQELDDLLVDLDHQ 592

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  694 SDKLNDLEKKHamlemnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 773
Cdd:pfam01576  593 RQLVSNLEKKQ-------KKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAE 665


                   ....
gi 2462529488  774 LENI 777
Cdd:pfam01576  666 MEDL 669
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
104-536 3.97e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 67.87  E-value: 3.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  104 QLEEDLVSARRRSDLY---ESELRESRLAAEEFKRKATECQHKL--LKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 178
Cdd:COG4717     75 ELEEELKEAEEKEEEYaelQEELEELEEELEELEAELEELREELekLEKLLQLLPLYQELEALEAELAELPERLEELEER 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  179 LEKAVKASTEATELLQNIRQAKERAERELEKLqnredsSEGIRKKLVEAEERRHSLENKVKRLetmERRENRLKDDIQTK 258
Cdd:COG4717    155 LEELRELEEELEELEAELAELQEELEELLEQL------SLATEEELQDLAEELEELQQRLAEL---EEELEEAQEELEEL 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  259 SQQIQQMADKILELEEKHR-------------------------------------EAQVSAQHLEVHLKQKEQHYEEKI 301
Cdd:COG4717    226 EEELEQLENELEAAALEERlkearlllliaaallallglggsllsliltiagvlflVLGLLALLFLLLAREKASLGKEAE 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  302 KVLDNQIKKDLADKEtLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ 381
Cdd:COG4717    306 ELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDE 384

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  382 EEMISELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 460
Cdd:COG4717    385 EELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELlEALDEEELEEELEELEEELEELEEELEELREELAELEAELE 463

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529488  461 ERESQ--LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctVITDLEEQLNQLTEDN 536
Cdd:COG4717    464 QLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP---------VLERASEYFSRLTDGR 532
C1_ScPKC1-like_rpt2 cd20823
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 935-992 7.34e-11

second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410373  Cd Length: 59  Bit Score: 58.86  E-value: 7.34e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 992
Cdd:cd20823      1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1192-1443 8.45e-11

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 67.22  E-value: 8.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1192 SDQVVLVGTEEGLYALNVLKNS--------LTHVPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1263
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1264 aqpDISPNIFEAVK-----GCHLFGAGKiENGLCICAAMPSKVVILRYN------ENLSKYCIRKEIETSEPCScIHFTN 1332
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNksgnlkKALTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1333 YSILIGTNKFYEI-DMKQYTLEEFLDKNDHSlaPAVFAASSNSFPVSIVQVNSagqreEYLLCFHEFGVFVDSYGRRSRT 1411
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462529488 1412 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1443
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 200-874 8.57e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.02  E-value: 8.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  200 KERAERELEKLQNREDSSEGIRKKLVE-----AEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEE 274
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEKRQqlerlRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  275 khreaqvSAQHLEVHLKQKEQHYEEKIKVLDnqikkdladkETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE 354
Cdd:TIGR02169  252 -------ELEKLTEEISELEKRLEEIEQLLE----------ELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKE 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  355 QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 434
Cdd:TIGR02169  315 RELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKL 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  435 REVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQlrqakteleettaeaeeeIQALTAHRDEIQRKfda 514
Cdd:TIGR02169  395 EKLKREIN----ELKRELDRLQEELQRLSEELADLNAAIAGIEAK------------------INELEEEKEDKALE--- 449

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  515 lrnsctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 594
Cdd:TIGR02169  450 -------IKKQEWKLEQLAADLSKYEQELYDLKEEYD----------RVEKELSKLQRELAEAEAQARASEERVRGGRAV 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  595 CTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF----------EC----RVRELQRM--LDTEKQSRARADQRI 658
Cdd:TIGR02169  513 EEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNvvveddavakEAiellKRRKAGRAtfLPLNKMRDERRDLSI 592

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  659 TESRQVVELAV-------KEHKAEILALQQALKEQKLKAE----------SLSDKLndLEKKHAM---------LEMNAR 712
Cdd:TIGR02169  593 LSEDGVIGFAVdlvefdpKYEPAFKYVFGDTLVVEDIEAArrlmgkyrmvTLEGEL--FEKSGAMtggsraprgGILFSR 670

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  713 SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-------LDRADLLKTERSDLEYQLENIQVLYSHEK 785
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAsrkigeiEKEIEQLEQEEEKLKERLEELEEDLSSLE 750

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  786 VKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS-RRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRS 864
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKLEEALNDlEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEY 830

                          730
                   ....*....|
gi 2462529488  865 AREEAAHRKA 874
Cdd:TIGR02169  831 LEKEIQELQE 840
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 3-773 1.09e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 66.99  E-value: 1.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQdlatyITECSSLKRSLEQARMEVSQEDDkALQLLHDIREQ 79
Cdd:TIGR00606  318 ERELVDCQRELEKLNKerrLLNQEKTELLVEQGRLQLQAD-----RHQEHIRARDSLIQSLATRLELD-GFERGPFSERQ 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   80 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYA 159
Cdd:TIGR00606  392 IKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSD 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  160 KLEKINAEQQLKIQELQEKLEKAVKASTEATEL-LQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKV 238
Cdd:TIGR00606  472 RILELDQELRKAERELSKAEKNSLTETLKKEVKsLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQI 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  239 KRLETMERRE-----------NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQH---YEEKIKvl 304
Cdd:TIGR00606  552 RKIKSRHSDEltsllgyfpnkKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQlssYEDKLF-- 629

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  305 dnqikkDLADKETLENMMQRHEEEAHEKGKilseQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 384
Cdd:TIGR00606  630 ------DVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEF 696

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  385 ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN-------RLLELETRLREVSLEHEEQKLELKRQLTELQL 457
Cdd:TIGR00606  697 ISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSiidlkekEIPELRNKLQKVNRDIQRLKNDIEEQETLLGT 776

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  458 SLQERES------QLTALQAARAALESQLRQ-AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC----TVITDLE 526
Cdd:TIGR00606  777 IMPEEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIelnrKLIQDQQ 856

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  527 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEalkttctmleeqvmDLE 606
Cdd:TIGR00606  857 EQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLE--------------KDQ 922

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  607 ALNDELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRqvvELAVKEHKAEILALQQALKEQ 686
Cdd:TIGR00606  923 QEKEELISSKET----------SNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGK---DDYLKQKETELNTVNAQLEEC 989

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  687 KLKAESLSDKLNDLEKKHAMLEMNARSLQQKL----------ETERELKQRLLE-----------EQAKLQQQMDLQKNH 745
Cdd:TIGR00606  990 EKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEELKQHLKEmgqmqvlqmkqEHQKLEENIDLIKRN 1069

                          810       820
                   ....*....|....*....|....*...
gi 2462529488  746 IFRLTQGLQEALDRADLLKTERSDLEYQ 773
Cdd:TIGR00606 1070 HVLALGRQKGYEKEIKHFKKELREPQFR 1097
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 7-740 1.16e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 66.74  E-value: 1.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    7 TRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQarmevSQEDDKALQLLHDIREQS----RK 82
Cdd:pfam01576  260 NNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELED-----TLDTTAAQQELRSKREQEvtelKK 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQEYQAQVEEMRLMMNQ----LEEDLVSARR-RSDL------YESELRESRLAAEEFKRKATECQHKLLKAKDQG 151
Cdd:pfam01576  335 ALEEETRSHEAQLQEMRQKHTQaleeLTEQLEQAKRnKANLekakqaLESENAELQAELRTLQQAKQDSEHKRKKLEGQL 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  152 KPEVGEYAKLEKINAEQQLKIQELQEKLE-----------KAVKASTEATEL------LQNIRQAKERAEREL-EKLQNR 213
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSKLQSELEsvssllneaegKNIKLSKDVSSLesqlqdTQELLQEETRQKLNLsTRLRQL 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  214 EDSSEGIRKKLVEAEERRHSLENKVKRL------------------ETMERRENRLKDDIQTKSQQIQQMADKILELEEK 275
Cdd:pfam01576  495 EDERNSLQEQLEEEEEAKRNVERQLSTLqaqlsdmkkkleedagtlEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKT 574

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  276 HREAQVSAQHLEVHLKQKEQ---HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEK-GKILSEQKAMINAMDSKir 351
Cdd:pfam01576  575 KNRLQQELDDLLVDLDHQRQlvsNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKeTRALSLARALEEALEAK-- 652

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  352 sleqriVELSEANKL--AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhSDKNRLLE 429
Cdd:pfam01576  653 ------EELERTNKQlrAEMEDLVSSKDDVGKN--VHELERSKRALEQQVEEMKTQLEELEDELQ-------ATEDAKLR 717

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  430 LETRLREVSLEH-----------EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEI 498
Cdd:pfam01576  718 LEVNMQALKAQFerdlqardeqgEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAV 797

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  499 QAL---TAHRDEIQRKFDALRNSCTVI-----------TDLEEQLNQLTEDNA------------------ELNNQNFYL 546
Cdd:pfam01576  798 KQLkklQAQMKDLQRELEEARASRDEIlaqskesekklKNLEAELLQLQEDLAaserarrqaqqerdeladEIASGASGK 877

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  547 SKQLDEASGANDEIVQLRSEVDHLRREI---TEREMQLTSQKQTME----ALKTTCTMLEEQVMDLEALNDELLEKERQW 619
Cdd:pfam01576  878 SALQDEKRRLEARIAQLEEELEEEQSNTellNDRLRKSTLQVEQLTtelaAERSTSQKSESARQQLERQNKELKAKLQEM 957

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  620 E-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITEsrqvvelavKEHKAEILALQqaLKEQKLKAESLSDKLn 698
Cdd:pfam01576  958 EgTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRR---------TEKKLKEVLLQ--VEDERRHADQYKDQA- 1025

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|..
gi 2462529488  699 dlEKKHAMLemnaRSLQQKLETERELKQRLLEEQAKLQQQMD 740
Cdd:pfam01576 1026 --EKGNSRM----KQLKRQLEEAEEEASRANAARRKLQRELD 1061
PRK01156 PRK01156
chromosome segregation protein; Provisional
 249-743 1.28e-10

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 66.46  E-value: 1.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  249 NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKETLENMMQRHEEE 328
Cdd:PRK01156   186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  329 AHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRK 408
Cdd:PRK01156   258 IKT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKK 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  409 LEE------QLEKISHQDHSDKNRLLELET----------RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAA 472
Cdd:PRK01156   331 LSVlqkdynDYIKKKSRYDDLNNQILELEGyemdynsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  473 RAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYLS 547
Cdd:PRK01156   411 LNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKIR 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  548 KQLDEASGANDEIVQLRSEVDHLR-----------REITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKE 616
Cdd:PRK01156   487 EIEIEVKDIDEKIVDLKKRKEYLEseeinksineyNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSK 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  617 R-QW------------EAWRSVLGDEKSQF---ECRVRELQ--------------RMLDTE------KQSRARADQRITE 660
Cdd:PRK01156   567 RtSWlnalavislidiETNRSRSNEIKKQLndlESRLQEIEigfpddksyidksiREIENEannlnnKYNEIQENKILIE 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  661 SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQ 736
Cdd:PRK01156   647 KLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETLE 726


                   ....*..
gi 2462529488  737 QQMDLQK 743
Cdd:PRK01156   727 SMKKIKK 733
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 939-987 1.77e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 2462529488   939 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 987
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 939-987 1.88e-10

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 57.53  E-value: 1.88e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462529488  939 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd00029      1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
327-778 2.03e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.09  E-value: 2.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  327 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 403
Cdd:COG4913    238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  404 AQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 479
Cdd:COG4913    316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  480 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 538
Cdd:COG4913    396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  539 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREI-TEREMQLTSQKQTMEALKTTctmleeqvmdle 606
Cdd:COG4913    476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLvYERVRTGLPDPERPRLDPDS------------ 535

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  607 aLNDELLEKERQWEAW-RSVLGDEKSqFEC--RVRELQR---------MLDTEKQSRARADQRITESRQV----VELAVK 670
Cdd:COG4913    536 -LAGKLDFKPHPFRAWlEAELGRRFD-YVCvdSPEELRRhpraitragQVKGNGTRHEKDDRRRIRSRYVlgfdNRAKLA 613

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  671 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEM---------NARSLQQKLETERELKQRLLEEQ---AKLQQQ 738
Cdd:COG4913    614 ALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAELEAELERLDASSddlAALEEQ 693

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2462529488  739 MDlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 778
Cdd:COG4913    694 LE-------ELEAELEELEEELDELKGEIGRLEKELEQAE 726
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2-417 3.25e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.04  E-value: 3.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 81
Cdd:TIGR04523  216 LESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKS 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   82 KLQEIKEQEYQAqveemrlMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQhKLLKAKDQGKPEVGEYAKl 161
Cdd:TIGR04523  296 EISDLNNQKEQD-------WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLK-KELTNSESENSEKQRELE- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  162 EKINAEQQLKiQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRL 241
Cdd:TIGR04523  367 EKQNEIEKLK-KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  242 E----TMERRENRLKDDIQTKSQQIQQMADKI----LELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLA 313
Cdd:TIGR04523  446 TnqdsVKELIIKNLDNTRESLETQLKVLSRSInkikQNLEQKQKELKSKEKELK-KLNEEKKELEEKVKDLTKKISSLKE 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  314 DKETLENmmqrheeEAHEKGKILSEQKAMINAMDS---------KIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 384
Cdd:TIGR04523  525 KIEKLES-------EKKEKESKISDLEDELNKDDFelkkenlekEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKE 597

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2462529488  385 ISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 417
Cdd:TIGR04523  598 KKDLIKEIEEKEKKISSLEKELEKAKKENEKLS 630
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
267-752 3.39e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.79  E-value: 3.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  267 DKILELEEKHREAQVSAQHLEVHLKQKEQhYEEKIKVLDNQIKKDLADKETLENMMQRHEeeAHEKGKILSEQkamINAM 346
Cdd:COG4717     71 KELKELEEELKEAEEKEEEYAELQEELEE-LEEELEELEAELEELREELEKLEKLLQLLP--LYQELEALEAE---LAEL 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  347 DSKIRSLEQRIVELSEankLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNR 426
Cdd:COG4717    145 PERLEELEERLEELRE---LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  427 LLELETRLREVSLEHEEQKLElkRQLTELQLSLqeresqltALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 506
Cdd:COG4717    222 LEELEEELEQLENELEAAALE--ERLKEARLLL--------LIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFL 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  507 EIQRKFDALRNSCTVITDLEEQLN-QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREitEREMQLTSQK 585
Cdd:COG4717    292 LLAREKASLGKEAEELQALPALEElEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEEL--EEELQLEELE 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  586 QTMEALkttctMLEEQVMDLEALNdELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARAD-QRITESRQV 664
Cdd:COG4717    370 QEIAAL-----LAEAGVEDEEELR-AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEElEELEEELEE 443

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  665 VELAVKEHKAEILALQQALK---------EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAkl 735
Cdd:COG4717    444 LEEELEELREELAELEAELEqleedgelaELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA-- 521

                          490
                   ....*....|....*...
gi 2462529488  736 qqqmdlqkNHIF-RLTQG 752
Cdd:COG4717    522 --------SEYFsRLTDG 531
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
65-663 5.02e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 64.55  E-value: 5.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   65 EDDKALQLLHDIreQSRK----LQE-IKEQ-----EYQAQVEEMRLMMNQL---EEDLVSARRRSDLyeseLRESRLAAE 131
Cdd:COG4913    189 GSEKALRLLHKT--QSFKpigdLDDfVREYmleepDTFEAADALVEHFDDLeraHEALEDAREQIEL----LEPIRELAE 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  132 EFKRKATECQHklLKAkdqgkpeVGEYAKLEkinaEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ 211
Cdd:COG4913    263 RYAAARERLAE--LEY-------LRAALRLW----FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  212 NREDSSEGIRKKLVEAEerrhsLENKVKRLETMERRENRLKDDIQT--------------KSQQIQQMADKILELEEKHR 277
Cdd:COG4913    330 AQIRGNGGDRLEQLERE-----IERLERELEERERRRARLEALLAAlglplpasaeefaaLRAEAAALLEALEEELEALE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  278 EAQVSAQHLEVHLKQKEQHYEEKIKVLDN--------------QIKKDLADKET----LENMMQRHEEEAHEKGKI---- 335
Cdd:COG4913    405 EALAEAEAALRDLRRELRELEAEIASLERrksniparllalrdALAEALGLDEAelpfVGELIEVRPEEERWRGAIervl 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  336 -------------LSEQKAMINAMDSKIR------------SLEQRIVELSEANKLAANSSLFTQRnmkAQEEM------ 384
Cdd:COG4913    485 ggfaltllvppehYAAALRWVNRLHLRGRlvyervrtglpdPERPRLDPDSLAGKLDFKPHPFRAW---LEAELgrrfdy 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  385 -----ISELRQQKFYLeTQAGKLeAQNRKLEEqlekisHQDHSdknrlleletRLREVSL---EHEEQKLELKRQLTELQ 456
Cdd:COG4913    562 vcvdsPEELRRHPRAI-TRAGQV-KGNGTRHE------KDDRR----------RIRSRYVlgfDNRAKLAALEAELAELE 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  457 LSLQERESQLTALQAARAALESQLRQakteleettaeaeeeIQALTAHRDEIQRKFDALRNsctvITDLEEQLNQLTEDN 536
Cdd:COG4913    624 EELAEAEERLEALEAELDALQERREA---------------LQRLAEYSWDEIDVASAERE----IAELEAELERLDASS 684

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  537 AELNNqnfyLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTctmLEEQVMDLEALNDELLEke 616
Cdd:COG4913    685 DDLAA----LEEQLEE---LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDR---LEAAEDLARLELRALLE-- 752

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 2462529488  617 rqwEAWRSVLGDEKSQfecRVRE-LQRMLDTEKQSRARADQRITESRQ 663
Cdd:COG4913    753 ---ERFAAALGDAVER---ELREnLEERIDALRARLNRAEEELERAMR 794
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
318-554 5.25e-10

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 64.27  E-value: 5.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  318 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 397
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  398 QAGKLEAQNRKLEEQLEKISHQ--DHSDKNRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 475
Cdd:COG3206    234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  476 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 554
Cdd:COG3206    303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
3-436 5.81e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 64.31  E-value: 5.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLAtyitecsSLKRSLEqarmevsqEDDKALQLLHDIREQ 79
Cdd:PRK03918   313 EKRLSRLEEEINGIEERIKEleeKEERLEELKKKLKELEKRLE-------ELEERHE--------LYEEAKAKKEELERL 377

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   80 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEC--------QHKLLKAKDQG 151
Cdd:PRK03918   378 KKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCpvcgreltEEHRKELLEEY 457

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  152 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER----ELEKLQNREDSSEGIRKKLVEA 227
Cdd:PRK03918   458 TAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKlkkyNLEELEKKAEEYEKLKEKLIKL 537

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  228 EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvSAQHLEVHLKQKEQHYEEKIKVLDnq 307
Cdd:PRK03918   538 KGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFE------SVEELEERLKELEPFYNEYLELKD-- 609

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  308 IKKDLadkETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISE 387
Cdd:PRK03918   610 AEKEL---EREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEE 684

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 2462529488  388 LRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhSDKNRLLELETRLRE 436
Cdd:PRK03918   685 LEKRREEIKKTLEKLKEELEEREKAKKEL-----EKLEKALERVEELRE 728
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
409-869 5.91e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.02  E-value: 5.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  409 LEEQLEKISHQDHSDKNRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 487
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  488 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgANDEIVQLRSEV 567
Cdd:COG4717    126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA--TEEELQDLAEEL 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  568 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNdELLEKERQWEAWRSVL-----GDEKSQFECRVRELQR 642
Cdd:COG4717    202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEE-RLKEARLLLLIAAALLallglGGSLLSLILTIAGVLF 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  643 MLdtekqSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE--MNARSLQQKLET 720
Cdd:COG4717    281 LV-----LGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLEllDRIEELQELLRE 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  721 ERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI-----QVLYSHEKVKMEG 790
Cdd:COG4717    356 AEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgeleELLEALDEEELEE 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  791 TISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE---ALQKTRIELRSARE 867
Cdd:COG4717    433 ELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewaALKLALELLEEARE 507


                   ..
gi 2462529488  868 EA 869
Cdd:COG4717    508 EY 509
PTZ00121 PTZ00121
MAEBL; Provisional
 81-876 6.14e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 64.39  E-value: 6.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   81 RKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEcQHKLLKAKDQGKPEVGEYAK 160
Cdd:PTZ00121  1027 EKIEELTEYGNNDDVLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKE-DNRADEATEEAFGKAEEAKK 1105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  161 LEKINAEQQLKIQELQEKLEKAVKAstEATELLQNIRQAKE--RAE--RELEKLQNREDSSEGIRKKLVE----AEERRH 232
Cdd:PTZ00121  1106 TETGKAEEARKAEEAKKKAEDARKA--EEARKAEDARKAEEarKAEdaKRVEIARKAEDARKAEEARKAEdakkAEAARK 1183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  233 SLEnkVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQhlEVHLKQKEQHYEEKIKVLDNQIKKDL 312
Cdd:PTZ00121  1184 AEE--VRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAE--EAKKDAEEAKKAEEERNNEEIRKFEE 1259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKiRSLEQRIVElsEANKLAANSSLFTQRNMKAQEemiSELRQQK 392
Cdd:PTZ00121  1260 ARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK-KAEEKKKAD--EAKKKAEEAKKADEAKKKAEE---AKKKADA 1333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  393 FYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAA 472
Cdd:PTZ00121  1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKA 1413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  473 RAAlESQLRQAKTELEETTAEAEEEIQALTAHR-DEIQRKFDALRNSctvitdleEQLNQLTEDnaelnnqnfylSKQLD 551
Cdd:PTZ00121  1414 AAA-KKKADEAKKKAEEKKKADEAKKKAEEAKKaDEAKKKAEEAKKA--------EEAKKKAEE-----------AKKAD 1473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  552 EASGANDEivqlRSEVDHLRREITEREMQLTSQKQTMEALKTTctmleeqvmdlealnDELLEKERQWEAWRSVLGDEKS 631
Cdd:PTZ00121  1474 EAKKKAEE----AKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------------DEAKKAEEAKKADEAKKAEEAK 1534

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  632 QFEcrvrELQRMLDTEKQSRARADQRITESRQV--VELAVKEHKAEILALQQAlkeqklkaeslsDKLNDLEKKHAMLEM 709
Cdd:PTZ00121  1535 KAD----EAKKAEEKKKADELKKAEELKKAEEKkkAEEAKKAEEDKNMALRKA------------EEAKKAEEARIEEVM 1598

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  710 NARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 789
Cdd:PTZ00121  1599 KLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAE 1678

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  790 gtisqqtklidflQAKMDQPAKKKKGLFSRRKEDPALPTQvplqynELKLALEKEKARCAEL--EEALQKTRIELRSARE 867
Cdd:PTZ00121  1679 -------------EAKKAEEDEKKAAEALKKEAEEAKKAE------ELKKKEAEEKKKAEELkkAEEENKIKAEEAKKEA 1739


                   ....*....
gi 2462529488  868 EAAHRKATD 876
Cdd:PTZ00121  1740 EEDKKKAEE 1748
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1-456 8.61e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 63.91  E-value: 8.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    1 MMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDL------ATYITECSSLKRSLEQARMEVSQEDDKAL---Q 71
Cdd:TIGR00606  588 QTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQRAMLAGATAvysQ 667

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   72 LLHDIREQSRKLQEIKEQEYQAQvEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAtECQHKLLKAKDQG 151
Cdd:TIGR00606  668 FITQLTDENQSCCPVCQRVFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLA-PGRQSIIDLKEKE 745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  152 KPEVGEyaKLEKINAEQQLKIQEL--QEKLEKAVKASTEATE-------LLQNIRQAKERAERELEKLQNREDSSEGIRK 222
Cdd:TIGR00606  746 IPELRN--KLQKVNRDIQRLKNDIeeQETLLGTIMPEEESAKvcltdvtIMERFQMELKDVERKIAQQAAKLQGSDLDRT 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  223 klveAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH---REAQVSAQHLEVHLKQKEQHYEE 299
Cdd:TIGR00606  824 ----VQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKlqiGTNLQRRQQFEEQLVELSTEVQS 899

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  300 KIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI-------RSLEQRIVE---------LSEA 363
Cdd:TIGR00606  900 LIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVknihgymKDIENKIQDgkddylkqkETEL 979

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  364 NKLAANSSLFTQRNMKAQEEM------ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLE-------L 430
Cdd:TIGR00606  980 NTVNAQLEECEKHQEKINEDMrlmrqdIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQmkqehqkL 1059

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 2462529488  431 ETRLREVSLEH----------EEQKLELKRQLTELQ 456
Cdd:TIGR00606 1060 EENIDLIKRNHvlalgrqkgyEKEIKHFKKELREPQ 1095
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
75-675 1.23e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.40  E-value: 1.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   75 DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 154
Cdd:COG4913    263 RYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQ 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  155 V-GEYAKLEKINAEQQLKIQELQEKLEKA-VKASTEATELLQNIRQAKERAER---ELEKLQNREDSsegIRKKLVEAEE 229
Cdd:COG4913    343 LeREIERLERELEERERRRARLEALLAALgLPLPASAEEFAALRAEAAALLEAleeELEALEEALAE---AEAALRDLRR 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  230 RRHSLENKVKRLE----TMERRENRLKDDIqtkSQQIQQMADKI------LELEEKHREAQ---------------VSAQ 284
Cdd:COG4913    420 ELRELEAEIASLErrksNIPARLLALRDAL---AEALGLDEAELpfvgelIEVRPEEERWRgaiervlggfaltllVPPE 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  285 HL--------EVHLKQK-------------------EQHYEEKIKVLDNQ----IKKDLADK------ETLENM------ 321
Cdd:COG4913    497 HYaaalrwvnRLHLRGRlvyervrtglpdperprldPDSLAGKLDFKPHPfrawLEAELGRRfdyvcvDSPEELrrhpra 576

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  322 -----MQRHEEEAHEKG---KILSEQ------KAMINAMDSKIRSLEQRIVELSEANKLAANSslftQRNMKAQEEMISE 387
Cdd:COG4913    577 itragQVKGNGTRHEKDdrrRIRSRYvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAE----LDALQERREALQR 652

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  388 LRQQKFYlETQAGKLEAQNRKLEEQLEKIShqdhSDKNRLLELETRLREVSLEH---EEQKLELKRQLTELQLSLQERES 464
Cdd:COG4913    653 LAEYSWD-EIDVASAEREIAELEAELERLD----ASSDDLAALEEQLEELEAELeelEEELDELKGEIGRLEKELEQAEE 727

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  465 QLTALQAA------------RAALESQLRQAKTELEETTAEAEEEiQALTAHRDEIQRKFDALRN------------SCT 520
Cdd:COG4913    728 ELDELQDRleaaedlarlelRALLEERFAAALGDAVERELRENLE-ERIDALRARLNRAEEELERamrafnrewpaeTAD 806

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  521 VITDLE------EQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDHLRREITER----------------- 577
Cdd:COG4913    807 LDADLEslpeylALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRRAIREIKERidplndslkripfgpgr 882

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  578 EMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKerqweawrsvlgdeksQFEcRVREL-QRMLDTEKQSRARADQ 656
Cdd:COG4913    883 YLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEA----------------RFA-ALKRLiERLRSEEEESDRRWRA 945

                          730
                   ....*....|....*....
gi 2462529488  657 RITESRQVVELAVKEHKAE 675
Cdd:COG4913    946 RVLDVRNHLEFDAEEIDRE 964
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 71-365 1.96e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 62.45  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   71 QLLHDIREQsRKLQEIKEQEYQAQVEEMRLMMNQlEEDLVSARRRSDLYESEL-------RESRLAAEEfKRKATECQHK 143
Cdd:pfam17380  273 QLLHIVQHQ-KAVSERQQQEKFEKMEQERLRQEK-EEKAREVERRRKLEEAEKarqaemdRQAAIYAEQ-ERMAMERERE 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  144 LLKAKDQGKP-------------EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATE----------LLQNIRQAK 200
Cdd:pfam17380  350 LERIRQEERKrelerirqeeiamEISRMRELERLQMERQQKNERVRQELEAARKVKILEEErqrkiqqqkvEMEQIRAEQ 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  201 ERA-ERELEKLQN-REDSSEGIRKklvEAEERRHSLEnKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHRE 278
Cdd:pfam17380  430 EEArQREVRRLEEeRAREMERVRL---EEQERQQQVE-RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERK 505

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  279 AQVSAQHLEVHLKQKEQhyEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDsKIRSLEQRIV 358
Cdd:pfam17380  506 QAMIEEERKRKLLEKEM--EERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAME-REREMMRQIV 582


                   ....*..
gi 2462529488  359 ELSEANK 365
Cdd:pfam17380  583 ESEKARA 589
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 26-480 2.57e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.05  E-value: 2.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   26 ELKASETQRSLLEQDLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqL 105
Cdd:pfam05483  339 ELNKAKAAHSFVVTEFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------L 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  106 EE-DLVSARRRSDLYESELRESrlAAEEFKRKATECQHkLLKAKDQGKPEVGEYAKLEKINAEQQLK-IQELQEKLEKAV 183
Cdd:pfam05483  408 EElKKILAEDEKLLDEKKQFEK--IAEELKGKEQELIF-LLQAREKEIHDLEIQLTAIKTSEEHYLKeVEDLKTELEKEK 484

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  184 KASTEATE-----LLQNIRQAKERAERELEKLQNREDSSEGIRKKlveaeerrhslENKVKRLETMERRENRLKDDIQTK 258
Cdd:pfam05483  485 LKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQE-----------ERMLKQIENLEEKEMNLRDELESV 553

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  259 SQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIkvldNQIKKDLADKEtlENMMQRHEEEAHEKGKILSE 338
Cdd:pfam05483  554 REEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC----NNLKKQIENKN--KNIEELHQENKALKKKGSAE 627

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  339 QKAMiNAMDSKIRSLEQrivelseanKLAANSSLFTQRNMKAQEEM-ISELRQQKFYLETQAGKLEAQNR-KLEEQLEKI 416
Cdd:pfam05483  628 NKQL-NAYEIKVNKLEL---------ELASAKQKFEEIIDNYQKEIeDKKISEEKLLEEVEKAKAIADEAvKLQKEIDKR 697

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  417 SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ-ERESQLTALQAARAALESQL 480
Cdd:pfam05483  698 CQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKaALEIELSNIKAELLSLKKQL 762
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 3-231 2.66e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.93  E-value: 2.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQE-IKEQEYQAQVEEMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKATEcqhklLKAKDQgkpevgeyaKL 161
Cdd:COG4942    106 LAElLRALYRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE-----LAALRA---------EL 169

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  162 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERR 231
Cdd:COG4942    170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
PTZ00121 PTZ00121
MAEBL; Provisional
 21-416 3.42e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 3.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   21 SQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALqllhdiREQSRKLQEIKEQEYQAQVEEMRL 100
Cdd:PTZ00121  1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK------KAEEDKNMALRKAEEAKKAEEARI 1594

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  101 MMNQLEEDLVSARRRSDLYESElrESRLAAEEFkRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLE 180
Cdd:PTZ00121  1595 EEVMKLYEEEKKMKAEEAKKAE--EAKIKAEEL-KKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE 1671

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  181 KAVKASTEATELLQNIRQA------KERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERR---ENRL 251
Cdd:PTZ00121  1672 EDKKKAEEAKKAEEDEKKAaealkkEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKkaeEAKK 1751

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  252 KDDIQTKSQQIQQMADKILELEEKHREAqVSAQHLEVHLKQKEQHYEEKIK-VLDN---------------QIKKDLADK 315
Cdd:PTZ00121  1752 DEEEKKKIAHLKKEEEKKAEEIRKEKEA-VIEEELDEEDEKRRMEVDKKIKdIFDNfaniieggkegnlviNDSKEMEDS 1830

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  316 ETLE----NMMQRHEEEAHEKGKIL--------SEQKAMINAMDSKIRSLEQRIVELSEANKLAAN--SSLFTQRNMKAQ 381
Cdd:PTZ00121  1831 AIKEvadsKNMQLEEADAFEKHKFNknnengedGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDdiEREIPNNNMAGK 1910

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2462529488  382 EEMIselrqqkfyLETQAGKLEAQNRKLEEQLEKI 416
Cdd:PTZ00121  1911 NNDI---------IDDKLDKDEYIKRDAEETREEI 1936
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 4-465 3.71e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 61.67  E-value: 3.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    4 QEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQARMEV-----------SQEDDKALQ 71
Cdd:pfam15921  370 QESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRNMEVqrleallkamkSECQGQMER 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   72 LLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLV--------SARRRSDLYESeLRESRLAAEEFKRKAT----- 138
Cdd:pfam15921  449 QMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTakkmtlesSERTVSDLTAS-LQEKERAIEATNAEITklrsr 525

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  139 ------ECQHkLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVK-----ASTEATELLQNIRQAKERAEREL 207
Cdd:pfam15921  526 vdlklqELQH-LKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQlvgqhGRTAGAMQVEKAQLEKEINDRRL 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  208 EkLQNREDSSEGIRKKLVEAEERRHSLE-NKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVsaqhL 286
Cdd:pfam15921  605 E-LQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEV----L 679

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  287 EVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL 366
Cdd:pfam15921  680 KRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTN 759

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  367 AANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlekishqdhsdknRLLELETRLREVSLEHEEQKL 446
Cdd:pfam15921  760 ANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE--------------KVANMEVALDKASLQFAECQD 825

                          490       500
                   ....*....|....*....|....
gi 2462529488  447 ELKRQLTE-----LQLSLQERESQ 465
Cdd:pfam15921  826 IIQRQEQEsvrlkLQHTLDVKELQ 849
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 197-889 4.62e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.52  E-value: 4.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  197 RQAKERAE--RELEKLQNREDSSEGIRKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSQqiqqmadkILELEE 274
Cdd:TIGR00618  160 AKSKEKKEllMNLFPLDQYTQLALMEFAKKKSLHGKAELLT---LRSQLLTLCTPCMPDTYHERKQ--------VLEKEL 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  275 KH-REAQVSAQHLEVHLKQKEQHYEEKIKvLDNQIKKDLADKETLENMMQRHE------EEAHEKGKILSEQKAMINaMD 347
Cdd:TIGR00618  229 KHlREALQQTQQSHAYLTQKREAQEEQLK-KQQLLKQLRARIEELRAQEAVLEetqeriNRARKAAPLAAHIKAVTQ-IE 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  348 SKIRSLEQRIVElseanKLAANSSLFTQRNMKAQEEmiSELRQQKFYLETqagkLEAQNRKLEEQLEK-ISHQDHSDKNR 426
Cdd:TIGR00618  307 QQAQRIHTELQS-----KMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQT----LHSQEIHIRDAHEVaTSIREISCQQH 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  427 LLELETRLREVSLEHEEQKLELKRQLTElqlSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiQALTAHRD 506
Cdd:TIGR00618  376 TLTQHIHTLQQQKTTLTQKLQSLCKELD---ILQREQATIDTRTSAFRDLQGQLAHAKKQ------------QELQQRYA 440

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  507 EIQRKFdalrnsctvitdLEEQLNQLTEDNAELNNqnfylskqldeasgandeivqlrsevdhLRREITEREMQLTSQKQ 586
Cdd:TIGR00618  441 ELCAAA------------ITCTAQCEKLEKIHLQE----------------------------SAQSLKEREQQLQTKEQ 480

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  587 TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVRELQRMLDTEKQSRARAD---QRITESRQ 663
Cdd:TIGR00618  481 IHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPAR-QDIDNPGPLTRRMQRGEQTYAQLETSEEDVYhqlTSERKQRA 559

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  664 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 743
Cdd:TIGR00618  560 SLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD---LTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQ 636

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  744 nhifrLTQGLQEALDRadlLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGLFSR---- 819
Cdd:TIGR00618  637 -----CSQELALKLTA---LHALQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLAQCqtll 706

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  820 RKEDPALPTQVPlQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 889
Cdd:TIGR00618  707 RELETHIEEYDR-EFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 195-779 4.75e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 61.39  E-value: 4.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  195 NIRQAKERAERELEKLQNREDSsEGIRKKLVEAEERRHSLENKVKRLETMERRenrLKDDIQTKSQQIQQMADKILELEE 274
Cdd:pfam12128  215 KSRLNRQQVEHWIRDIQAIAGI-MKIRPEFTKLQQEFNTLESAELRLSHLHFG---YKSDETLIASRQEERQETSAELNQ 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  275 KHREaqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINamdskirsle 354
Cdd:pfam12128  291 LLRT-------LDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQ---------- 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  355 qrivelSEANKLAANSSLFTQRNMKAQEEMisELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 434
Cdd:pfam12128  354 ------SELENLEERLKALTGKHQDVTAKY--NRRRSKIKEQNNR-DIAGIKDKLAKIREARDRQLAVAEDDLQALESEL 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  435 REvslEHEEQKLELKRQLTELQLSLQERESQLTALQAaraalESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ---RK 511
Cdd:pfam12128  425 RE---QLEAGKLEFNEEEYRLKSRLGELKLRLNQATA-----TPELLLQLENFDERIERAREEQEAANAEVERLQselRQ 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  512 FDALRNSCTVITDLEEQ-LNQLTEDNAELNNQNF--------YLSKqldEASGANDEIVQLRSEvDHLRREITEREMQLT 582
Cdd:pfam12128  497 ARKRRDQASEALRQASRrLEERQSALDELELQLFpqagtllhFLRK---EAPDWEQSIGKVISP-ELLHRTDLDPEVWDG 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  583 SQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARADQRIT 659
Cdd:pfam12128  573 SVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFARTALK 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  660 ESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELKQRLLE 730
Cdd:pfam12128  650 NARLDLRRLFDEKQSEKDKKNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVEGALDA 729

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  731 EQAKLQQQMDLQKNHIFRLTQGLQEALDRaDL------------LKTERSDLEYQLENIQV 779
Cdd:pfam12128  730 QLALLKAAIAARRSGAKAELKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 168-416 1.52e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.62  E-value: 1.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  168 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQnredssegirKKLVEAEERRHSLEnkvKRLETMERR 247
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE----------RRIAALARRIRALE---QELAALEAE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  248 ENRLKDDIQTKSQQIQQMADkilELEEKHREAQVSAQHlevhlkqkeqhyeEKIKVLDNQikKDLADKETLENMMQRHEE 327
Cdd:COG4942     85 LAELEKEIAELRAELEAQKE---ELAELLRALYRLGRQ-------------PPLALLLSP--EDFLDAVRRLQYLKYLAP 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  328 EAHEKGKILSEQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 407
Cdd:COG4942    147 ARREQAEELRADLAELAA---LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223


                   ....*....
gi 2462529488  408 KLEEQLEKI 416
Cdd:COG4942    224 ELEALIARL 232
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 409-856 1.82e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 59.36  E-value: 1.82e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  409 LEEQLEKISHQdhsdknrLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR-------AALESQLR 481
Cdd:pfam15921   76 IERVLEEYSHQ-------VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQ 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  482 QAKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQ--------------------------LNQ 531
Cdd:pfam15921  149 NTVHELEAAKCLKEDMLEDSNTQIEQLRKMMlsheGVLQEIRSILVDFEEAsgkkiyehdsmstmhfrslgsaiskiLRE 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  532 LTEDNAELNNQNFYLSKQLD--EASGANDEIVQLRSEVDHLRREITEREMQLT-------SQKQTMEALKTTCTMLEEQV 602
Cdd:pfam15921  229 LDTEISYLKGRIFPVEDQLEalKSESQNKIELLLQQHQDRIEQLISEHEVEITgltekasSARSQANSIQSQLEIIQEQA 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  603 MDLEALN-DELLEKERQWEAWRSVLGDEKSQFECRVRELQRML---DTE-KQSRARADQRITES----RQVVELAVKEHK 673
Cdd:pfam15921  309 RNQNSMYmRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLvlaNSElTEARTERDQFSQESgnldDQLQKLLADLHK 388

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  674 AEilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-QKLETerELKQRLLEEQAKLQQQMdlqknhifRLTQG 752
Cdd:pfam15921  389 RE---KELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEvQRLEA--LLKAMKSECQGQMERQM--------AAIQG 455

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  753 LQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQakmdqpaKKKKGLFSRRKEDPALPTQVPL 832
Cdd:pfam15921  456 KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-------EKERAIEATNAEITKLRSRVDL 528

                          490       500
                   ....*....|....*....|....*.
gi 2462529488  833 QYNELK-LALEKEKARCAELE-EALQ 856
Cdd:pfam15921  529 KLQELQhLKNEGDHLRNVQTEcEALK 554
C1_KSR cd20812
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ...
 937-988 2.55e-08

protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410362  Cd Length: 48  Bit Score: 51.56  E-value: 2.55e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  937 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20812      1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 165-864 2.91e-08

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 58.68  E-value: 2.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  165 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM 244
Cdd:pfam10174   69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  245 ERRENRLKDDIQTKSQQIQQMAD--------KILELEEKHR-----EAQVSAQHLEVHLKQKEqhyeekikvldnqiKKD 311
Cdd:pfam10174  143 ELRIETQKQTLGARDESIKKLLEmlqskglpKKSGEEDWERtrriaEAEMQLGHLEVLLDQKE--------------KEN 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  312 LADKETLENMMQRHEEEAHEKGkilseQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTqrnmkaqEEMISELRQ 390
Cdd:pfam10174  209 IHLREELHRRNQLQPDPAKTKA-----LQTVIEMKDTKISSLERNIRDLEdEVQMLKTNGLLHT-------EDREEEIKQ 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  391 QKFYletqagkleaqnrkleeqlekishQDHSDKnrlleletrlrevsleheeqkleLKRQLTELQLSLQERESQLTALQ 470
Cdd:pfam10174  277 MEVY------------------------KSHSKF-----------------------MKNKIDQLKQELSKKESELLALQ 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  471 AARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQN 543
Cdd:pfam10174  310 TKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKSTLAGEI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  544 FYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEalnDELLEKERQWEAWR 623
Cdd:pfam10174  383 RDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLE---EALSEKERIIERLK 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  624 svlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHkAEILALQQALKEQKLKA--------- 690
Cdd:pfam10174  457 -----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH-ASSLASSGLKKDSKLKSleiaveqkk 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  691 ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDlqknhifRLTQGLQEAldradllKTER 767
Cdd:pfam10174  531 EECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE-------RLLGILREV-------ENEK 595

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  768 SDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRKEDPALPTQVPLQYNELKLALEkekar 847
Cdd:pfam10174  596 NDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QLLEEARRREDNLADNSQQLQLE----- 658

                          730
                   ....*....|....*..
gi 2462529488  848 caELEEALQKTRIELRS 864
Cdd:pfam10174  659 --ELMGALEKTRQELDA 673
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 366-618 2.97e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 2.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  366 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVslehEEQK 445
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL----EAEL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  446 LELKRQLTELQLSLQEResqltalqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDL 525
Cdd:COG4942     86 AELEKEIAELRAELEAQ----------KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPAR 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  526 EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL 605
Cdd:COG4942    149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAA---LEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225

                          250
                   ....*....|...
gi 2462529488  606 EALNDELLEKERQ 618
Cdd:COG4942    226 EALIARLEAEAAA 238
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 68-812 3.09e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.90  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   68 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKATECQ 141
Cdd:TIGR00606  186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  142 HKLLKAKDQGKpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA--------ERELEKLqNR 213
Cdd:TIGR00606  259 HNLSKIMKLDN----EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREkerelvdcQRELEKL-NK 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  214 EDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH--------REAQVSAQH 285
Cdd:TIGR00606  334 ERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHtlvierqeDEAKTAAQL 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  286 LEvHLKQKEQHYEEKIKVLDNQIKkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 365
Cdd:TIGR00606  414 CA-DLQSKERLKQEQADEIRDEKK---GLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSK 489

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  366 LAANSSLFTqrnmkaqeemiseLRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLL------ELETRLREVSL 439
Cdd:TIGR00606  490 AEKNSLTET-------------LKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmDKDEQIRKIKS 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  440 EHEEqklELKRQLTELQLSLQeRESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC 519
Cdd:TIGR00606  557 RHSD---ELTSLLGYFPNKKQ-LEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVC 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  520 TViTDLEEQLNQLTEDNAELNNQNFYLSKqldeASGANDEIVQLRSEVDHLRREITEREMQltSQKQTMEALKTTCTMLE 599
Cdd:TIGR00606  633 GS-QDEESDLERLKEEIEKSSKQRAMLAG----ATAVYSQFITQLTDENQSCCPVCQRVFQ--TEAELQEFISDLQSKLR 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  600 EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRITESRQVVELAV---KEHKAE 675
Cdd:TIGR00606  706 LAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKNDIEEQETLLGTimpEEESAK 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  676 IL--------ALQQALKEQKLKAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERELKQRLLEEQAKLQQQMDLQ 742
Cdd:TIGR00606  786 VCltdvtimeRFQMELKDVERKIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIELNRKLIQDQQEQIQHLKSK 865

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  743 KNHIFRLTQGLQEALDRADLLKTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 812
Cdd:TIGR00606  866 TNELKSEKLQIGTNLQRRQQFEEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK 932
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-741 3.43e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 58.65  E-value: 3.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSL---KRSLEQARMEVSQEddkalqlLHDIRE 78
Cdd:pfam01576  101 MQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLskeRKLLEERISEFTSN-------LAEEEE 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   79 QSRKLQEIKEQeYQAQVEEMRLMMNQLE---EDLVSARRRSDLYESELRES----RLAAEEFKRKATECQHKLLKAKDQG 151
Cdd:pfam01576  174 KAKSLSKLKNK-HEAMISDLEERLKKEEkgrQELEKAKRKLEGESTDLQEQiaelQAQIAELRAQLAKKEEELQAALARL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  152 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIR-KKLVEAEER 230
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRsKREQEVTEL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  231 RHSLENKVKRLETmerrenRLKDDIQTKSQQIQQMADKI---------LELEEKHREAQVSAQHLEVH-LKQKEQHYEEK 300
Cdd:pfam01576  333 KKALEEETRSHEA------QLQEMRQKHTQALEELTEQLeqakrnkanLEKAKQALESENAELQAELRtLQQAKQDSEHK 406

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  301 IKVLDNQikkdladketLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAanSSLFTQrnMKA 380
Cdd:pfam01576  407 RKKLEGQ----------LQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDV--SSLESQ--LQD 472

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  381 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdknrlleletrlrevslEHEEQKLELKRQLTELQLSLQ 460
Cdd:pfam01576  473 TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLE-------------------------EEEEAKRNVERQLSTLQAQLS 527

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  461 ERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA---------------------------LTAHRDEIQRKFD 513
Cdd:pfam01576  528 DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAydklektknrlqqelddllvdldhqrqLVSNLEKKQKKFD 607

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  514 -ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI----VQLRSEVDHL-------RREITEREMQL 581
Cdd:pfam01576  608 qMLAEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELertnKQLRAEMEDLvsskddvGKNVHELERSK 687

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  582 TSQKQTMEALKTTCTMLEEQvmdLEALNDELLEKERQWEAW----------RSVLGDEKS-QFECRVRELQRMLDTEKQS 650
Cdd:pfam01576  688 RALEQQVEEMKTQLEELEDE---LQATEDAKLRLEVNMQALkaqferdlqaRDEQGEEKRrQLVKQVRELEAELEDERKQ 764

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  651 RARAdqriTESRQVVELAVKEHKAEILALQQ----ALKEQKLKAESLSDKLNDLEKKHAMLEmnaRSLQQKLETERELKQ 726
Cdd:pfam01576  765 RAQA----VAAKKKLELDLKELEAQIDAANKgreeAVKQLKKLQAQMKDLQRELEEARASRD---EILAQSKESEKKLKN 837

                          810
                   ....*....|....*
gi 2462529488  727 RlleEQAKLQQQMDL 741
Cdd:pfam01576  838 L---EAELLQLQEDL 849
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 15-294 4.38e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 58.21  E-value: 4.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   15 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLhdirEQSRKlQEIKEQEYQAQ 94
Cdd:pfam17380  340 ERMAMERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQEL----EAARK-VKILEEERQRK 414

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   95 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLaaEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQE 174
Cdd:pfam17380  415 IQQQKVEMEQIRAEQEEARQREVRRLEEERAREM--ERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQ 492

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  175 LQEKLEKAVKASTEAteLLQNIRQAKeRAERELEKLQNredssegirkKLVEAEERRHSLENKVKRLETMERREnrlkdd 254
Cdd:pfam17380  493 RRKILEKELEERKQA--MIEEERKRK-LLEKEMEERQK----------AIYEEERRREAEEERRKQQEMEERRR------ 553

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2462529488  255 IQtksQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKE 294
Cdd:pfam17380  554 IQ---EQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
297-868 4.39e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.15  E-value: 4.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  297 YEEKIKVLDNQIKKDLADKETLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 376
Cdd:PRK03918   160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  377 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKNRLLELETRLREV-SLEHEEQK-LELKRQLTE 454
Cdd:PRK03918   232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  455 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 534
Cdd:PRK03918   305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  535 DNAELNNQNF-YLSKQLDEASGANDEIvqlRSEVDHLRREITEREMQLTSQKQTMEALKT------TCTMLEEQVMDLEA 607
Cdd:PRK03918   377 LKKRLTGLTPeKLEKELEELEKAKEEI---EEEISKITARIGELKKEIKELKKAIEELKKakgkcpVCGRELTEEHRKEL 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  608 LNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEilalqqALKEQK 687
Cdd:PRK03918   454 LEEYTAELKRI-EKELKEIEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLE------ELEKKA 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  688 LKAESLSDKLNDLEKKhamlemnARSLQQKLETERELKQRLLEEQAKLQQqmdlqknhifrltqglqealdradlLKTER 767
Cdd:PRK03918   525 EEYEKLKEKLIKLKGE-------IKSLKKELEKLEELKKKLAELEKKLDE-------------------------LEEEL 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  768 SDLEYQLENIQVLYSHEkvkMEGTISQQTKLID-FLQAKmdqPAKKKKglfsRRKEDpalptqvplqynelklALEKEKA 846
Cdd:PRK03918   573 AELLKELEELGFESVEE---LEERLKELEPFYNeYLELK---DAEKEL----EREEK----------------ELKKLEE 626

                          570       580
                   ....*....|....*....|..
gi 2462529488  847 RCAELEEALQKTRIELRSAREE 868
Cdd:PRK03918   627 ELDKAFEELAETEKRLEELRKE 648
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1020-1139 6.95e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 6.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1099
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462529488 1100 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 253-483 7.79e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 7.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  253 DDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKDLADKETLENMMQRHEEEAHEK 332
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER----RIAALARRIRALEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  333 GKILSEQKAMinamdskirsLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 412
Cdd:COG4942     96 RAELEAQKEE----------LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  413 LEKISHQdhsdKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 483
Cdd:COG4942    166 RAELEAE----RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 290-484 8.89e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 8.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  290 LKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS---EANKL 366
Cdd:COG4942     25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRaelEAQKE 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  367 AANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGKLEAQNRKLEEQLEKIshqdHSDKNRLLELETRLREVSLEHEEQK 445
Cdd:COG4942    105 ELAELLRALYRLGRQPPLALLLSPEDFLdAVRRLQYLKYLAPARREQAEEL----RADLAELAALRAELEAERAELEALL 180

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2462529488  446 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 484
Cdd:COG4942    181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
2-359 9.82e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 56.97  E-value: 9.82e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATY----------ITECSSLKRSLEQARMEVSQ---EDDK 68
Cdd:PRK02224   354 LEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELrerfgdapvdLGNAEDFLEELREERDELREreaELEA 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   69 ALQLLHDIREQSRKL----------QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaAEEFKRKAT 138
Cdd:PRK02224   434 TLRTARERVEEAEALleagkcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLER----AEDLVEAED 509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  139 ECQHKLLKAKDQGKpevgEYAKLEKINAEQQLKIQELQEKLE----KAVKASTEATELLQNIRQAKERA---ERELEKLQ 211
Cdd:PRK02224   510 RIERLEERREDLEE----LIAERRETIEEKRERAEELRERAAeleaEAEEKREAAAEAEEEAEEAREEVaelNSKLAELK 585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  212 NREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILE--LEEKHREAQVSAQHLEvH 289
Cdd:PRK02224   586 ERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEarIEEAREDKERAEEYLE-Q 664

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  290 LKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE--EEAHEKGKILSEQKAMINAMDSKIRS-LEQRIVE 359
Cdd:PRK02224   665 VEEKLDELREERDDLQAEIGAVENELEELEELRERREalENRVEALEALYDEAEELESMYGDLRAeLRQRNVE 737
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
506-785 1.03e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 1.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  506 DEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLtsQK 585
Cdd:COG4913    228 DALVEHFDDLERAHEALEDAREQIELLEP-----------IRELAERYAAARERLAELEYLRAALRLWFAQRRLEL--LE 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  586 QTMEALKTTCTMLEEQVMDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQV 664
Cdd:COG4913    295 AELEELRAELARLEAELERLEARLDALREELDELEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AA 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  665 VELAVKEHKAEILALQQALKEQKLKAESLSDKlndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKN 744
Cdd:COG4913    371 LGLPLPASAEEFAALRAEAAALLEALEEELEA-----------------LEEALAEAEAALRDLRRELRELEAEIASLER 433

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 2462529488  745 HIFRLTQGLQEALDR-ADLLKTERSDLEYQLENIQVLYSHEK 785
Cdd:COG4913    434 RKSNIPARLLALRDAlAEALGLDEAELPFVGELIEVRPEEER 475
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
508-740 1.03e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.95  E-value: 1.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  508 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 581
Cdd:COG3206    166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  582 TSQKQTMEALKTTCTMLEEQVMdLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITES 661
Cdd:COG3206    243 AALRAQLGSGPDALPELLQSPV-IQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQQEAQRILAS 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  662 RQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE--EQAKLQQQM 739
Cdd:COG3206    318 LEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrlEEARLAEAL 383


                   .
gi 2462529488  740 D 740
Cdd:COG3206    384 T 384
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 659-870 1.13e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 1.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  659 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 738
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  739 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 800
Cdd:COG4942     99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  801 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 870
Cdd:COG4942    175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
376-771 1.28e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  376 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKNRLLELETRLREVSlEHEEQKLELKRQLT 453
Cdd:COG4717     71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  454 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 533
Cdd:COG4717    150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  534 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQTM 588
Cdd:COG4717    227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  589 EALKTTCTMLEEQV---------MDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 653
Cdd:COG4717    307 LQALPALEELEEEEleellaalgLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  654 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 733
Cdd:COG4717    387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2462529488  734 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 771
Cdd:COG4717    457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 402-859 1.38e-07

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 55.84  E-value: 1.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  402 LEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALESQLR 481
Cdd:pfam19220   25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGK----LRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  482 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 561
Cdd:pfam19220  101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  562 QLRSEVDHLRREITEREMQLTSQKQTMEALkttctmLEEQVMDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQ 641
Cdd:pfam19220  153 KALQRAEGELATARERLALLEQENRRLQAL------SEEQAAELAELTRRLAELETQLDATRA-----------RLRALE 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  642 RMLDTEKQSRARADQRItesrqvvELAVKEHKAEILALqqalkeqKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETE 721
Cdd:pfam19220  216 GQLAAEQAERERAEAQL-------EEAVEAHRAERASL-------RMKLEALTARAAATEQ---LLAEARNQLRDRDEAI 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  722 RELKQRLLE---EQAKLQQQMDLQKNHIFRLTQGLQEaLDRADLLKTERSDLEyqlenIQVLYSHEKvkmegTISQQTKL 798
Cdd:pfam19220  279 RAAERRLKEasiERDTLERRLAGLEADLERRTQQFQE-MQRARAELEERAEML-----TKALAAKDA-----ALERAEER 347

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  799 IDFLQAKMDQPAKKkkglfsRRKEDPALPTQVplqyNELKLALEKEKARCAELEEALQKTR 859
Cdd:pfam19220  348 IASLSDRIAELTKR------FEVERAALEQAN----RRLKEELQRERAERALAQGALEIAR 398
PRK12704 PRK12704
phosphodiesterase; Provisional
 171-334 1.46e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 55.94  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  171 KIQELQEKLEKAVK-ASTEATELLQN-IRQAKERAERELEKLqnrEDSSEGIRKKLVEAEERRHSLENKV-KRLETMERR 247
Cdd:PRK12704    32 KIKEAEEEAKRILEeAKKEAEAIKKEaLLEAKEEIHKLRNEF---EKELRERRNELQKLEKRLLQKEENLdRKLELLEKR 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  248 ENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaQHLEVHLK-QKEQHYEEKIKVLDNQIKKDLAdketleNMMQRHE 326
Cdd:PRK12704   109 EEELEKKEKELEQKQQELEKKEEELEELIEEQL---QELERISGlTAEEAKEILLEKVEEEARHEAA------VLIKEIE 179


                   ....*...
gi 2462529488  327 EEAHEKGK 334
Cdd:PRK12704   180 EEAKEEAD 187
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 307-865 2.08e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 55.90  E-value: 2.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  307 QIKKDLADKEtLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 384
Cdd:pfam05557   13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  385 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 461
Cdd:pfam05557   75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  462 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 536
Cdd:pfam05557  151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  537 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM---EALKTTCTMLEEQVMDLEALNDELL 613
Cdd:pfam05557  224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLrspEDLSRRIEQLQQREIVLKEENSSLT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  614 EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALKEQKLKA 690
Cdd:pfam05557  304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSPQLLERI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  691 ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDRADLLKT 765
Cdd:pfam05557  383 EEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELERQRLRE 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  766 ERSDLEYQLE--NIQVLYSHEKVKM-------EGTISQQTK-LIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL--- 832
Cdd:pfam05557  463 QKNELEMELErrCLQGDYDPKKTKVlhlsmnpAAEAYQQRKnQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTmnf 542

                          570       580       590
                   ....*....|....*....|....*....|....
gi 2462529488  833 -QYNELKLALEKEKARCAELEEALQKTRIELRSA 865
Cdd:pfam05557  543 kEVLDLRKELESAELKNQRLKEVFQAKIQEFRDV 576
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 433-759 2.17e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 56.11  E-value: 2.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  433 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettAEAEEEIQALTAHRDEIQRKF 512
Cdd:COG3096    282 ELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAA--------SDHLNLVQTALRQQEKIERYQ 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  513 DALrnsctviTDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:COG3096    354 EDL-------EELTERLEEQEEVVEEAAEQ---LAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALE 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  593 TTCTMLEEQVMDLEALNDELLE-KERQWEAWRSVLGDE---------KSQFECRVRELQRMLDTEKQSRA--RADQRITE 660
Cdd:COG3096    424 KARALCGLPDLTPENAEDYLAAfRAKEQQATEEVLELEqklsvadaaRRQFEKAYELVCKIAGEVERSQAwqTARELLRR 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  661 SRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHA-------MLEMNARSLQQKLETERELKQRLLEE 731
Cdd:COG3096    504 YRSQQALAQRLQqlRAQLAELEQRLRQQQ-NAERL---LEEFCQRIGqqldaaeELEELLAELEAQLEELEEQAAEAVEQ 579

                          330       340       350
                   ....*....|....*....|....*....|....
gi 2462529488  732 QAKLQQQMDLQKNHIFRLTQ------GLQEALDR 759
Cdd:COG3096    580 RSELRQQLEQLRARIKELAArapawlAAQDALER 613
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
8-577 2.33e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.08  E-value: 2.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    8 RLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATyitecssLKRSLEQARMEVSQEDDKAL-QLLHDIREQSRKLQEI 86
Cdd:COG4913    285 FAQRRLELLEAELEELRAELARLEAELERLEARLDA-------LREELDELEAQIRGNGGDRLeQLEREIERLERELEER 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   87 KE--QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEK- 163
Cdd:COG4913    358 ERrrARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSn 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  164 INAEQqlkiQELQEKLEKAVKASTE----ATELLQnIRQAKER----AEREL-----------------------EKLQN 212
Cdd:COG4913    438 IPARL----LALRDALAEALGLDEAelpfVGELIE-VRPEEERwrgaIERVLggfaltllvppehyaaalrwvnrLHLRG 512

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  213 REDsSEGIRKKLVEAEERR---HSLENKVKRLET---------MERRENRLK-DDIQ---------TKSQQIQQMAdkil 270
Cdd:COG4913    513 RLV-YERVRTGLPDPERPRldpDSLAGKLDFKPHpfrawleaeLGRRFDYVCvDSPEelrrhpraiTRAGQVKGNG---- 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  271 ELEEKHREAQVSAQHLevhL----KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAM 346
Cdd:COG4913    588 TRHEKDDRRRIRSRYV---LgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVA 664

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  347 --DSKIRSLEQRIVELSEAN-KLAAnsslfTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsd 423
Cdd:COG4913    665 saEREIAELEAELERLDASSdDLAA-----LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD--------- 730

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  424 knrllELETRLREV-SLEHEEQKLELKRQLTELQLSLQERESQlTALQAARAALESQLRQAKteleettaeaeeeiQALT 502
Cdd:COG4913    731 -----ELQDRLEAAeDLARLELRALLEERFAAALGDAVERELR-ENLEERIDALRARLNRAE--------------EELE 790

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  503 AHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDHLRREITER 577
Cdd:COG4913    791 RAMRAFNREWPAETADLDAdlesLPEYLALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRRAIREIKER 865
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 553-815 2.63e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  553 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTtctmleeqvmDLEALNDELLEKERQweawrsvlgdeksq 632
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK----------QLAALERRIAALARR-------------- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  633 fecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 712
Cdd:COG4942     71 ----IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  713 SLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTI 792
Cdd:COG4942    147 ARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA 222

                          250       260
                   ....*....|....*....|...
gi 2462529488  793 SQQTKLIDFLQAKMDQPAKKKKG 815
Cdd:COG4942    223 EELEALIARLEAEAAAAAERTPA 245
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1020-1139 2.67e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.67e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1099
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 2462529488  1100 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 120-739 2.83e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 55.61  E-value: 2.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  120 ESELRES---RLAAEEFKRKATECQ-HKLLKAKDQGKPEVGEyaKLEKINAEQQLKIQELQEKL---EKAVKASTEATEL 192
Cdd:pfam12128  249 EFNTLESaelRLSHLHFGYKSDETLiASRQEERQETSAELNQ--LLRTLDDQWKEKRDELNGELsaaDAAVAKDRSELEA 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  193 LQNirQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLE-TMERRENRLKDDIQTKSQQIQQMADKILE 271
Cdd:pfam12128  327 LED--QHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTaKYNRRRSKIKEQNNRDIAGIKDKLAKIRE 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  272 LEEKHREAQVSA-QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 350
Cdd:pfam12128  405 ARDRQLAVAEDDlQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDERIERAREEQEAAN 484

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  351 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKlEEQLEKISHQDHSDKNRLL-- 428
Cdd:pfam12128  485 AEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLHFLRK-EAPDWEQSIGKVISPELLHrt 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  429 ELETRLREVSLEHEEQ----KLELKR----QLTELQLSLQERESQL-TALQAAR---AALESQLRQAKTELEETTAEAEE 496
Cdd:pfam12128  564 DLDPEVWDGSVGGELNlygvKLDLKRidvpEWAASEEELRERLDKAeEALQSARekqAAAEEQLVQANGELEKASREETF 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  497 EIQALTAHRDEIQRKFDALRNSCTVITD--------LEEQLNQL-TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEV 567
Cdd:pfam12128  644 ARTALKNARLDLRRLFDEKQSEKDKKNKalaerkdsANERLNSLeAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVV 723

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  568 dhlrreITEREMQLTSQKQTMEALKTTctmLEEQVMDLEALNDELLEKerqweawRSVLGDEKSQFECRVRELQRMLDTE 647
Cdd:pfam12128  724 ------EGALDAQLALLKAAIAARRSG---AKAELKALETWYKRDLAS-------LGVDPDVIAKLKREIRTLERKIERI 787

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  648 KQSRaradQRITESRQVVELAVKEHKaeilalqQALKEQKLKAESlsdKLNDLEKKHAMLEMNARSLQQKLETER----E 723
Cdd:pfam12128  788 AVRR----QEVLRYFDWYQETWLQRR-------PRLATQLSNIER---AISELQQQLARLIADTKLRRAKLEMERkaseK 853

                          650
                   ....*....|....*.
gi 2462529488  724 LKQRLLEEQAKLQQQM 739
Cdd:pfam12128  854 QQVRLSENLRGLRCEM 869
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1-276 3.30e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.46  E-value: 3.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    1 MMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQED-DKALQLLHDIREQ 79
Cdd:TIGR02169  727 QLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRiPEIQAELSKLEEE 806

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   80 SRKLQEI------KEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDqgkp 153
Cdd:TIGR02169  807 VSRIEARlreieqKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLES---- 882

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  154 evgEYAKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNIRQAKeraereLEKLQNREDSSEGIRKKLVEAEERRHS 233
Cdd:TIGR02169  883 ---RLGDLKKERDELEAQLRELERKIEEL-EAQIEKKRKRLSELKAK------LEALEEELSEIEDPKGEDEEIPEEELS 952

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 2462529488  234 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH 276
Cdd:TIGR02169  953 LEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKR 995
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 157-319 3.58e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.00  E-value: 3.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEgirKKLVEAeerrhsleN 236
Cdd:COG1579     18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNV--------R 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  237 KVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 316
Cdd:COG1579     87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                   ...
gi 2462529488  317 TLE 319
Cdd:COG1579    167 ELA 169
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
500-869 3.75e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.05  E-value: 3.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  500 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 579
Cdd:PRK02224   188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  580 QLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS--------- 650
Cdd:PRK02224   266 TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAaqahneeae 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  651 --RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRL 728
Cdd:PRK02224   346 slREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDEL 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  729 LEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshEKVKMEGTIS 793
Cdd:PRK02224   425 REREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----EVEEVEERLE 499

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  794 QQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEA 869
Cdd:PRK02224   500 RAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEA 567
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 443-705 4.11e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 4.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  443 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 522
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  523 tDLEEQLNQLTEDNAELNNQnfylskqldeasgandeIVQLRSEVDHLRREITE--REMQLTSQKQTMEALKTTCTMLE- 599
Cdd:COG4942     73 -ALEQELAALEAELAELEKE-----------------IAELRAELEAQKEELAEllRALYRLGRQPPLALLLSPEDFLDa 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  600 -EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelaVKEHKAEILA 678
Cdd:COG4942    135 vRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKL----LARLEKELAE 210

                          250       260
                   ....*....|....*....|....*..
gi 2462529488  679 LQQALKEQKLKAESLSDKLNDLEKKHA 705
Cdd:COG4942    211 LAAELAELQQEAEELEALIARLEAEAA 237
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
8-328 4.15e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.77  E-value: 4.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    8 RLHRRVSEVEAVLSQKEV---ELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQ-LLHDIREQSRKL 83
Cdd:COG4717    129 PLYQELEALEAELAELPErleELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQdLAEELEELQQRL 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   84 QEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRESRLAA------------------------------- 130
Cdd:COG4717    209 AELEEELEEAQEELEELEeeLEQLENELEAAALEERLKEARLLLLIAAAllallglggsllsliltiagvlflvlgllal 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  131 --EEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELE 208
Cdd:COG4717    289 lfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEEL 368

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  209 KLQNRE-------DSSEGIRKKLvEAEERRHSLENKVKRLETMERREN-------------RLKDDIQTKSQQIQQMADK 268
Cdd:COG4717    369 EQEIAAllaeagvEDEEELRAAL-EQAEEYQELKEELEELEEQLEELLgeleellealdeeELEEELEELEEELEELEEE 447

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  269 ILELEEKHREAQVSAQHLE-----VHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE 328
Cdd:COG4717    448 LEELREELAELEAELEQLEedgelAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 164-584 4.33e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 54.75  E-value: 4.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  164 INAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRH----------- 232
Cdd:pfam05557   12 SQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALReqaelnrlkkk 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  233 SLENKVKRLETMERRENRLKDDIQTKSQQI----QQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDNQi 308
Cdd:pfam05557   84 YLEALNKKLNEKESQLADAREVISCLKNELselrRQIQRAELELQSTNSELEELQERLDL-LKAKASEAEQLRQNLEKQ- 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  309 KKDLADKE----TLENMMQRHEEEAHEKGKILSEQkAMINAMDSKIRSLEQRIVELSEANKlaaNSSLFTQ--------- 375
Cdd:pfam05557  162 QSSLAEAEqrikELEFEIQSQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIE---NKLLLKEevedlkrkl 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  376 -RNMKAQEEMIS-ELRQQKFYLETQAGKLEAQNRKLE--------EQLEKISHQD--HSDKNRLLELETR-LREVSLEHE 442
Cdd:pfam05557  238 eREEKYREEAATlELEKEKLEQELQSWVKLAQDTGLNlrspedlsRRIEQLQQREivLKEENSSLTSSARqLEKARRELE 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  443 EQKLELKRQLTELQLSLQERESQLTALQ-----------AARAALES-----QLRQAKTELEETTAEAEEEIQALTAHRD 506
Cdd:pfam05557  318 QELAQYLKKIEDLNKKLKRHKALVRRLQrrvllltkerdGYRAILESydkelTMSNYSPQLLERIEEAEDMTQKMQAHNE 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  507 EIQRKFDALRNSCTVITD----LEEQLNQLTEDnaELNNQNFYLSKQLDEASGANDEivqLRSEVDHLRREITEREMQLT 582
Cdd:pfam05557  398 EMEAQLSVAEEELGGYKQqaqtLERELQALRQQ--ESLADPSYSKEEVDSLRRKLET---LELERQRLREQKNELEMELE 472


                   ..
gi 2462529488  583 SQ 584
Cdd:pfam05557  473 RR 474
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 170-319 5.09e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.62  E-value: 5.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  170 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRedsSEGIRKKLVEAEERRHSLENKVKRLET--MERR 247
Cdd:COG1579     10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---LEDLEKEIKRLELEIEEVEARIKKYEEqlGNVR 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  248 ENR----LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 319
Cdd:COG1579     87 NNKeyeaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 598-891 5.10e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.68  E-value: 5.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  598 LEEQVMDLEALNDELLEKERQWEawrsvlgdeksqfecrvrELQRmldtekqsRARADQRITESRQvvelAVKEHKAEIL 677
Cdd:TIGR02168  181 LERTRENLDRLEDILNELERQLK------------------SLER--------QAEKAERYKELKA----ELRELELALL 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  678 ALQqaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL 757
Cdd:TIGR02168  231 VLR--LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILR 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  758 DRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQY 834
Cdd:TIGR02168  309 ERLANLERQLEELEAQLEELEsklDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV 388

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  835 NELKLALEKEKARCAELEEalQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIA 891
Cdd:TIGR02168  389 AQLELQIASLNNEIERLEA--RLERLEDRRERLQQEIEELLKKLEEAELKELQAELE 443
mukB PRK04863
chromosome partition protein MukB;
197-578 7.30e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 54.19  E-value: 7.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  197 RQAKERAERELEKLQNREDSSeGIRKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------QQIQ 263
Cdd:PRK04863   276 RHANERRVHLEEALELRRELY-TSRRQLAAEQYR---LVEMARELAELNEAESDLEQDYQAASdhlnlvqtalrqqEKIE 351

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  264 QMADKILELEEK-------HREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKETLENMMQRHEEEAHEKGKIL 336
Cdd:PRK04863   352 RYQADLEELEERleeqnevVEEADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQAL 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  337 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEE 411
Cdd:PRK04863   424 ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLR 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  412 QLEKISHQDhsdkNRLLELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELE 488
Cdd:PRK04863   504 RLREQRHLA----EQLQQLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEAR 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  489 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 568
Cdd:PRK04863   579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALD 658

                          410
                   ....*....|
gi 2462529488  569 HLRREITERE 578
Cdd:PRK04863   659 EEIERLSQPG 668
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 30-822 9.45e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 54.29  E-value: 9.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   30 SETQRSLLE--QDLAT------YITECSSLKRSLEQAR----------------------MEVSQEDDKALQLLHDIREQ 79
Cdd:TIGR01612  900 NEINKSIEEeyQNINTlkkvdeYIKICENTKESIEKFHnkqnilkeilnknidtikesnlIEKSYKDKFDNTLIDKINEL 979

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   80 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLvSARRRSDLYEsELRESRLAAEEFKRKATECQhkllkaKDQGKPEVGEYA 159
Cdd:TIGR01612  980 DKAFKDASLNDYEAKNNELIKYFNDLKANL-GKNKENMLYH-QFDEKEKATNDIEQKIEDAN------KNIPNIEIAIHT 1051

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  160 KLEKINAEQQLKIQELQEKLEKAV--KASTEATellqNIRQAKERAereleKLQNREDSSEgirkklveaeerrhslENK 237
Cdd:TIGR01612 1052 SIYNIIDEIEKEIGKNIELLNKEIleEAEINIT----NFNEIKEKL-----KHYNFDDFGK----------------EEN 1106

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  238 VKRLETMerreNRLKDDIQTKSQQIQQmadKILELEEkhreaqvsaqhlevhLKQKEQHYEEKIKVLDNQIkKDLADK-- 315
Cdd:TIGR01612 1107 IKYADEI----NKIKDDIKNLDQKIDH---HIKALEE---------------IKKKSENYIDEIKAQINDL-EDVADKai 1163

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  316 -----ETLENMMQRHEEEAHEKGKILSEQKAMINAMdSKIR----SLEQ-RIVELSEANKLAA----------NSSLFTQ 375
Cdd:TIGR01612 1164 snddpEEIEKKIENIVTKIDKKKNIYDEIKKLLNEI-AEIEkdktSLEEvKGINLSYGKNLGKlflekideekKKSEHMI 1242

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  376 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEeqLEKISHQDHSDKNrlleletrlrEVSLEHEEQKLELKrqltEL 455
Cdd:TIGR01612 1243 KAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEME--TFNISHDDDKDHH----------IISKKHDENISDIR----EK 1306

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  456 QLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiqaLTAHRDEIQRKFDALR--NSCTVITDLEEQLNQLT 533
Cdd:TIGR01612 1307 SLKIIEDFSEESDINDIKKELQKNLLDAQKHNSD-----------INLYLNEIANIYNILKlnKIKKIIDEVKEYTKEIE 1375

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  534 EDNAELNNQ---NFYLSKQLDEASGANDEIVQLRS-----EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMdL 605
Cdd:TIGR01612 1376 ENNKNIKDEldkSEKLIKKIKDDINLEECKSKIEStlddkDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVL-L 1454

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  606 EALNDELLEKERQWeawrsVLGDEK----SQFECRVRELQRMLDTEKQSRARADQRITESRQVVELaVKEHKAEILALQQ 681
Cdd:TIGR01612 1455 LFKNIEMADNKSQH-----ILKIKKdnatNDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKEL-FEQYKKDVTELLN 1528

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  682 ALKEQKLK---AESLSDK---LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ----MDLQKNhifrlTQ 751
Cdd:TIGR01612 1529 KYSALAIKnkfAKTKKDSeiiIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSnkaaIDIQLS-----LE 1603

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  752 GLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGT-ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKE 822
Cdd:TIGR01612 1604 NFENKFLKISDIKKKINDCLKETESIEKKISSFSIDSQDTeLKENGDNLNSLQEFLESLKDQKKNIEDKKKE 1675
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 313-538 1.02e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQK 392
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA-------LEQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  393 FYLETQAGKLEAQNRKLEEQLEKISHQDH-------SDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQ 465
Cdd:COG4942     93 AELRAELEAQKEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  466 LTALQAARAALESQlrqaKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 538
Cdd:COG4942    173 RAELEALLAELEEE----RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 522-744 1.08e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  522 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 601
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  602 vmdLEALNDELleKERQWEAWRS---------VLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVKEH 672
Cdd:COG4942     99 ---LEAQKEEL--AELLRALYRLgrqpplallLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRAEL 169

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  673 KAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 744
Cdd:COG4942    170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 324-752 1.27e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 53.42  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  324 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 398
Cdd:COG3096    275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  399 AGKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 478
Cdd:COG3096    353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  479 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 555
Cdd:COG3096    424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  556 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEkerqWEAWRSV 625
Cdd:COG3096    493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAE----LEAQLEE 568

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  626 LGDEKSQFECRVRELQRmldTEKQSRARADqritesrqvvELAVKEhkAEILALQQALkeqklkaESLSDKLND-LEKKH 704
Cdd:COG3096    569 LEEQAAEAVEQRSELRQ---QLEQLRARIK----------ELAARA--PAWLAAQDAL-------ERLREQSGEaLADSQ 626

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  705 AMleMNARslQQKLETERELKQ---RLLEEQAKLQQQmdlqknhIFRLTQG 752
Cdd:COG3096    627 EV--TAAM--QQLLEREREATVerdELAARKQALESQ-------IERLSQP 666
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 934-989 1.91e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.91e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  934 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 989
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 499-719 1.97e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 1.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  499 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREI 574
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALarriRALEQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  575 TEREMQLTSQKQTM-EALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRar 653
Cdd:COG4942     93 AELRAELEAQKEELaELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAALR-- 166

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  654 adQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 719
Cdd:COG4942    167 --AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
249-778 2.32e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 52.35  E-value: 2.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  249 NRLKDDiqtKSQQIQQMADKILELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE 328
Cdd:PRK02224   179 ERVLSD---QRGSLDQLKAQIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  329 AHEkgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrk 408
Cdd:PRK02224   250 REE------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE---------- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  409 LEEQLEKISHQDHSDKNRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 488
Cdd:PRK02224   295 RDDLLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA 366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  489 ETTaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSE 566
Cdd:PRK02224   367 ELE--------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREE 420

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  567 VDHLRreitEREMQLTSQKQTmealkttctmLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDT 646
Cdd:PRK02224   421 RDELR----EREAELEATLRT----------ARERVEEAEALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELED 486

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  647 EKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 722
Cdd:PRK02224   487 LEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAE 564

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  723 ELKQRLLEEQAKLQQQMDLQKNHIFRLTQgLQEALDRADLLKTERSDLEYQLENIQ 778
Cdd:PRK02224   565 EEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALA 619
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 650-927 2.40e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 2.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  650 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 727
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  728 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 804
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  805 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 884
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 2462529488  885 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 927
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 375-590 2.40e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 2.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  375 QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTE 454
Cdd:COG4942     33 QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRA 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  455 LQLSLQERE-----SQLTALQAARAA--LESQLRQAKTELEETTaeaeEEIQALTAHRDEIQRKFDALRnscTVITDLEE 527
Cdd:COG4942    113 LYRLGRQPPlalllSPEDFLDAVRRLqyLKYLAPARREQAEELR----ADLAELAALRAELEAERAELE---ALLAELEE 185

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  528 QLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 590
Cdd:COG4942    186 ERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
46 PHA02562
endonuclease subunit; Provisional
 360-612 3.44e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 51.55  E-value: 3.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  360 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKNrllELETRLREVSL 439
Cdd:PHA02562   165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  440 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE------------ETTAEAEEEIQALTAHRDE 507
Cdd:PHA02562   231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcptctQQISEGPDRITKIKDKLKE 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  508 IQRKFDALRNSctvITDLEEQLNQ-------LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 580
Cdd:PHA02562   311 LQHSLEKLDTA---IDELEEIMDEfneqskkLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDE 387

                          250       260       270
                   ....*....|....*....|....*....|..
gi 2462529488  581 LTsqkqtmeALKTTCTMLEEQVMDLEALNDEL 612
Cdd:PHA02562   388 LD-------KIVKTKSELVKEKYHRGIVTDLL 412
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-565 4.07e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.71  E-value: 4.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYIT---ECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 78
Cdd:pfam01576  515 VERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQqleEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQ 594

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   79 QSRKLqEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYES-------ELRESRLAAEEFKRkatecQHKLLKA---- 147
Cdd:pfam01576  595 LVSNL-EKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETralslarALEEALEAKEELER-----TNKQLRAemed 668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  148 ----KDQGKPEVGEYAKlEKINAEQQLKIQELQ-EKLEKAVKASTEATELLQ-NIRQAKERAERELeklQNREDssegir 221
Cdd:pfam01576  669 lvssKDDVGKNVHELER-SKRALEQQVEEMKTQlEELEDELQATEDAKLRLEvNMQALKAQFERDL---QARDE------ 738

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  222 kklvEAEERRHSLENKVKRLETMerrenrLKDDIQTKSQQIQqmADKILELEEKHREAQVSAQHlevhlkqkeQHYEEKI 301
Cdd:pfam01576  739 ----QGEEKRRQLVKQVRELEAE------LEDERKQRAQAVA--AKKKLELDLKELEAQIDAAN---------KGREEAV 797

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  302 KvldnQIKKDLADKETLenmmQRHEEEAHekgkiLSEQKAMINAMDS--KIRSLEQRIVELSEanKLAANSSLFTQRNMK 379
Cdd:pfam01576  798 K----QLKKLQAQMKDL----QRELEEAR-----ASRDEILAQSKESekKLKNLEAELLQLQE--DLAASERARRQAQQE 862

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  380 aQEEMISELRQQ---KFYLETQAGKLEAQNRKLEEQLEKISHQDH--SDKNRLLELETRLREVSLEHEE---QKLE---- 447
Cdd:pfam01576  863 -RDELADEIASGasgKSALQDEKRRLEARIAQLEEELEEEQSNTEllNDRLRKSTLQVEQLTTELAAERstsQKSEsarq 941

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  448 -LKRQLTELQLSLQERESQ--------LTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEIQR 510
Cdd:pfam01576  942 qLERQNKELKAKLQEMEGTvkskfkssIAALEAKIAQLEEQLEQesrerqaaNKLVRRTEKKLKEVLLQVEDERRHADQY 1021

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  511 KfDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND----EIVQLRS 565
Cdd:pfam01576 1022 K-DQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNEsmnrEVSTLKS 1079
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1496-1585 4.09e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 4.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1496 ESGTEHHRGPSTSRSSPNKRGPPtyNEHITKRVASSPAP---------------PEGPSH---PREPSTPHRYREGRTEL 1557
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKP--GETKEGEVGKKPGPakehkpskiptlskkPEFPKDpkhPKDPEEPKKPKRPRSAQ 604

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462529488 1558 R--RDKSPGRP--LEREKSPGRMLSTRRERSP 1585
Cdd:PTZ00449   605 RptRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 77-777 4.92e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.36  E-value: 4.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   77 REQSRKLQEIKEQEYQAQVE--EMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 154
Cdd:pfam10174   49 KEEAARISVLKEQYRVTQEEnqHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQ 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  155 VGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNirqakeraeRELEKLQNREDSSEGIRkkLVEAEERRHSL 234
Cdd:pfam10174  129 AKELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEMLQS---------KGLPKKSGEEDWERTRR--IAEAEMQLGHL 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  235 EN--------KVKRLETMERRENRLKDDIQTKS-QQIQQMAD-KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVL 304
Cdd:pfam10174  198 EVlldqkekeNIHLREELHRRNQLQPDPAKTKAlQTVIEMKDtKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQM 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  305 D-------------NQIKKDLADKETLENMMQRHEEEAHEKGkilSEQKAMINAMDSKIRSLEQRIVEL-SEANKLAANS 370
Cdd:pfam10174  278 EvykshskfmknkiDQLKQELSKKESELLALQTKLETLTNQN---SDCKQHIEVLKESLTAKEQRAAILqTEVDALRLRL 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  371 SLfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLEEQLEKIshqdhsdkNRLLELETRLREVSLEHEEQKLELKR 450
Cdd:pfam10174  355 EE-KESFLNKKTKQLQDLTEEK---STLAGEIRDLKDMLDVKERKI--------NVLQKKIENLQEQLRDKDKQLAGLKE 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  451 QLTELQLSLQERESQLTALQAARAALEsqlrqakteleettaeaeEEIQALTAHRD-EIQRKFDALRNSCTVITDLEEQL 529
Cdd:pfam10174  423 RVKSLQTDSSNTDTALTTLEEALSEKE------------------RIIERLKEQRErEDRERLEELESLKKENKDLKEKV 484

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  530 NQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqltsQKQTMEALKTTCTMLEEQVMDLEA-L 608
Cdd:pfam10174  485 SAL---QPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAV---------EQKKEECSKLENQLKKAHNAEEAVrT 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  609 NDELLEKERQWEAWRSVLGDE--KSQFEC-RVRELQRMLDTEKQSRaraDQRITEsrqvvelavkehkAEILALQQaLKE 685
Cdd:pfam10174  553 NPEINDRIRLLEQEVARYKEEsgKAQAEVeRLLGILREVENEKNDK---DKKIAE-------------LESLTLRQ-MKE 615

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  686 QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ--RLLEEQAKLQQQMDLQKNHIFRLTQGLQEaldRADLL 763
Cdd:pfam10174  616 QNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQleELMGALEKTRQELDATKARLSSTQQSLAE---KDGHL 692

                          730
                   ....*....|....
gi 2462529488  764 KTERSDLEYQLENI 777
Cdd:pfam10174  693 TNLRAERRKQLEEI 706
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 261-741 5.91e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 51.34  E-value: 5.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  261 QIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKETLEnmmqrheeEAHEKGKILSEQK 340
Cdd:PRK10246   434 QIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTIC--------EQEARIKDLEAQR 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  341 AMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLEtqaGKLEAqnrkLEEQLekisH 418
Cdd:PRK10246   498 AQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR---GQLDA----LTKQL----Q 561

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  419 QDHSDKNRLLELETRLRE----------VSL-------------EHEEQKLELKRQLTELQLSLQERESQLTALQAARAA 475
Cdd:PRK10246   562 RDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIEQ 641

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  476 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELnnqnfylsKQLDEASg 555
Cdd:PRK10246   642 RQQQLLTALAGYALTLPQEDEEASWLATRQQEAQS----WQQRQNELTALQNRIQQLTPLLETL--------PQSDDLP- 708

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  556 ANDEIVQLrsevDHLrREITEREMQLTSQKQTMEALkttctmleeqvmdlealndELLEKERQWEA---WRSVLgdEKSQ 632
Cdd:PRK10246   709 HSEETVAL----DNW-RQVHEQCLSLHSQLQTLQQQ-------------------DVLEAQRLQKAqaqFDTAL--QASV 762

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  633 FECRVRELQRMLDTEkqsrarADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 712
Cdd:PRK10246   763 FDDQQAFLAALLDEE------TLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQLAQ 836

                          490       500
                   ....*....|....*....|....*....
gi 2462529488  713 SLQQKLETERELKQRLLEEQAKLQQQMDL 741
Cdd:PRK10246   837 QLRENTTRQGEIRQQLKQDADNRQQQQAL 865
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
159-514 7.02e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 50.29  E-value: 7.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  159 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegirkklvEAEERRHSLENKV 238
Cdd:COG4372     27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-------------ELEELNEQLQAAQ 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  239 KRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKETL 318
Cdd:COG4372     94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAERE----EELKELEEQLESLQEELAAL 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  319 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 398
Cdd:COG4372    170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  399 AGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 478
Cdd:COG4372    250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 2462529488  479 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 514
Cdd:COG4372    330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 3-283 7.78e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.84  E-value: 7.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLA-TYITECSSLKRSLEQARMEVS---QEDDKALQLLHDIRE 78
Cdd:TIGR02169  750 EQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLShSRIPEIQAELSKLEEEVSRIEarlREIEQKLNRLTLEKE 829

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   79 QSRKL-QEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEV 155
Cdd:TIGR02169  830 YLEKEiQELQEQriDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELE 909

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  156 GEYAKLEKINAEQQLKIQELQEKL---EKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRH 232
Cdd:TIGR02169  910 AQIEKKRKRLSELKAKLEALEEELseiEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLD 989

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  233 SLENKVKRLETmERREnrlkddiqtksqqiqqMADKILELEEKHREAQVSA 283
Cdd:TIGR02169  990 ELKEKRAKLEE-ERKA----------------ILERIEEYEKKKREVFMEA 1023
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 134-329 7.93e-06

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 48.87  E-value: 7.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  134 KRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNR 213
Cdd:pfam00261    7 KEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESERGRKVLENR 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  214 ----EDSSEGIRKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVH 289
Cdd:pfam00261   87 alkdEEKMEILEAQLKEAKEIAEEAD---RKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLEAS 163

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2462529488  290 LK---QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEA 329
Cdd:pfam00261  164 EEkasEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEV 206
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
71-273 7.99e-06

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 50.33  E-value: 7.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   71 QLLHDIREQSRklqeikeQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESEL---RESRLAAEEFKRKATECQHKLLKA 147
Cdd:COG4487     18 SLYADIVKQRR-------AEFEKELAERLADAAKREAALELAEAKAKAQLQEQvaeKDAEIAELRARLEAEERKKALAVA 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  148 KDQGKpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATEllqnirqAKERAERELEK--LQNREDSSEGIRKKLV 225
Cdd:COG4487     91 EEKEK----ELAALQEALAEKDAKLAELQAKELELLKKERELED-------AKREAELTVEKerDEELDELKEKLKKEEE 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462529488  226 EAEERRHSLEN--KVKRLETMERRENRLKDDIQtksQQIQQMADKILELE 273
Cdd:COG4487    160 EKQLAEKSLKVaeYEKQLKDMQEQIEELKRKKE---QGSTQLQGEVLELE 206
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 566-872 8.17e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 50.99  E-value: 8.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  566 EVDHLRREITEREmQLTSQKQTMEALKTTctMLEEQVMDLEALNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLD 645
Cdd:pfam12128  229 DIQAIAGIMKIRP-EFTKLQQEFNTLESA--ELRLSHLHFGYKSDETLIASRQ-EERQETSAELNQLLRTLDDQWKEKRD 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  646 TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETEREL- 724
Cdd:pfam12128  305 ELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKi 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  725 KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQA 804
Cdd:pfam12128  385 KEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA 458

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529488  805 kmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQKTRIELRSAREEAAHR 872
Cdd:pfam12128  459 ------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQSELRQARKRRDQASEA 507
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 14-484 8.89e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 50.61  E-value: 8.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   14 SEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSL--------------EQARMEVSQEDDKALQLLHD---- 75
Cdd:pfam12128  322 SELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLkaltgkhqdvtakyNRRRSKIKEQNNRDIAGIKDklak 401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   76 IREQSRKLQEIKEQEYQAQVEEMRlmmNQLEEDLVSARRRSDLYESELRESRL------AAEEFKRKATECQHKLLKAKD 149
Cdd:pfam12128  402 IREARDRQLAVAEDDLQALESELR---EQLEAGKLEFNEEEYRLKSRLGELKLrlnqatATPELLLQLENFDERIERARE 478

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  150 qgkpevgeyaKLEKINAEQqlkiQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNR---------------- 213
Cdd:pfam12128  479 ----------EQEAANAEV----ERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhflrkea 544

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  214 EDSSEGIRKKLVEAEERR------------------HSLENKVKRL---------ETMERRENRLKDDIQTKSQQIQ--- 263
Cdd:pfam12128  545 PDWEQSIGKVISPELLHRtdldpevwdgsvggelnlYGVKLDLKRIdvpewaaseEELRERLDKAEEALQSAREKQAaae 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  264 -QMADKILELEEKHREAQVSAQHL--------------EVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE 328
Cdd:pfam12128  625 eQLVQANGELEKASREETFARTALknarldlrrlfdekQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEE 704

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  329 AHEKGKILSEQK-----AMINAMDSKIRSLEQRIVELSEANKlAANSSLFTQ--RNMKAQ---EEMISELRQQKFYLETq 398
Cdd:pfam12128  705 QKEQKREARTEKqaywqVVEGALDAQLALLKAAIAARRSGAK-AELKALETWykRDLASLgvdPDVIAKLKREIRTLER- 782

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  399 agKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 478
Cdd:pfam12128  783 --KIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSE 860


                   ....*.
gi 2462529488  479 QLRQAK 484
Cdd:pfam12128  861 NLRGLR 866
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 190-535 9.51e-06

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 50.07  E-value: 9.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  190 TELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLET-MERRENRLKDDIQTKSQQIQQMADK 268
Cdd:pfam19220   37 EAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVArLAKLEAALREAEAAKEELRIELRDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  269 ILELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDS 348
Cdd:pfam19220  117 TAQAEALERQLAAETEQNR-ALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTR 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  349 KIRSLEQRI------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishqd 420
Cdd:pfam19220  196 RLAELETQLdatrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL------- 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  421 hsdknrLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA 500
Cdd:pfam19220  264 ------LAEARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTKA 333

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2462529488  501 LTAHRdeiqrkfDALRNSCTVITDLEEQLNQLTED 535
Cdd:pfam19220  334 LAAKD-------AALERAEERIASLSDRIAELTKR 361
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 5-465 1.14e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.12  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    5 EMTRLHRRVSEVEAVLSQKEV---------ELKASETQRSLLE-----QDLATYIT---ECSSLKRSLEQARMEVSQEDD 67
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELehkrarielEKKASALKRQLDResdrnQELQKRIRlleKREAEAEEALREQAELNRLKK 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   68 KALQLLHD-IREQSRKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESrlaaeEFKRKA 137
Cdd:pfam05557   83 KYLEALNKkLNEKESQLADAREvisclknelSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEA-----EQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  138 TECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQE---KLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE 214
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELAripELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  215 DSSEGIRKKLVEAEERRHSLENKVK---RLETMERRENRLKDDIQTKSQQIQQmadkilelEEKHREAQVSAqhlevhLK 291
Cdd:pfam05557  238 EREEKYREEAATLELEKEKLEQELQswvKLAQDTGLNLRSPEDLSRRIEQLQQ--------REIVLKEENSS------LT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  292 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEkgkiLSEQKAMInamdSKIRSLEQRIVELSEANKLAANSS 371
Cdd:pfam05557  304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRR----LQRRVLLL----TKERDGYRAILESYDKELTMSNYS 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  372 LFTQRNMKAQEEMI-------SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEE 443
Cdd:pfam05557  376 PQLLERIEEAEDMTqkmqahnEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQeSLADPSYSKEEVDSLRRKLETLEL 455

                          490       500
                   ....*....|....*....|..
gi 2462529488  444 QKLELKRQLTELQLSLQERESQ 465
Cdd:pfam05557  456 ERQRLREQKNELEMELERRCLQ 477
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
333-760 1.20e-05

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 49.99  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  333 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 412
Cdd:COG5281      3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  413 LEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 492
Cdd:COG5281     83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  493 EAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 572
Cdd:COG5281    160 AAAAAAAAAAAAAAAAAAALAAASAAAAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQAALAA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  573 EITE--REMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRMLDTEKQS 650
Cdd:COG5281    240 ASAAaqALAALAAAAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAAAAQLAAA 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  651 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLE 730
Cdd:COG5281    317 AAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAGAKAALAE 391

                          410       420       430
                   ....*....|....*....|....*....|
gi 2462529488  731 EQAKLQQQMDLQKNHIFRLTQGLQEALDRA 760
Cdd:COG5281    392 YADSATNVAAQVAQAATSAFSGLTDALAGA 421
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 482-751 1.40e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 49.04  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  482 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND--- 558
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNEllk 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  559 -----------------EIVQLRSEVDHLRREITER----EMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDElleker 617
Cdd:pfam15905  143 akfsedgtqkkmsslsmELMKLRNKLEAKMKEVMAKqegmEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIE------ 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  618 qweawrsvlgdEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKL 697
Cdd:pfam15905  217 -----------EKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQI 277

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  698 NDLEKKHAMLEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 751
Cdd:pfam15905  278 KDLNEKCKLLE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 339-542 1.45e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  339 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 418
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  419 QDHSDKNRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 491
Cdd:COG4942     98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  492 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 542
Cdd:COG4942    178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
 78-306 1.65e-05

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 49.94  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   78 EQSRKLQEIKEQEYQAQVEEMR----LMMNQ----------LEEDLVSA----RRRSDLYESELRESRLAAEEFKRKATE 139
Cdd:pfam15818  119 EQKLQLHLLAKEDHHKQLNEIEkyyaTITGQfglvkenhgkLEQNVQEAiqlnKRLSALNKKQESEICSLKKELKKVTSD 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  140 cqhkLLKAKDQGKPEVGEyaklEKIN-AEQQLKIQELQEKL----EKAVKASTEAT-----------------ELLQNIR 197
Cdd:pfam15818  199 ----LIKSKVTCQYKMGE----ENINlTIKEQKFQELQERLnmelELNKKINEEIThiqeekqdiiisfqhmqQLLQQQT 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  198 QAKERAEREL----EKLQNREDSSEGIRKKLVEAEERRHSLENKvkrletMERRENRLKDDIQTKSQQIQQMADKILELE 273
Cdd:pfam15818  271 QANTEMEAELkalkENNQTLERDNELQREKVKENEEKFLNLQNE------HEKALGTWKKHVEELNGEINEIKNELSSLK 344

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462529488  274 EKHREAQvsaqhlEVHLKQKEQHYEEKIKVLDN 306
Cdd:pfam15818  345 ETHIKLQ------EHYNKLCNQKKFEEDKKFQN 371
C1_SpBZZ1-like cd20824
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ...
 938-988 1.98e-05

protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410374  Cd Length: 53  Bit Score: 43.46  E-value: 1.98e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  938 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20824      1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 71-283 2.10e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   71 QLLHDIREQSRKLQEIKEQEYQAQVEemrlmMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQ 150
Cdd:COG4942     31 QLQQEIAELEKELAALKKEEKALLKQ-----LAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  151 GKPEVGEYAKLEKI----------NAEQQLKIQELQEKLEKAVKASTEA-TELLQNIRQAKERAERELEKLQNREDSSEG 219
Cdd:COG4942    106 LAELLRALYRLGRQpplalllspeDFLDAVRRLQYLKYLAPARREQAEElRADLAELAALRAELEAERAELEALLAELEE 185

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  220 IRKKLVEAEERRHSLENKV-KRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSA 283
Cdd:COG4942    186 ERAALEALKAERQKLLARLeKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
242-482 2.33e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.24  E-value: 2.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  242 ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 321
Cdd:COG3206    164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR--QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  322 MQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkfyLETQA 399
Cdd:COG3206    242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ---LQQEA 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  400 GKLEAQnrkLEEQLEKISHQDHSDKNRLLELETRLREVSleheeqklELKRQLTELQLSLQERESQLTALQAARAALESQ 479
Cdd:COG3206    312 QRILAS---LEAELEALQAREASLQAQLAQLEARLAELP--------ELEAELRRLEREVEVARELYESLLQRLEEARLA 380


                   ...
gi 2462529488  480 LRQ 482
Cdd:COG3206    381 EAL 383
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 201-641 2.75e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 49.18  E-value: 2.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  201 ERAERELEKLQNREDSSEGIRKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS------QQIQQMADKI----- 269
Cdd:COG3096    278 NERRELSERALELRRELFGARRQLAEEQYR---LVEMARELEELSARESDLEQDYQAASdhlnlvQTALRQQEKIeryqe 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  270 --LELEEKHREAQ-VSAQHLEVHLKQKEQ--HYEEKIKVLDNQikkdLADKETLENMMQRheeeahekgKILSEQKAmin 344
Cdd:COG3096    355 dlEELTERLEEQEeVVEEAAEQLAEAEARleAAEEEVDSLKSQ----LADYQQALDVQQT---------RAIQYQQA--- 418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  345 amdskIRSLEqRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkleaqnrkleeqlekishqdhsdk 424
Cdd:COG3096    419 -----VQALE-KARALCGLPDLTPENAEDYLAAFRAKEQQATE------------------------------------- 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  425 nRLLELETRLReVSLEHEEQkLELKRQLTELQLSLQEREsqlTALQAARAALEsQLRQAKTELEETtaeaeeeiQALTAH 504
Cdd:COG3096    456 -EVLELEQKLS-VADAARRQ-FEKAYELVCKIAGEVERS---QAWQTARELLR-RYRSQQALAQRL--------QQLRAQ 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  505 RDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ 584
Cdd:COG3096    521 LAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAAR 600

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  585 K----QTMEALKTTCTMLEEQVMDLEALND---ELLEKERQWEAWRSVLGDEKSQFECRVRELQ 641
Cdd:COG3096    601 ApawlAAQDALERLREQSGEALADSQEVTAamqQLLEREREATVERDELAARKQALESQIERLS 664
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 551-740 3.88e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 3.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  551 DEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLGDek 630
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE---IDKLQAEIAEAEAEIEERREELGE-- 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  631 sqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKLNDLE 701
Cdd:COG3883     91 -----RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKLAELE 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2462529488  702 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 740
Cdd:COG3883    161 ALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2-365 4.79e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 48.09  E-value: 4.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 81
Cdd:TIGR04523  340 LNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ 419

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   82 KLQEIkEQEYQaqveemrlmmNQLEEDLVSARRRSDLyESELRESRLAAEEFKRKATECQHKLLKAKDQgkpevgeyakL 161
Cdd:TIGR04523  420 EKELL-EKEIE----------RLKETIIKNNSEIKDL-TNQDSVKELIIKNLDNTRESLETQLKVLSRS----------I 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  162 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVeaeerrhSLENKVKRL 241
Cdd:TIGR04523  478 NKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKIS-------DLEDELNKD 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  242 ETMERRENrLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQI-------KKD 311
Cdd:TIGR04523  551 DFELKKEN-LEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEkekKDLIKEIEEKEKKISSLEKELekakkenEKL 629

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  312 LADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 365
Cdd:TIGR04523  630 SSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMK 683
Filament pfam00038
Intermediate filament protein;
349-645 5.12e-05

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 47.22  E-value: 5.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  349 KIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKNRL 427
Cdd:pfam00038   19 KVRFLEQQNKLLeTKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAEDF-------RQKY 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  428 lELETRLREvslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALE-------SQLRQAKTELEETTAEAEEEIQA 500
Cdd:pfam00038   92 -EDELNLRT---SAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKknheeevRELQAQVSDTQVNVEMDAARKLD 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  501 LTAHRDEIQRKFDALRNSCTviTDLEEQLNQLTEdnaELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQ 580
Cdd:pfam00038  168 LTSALAEIRAQYEEIAAKNR--EEAEEWYQSKLE---ELQ----------QAAARNGDALRSAKEEITELRRTIQSLEIE 232

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  581 LTSQKQTMEALKTTCTMLEEQ-VMDLEALNDELLEKERQweawrsvLGDEKSQFECRVRELQRMLD 645
Cdd:pfam00038  233 LQSLKKQKASLERQLAETEERyELQLADYQELISELEAE-------LQETRQEMARQLREYQELLN 291
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 279-503 5.13e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 5.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  279 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 358
Cdd:COG3883      3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  359 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKNRLLELETR 433
Cdd:COG3883     83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  434 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 503
Cdd:COG3883    152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 157-334 5.15e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 5.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERR----- 231
Cdd:COG4942     35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELlraly 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  232 --------------HSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 297
Cdd:COG4942    115 rlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALK 194

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2462529488  298 EEKIKVLD----------NQIKKDLADKETLENMMQRHEEEAHEKGK 334
Cdd:COG4942    195 AERQKLLArlekelaelaAELAELQQEAEELEALIARLEAEAAAAAE 241
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 234-415 5.45e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 5.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  234 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK---- 309
Cdd:COG3883     18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARalyr 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  310 -----------------KDLADKETLENMMQRHEeeahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 372
Cdd:COG3883     98 sggsvsyldvllgsesfSDFLDRLSALSKIADAD------ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2462529488  373 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 415
Cdd:COG3883    172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
C1_CeDKF1-like_rpt2 cd20798
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ...
 938-989 5.87e-05

second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410348  Cd Length: 54  Bit Score: 42.10  E-value: 5.87e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  938 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 989
Cdd:cd20798      1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1021-1066 6.53e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.88  E-value: 6.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2462529488 1021 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1066
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
443-734 6.57e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.83  E-value: 6.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  443 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDeiqrKFDALRNSctvI 522
Cdd:COG1340      1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELRE----KRDELNEK---V 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  523 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV 602
Cdd:COG1340     74 KELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKELEKELEKAK 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  603 MDLEaLNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvelavKEHKAEILALQQA 682
Cdd:COG1340    154 KALE-KNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA-------DELHKEIVEAQEK 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  683 LKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 734
Cdd:COG1340    225 ADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 174-672 6.66e-05

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 47.90  E-value: 6.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  174 ELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKK--LVEAEERRHSLE---------NKV---- 238
Cdd:PTZ00440  2171 EIIENIKKEIIEINENTEM-NTLENTADKLKELYENLKKKKNIINNIYKKinFIKLQEIENSSEkyndisklfNNVvetq 2249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  239 -KRLETMERRENRLKDDIQTKSQQIQQmADKILELEEKhREAQVSAQHLEVHLKQKEQHYEEKIKVLDN------QIKKD 311
Cdd:PTZ00440  2250 kKKLLDNKNKINNIKDKINDKEKELIN-VDSSFTLESI-KTFNEIYDDIKSNIGDLYKLEDTNNDELKKvklyieNITHL 2327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  312 LADKETLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQ 391
Cdd:PTZ00440  2328 LNRINTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINNLKEEFSK-------LLKNIKRNNTLCNNNNIK 2396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  392 KFYLETqAGKLEAQNRKLEEQLEkishqdhsdknrlleletrLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 471
Cdd:PTZ00440  2397 DFISNI-GKSVETIKQRFSSNLP-------------------EKEKLHQIEENLNEIKNIMNETKRISNVDAFTNKILQD 2456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  472 ARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQ-NFYL 546
Cdd:PTZ00440  2457 IDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDALRRVKEKKDEMNKLFNSLTENNNNNNNSaKNIV 2530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  547 SKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSqkqtmealkttctMLEEQVMDLEALNDELLEKERQweawrsvl 626
Cdd:PTZ00440  2531 DNSTYIINELESHVSKLNELLSYIDNEIKELENEKLK-------------LLEKAKIEESRKERERIESETQ-------- 2589

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 2462529488  627 GDEKSQFECRVRELQRMLDTEKQsRARADQRITESRQVVELAVKEH 672
Cdd:PTZ00440  2590 EDNTDEEQINRQQQERLQKEEEQ-KAYSQERLNREVSGTDDTNKNH 2634
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
3-357 7.31e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 7.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ--DLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS 80
Cdd:COG4717     87 EEEYAELQEELEELEEELEELEAELEELREELEKLEKllQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELE 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   81 RKLQEIKE--------------------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE---LRESRLAAEEFKRKA 137
Cdd:COG4717    167 ELEAELAElqeeleelleqlslateeelQDLAEELEELQQRLAELEEELEEAQEELEELEEEleqLENELEAAALEERLK 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  138 TECQH----------------------------------------KLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQE 177
Cdd:COG4717    247 EARLLlliaaallallglggsllsliltiagvlflvlgllallflLLAREKASLGKEAEELQALPALEELEEEELEELLA 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  178 KLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLQNREDSSEGIRKKLVEAEErrhSLENKVKRLEtmerRENR 250
Cdd:COG4717    327 ALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEELEQEIAALLAEAGVEDEE---ELRAALEQAE----EYQE 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  251 LKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEah 330
Cdd:COG4717    400 LKEELEELEEQLEELLGELEELLEALDEEE---------LEEELEELEEELEELEEELEELREELAELEAELEQLEED-- 468

                          410       420
                   ....*....|....*....|....*..
gi 2462529488  331 ekgKILSEQKAMINAMDSKIRSLEQRI 357
Cdd:COG4717    469 ---GELAELLQELEELKAELRELAEEW 492
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 166-470 7.38e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 46.73  E-value: 7.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  166 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM 244
Cdd:pfam15905   52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  245 ERRENRLKDDIQTK-SQQIQQMADKILELEekhreaqVSAQHLEVHLKQKEqhyeekikVLDNQIKKDLADKETLENMMQ 323
Cdd:pfam15905  131 LLELTRVNELLKAKfSEDGTQKKMSSLSME-------LMKLRNKLEAKMKE--------VMAKQEGMEGKLQVTQKNLEH 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  324 RHEEEAHEKGKILSEQKAMINAmDSKIRSLEQRIVELSEANKLAANSSLftqrnmkaqeemisELRQQKFYLETQAGKLE 403
Cdd:pfam15905  196 SKGKVAQLEEKLVSTEKEKIEE-KSETEKLLEYITELSCVSEQVEKYKL--------------DIAQLEELLKEKNDEIE 260

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  404 AQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 470
Cdd:pfam15905  261 SLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
51-284 7.74e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 7.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   51 LKRSLEQARMEVSQEDDKalqlLHDIREQSrKLQEIKEQE--YQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRL 128
Cdd:COG3206    180 LEEQLPELRKELEEAEAA----LEEFRQKN-GLVDLSEEAklLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  129 AAEEFKRKATecqhkLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKA-STEATELLQNIRQAKERAEREL 207
Cdd:COG3206    255 ALPELLQSPV-----IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQlQQEAQRILASLEAELEALQARE 329

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  208 EKLQNREDssegirkklveaeerrhSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQ 284
Cdd:COG3206    330 ASLQAQLA-----------------QLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVR 389
PH_MRCK cd01243
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ...
 1023-1138 7.78e-05

MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269949  Cd Length: 135  Bit Score: 44.21  E-value: 7.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1023 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1099
Cdd:cd01243     15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462529488 1100 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1138
Cdd:cd01243     91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
C1_Munc13-1 cd20858
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ...
 937-987 8.27e-05

protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410408  Cd Length: 60  Bit Score: 42.00  E-value: 8.27e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  937 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20858      6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
C1_aPKC cd20794
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 940-988 8.53e-05

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410344  Cd Length: 55  Bit Score: 41.87  E-value: 8.53e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462529488  940 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20794      9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
mukB PRK04863
chromosome partition protein MukB;
254-567 8.56e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.64  E-value: 8.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  254 DIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHyEEKIKVLDNqikkdladketlENMMQRHEEeAHEKG 333
Cdd:PRK04863   838 ELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRL-LPRLNLLAD------------ETLADRVEE-IREQL 903

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  334 KILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftqrnmKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL 413
Cdd:PRK04863   904 DEAEEAKRFVQQHGNALAQLEPIVSVL------------------QSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVV 965

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  414 EKISHQDHSDKNRLL----ELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 489
Cdd:PRK04863   966 QRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQD 1045

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  490 T-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLTEdnAELNNQNfylsKQLDEasgANDEIVQLRSEV 567
Cdd:PRK04863  1046 LgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFCE--AEMDNLT----KKLRK---LERDYHEMREQV 1111
46 PHA02562
endonuclease subunit; Provisional
 76-323 8.69e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.32  E-value: 8.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   76 IREQSrklQEIKEQEYQAQVEEMRLMM---NQLEEDLVSARRRSDL---YESELREsrlaAEEFKRKATECQHKLLK-AK 148
Cdd:PHA02562   176 IRELN---QQIQTLDMKIDHIQQQIKTynkNIEEQRKKNGENIARKqnkYDELVEE----AKTIKAEIEELTDELLNlVM 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  149 DQGKPEvgeyAKLEKINAEQ---QLKIQELQeKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegIRKKLV 225
Cdd:PHA02562   249 DIEDPS----AALNKLNTAAakiKSKIEQFQ-KVIKMYEKGGVCPTCTQQISEGPDRITKIKDKLKE-------LQHSLE 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  226 EAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 305
Cdd:PHA02562   317 KLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKS 396

                          250
                   ....*....|....*...
gi 2462529488  306 NqIKKDLADKETLENMMQ 323
Cdd:PHA02562   397 E-LVKEKYHRGIVTDLLK 413
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 345-514 8.99e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 8.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  345 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 424
Cdd:COG1579     14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  425 NRLLELETRLREVS-------LEHEEQKLELKRQLTELQLS-----LQERESQLTALQAARAALESQLRQAKTELEETTA 492
Cdd:COG1579     73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEDEILelmerIEELEEELAELEAELAELEAELEEKKAELDEELA 152

                          170       180
                   ....*....|....*....|..
gi 2462529488  493 EAEEEIQALTAHRDEIQRKFDA 514
Cdd:COG1579    153 ELEAELEELEAEREELAAKIPP 174
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 454-813 9.34e-05

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 46.99  E-value: 9.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  454 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 529
Cdd:pfam05622   11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  530 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQTMEA- 590
Cdd:pfam05622   69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKKKLEDl 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  591 --LKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSRA----- 652
Cdd:pfam05622  148 gdLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLEEkleal 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  653 -RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMNAR---- 712
Cdd:pfam05622  224 qKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLGQEgsyr 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  713 ----SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKvkm 788
Cdd:pfam05622  304 erltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEAQSE--- 378

                          410       420
                   ....*....|....*....|....*
gi 2462529488  789 egtISQQTKLIDFLQAKMDQPAKKK 813
Cdd:pfam05622  379 ---LQKKKEQIEELEPKQDSNLAQK 400
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 381-721 9.36e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 9.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  381 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELEtRLREVSLEHEEQKLELKRQLTELQlsLQ 460
Cdd:pfam17380  280 HQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD-RQAAIYAEQERMAMERERELERIR--QE 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  461 ERESQLTALQAARAALE-SQLRQAKTELEETTAEAEEEIQALTAHR------DEIQRKfdalrnsctvitdLEEQLNQLT 533
Cdd:pfam17380  357 ERKRELERIRQEEIAMEiSRMRELERLQMERQQKNERVRQELEAARkvkileEERQRK-------------IQQQKVEME 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  534 EDNAELNNQNFYLSKQLDEasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMD---LEALND 610
Cdd:pfam17380  424 QIRAEQEEARQREVRRLEE---------ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDrkrAEEQRR 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  611 ELLEKErqWEAWRSVLGDEKSQfecrvrelQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEilaLQQALKEQKLKA 690
Cdd:pfam17380  495 KILEKE--LEERKQAMIEEERK--------RKLLEKEMEERQKAIYEEERRREAEEERRKQQEME---ERRRIQEQMRKA 561

                          330       340       350
                   ....*....|....*....|....*....|.
gi 2462529488  691 ESLSDKLNDLEKKHAMLEMNARSLQQKLETE 721
Cdd:pfam17380  562 TEERSRLEAMEREREMMRQIVESEKARAEYE 592
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 455-774 1.07e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.81  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  455 LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdALRNSCTVITDLEEQLNQLTE 534
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE---ELRQSREKHEELEEKYKELSA 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  535 DNAELNNQNFYLSKQLDEASGandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLE 614
Cdd:pfam07888  109 SSEELSEEKDALLAQRAAHEA---RIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEE 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  615 KERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEILALQQALKEQKLKAESLS 694
Cdd:pfam07888  186 ELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELRSLQERLNASERKVEGLG 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  695 DKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 763
Cdd:pfam07888  258 EELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEE 337

                          330
                   ....*....|.
gi 2462529488  764 KTERSDLEYQL 774
Cdd:pfam07888  338 RMEREKLEVEL 348
C1_nPKC_theta-like_rpt2 cd20837
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ...
 939-987 1.18e-04

second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410387  Cd Length: 50  Bit Score: 41.27  E-value: 1.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  939 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20837      1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
637-891 1.23e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  637 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 708
Cdd:COG4913    213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  709 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 787
Cdd:COG4913    290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  788 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 867
Cdd:COG4913    358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426

                          250       260
                   ....*....|....*....|....
gi 2462529488  868 EAAHRKATDHPHPSTPATARQQIA 891
Cdd:COG4913    427 EIASLERRKSNIPARLLALRDALA 450
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1497-1606 1.42e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 1.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488 1497 SGTEHHRGPSTSRSSPNKRGPPTynehiTKRVASSPAPPEGPSHPREPSTPH-RYREGRTELRRDKSPgrplerekspgr 1575
Cdd:PHA03307   343 PGPSPSRSPSPSRPPPPADPSSP-----RKRPRPSRAPSSPAASAGRPTRRRaRAAVAGRARRRDATG------------ 405

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462529488 1576 mlstRRERSPGRLFEDSSRGRLPAGAVRTPL 1606
Cdd:PHA03307   406 ----RFPAGRPRPSPLDAGAASGAFYARYPL 432
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 507-807 1.47e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.49  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  507 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITERE---- 578
Cdd:COG5185    233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTksid 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  579 -----MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 651
Cdd:COG5185    307 ikkatESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  652 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 731
Cdd:COG5185    387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  732 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 807
Cdd:COG5185    458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
mukB PRK04863
chromosome partition protein MukB;
433-760 1.52e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.87  E-value: 1.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  433 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 512
Cdd:PRK04863   283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  513 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEV-DHLRR--EITEREMQLTSQKQTME 589
Cdd:PRK04863   355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAA---EEEVDELKSQLaDYQQAldVQQTRAIQYQQAVQALE 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  590 ALKTTC-----------TMLEEQVMDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--ADQ 656
Cdd:PRK04863   425 RAKQLCglpdltadnaeDWLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvARE 500

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  657 RITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 734
Cdd:PRK04863   501 LLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSE 576

                          330       340
                   ....*....|....*....|....*.
gi 2462529488  735 LQQQMDLQKNHIFRLTQGLQEALDRA 760
Cdd:PRK04863   577 ARERRMALRQQLEQLQARIQRLAARA 602
C1_aPKC_iota cd21094
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 939-990 1.58e-04

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410447  Cd Length: 55  Bit Score: 41.14  E-value: 1.58e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  939 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd21094      3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 655-812 1.75e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  655 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 730
Cdd:COG1579     16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  731 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 809
Cdd:COG1579     89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168


                   ...
gi 2462529488  810 AKK 812
Cdd:COG1579    169 AAK 171
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 339-771 1.86e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 46.20  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  339 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 416
Cdd:PRK10929    43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  417 SHQdHSDKNRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAlesqLRQAKTEleetta 492
Cdd:PRK10929   115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLAQAQLT----ALQAESA------ 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  493 eaeeeiqALTAHRDEIqrkfdalrnsctvitdleeQLNQLTEDNAElnnqnfylskqldeasgandEIVQLRSEV----- 567
Cdd:PRK10929   184 -------ALKALVDEL-------------------ELAQLSANNRQ--------------------ELARLRSELakkrs 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  568 DHLRREITEREMQLTSQKQ--TMEALKTTcTMLEEQVMDLEALNDELLEKERQweawrsvLGDEKSQfecrvrELQRMLD 645
Cdd:PRK10929   218 QQLDAYLQALRNQLNSQRQreAERALEST-ELLAEQSGDLPKSIVAQFKINRE-------LSQALNQ------QAQRMDL 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  646 TEKQSRaRADQRITESRQVveLAVKEHKAEILALQQALKEqKLKAEslSDKLNDLEKKhamlemnarslqQKLETER-EL 724
Cdd:PRK10929   284 IASQQR-QAASQTLQVRQA--LNTLREQSQWLGVSNALGE-ALRAQ--VARLPEMPKP------------QQLDTEMaQL 345

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462529488  725 K-QRLLEEQ--AKLQQQMDLQKNHIFRLTQGLQEALDraDLLKTERSDLE 771
Cdd:PRK10929   346 RvQRLRYEDllNKQPQLRQIRQADGQPLTAEQNRILD--AQLRTQRELLN 393
COG5022 COG5022
Myosin heavy chain [General function prediction only];
172-782 1.87e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 46.61  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  172 IQELQEKLEKavkasteatELLQNIRQAKERAERELEKLQNREDSSEgiRKKLVEAEERRHSLENKVKRLETMERRENRL 251
Cdd:COG5022    819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEVLIQKFGRSLK--AKKRFSLLKKETIYLQSAQRVELAERQLQEL 887

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  252 KDDIQTksqqIQQMADKILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDN-QIKKDLA-DKETLENMMQRHEEE 328
Cdd:COG5022    888 KIDVKS----ISSLKLVNLELESEIIELKKSLSSDLIeNLEFKTELIARLKKLLNNiDLEEGPSiEYVKLPELNKLHEVE 963

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  329 A--HEKGKILSeqkAMINAMDSKIRSLEQRIVELSEANKLAAnsslftqrnmkaqeemisELRQQKFYLETQAGKLEAQN 406
Cdd:COG5022    964 SklKETSEEYE---DLLKKSTILVREGNKANSELKNFKKELA------------------ELSKQYGALQESTKQLKELP 1022

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  407 RKLEE--QLEKISHQDHSDKNRLLELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAK 484
Cdd:COG5022   1023 VEVAElqSASKIISSESTELSILKPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLE 1087

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  485 TELEETTAEAEEEIQALTahrdeiqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 564
Cdd:COG5022   1088 STENLLKTINVKDLEVTN-------RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGL 1159

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  565 SEVDHLRREITEREMQLTSQKQTME--ALKTTCTMLEEQVMDLEalnDELLEKERQ-WEAWRSVLGDEKSQFECRVRELQ 641
Cdd:COG5022   1160 FWEANLEALPSPPPFAALSEKRLYQsaLYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISEGWVPTEY 1236

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  642 RMLDTEKQSRAR--ADQRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----LEMNARSL 714
Cdd:COG5022   1237 STSLKGFNNLNKkfDTPASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaLRTKASSL 1308

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529488  715 QQKLETERELKQRLLEEQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 782
Cdd:COG5022   1309 RWKSATEVNYNSEELDDWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
159-250 1.88e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.00  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  159 AKLEKINAEQQLKIQELQEKLEKAvkaSTEATELLQNIRqAKERAERELEKLQNREDSsegIRKKLVEAEERRHSLENKV 238
Cdd:COG2433    423 ERLEAEVEELEAELEEKDERIERL---ERELSEARSEER-REIRKDREISRLDREIER---LERELEEERERIEELKRKL 495

                           90
                   ....*....|..
gi 2462529488  239 KRLETMERRENR 250
Cdd:COG2433    496 ERLKELWKLEHS 507
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 220-616 1.91e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 46.00  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  220 IRKKLVEAEE--RRHSLeNKVKRleTMERRENRLkDDIQTKSQQIQQMADKILELEEKHREAqvsAQHLEVH-------L 290
Cdd:pfam06160   65 IEELLFEAEElnDKYRF-KKAKK--ALDEIEELL-DDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktL 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  291 KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaan 369
Cdd:pfam06160  138 LANRFSYGPAIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  370 sslftQRNMKAQ----EEMISELRQQKFYLETQagkleaqnrKLEEQLEKISHQDHSDKNRLLELEtrlrevsLEHEEQK 445
Cdd:pfam06160  206 -----KTELPDQleelKEGYREMEEEGYALEHL---------NVDKEIQQLEEQLEENLALLENLE-------LDEAEEA 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  446 LE-LKRQLTELQLSLqEREsqltalqaaraalesqlrqakteleettaeaeeeIQAltahRDEIQRKFDALRNSctvITD 524
Cdd:pfam06160  265 LEeIEERIDQLYDLL-EKE----------------------------------VDA----KKYVEKNLPEIEDY---LEH 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  525 LEEQLNQLTEDNAELnNQNFYLS-KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 603
Cdd:pfam06160  303 AEEQNKELKEELERV-QQSYTLNeNELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQE 381

                          410
                   ....*....|....
gi 2462529488  604 DL-EALNDelLEKE 616
Cdd:pfam06160  382 EFkESLQS--LRKD 393
C1_MTMR-like cd20828
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ...
 935-988 1.92e-04

protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410378  Cd Length: 57  Bit Score: 40.89  E-value: 1.92e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  935 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20828      2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 442-656 1.95e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  442 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRN---- 517
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErara 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  518 ---SCTVITDLEEQLNQltEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 594
Cdd:COG3883     95 lyrSGGSVSYLDVLLGS--ESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  595 ctmLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 656
Cdd:COG3883    173 ---LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 30-229 2.04e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   30 SETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRlmmNQLEE 107
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEiaEAEAEIEERR---EELGE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  108 DLVSARR--RSDLYESELRESRLAAEEFKR-----KATECQHKLLKA--KDQGKPEVGEyAKLEKINAEQQLKIQELQEK 178
Cdd:COG3883     91 RARALYRsgGSVSYLDVLLGSESFSDFLDRlsalsKIADADADLLEElkADKAELEAKK-AELEAKLAELEALKAELEAA 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  179 LEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEE 229
Cdd:COG3883    170 KAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 176-470 2.08e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 2.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  176 QEKLEKAVKasteatellQNIRQAKERAERELEKlqnredssegiRKKLVEAEERRHSlenKVKRLETMERRENRLKDDI 255
Cdd:pfam17380  290 QEKFEKMEQ---------ERLRQEKEEKAREVER-----------RRKLEEAEKARQA---EMDRQAAIYAEQERMAMER 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  256 QTKSQQIQQmadkilelEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKETLENMMQRHEEEAHEKGK 334
Cdd:pfam17380  347 ERELERIRQ--------EERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAARKVK 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  335 ILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEEQLE 414
Cdd:pfam17380  406 ILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQQVE 463

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  415 KISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 470
Cdd:pfam17380  464 RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 34-484 2.25e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 2.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   34 RSLLEQDLATYITECSSLK---RSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQ-AQVEEMRLMMNQLEEDL 109
Cdd:COG5185    120 ISLLYLYKSEIVALKDELIkveKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKKLEIfGLTLGLLKGISELKKAE 199

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  110 VSARRRSDLYESELRES------RLAAEEFKRKATEcqhKLLKAKDQGKPEVGEYA-KLEK-INAEQQLKIQELQEKLEK 181
Cdd:COG5185    200 PSGTVNSIKESETGNLGsestllEKAKEIINIEEAL---KGFQDPESELEDLAQTSdKLEKlVEQNTDLRLEKLGENAES 276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  182 AVKASTEATELLQNIRQAKERAeRELEKLQNREDSSEGIRKKLVEAEERRHsLENKVKRLETMerrenrlkddIQTKSQQ 261
Cdd:COG5185    277 SKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEAEQE-LEESKRETETG----------IQNLTAE 344

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  262 IQQMADKILELEEKHREaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQka 341
Cdd:COG5185    345 IEQGQESLTENLEAIKE-EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAADRQ-- 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  342 mINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLEtqagkLEAQNRKLEEQLEKIshqdh 421
Cdd:COG5185    422 -IEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRS-----VRSKKEDLNEELTQI----- 490

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  422 sdKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlTALQAARAALESQLRQAK 484
Cdd:COG5185    491 --ESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFM---RARGYAHILALENLIPAS 548
PRK11281 PRK11281
mechanosensitive channel MscK;
434-751 2.34e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.06  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  434 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 510
Cdd:PRK11281    48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  511 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQKQT 587
Cdd:PRK11281   116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLKG 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  588 MEALKTTCTMLEEQVMDLE-ALNDELLEKERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrARADQRITESRQVV- 665
Cdd:PRK11281   182 GKVGGKALRPSQRVLLQAEqALLNAQNDLQRKSLEGNTQLQD--------LLQKQRDYLTARI--QRLEHQLQLLQEAIn 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  666 --ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQ--QMDL 741
Cdd:PRK11281   252 skRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLLKATEKLNTltQQNL 309

                          330
                   ....*....|.
gi 2462529488  742 Q-KNHIFRLTQ 751
Cdd:PRK11281   310 RvKNWLDRLTQ 320
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 52-227 2.70e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.33  E-value: 2.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   52 KRSLEQARMEVSQEDDKALQllHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV----SARRRSDLYESELRESR 127
Cdd:pfam15709  345 MRRLEVERKRREQEEQRRLQ--QEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQrqeeEERKQRLQLQAAQERAR 422

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  128 LAAEEFKRKATECQHKllkaKDQgkpEVGEYAKLEKiNAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL 207
Cdd:pfam15709  423 QQQEEFRRKLQELQRK----KQQ---EEAERAEAEK-QRQKELEMQLAEEQKRLMEMAEEERLEYQRQKQEAEEKARLEA 494

                          170       180
                   ....*....|....*....|
gi 2462529488  208 EKLQNREDssEGIRKKLVEA 227
Cdd:pfam15709  495 EERRQKEE--EAARLALEEA 512
C1_PKD2_rpt2 cd20843
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ...
 937-987 2.80e-04

second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410393  Cd Length: 79  Bit Score: 41.11  E-value: 2.80e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  937 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20843     10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 162-362 3.46e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 45.30  E-value: 3.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  162 EKINAEQQLKIQELQEKLEKAV---KASTEATELLQNIRQAKEraERELEKLQNREDSS-EGIRKKLVEAEERRHSLENK 237
Cdd:PRK05771    38 EELSNERLRKLRSLLTKLSEALdklRSYLPKLNPLREEKKKVS--VKSLEELIKDVEEElEKIEKEIKELEEEISELENE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  238 VKRLETMERRENRLKD-DIqtksqqiqqmaDKILELEEKH---REAQVSAQHLEVHLKQKEQHYEEKIKVLDN------Q 307
Cdd:PRK05771   116 IKELEQEIERLEPWGNfDL-----------DLSLLLGFKYvsvFVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvV 184

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  308 IKKDLADKetLENMMQRHE---EEAHEKGK---ILSEQKAMINAMDSKIRSLEQRIVELSE 362
Cdd:PRK05771   185 VLKELSDE--VEEELKKLGferLELEEEGTpseLIREIKEELEEIEKERESLLEELKELAK 243
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 11-479 4.11e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 45.13  E-value: 4.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   11 RRVSEV-EAVLSQKEVELKasETQRSLLEQDLATYITECSSLKRSL-EQARMEVSQ-----EDDKALQLLHDIREQSRKL 83
Cdd:pfam07111  184 KRAGEAkQLAEAQKEAELL--RKQLSKTQEELEAQVTLVESLRKYVgEQVPPEVHSqtwelERQELLDTMQHLQEDRADL 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   84 QEIKEQeYQAQVEEMRLMMNQLEEDLVSARRRSDLYESEL-RESRLAAEEFKRKATECQHKLlKAKDqgkpevgeyakLE 162
Cdd:pfam07111  262 QATVEL-LQVRVQSLTHMLALQEEELTRKIQPSDSLEPEFpKKCRSLLNRWREKVFALMVQL-KAQD-----------LE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  163 KINAEQQLKIQ--ELQEKlekaVKASTEATELLQNIRQAKErAERELEKLqnredSSEGIRKKLVEAEERRHSLENKVKR 240
Cdd:pfam07111  329 HRDSVKQLRGQvaELQEQ----VTSQSQEQAILQRALQDKA-AEVEVERM-----SAKGLQMELSRAQEARRRQQQQTAS 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  241 LETMER----RENRLKDDIQTKSQQIQQMADKILELEEK--------HREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQ 307
Cdd:pfam07111  399 AEEQLKfvvnAMSSTQIWLETTMTRVEQAVARIPSLSNRlsyavrkvHTIKGLMARKVALaQLRQESCPPPPPAPPVDAD 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  308 IKKDLadkETLENMMQRHEEEAHEKGKILSEQKAminamdskiRSLEQRIVELSEANKLAANsslFTQRNMKAQEEMISE 387
Cdd:pfam07111  479 LSLEL---EQLREERNRLDAELQLSAHLIQQEVG---------RAREQGEAERQQLSEVAQQ---LEQELQRAQESLASV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  388 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSL-------- 459
Cdd:pfam07111  544 GQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLrqiqhrat 623

                          490       500
                   ....*....|....*....|..
gi 2462529488  460 --QERESQLTALQAARAALESQ 479
Cdd:pfam07111  624 qeKERNQELRRLQDEARKEEGQ 645
C1_Munc13-2-like cd20859
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ...
 933-987 4.19e-04

protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410409  Cd Length: 82  Bit Score: 40.82  E-value: 4.19e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  933 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20859     14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
159-415 4.48e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.13  E-value: 4.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  159 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKV 238
Cdd:COG1340     36 EELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  239 KRLETMERRenrlkddIQTKS---QQIQQMADKILELEEKHREAQvsaqhlevhlKQKEQHyeEKIKVLDNQIKKDLADK 315
Cdd:COG1340    116 KEIERLEWR-------QQTEVlspEEEKELVEKIKELEKELEKAK----------KALEKN--EKLKELRAELKELRKEA 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  316 ETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaansslftqrnMKAQEEMISELRQQKFYL 395
Cdd:COG1340    177 EEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEK--------------ADELHEEIIELQKELREL 242

                          250       260
                   ....*....|....*....|
gi 2462529488  396 ETQAGKLEAQNRKLEEQLEK 415
Cdd:COG1340    243 RKELKKLRKKQRALKREKEK 262
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
76-393 5.28e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 5.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   76 IREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKP 153
Cdd:COG4372     33 LRKALFELDKLQEEleQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  154 EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS 233
Cdd:COG4372    113 LQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEA 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  234 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 313
Cdd:COG4372    193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKD 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  314 DKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 393
Cdd:COG4372    273 TEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLD 352
COG5022 COG5022
Myosin heavy chain [General function prediction only];
3-773 5.79e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 44.68  E-value: 5.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLATyitECSSLKRSL---EQARMEVSQEDDKALQLLHDI 76
Cdd:COG5022    799 LQPLLSLLGSRKEYRSYLACiikLQKTIKREKKLRETEEVEFSL---KAEVLIQKFgrsLKAKKRFSLLKKETIYLQSAQ 875

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   77 REQS--RKLQEIKEQEyqAQVEEMRLMMNQLEEDLVsaRRRSDLYESELRESRLAAEEFKRkaTECQHKLLKAKDQGKPE 154
Cdd:COG5022    876 RVELaeRQLQELKIDV--KSISSLKLVNLELESEII--ELKKSLSSDLIENLEFKTELIAR--LKKLLNNIDLEEGPSIE 949

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  155 VGEYAKLEKINaEQQLKIQELQEKLEKAVKASTEatellqnirqakeraerELEKLQNREDSSEGIRKKLVEAEERRHSL 234
Cdd:COG5022    950 YVKLPELNKLH-EVESKLKETSEEYEDLLKKSTI-----------------LVREGNKANSELKNFKKELAELSKQYGAL 1011

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  235 ENKVKRLETMERRENRLKDDIQTKSQqiqqmadkilELEEKHREAQVsaQHLEVHLKQKEQHYEEKIKVLDNQIkkdlad 314
Cdd:COG5022   1012 QESTKQLKELPVEVAELQSASKIISS----------ESTELSILKPL--QKLKGLLLLENNQLQARYKALKLRR------ 1073

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  315 ketlenmmqrheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANklAANSSLFTQRNMKAqeemiselrQQKFY 394
Cdd:COG5022   1074 ----------------ENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN--LVKPANVLQFIVAQ---------MIKLN 1126

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  395 LETQAGKLEAQNRKLEEQLEKishqdhSDKNRLLELETRLREVSLEHEEQKLELKRQltelqlsLQERESQLTALQAARA 474
Cdd:COG5022   1127 LLQEISKFLSQLVNTLEPVFQ------KLSVLQLELDGLFWEANLEALPSPPPFAAL-------SEKRLYQSALYDEKSK 1193

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  475 ALESQLRQAKTELeettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAS 554
Cdd:COG5022   1194 LSSSEVNDLKNEL------------------IALFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPAS 1255

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  555 GANDEIVQLRSEVDHLRRE-ITEREMQLTSQKQTMealkttctmleeQVMDLEALNdELLEKERQWEaWRSVLGDEKSQF 633
Cdd:COG5022   1256 MSNEKLLSLLNSIDNLLSSyKLEEEVLPATINSLL------------QYINVGLFN-ALRTKASSLR-WKSATEVNYNSE 1321

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  634 E----CRVRELQRmLDTEKQSraradqrITESRQVVELAVK--EHKAEILALQQALKE---QKLKAE-SLSDKLNDLEKK 703
Cdd:COG5022   1322 ElddwCREFEISD-VDEELEE-------LIQAVKVLQLLKDdlNKLDELLDACYSLNPaeiQNLKSRyDPADKENNLPKE 1393

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  704 HaMLEMNARSLQQKLETERELKQRLleeQAKLQQQMDLQKNHIFRLTQGLQ--EALDR--ADLLKTERSDLEYQ 773
Cdd:COG5022   1394 I-LKKIEALLIKQELQLSLEGKDET---EVHLSEIFSEEKSLISLDRNSIYkeEVLSSlsALLTKEKIALLDRK 1463
PRK09039 PRK09039
peptidoglycan -binding protein;
565-698 5.99e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.80  E-value: 5.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  565 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELlekerqwEAWRSVLGDEKSQFECRVRELQRML 644
Cdd:PRK09039    53 SALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRL-------QALLAELAGAGAAAEGRAGELAQEL 125

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  645 DTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 698
Cdd:PRK09039   126 DSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 520-739 6.12e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 6.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  520 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL---- 591
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaral 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  592 ---KTTCTMLEeQVMDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELA 668
Cdd:COG3883     96 yrsGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELEAA 169

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  669 VKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 739
Cdd:COG3883    170 KAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
545-780 6.16e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 6.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  545 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS--QKQTMEALKTTCTMLEEQVMDLE----ALNDELLEKER 617
Cdd:COG3206    161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLLQQLSELEsqlaEARAELAEAEA 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  618 QWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQKLKAe 691
Cdd:COG3206    241 RLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEAQRI- 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  692 slsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTERSdle 771
Cdd:COG3206    315 -----LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAEA--- 382


                   ....*....
gi 2462529488  772 YQLENIQVL 780
Cdd:COG3206    383 LTVGNVRVI 391
C1_dGM13116p-like cd20831
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ...
 950-987 6.77e-04

protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410381  Cd Length: 58  Bit Score: 39.25  E-value: 6.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462529488  950 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20831     17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 3-407 7.05e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 7.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLeqarmevsQEDDKALQLLHDIREQSrk 82
Cdd:pfam10174  393 ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEAL--------SEKERIIERLKEQRERE-- 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 lqeikEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 162
Cdd:pfam10174  463 -----DRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLE 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  163 KinaeQQLKIQElqekLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIrkkLVEAEERRHSLENKVKRLE 242
Cdd:pfam10174  538 N----QLKKAHN----AEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGI---LREVENEKNDKDKKIAELE 606

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  243 TMERRenrlkddiQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdlaDKETLENMM 322
Cdd:pfam10174  607 SLTLR--------QMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEK---TRQELDATK 675

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  323 QRHEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS---------SLFTQRNMKAQEEMISeLRQQKF 393
Cdd:pfam10174  676 ARLSSTQQS----LAEKDGHLTNLRAERRKQLEEILEMKQEALLAAISekdaniallELSSSKKKKTQEEVMA-LKREKD 750

                          410
                   ....*....|....
gi 2462529488  394 YLETQAgKLEAQNR 407
Cdd:pfam10174  751 RLVHQL-KQQTQNR 763
46 PHA02562
endonuclease subunit; Provisional
 645-804 7.47e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 7.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  645 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 715
Cdd:PHA02562   202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  716 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 785
Cdd:PHA02562   282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356

                          170
                   ....*....|....*....
gi 2462529488  786 vkmEGTISQQTKLIDFLQA 804
Cdd:PHA02562   357 ---VDKAKKVKAAIEELQA 372
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 451-668 8.01e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  451 QLTELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQRKFDALRNSctvITDLEEQLN 530
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEE-----------YNELQAELEALQAEIDKLQAE---IAEAEAEIE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  531 QLTEDNAELNNQNF---YLSKQLDEASGANDeIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEA 607
Cdd:COG3883     83 ERREELGERARALYrsgGSVSYLDVLLGSES-FSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  608 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 668
Cdd:COG3883    162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAA 222
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 191-630 8.99e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 8.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  191 ELLQNIRQAKERAERELekLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETmerrenrlkdDIQTKSQQIQQMADKIL 270
Cdd:pfam07888   30 ELLQNRLEECLQERAEL--LQAQEAANRQREKEKERYKRDREQWERQRRELES----------RVAELKEELRQSREKHE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  271 ELEEKHREAQVS----AQHLEVHLKQKEQHyEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAM 346
Cdd:pfam07888   98 ELEEKYKELSASseelSEEKDALLAQRAAH-EARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQL 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  347 DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyleTQAGKLEAQNRKLEEQLEKISHQDHSDKNR 426
Cdd:pfam07888  177 QAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKL----TTAHRKEAENEALLEELRSLQERLNASERK 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  427 LLELETRLREVSLEHEEQKLELKR-QLTELQLSLQERESQLtALQAARAalesQLRQAKTELEETTAEAEEEIQALTAhr 505
Cdd:pfam07888  253 VEGLGEELSSMAAQRDRTQAELHQaRLQAAQLTLQLADASL-ALREGRA----RWAQERETLQQSAEADKDRIEKLSA-- 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  506 dEIQRKfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqldeasgandeiVQLRSEVDHLRREITEREMQLTSQK 585
Cdd:pfam07888  326 -ELQRL--------------EERLQEERMEREKLE--------------------VELGREKDCNRVQLSESRRELQELK 370

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 2462529488  586 QTMEALKTTctmlEEQvmdLEALNDELLEKERQWEAWRSVLGDEK 630
Cdd:pfam07888  371 ASLRVAQKE----KEQ---LQAEKQELLEYIRQLEQRLETVADAK 408
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 52-478 8.99e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 8.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   52 KRSLEQARMEVSQEDD----KALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEdlvsarrrsdlyesELRESR 127
Cdd:pfam07888   28 RAELLQNRLEECLQERaellQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE--------------ELRQSR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  128 LAAEEFKRKATEcqhkllkAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEK-AVKASTEATELlqniRQAKERAERE 206
Cdd:pfam07888   94 EKHEELEEKYKE-------LSASSEELSEEKDALLAQRAAHEARIRELEEDIKTlTQRVLERETEL----ERMKERAKKA 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  207 LEKLQNREDSSEGIRKKLVEAEERRHSLENKVKrletmerrenRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhl 286
Cdd:pfam07888  163 GAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQ----------ELRNSLAQRDTQVLQLQDTITTLTQKLTTAH------ 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  287 evhlkQKEQHYEekikvldnQIKKDLADKETLENMMQRHEEeahekgKILSEQKAMINAMDSKIRSLEQRIVELSEANKL 366
Cdd:pfam07888  227 -----RKEAENE--------ALLEELRSLQERLNASERKVE------GLGEELSSMAAQRDRTQAELHQARLQAAQLTLQ 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  367 AANSSLF--------------TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL--EKISH--QDHSDKNRLL 428
Cdd:pfam07888  288 LADASLAlregrarwaqeretLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELgrEKDCNrvQLSESRRELQ 367

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462529488  429 ELETRLReVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 478
Cdd:pfam07888  368 ELKASLR-VAQKEKEQLQAEKQELLEYIRQLEQRLETVADAKWSEAALTS 416
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 211-299 9.45e-04

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 41.18  E-value: 9.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  211 QNREDSSEGIRKKLVEAEERRHSLE-NKVKRL-ETMER-RENRLKDDIQTK--SQQIQQMADKILELEEKHREAQVSAqh 285
Cdd:pfam00836   38 KKKDSSLEEIQKKLEAAEERRKSLEaQKLKQLaEKREKeEEALQKADEENNnfSKMAEEKLKQKMEAYKENREAQIAA-- 115

                           90
                   ....*....|....
gi 2462529488  286 LEVHLKQKEQHYEE 299
Cdd:pfam00836  116 LKEKLKEKEKHVEE 129
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 292-820 9.81e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.06  E-value: 9.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  292 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEAnklaANSS 371
Cdd:pfam12128  237 MKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASR---QEERQETSAELNQLLRTLDDQWKEKRDE----LNGE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  372 LFTQRnmkaqeEMISELRQQKFYLETQAGKLE---AQNRKLE-EQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLE 447
Cdd:pfam12128  310 LSAAD------AAVAKDRSELEALEDQHGAFLdadIETAAADqEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSK 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  448 LKRQLT--------ELQLSLQERESQLTALQAARAALESQLRQAKTeleettaeaeeeiQALTAHRDEIQRKFDALRNSC 519
Cdd:pfam12128  384 IKEQNNrdiagikdKLAKIREARDRQLAVAEDDLQALESELREQLE-------------AGKLEFNEEEYRLKSRLGELK 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  520 TVITDL---EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK---- 592
Cdd:pfam12128  451 LRLNQAtatPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELElqlf 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  593 ----TTCTMLEEQVMDLE-----ALNDELLEK-ERQWEAWRSVLGDEKSQFECRVReLQRM-----LDTEKQSRARADQr 657
Cdd:pfam12128  531 pqagTLLHFLRKEAPDWEqsigkVISPELLHRtDLDPEVWDGSVGGELNLYGVKLD-LKRIdvpewAASEEELRERLDK- 608

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  658 itesrqvvelaVKEhkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 737
Cdd:pfam12128  609 -----------AEE------ALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNK 671

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  738 QmdlqknhifrLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLF 817
Cdd:pfam12128  672 A----------LAERKDSANERLNSLEAQLKQLDKKHQ--AWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIA 739


                   ...
gi 2462529488  818 SRR 820
Cdd:pfam12128  740 ARR 742
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 124-468 1.09e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.05  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  124 RESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA 203
Cdd:PTZ00440   435 LYSNLEIIEIKKKYDEKINELKKSINQLKTLISIMKSFYDLIISEKDSMDSKEKKESSDSNYQEKVDELLQIINSIKEKN 514

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  204 ERELEKLQNREDSS---EGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ 280
Cdd:PTZ00440   515 NIVNNNFKNIEDYYitiEGLKNEIEGLIELIKYYLQSIETLIKDEKLKRSMKNDIKNKIKYIEENVDHIKDIISLNDEID 594

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  281 VSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLadKETLENMMQRH-EEEAHEKGKILSEQKAMINAMDSKirsleQRIVE 359
Cdd:PTZ00440   595 NIIQQIE-ELINEALFNKEKFINEKNDLQEKV--KYILNKFYKGDlQELLDELSHFLDDHKYLYHEAKSK-----EDLQT 666

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  360 L-----SEANKLA-ANSSLFTQ--RNMKAQEEMISELRQQkfyletqagkleaqnrKLEEQLEKIsHQDHSDK-NRLLEL 430
Cdd:PTZ00440   667 LlntskNEYEKLEfMKSDNIDNiiKNLKKELQNLLSLKEN----------------IIKKQLNNI-EQDISNSlNQYTIK 729

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462529488  431 ETRLREV--SLEHEEQKLELKRQ-----LTELQLSLQERESQLTA 468
Cdd:PTZ00440   730 YNDLKSSieEYKEEEEKLEVYKHqiinrKNEFILHLYENDKDLPD 774
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 166-391 1.19e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  166 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRKKLVEAEERRHSLENKV-KRLETM 244
Cdd:COG3883     19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDK---LQAEIAEAEAEIEERREELgERARAL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  245 ERRENRLKD-DIQTKSQQIQQMADKILELEekhreaQVSAQHLEVHLKQKEQhyEEKIKVLDNQIKKDLADKETLENMMQ 323
Cdd:COG3883     96 YRSGGSVSYlDVLLGSESFSDFLDRLSALS------KIADADADLLEELKAD--KAELEAKKAELEAKLAELEALKAELE 167

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529488  324 RHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 391
Cdd:COG3883    168 AAKAELEAQ---QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 4-301 1.28e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    4 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKL 83
Cdd:TIGR04523  433 ETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKV 512

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   84 QEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARR---------RSDLYESELRESRLAAEEFKrkatECQHKLLKAKDQGK 152
Cdd:TIGR04523  513 KDLTKKisSLKEKIEKLESEKKEKESKISDLEDelnkddfelKKENLEKEIDEKNKEIEELK----QTQKSLKKKQEEKQ 588

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  153 PEVGEYAK----LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDsseGIRKKLVEAE 228
Cdd:TIGR04523  589 ELIDQKEKekkdLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIK---EIRNKWPEII 665

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  229 ERRHSLENKV-KRLETMERREN----RLKDDI--QTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKI 301
Cdd:TIGR04523  666 KKIKESKTKIdDIIELMKDWLKelslHYKKYItrMIRIKDLPKLEEKYKEIEKELKKLDEFSKELENIIKNFNKKFDDAF 745
C1_MRCK cd20809
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ...
 939-990 1.33e-03

protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410359  Cd Length: 53  Bit Score: 38.41  E-value: 1.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462529488  939 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20809      1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
C1_MRCKalpha cd20864
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ...
 939-992 1.38e-03

protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410414  Cd Length: 60  Bit Score: 38.46  E-value: 1.38e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  939 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 992
Cdd:cd20864      3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 4-237 1.42e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.88  E-value: 1.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    4 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQE-DDKALQLLHDIREQSRK 82
Cdd:pfam15905   87 QERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNELLKAKFSEDgTQKKMSSLSMELMKLRN 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK---RKATECQHKLLKAKDQGKPEVGEYA 159
Cdd:pfam15905  167 KLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKsetEKLLEYITELSCVSEQVEKYKLDIA 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  160 KLEKINAEQQLKIQELQEKL-EKAVKAST---EATELLQNIRQAKERAEREL-EKLQNREDSSEGIRKKLVEAEERRHSL 234
Cdd:pfam15905  247 QLEELLKEKNDEIESLKQSLeEKEQELSKqikDLNEKCKLLESEKEELLREYeEKEQTLNAELEELKEKLTLEEQEHQKL 326


                   ...
gi 2462529488  235 ENK 237
Cdd:pfam15905  327 QQK 329
46 PHA02562
endonuclease subunit; Provisional
 503-703 1.48e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  503 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEASGA----NDEIVQLRSEVDHLRREITERE 578
Cdd:PHA02562   213 ENIARKQNKYDELVEE---AKTIKAEIEELTDELLNLV-------MDIEDPSAAlnklNTAAAKIKSKIEQFQKVIKMYE 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  579 ---------MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQRMLDTEKQ 649
Cdd:PHA02562   283 kggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSK-----------KLLELKNKISTNKQ 351

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  650 SRARADQRITESRQVVELAVKE---HKAEILALQQALKEqklkaesLSDKLNDLEKK 703
Cdd:PHA02562   352 SLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDK-------IVKTKSELVKE 401
PLN02939 PLN02939
transferase, transferring glycosyl groups
 2-238 1.50e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    2 MEQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEqarMEVSQEDDKALQLLHDIRE 78
Cdd:PLN02939   168 LQGKINILEMRLSETDArikLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLS---KELDVLKEENMLLKDDIQF 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   79 QSRKLQEIKE-QEYQAQVEEMRLMMNQLEEDLVSarRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQgkpeVGE 157
Cdd:PLN02939   245 LKAELIEVAEtEERVFKLEKERSLLDASLRELES--KFIVAQEDVSKLSPLQYDCWWEKVENLQDLLDRATNQ----VEK 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  158 YAKLEKINAEQQLKIQELQEKLEKAV--KASTEATELLQN-IRQAKERAER-------ELEKLQNREDSSEGIRKKLVEA 227
Cdd:PLN02939   319 AALVLDQNQDLRDKVDKLEASLKEANvsKFSSYKVELLQQkLKLLEERLQAsdheihsYIQLYQESIKEFQDTLSKLKEE 398

                          250
                   ....*....|.
gi 2462529488  228 EERRhSLENKV 238
Cdd:PLN02939   399 SKKR-SLEHPA 408
46 PHA02562
endonuclease subunit; Provisional
 240-539 1.62e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 1.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  240 RLETMERREnRLKD--DIQTKSQqiqqMaDKILEleEKHREAQVSAQHLEV---HLKQKEQHYEEKIKVLDNQIKKDLAD 314
Cdd:PHA02562   146 QLSAPARRK-LVEDllDISVLSE----M-DKLNK--DKIRELNQQIQTLDMkidHIQQQIKTYNKNIEEQRKKNGENIAR 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  315 KEtleNMMQRHEEEAhekgkilseqkamiNAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEEMISELRQQKF 393
Cdd:PHA02562   218 KQ---NKYDELVEEA--------------KTIKAEIEELTDELLNLVmDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKM 280

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  394 YLETQAGKLEAQNrkLEEQLEKIShqdhSDKNRLLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 473
Cdd:PHA02562   281 YEKGGVCPTCTQQ--ISEGPDRIT----KIKDKLKELQHSLEKLD-TAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  474 AALESQLRQAKteleettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 539
Cdd:PHA02562   354 ITLVDKAKKVK---------------------AAIEELQAEFVDNAEELAKLQDELDKIVKTKSEL 398
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 84-481 1.63e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.12  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   84 QEIKEQE-----YQAQ-VEEMRLMMNQLEEDLVSARRrsdlyeseLRESRLAAEEFKRKATECQHKLLKAKDQGKPevge 157
Cdd:PRK10929    30 QELEQAKaaktpAQAEiVEALQSALNWLEERKGSLER--------AKQYQQVIDNFPKLSAELRQQLNNERDEPRS---- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  158 yaklekinAEQQLKIQELQEKLekaVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENK 237
Cdd:PRK10929    98 --------VPPNMSTDALEQEI---LQVSSQLLEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIERRLQTLGTP 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  238 VKRLEtmerrenrlkdDIQTKSQQIQQMADKIL--ELEEkhreAQVSA---QHL-----EVHLKQKEQhyeekikvLDNQ 307
Cdd:PRK10929   167 NTPLA-----------QAQLTALQAESAALKALvdELEL----AQLSAnnrQELarlrsELAKKRSQQ--------LDAY 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  308 IKkdlADKETLENMMQRHEEEAHEKGKILSEQKAminAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRNMKAQEEMIs 386
Cdd:PRK10929   224 LQ---ALRNQLNSQRQREAERALESTELLAEQSG---DLPKSIVAQFKINRELSQAlNQQAQRMDLIASQQRQAASQTL- 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  387 ELRQQKFYLETQAGKLEAQN---RKLEEQLEKIshqdhSDKNRLLELET---RLREVSLEHEEQkLELKRQLTELQlslQ 460
Cdd:PRK10929   297 QVRQALNTLREQSQWLGVSNalgEALRAQVARL-----PEMPKPQQLDTemaQLRVQRLRYEDL-LNKQPQLRQIR---Q 367

                          410       420
                   ....*....|....*....|.
gi 2462529488  461 ERESQLTALQaaRAALESQLR 481
Cdd:PRK10929   368 ADGQPLTAEQ--NRILDAQLR 386
C1_TNS1_v cd20888
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ...
 939-986 1.72e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410438  Cd Length: 57  Bit Score: 38.31  E-value: 1.72e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  939 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 986
Cdd:cd20888      6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
mukB PRK04863
chromosome partition protein MukB;
120-376 1.72e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.41  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  120 ESELRESRLAAEEFKRKATECQHKLLKAK---DQGKPEVGEYAKLE---KINAEQQL--KIQELQEKLEKAvkasTEATE 191
Cdd:PRK04863   836 EAELRQLNRRRVELERALADHESQEQQQRsqlEQAKEGLSALNRLLprlNLLADETLadRVEEIREQLDEA----EEAKR 911

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  192 LLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRL-ETMERRENRLKDDIQTKSQQIQQMADKil 270
Cdd:PRK04863   912 FVQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALtEVVQRRAHFSYEDAAEMLAKNSDLNEK-- 989

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  271 eLEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDN-----QIKKDLAD--KETLENMMQRHEEEAHEKGKILSEQ-KAM 342
Cdd:PRK04863   990 -LRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASlkssyDAKRQMLQelKQELQDLGVPADSGAEERARARRDElHAR 1068

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2462529488  343 INAMDSKIRSLEQRIV----ELSEANKL--AANSSLFTQR 376
Cdd:PRK04863  1069 LSANRSRRNQLEKQLTfceaEMDNLTKKlrKLERDYHEMR 1108
PRK12704 PRK12704
phosphodiesterase; Provisional
 251-450 1.79e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.84  E-value: 1.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  251 LKDDIQTKSQQIQQMADKILEleEKHREAqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKET----LENMMQRHE 326
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILE--EAKKEA-------EAIKKEALLEAKEEIHKLRNEFEKELRERRNelqkLEKRLLQKE 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  327 EeahekgkilseqkaminAMDSKIRSLEQRIVELseanklaansslftqrnmkaqEEMISELRQQKFYLETQAGKLEAQN 406
Cdd:PRK12704    96 E-----------------NLDRKLELLEKREEEL---------------------EKKEKELEQKQQELEKKEEELEELI 137

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  407 RKLEEQLEKISHQDHSD-KNRLLE-LETRLRE-----VSLEHEEQKLELKR 450
Cdd:PRK12704   138 EEQLQELERISGLTAEEaKEILLEkVEEEARHeaavlIKEIEEEAKEEADK 188
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 20-184 1.84e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   20 LSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyQAQVEEMR 99
Cdd:COG1579     12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ--LGNVRNNK 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  100 lMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEyakLEKINAEQQLKIQELQEKL 179
Cdd:COG1579     90 -EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE---LDEELAELEAELEELEAER 165


                   ....*
gi 2462529488  180 EKAVK 184
Cdd:COG1579    166 EELAA 170
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 450-872 1.85e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.12  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  450 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 524
Cdd:PRK10929     2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  525 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTsQKQTmEALKt 593
Cdd:PRK10929    82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLP-QQQT-EARR- 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  594 tctMLEEQVMDLEALNDELLEKErqwEAWRSVLGDEKSQFECRVRELQrmldtekQSRARADQRITESRQVVELAVKEHk 673
Cdd:PRK10929   152 ---QLNEIERRLQTLGTPNTPLA---QAQLTALQAESAALKALVDELE-------LAQLSANNRQELARLRSELAKKRS- 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  674 AEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrLLEEQAklqQQMDL 741
Cdd:PRK10929   218 QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-ALNQQA---QRMDL 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  742 ----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKL 798
Cdd:PRK10929   284 iasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPQL 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  799 IDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTRielrsareEAAHR 872
Cdd:PRK10929   363 RQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN--------EATHR 429
C1_ScPKC1-like_rpt1 cd20822
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 934-987 1.89e-03

first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410372  Cd Length: 52  Bit Score: 37.65  E-value: 1.89e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  934 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20822      3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
21-322 2.04e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.21  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   21 SQKEVELKASE--TQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVE 96
Cdd:COG1340      9 SLEELEEKIEElrEEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEErdELNEKLN 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   97 EMRLMMNQLEEDLvsarrrsdlyeSELRESRLAAEEFKRkatecqhkllkakdqgkpevgEYAKLEK--------INAEQ 168
Cdd:COG1340     89 ELREELDELRKEL-----------AELNKAGGSIDKLRK---------------------EIERLEWrqqtevlsPEEEK 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  169 QL--KIQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLenkVKRLET 243
Cdd:COG1340    137 ELveKIKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADEL---RKEADE 213

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  244 MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhYEEKIKVLDNQIKKdlADKETLENMM 322
Cdd:COG1340    214 LHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEE--LEEKAEEIFEKLKK--GEKLTTEELK 288
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 522-702 2.13e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 42.71  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  522 ITDLEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 601
Cdd:pfam05667  337 LEELQEQLEDLESSIQELE----------KEIKKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDLLPDAEENIAKL 406

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  602 VMDLEALNDELLEKERQWEAWRSVLGDEksqfecrVRELqrmldtekqsRARADQRITESRQVVElAVKEHKAEIlalQQ 681
Cdd:pfam05667  407 QALVDASAQRLVELAGQWEKHRVPLIEE-------YRAL----------KEAKSNKEDESQRKLE-EIKELREKI---KE 465

                          170       180
                   ....*....|....*....|.
gi 2462529488  682 ALKEQKLKAESLSDKLNDLEK 702
Cdd:pfam05667  466 VAEEAKQKEELYKQLVAEYER 486
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
3-210 2.27e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 2.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ---------DLATYITECSS-----------------LKRSLE 56
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAEleaelerldassddlaaLEEQLE 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   57 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEM-------------------------RLMMNQLEEDL 109
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEEldELQDRLEAAedlarlelralleerfaaalgdaveRELRENLEERI 775

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  110 VSARRRSDLYESELREsrlAAEEFKRKATECQHKLlkakDQGKPEVGEY-AKLEKINAEqqlKIQELQEKLEKAVKASTE 188
Cdd:COG4913    776 DALRARLNRAEEELER---AMRAFNREWPAETADL----DADLESLPEYlALLDRLEED---GLPEYEERFKELLNENSI 845

                          250       260
                   ....*....|....*....|....
gi 2462529488  189 A--TELLQNIRQAKERAERELEKL 210
Cdd:COG4913    846 EfvADLLSKLRRAIREIKERIDPL 869
PLN02939 PLN02939
transferase, transferring glycosyl groups
 197-471 2.45e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 42.58  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  197 RQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRlETMERRENRLKDDIQTKSQQIQQmADKILELEEKH 276
Cdd:PLN02939    38 RRRGFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLR-TVMELPQKSTSSDDDHNRASMQR-DEAIAAIDNEQ 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  277 RE-----AQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKEtlenmmqrheeeahekgKILSEQKAMinamDSKIR 351
Cdd:PLN02939   116 QTnskdgEQLSDFQLE-DLVGMIQNAEKNILLLNQARLQALEDLE-----------------KILTEKEAL----QGKIN 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  352 SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAqnrkLEEQLEKISHQDHSDKNRLLELE 431
Cdd:PLN02939   174 ILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIR---GATEGLCVHS----LSKELDVLKEENMLLKDDIQFLK 246

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2462529488  432 TRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQA 471
Cdd:PLN02939   247 AELIEVA-ETEERVFKLEKERSLLDASLRELESKFIVAQE 285
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 4-283 2.58e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.63  E-value: 2.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    4 QEMTRLHRRVSE------VEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQ-----------ED 66
Cdd:COG3096    809 QKLQRLHQAFSQfvgghlAVAFAPDPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLlnkllpqanllAD 888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   67 DKALQLLHDIREQSRKLQEIKE--QEYQAQVEEMrlmmnqleEDLVSARRRSDLYESELRESRLAAEEfKRKATECQHKL 144
Cdd:COG3096    889 ETLADRLEELREELDAAQEAQAfiQQHGKALAQL--------EPLVAVLQSDPEQFEQLQADYLQAKE-QQRRLKQQIFA 959

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  145 LKAKDQGKPEVGeYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNI-----------------RQAKER----A 203
Cdd:COG3096    960 LSEVVQRRPHFS-YEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAqaqysqynqvlaslkssRDAKQQtlqeL 1038

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  204 ERELEKLQNREDSSEGIRkklveAEERRHSLENKVKRLETmerRENRLKDDIQTKSQQIQQMADKILELEEKH---REAQ 280
Cdd:COG3096   1039 EQELEELGVQADAEAEER-----ARIRRDELHEELSQNRS---RRSQLEKQLTRCEAEMDSLQKRLRKAERDYkqeREQV 1110


                   ...
gi 2462529488  281 VSA 283
Cdd:COG3096   1111 VQA 1113
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 459-615 2.70e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 40.69  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  459 LQERESQLTALQAA-RAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTvitDLEEQLNQLTEDNA 537
Cdd:pfam08614   12 LLDRTALLEAENAKlQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRG---ELAQRLVDLNEELQ 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529488  538 ELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEK 615
Cdd:pfam08614   89 ELEKKLREDERRLAALE---AERAQLEEKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENRELVER 163
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 63-324 2.74e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.73  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   63 SQEDDKALQLL-HDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARR---RSDLYESELRESRLAAEEFKRKAT 138
Cdd:TIGR01612 1445 ADENNENVLLLfKNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGckdEADKNAKAIEKNKELFEQYKKDVT 1524

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  139 ECQHKL----LKAK-DQGKP-------EVGEYAK---LEKINAEQQL-KIQELQEKLEKAVKASTEATELLQNIRQAKER 202
Cdd:TIGR01612 1525 ELLNKYsalaIKNKfAKTKKdseiiikEIKDAHKkfiLEAEKSEQKIkEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLEN 1604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  203 AERELEKLQNredssegIRKKLVEAEERRHSLENKVK---------RLETMERRENRLKDDIQTKSQQIQQMADKILELE 273
Cdd:TIGR01612 1605 FENKFLKISD-------IKKKINDCLKETESIEKKISsfsidsqdtELKENGDNLNSLQEFLESLKDQKKNIEDKKKELD 1677

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462529488  274 EKHREaqvsAQHLEVHLKQKEQHYE----EKIKVLDNQIKKDL-ADKETLENMMQR 324
Cdd:TIGR01612 1678 ELDSE----IEKIEIDVDQHKKNYEigiiEKIKEIAIANKEEIeSIKELIEPTIEN 1729
PRK12704 PRK12704
phosphodiesterase; Provisional
 654-790 2.79e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  654 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 733
Cdd:PRK12704    62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  734 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 790
Cdd:PRK12704   139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
50-256 3.11e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   50 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQL--------EEDLVSARRRSDLYES 121
Cdd:COG4717    320 ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlaeagvedEEELRAALEQAEEYQE 399

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  122 ELRESRLAAEEFKRKATECQHKLlkakdqgkpevgEYAKLEKINAEqqlkIQELQEKLEkavkastEATELLQNIRQAKE 201
Cdd:COG4717    400 LKEELEELEEQLEELLGELEELL------------EALDEEELEEE----LEELEEELE-------ELEEELEELREELA 456

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462529488  202 RAERELEKLQNREDSSEgIRKKLVEAEERRHSLENKVKRL----ETMERRENRLKDDIQ 256
Cdd:COG4717    457 ELEAELEQLEEDGELAE-LLQELEELKAELRELAEEWAALklalELLEEAREEYREERL 514
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 57-434 3.57e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.08  E-value: 3.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   57 QARME--VSQEDDKAlQLLHDIrEQSRKLQEikeqeyqAQVEEMRLMMNQLEEDLVS---ARRRSDL--------YESEL 123
Cdd:pfam01576  663 RAEMEdlVSSKDDVG-KNVHEL-ERSKRALE-------QQVEEMKTQLEELEDELQAtedAKLRLEVnmqalkaqFERDL 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  124 RESRLAAEEFKR----KATECQHKLLKAKDQGKPEVGEYAKLEkinaeqqLKIQELQEKLEKAVKASTEATELLQNIRQA 199
Cdd:pfam01576  734 QARDEQGEEKRRqlvkQVRELEAELEDERKQRAQAVAAKKKLE-------LDLKELEAQIDAANKGREEAVKQLKKLQAQ 806

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  200 KERAERELEKLQNredSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQ---------------- 263
Cdd:pfam01576  807 MKDLQRELEEARA---SRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELAdeiasgasgksalqde 883

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  264 --QMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKETLENMMQRHEEEAHE--------KG 333
Cdd:pfam01576  884 krRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQ----LTTELAAERSTSQKSESARQQLERQNKElkaklqemEG 959

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  334 KILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMI--------------------SELRQQKF 393
Cdd:pfam01576  960 TVKSKFKSSIAALEAKIAQLEEQLEQ--ESRERQAANKLVRRTEKKLKEVLLqvederrhadqykdqaekgnSRMKQLKR 1037

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2462529488  394 YL---ETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 434
Cdd:pfam01576 1038 QLeeaEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 172-299 3.68e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.12  E-value: 3.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  172 IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDssegirKKLVEAEERrhsLENKVKrlETMERRENRL 251
Cdd:PRK00409   522 IASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEED------KLLEEAEKE---AQQAIK--EAKKEADEII 590

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462529488  252 KDDIQTKSQQIQQMADKilELEEKHREAQVSAQHLEVHLKQKEQHYEE 299
Cdd:PRK00409   591 KELRQLQKGGYASVKAH--ELIEARKRLNKANEKKEKKKKKQKEKQEE 636
mukB PRK04863
chromosome partition protein MukB;
552-872 3.74e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 3.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  552 EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEeqvMDLEALNDEL---LEKERQWEAWRSVLGD 628
Cdd:PRK04863   280 ERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLE---QDYQAASDHLnlvQTALRQQEKIERYQAD 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  629 eksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELA---VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHA 705
Cdd:PRK04863   357 --------LEELEERLEEQNEVVEEADEQQEENEARAEAAeeeVDELKSQLADYQQALDVQQTRAIQYQQAVQALERAKQ 428

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  706 ML---EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ------------EALDRADLLKTERSDL 770
Cdd:PRK04863   429 LCglpDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQlvrkiagevsrsEAWDVARELLRRLREQ 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  771 EYQLENIQVLYSHEKvKMEGTISQQTKLIDFLQAkmdqpAKKKkglFSRRKEDPALPTQVPLQYNELKLALEKEKARCAE 850
Cdd:PRK04863   509 RHLAEQLQQLRMRLS-ELEQRLRQQQRAERLLAE-----FCKR---LGKNLDDEDELEQLQEELEARLESLSESVSEARE 579

                          330       340
                   ....*....|....*....|..
gi 2462529488  851 LEEALQKTRIELRSAREEAAHR 872
Cdd:PRK04863   580 RRMALRQQLEQLQARIQRLAAR 601
PRK12704 PRK12704
phosphodiesterase; Provisional
 52-210 3.82e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 3.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   52 KRSLEQARMEVSQEDDKAL----QLLHDIREQ-----SRKLQEIKEQEYQAQVEEMRLmmNQLEEDLVSARRRSDLYESE 122
Cdd:PRK12704    41 KRILEEAKKEAEAIKKEALleakEEIHKLRNEfekelRERRNELQKLEKRLLQKEENL--DRKLELLEKREEELEKKEKE 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  123 LRESRlaaEEFKRKATECQHKLLKAKDqgkpevgeyaKLEKI---NAEQqlKIQELQEKLEKavKASTEATELLQNI-RQ 198
Cdd:PRK12704   119 LEQKQ---QELEKKEEELEELIEEQLQ----------ELERIsglTAEE--AKEILLEKVEE--EARHEAAVLIKEIeEE 181

                          170
                   ....*....|..
gi 2462529488  199 AKERAERELEKL 210
Cdd:PRK12704   182 AKEEADKKAKEI 193
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 163-310 3.85e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 40.27  E-value: 3.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  163 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRedsSEGIRKKLVEAEERRHSLENKVKRLE 242
Cdd:pfam13851   19 DITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEE---VEELRKQLENYEKDKQSLKNLKARLK 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  243 TMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhLEVHLKQKEQHY--EEKIKVLDNQIKK 310
Cdd:pfam13851   96 VLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAI-----QDVQQKTGLKNLllEKKLQALGETLEK 160
C1_TNS2 cd20887
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ...
 938-990 4.22e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410437  Cd Length: 53  Bit Score: 37.07  E-value: 4.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  938 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20887      2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
mukB PRK04863
chromosome partition protein MukB;
324-737 4.39e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.87  E-value: 4.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  324 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 399
Cdd:PRK04863   276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  400 GKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESq 479
Cdd:PRK04863   355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALER- 425

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  480 LRQAKTELEETTAEAEEEIQALTAHRDEIQrkfDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLdeasgaNDE 559
Cdd:PRK04863   426 AKQLCGLPDLTADNAEDWLEEFQAKEQEAT---EELL-------SLEQKLS-VAQAAHSQFEQAYQLVRKI------AGE 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  560 IVqlRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE---EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECR 636
Cdd:PRK04863   489 VS--RSEAWDVARELLRRLREQRHLAEQLQQLRMRLSELEqrlRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEAR 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  637 VRELqrmldteKQSRARADQRITESRQVVElavkEHKAEIlalqQALKEQKLKAESLSDKLNDL-EKKHAMLEMNAR--- 712
Cdd:PRK04863   567 LESL-------SESVSEARERRMALRQQLE----QLQARI----QRLAARAPAWLAAQDALARLrEQSGEEFEDSQDvte 631

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2462529488  713 SLQQKLETEREL----------KQRLLEEQAKLQQ 737
Cdd:PRK04863   632 YMQQLLERERELtverdelaarKQALDEEIERLSQ 666
C1_PKD_rpt2 cd20796
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ...
 938-987 4.41e-03

second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410346  Cd Length: 54  Bit Score: 36.88  E-value: 4.41e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  938 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20796      1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 562-882 4.98e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 4.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  562 QLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ---VMDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVR 638
Cdd:pfam17380  300 RLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQermAMERERELERIRQEERKRELER-IRQEEIAMEISRMR 378

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  639 ELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNARSLQ-QK 717
Cdd:pfam17380  379 ELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEARQREvRR 439

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  718 LETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKVKMEGTIS 793
Cdd:pfam17380  440 LEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEERKQAMIE 510

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  794 QQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIELRSAREEA 869
Cdd:pfam17380  511 EERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMMRQIVESE 585

                          330
                   ....*....|...
gi 2462529488  870 AHRKATDHPHPST 882
Cdd:pfam17380  586 KARAEYEATTPIT 598
PRK12705 PRK12705
hypothetical protein; Provisional
 158-294 4.99e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 41.23  E-value: 4.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  158 YAKLEKINAEQQLKIQELQEKLEKAVKASTEAT--ELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PRK12705    32 AKEAERILQEAQKEAEEKLEAALLEAKELLLRErnQQRQEARREREELQREEERLVQKEEQLDARAEKLDNLENQLEERE 111

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462529488  236 NKVK-----RLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ-VSAQHLEVHLKQKE 294
Cdd:PRK12705   112 KALSareleLEELEKQLDNELYRVAGLTPEQARKLLLKLLDAELEEEKAQrVKKIEEEADLEAER 176
pepcterm_ChnLen TIGR03007
polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this ...
 563-742 5.05e-03

polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this protein family belong to the family of polysaccharide chain length determinant proteins (pfam02706). All are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria, and are found near the epsH homolog that is the putative exosortase gene. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274386 [Multi-domain]  Cd Length: 498  Bit Score: 41.19  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE-----EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRV 637
Cdd:TIGR03007  202 YYSEISEAQEELEAARLELNEAIAQRDALKRQLGGEEpvllaGSSVANSELDGRIEALEKQLDALRLRYTDKHPDVI-AT 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  638 RELQRMLDTEKQSRARADQRITESR-------QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmn 710
Cdd:TIGR03007  281 KREIAQLEEQKEEEGSAKNGGPERGeianpvyQQLQIELAEAEAEIASLEARVAELTARIERLESLLRTIPEVEAELT-- 358

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2462529488  711 arSLQQKLETERELKQRLLE--EQAKLQQQMDLQ 742
Cdd:TIGR03007  359 --QLNRDYEVNKSNYEQLLTrrESAEVSKQMEVQ 390
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 298-480 5.33e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 5.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  298 EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRivelseanklaanssLFTQRN 377
Cdd:COG1579     23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---------------LGNVRN 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  378 MKAQEEMISELRqqkfYLETQAGKLEAQNRKLEEQLEkishqdhsdknrllELETRLREVSLEHEEQKLELKRQLTELQL 457
Cdd:COG1579     88 NKEYEALQKEIE----SLKRRISDLEDEILELMERIE--------------ELEEELAELEAELAELEAELEEKKAELDE 149

                          170       180
                   ....*....|....*....|...
gi 2462529488  458 SLQERESQLTALQAARAALESQL 480
Cdd:COG1579    150 ELAELEAELEELEAEREELAAKI 172
PRK11281 PRK11281
mechanosensitive channel MscK;
159-606 5.55e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 5.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  159 AKLEKIN------AEQQLKIQELQEKLE---KAVKASTEATELLQNIRQAKER---AERELEKLQNREDSSEGIR-KKL- 224
Cdd:PRK11281    43 AQLDALNkqklleAEDKLVQQDLEQTLAlldKIDRQKEETEQLKQQLAQAPAKlrqAQAELEALKDDNDEETRETlSTLs 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  225 ---VEA--EERRHSLENKVKRLETM-----------ERRENRLkDDIQTKSQQIQQMADKILELEEKHREAQVSaqhlev 288
Cdd:PRK11281   123 lrqLESrlAQTLDQLQNAQNDLAEYnsqlvslqtqpERAQAAL-YANSQRLQQIRNLLKGGKVGGKALRPSQRV------ 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  289 hLKQKEQHYeekikvLDNQI---KKDLADKETLENMMQRHEEEAHEKgkilseqkaminamdskIRSLEQRIVELSEAnk 365
Cdd:PRK11281   196 -LLQAEQAL------LNAQNdlqRKSLEGNTQLQDLLQKQRDYLTAR-----------------IQRLEHQLQLLQEA-- 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  366 laansslFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ----NRKLEEqlekishqdhsdknRLLELETRLREVSleh 441
Cdd:PRK11281   250 -------INSKRLTLSEKTVQEAQSQDEAARIQANPLVAQeleiNLQLSQ--------------RLLKATEKLNTLT--- 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  442 eEQKLELKRQLTELQLSLQERESQLTALQA----ARAALESQ--LRQAKteleeTTAEAEEEIQALTAHRDEIQRKFDAL 515
Cdd:PRK11281   306 -QQNLRVKNWLDRLTQSERNIKEQISVLKGslllSRILYQQQqaLPSAD-----LIEGLADRIADLRLEQFEINQQRDAL 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  516 RNSCTVITDLEEqlNQLTEDNAELNNQnfyLSKQLDEASGANDEIV-QLRSEvdhLRREITereMQLTsQKQTM---EAL 591
Cdd:PRK11281   380 FQPDAYIDKLEA--GHKSEVTDEVRDA---LLQLLDERRELLDQLNkQLNNQ---LNLAIN---LQLN-QQQLLsvsDSL 447

                          490       500
                   ....*....|....*....|...
gi 2462529488  592 KTTctmLEEQV--------MDLE 606
Cdd:PRK11281   448 QST---LTQQIfwvnsnkpMDLD 467
PRK12704 PRK12704
phosphodiesterase; Provisional
 670-797 5.57e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 5.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  670 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 746
Cdd:PRK12704    32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462529488  747 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 797
Cdd:PRK12704   103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
424-787 5.87e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 5.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  424 KNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTA 503
Cdd:COG4372     12 RLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLE-------EELEE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  504 HRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTS 583
Cdd:COG4372     85 LNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ---LEAQIAELQSEIAEREEELKELEEQLES 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  584 QKQTMEALKTTCTMLEEQVMDlEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 663
Cdd:COG4372    162 LQEELAALEQELQALSEAEAE-QALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  664 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 743
Cdd:COG4372    241 ALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALEL-EALEEAALELKLLALLLNLAALSLIGALEDALLA 319

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 2462529488  744 NHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK 787
Cdd:COG4372    320 ALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGA 363
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 171-755 6.32e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 41.28  E-value: 6.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  171 KIQELQeKLEKAVKASTEaTELLQNIRQakERAERELEKLQNREDS----SEGIRKKLVEAEERRHSLEN-KVKRLETME 245
Cdd:pfam07111   71 QLQELR-RLEEEVRLLRE-TSLQQKMRL--EAQAMELDALAVAEKAgqaeAEGLRAALAGAEMVRKNLEEgSQRELEEIQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  246 R-RENRLKDDIQTKSQQIQQMADKILELE------EKHR--------EAQVSAQHLEVHLKQKEQHYEEKIKVLDNqIKK 310
Cdd:pfam07111  147 RlHQEQLSSLTQAHEEALSSLTSKAEGLEkslnslETKRageakqlaEAQKEAELLRKQLSKTQEELEAQVTLVES-LRK 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  311 DLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISELRQ 390
Cdd:pfam07111  226 YVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRKIQ 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  391 QKFYLETQAGKleaqnrkleeqleKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTE--------------LQ 456
Cdd:pfam07111  292 PSDSLEPEFPK-------------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAElqeqvtsqsqeqaiLQ 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  457 LSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN 536
Cdd:pfam07111  359 RALQDKAAEVEVERMSAKGLQMELSRAQEARRRQQ-------QQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARI 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  537 AELNNQNFYLSKQLDEASG---ANDEIVQLRSEVDHLRREITEREMQLTSQkqtMEALKTTCTMLEEQV-MDLEALNDEL 612
Cdd:pfam07111  432 PSLSNRLSYAVRKVHTIKGlmaRKVALAQLRQESCPPPPPAPPVDADLSLE---LEQLREERNRLDAELqLSAHLIQQEV 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  613 LEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 692
Cdd:pfam07111  509 GRAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVET 588

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  693 -----LSD---KLNDLEKKHAMLEMNARSLQQKLETERELKQRL--LEEQAKLQQQMdlqknhifRLTQGLQE 755
Cdd:pfam07111  589 rlreqLSDtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQELrrLQDEARKEEGQ--------RLARRVQE 653
Caldesmon pfam02029
Caldesmon;
3-338 6.72e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.01  E-value: 6.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    3 EQEMTRlHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYiTECSSLKRSleqarMEVSQEDDKALQLLHDIREQSRK 82
Cdd:pfam02029    4 EEEAAR-ERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSY-EEDSELKPS-----GQGGLDEEEAFLDRTAKREERRQ 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   83 LQEIKEQEYQAQVEE--------MRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQ---HKLLKAKDQG 151
Cdd:pfam02029   77 KRLQEALERQKEFDPtiadekesVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENkwsTEVRQAEEEG 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  152 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIR----QAKERAERELEKLQNREDSSEGIRKKLVEA 227
Cdd:pfam02029  157 EEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRghpeVKSQNGEEEVTKLKVTTKRRQGGLSQSQER 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  228 EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMAdkILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldnQ 307
Cdd:pfam02029  237 EEEAEVFLEAEQKLEELRRRRQEKESEEFEKLRQKQQEA--ELELEELKKKREERRKLLEEEEQRRKQEEAER------K 308

                          330       340       350
                   ....*....|....*....|....*....|.
gi 2462529488  308 IKKDlADKETLENMMQRHEEEAHEKGKILSE 338
Cdd:pfam02029  309 LREE-EEKRRMKEEIERRRAEAAEKRQKLPE 338
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 1-251 6.82e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 40.83  E-value: 6.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    1 MMEQEMTRLHRRVSEvEAVLSQK-EVELKASETQRSLLEQDLATYITECSSLKRSLEQAR-MEVSQEDDKALQLLH---- 74
Cdd:pfam05622  187 TYKRQVQELHGKLSE-ESKKADKlEFEYKKLEEKLEALQKEKERLIIERDTLRETNEELRcAQLQQAELSQADALLspss 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   75 -------------DIREQSRKLQ--------------EIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESR 127
Cdd:pfam05622  266 dpgdnlaaeimpaEIREKLIRLQhenkmlrlgqegsyRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQ 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  128 LAAEE----------FKRKATECQHKLLKAKDQGKPEVGEYAKLE-KINAEQQLKIQELQEKLEKAVkasteatellQNI 196
Cdd:pfam05622  346 KALQEqgskaedsslLKQKLEEHLEKLHEAQSELQKKKEQIEELEpKQDSNLAQKIDELQEALRKKD----------EDM 415

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462529488  197 RQAKERAERELEKL----------QNREDSSE--GIRKKLVEAEERRHSLENKVKRLETMERRENRL 251
Cdd:pfam05622  416 KAMEERYKKYVEKAksviktldpkQNPASPPEiqALKNQLLEKDKKIEHLERDFEKSKLQREQEEKL 482
C1_Munc13 cd20807
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ...
 939-987 6.87e-03

protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410357  Cd Length: 53  Bit Score: 36.30  E-value: 6.87e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462529488  939 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20807      1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
571-712 7.06e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.00  E-value: 7.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  571 RREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEalnDELLEKERqweawrsvlgdeksqfecRVRELQRMLDTEKQS 650
Cdd:COG2433    398 EREKEHEERELTEEEEEIRRLEEQVERLEAEVEELE---AELEEKDE------------------RIERLERELSEARSE 456

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  651 RARadqRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDLeKKHAMLEMNAR 712
Cdd:COG2433    457 ERR---EIRKDREISRL-----DREIERLERELEEERERIEELKRKLERL-KELWKLEHSGE 509
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 374-581 7.17e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.50  E-value: 7.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  374 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKR 450
Cdd:pfam15619    2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  451 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 530
Cdd:pfam15619   82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462529488  531 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 581
Cdd:pfam15619  141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 95-235 8.29e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.97  E-value: 8.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   95 VEEMRLMMNQLEEDLvsarrrSDLYESeLRESRLAAEEfkrKATECQHKLLKAKDQgKPEVGEyaKLEKINAEQQLKIQE 174
Cdd:PRK00409   504 IEEAKKLIGEDKEKL------NELIAS-LEELERELEQ---KAEEAEALLKEAEKL-KEELEE--KKEKLQEEEDKLLEE 570

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529488  175 LQEKLEKAVKAST-EATELLQNIR-----QAKERAEREL-EKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PRK00409   571 AEKEAQQAIKEAKkEADEIIKELRqlqkgGYASVKAHELiEARKRLNKANEKKEKKKKKQKEKQEELK 638
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 157-451 8.54e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 8.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNirQAKERAERELEKLQNREDSSEGIRKKL--VEAEERRHSL 234
Cdd:pfam13868   42 ERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEE--QIEEREQKRQEEYEEKLQEREQMDEIVerIQEEDQAEAE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  235 ENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLAD 314
Cdd:pfam13868  120 EKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDE 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  315 KETLENMMQR-----HEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnKLAANSSLFTQRNMKAQEEMISELR 389
Cdd:pfam13868  200 KAERDELRAKlyqeeQERKERQKEREEAEKKARQRQELQQAREEQIELKERRLA-EEAEREEEEFERMLRKQAEDEEIEQ 278

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462529488  390 QQKfylETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREvSLEHEEQKLELKRQ 451
Cdd:pfam13868  279 EEA---EKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLRE-EEAERRERIEEERQ 336
Filament pfam00038
Intermediate filament protein;
423-740 9.11e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 40.29  E-value: 9.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  423 DKNRLLELETRLREVSL-EHEEQKLELKRQLTEL-QLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqa 500
Cdd:pfam00038   18 DKVRFLEQQNKLLETKIsELRQKKGAEPSRLYSLyEKEIEDLRRQLDTLTVERARLQLELDNL----------------- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  501 ltahRDEIQRkfdaLRNSctvitdLEEQLNQLTEDNAELNNqnfyLSKQLDEASGANDE----IVQLRSEVDHLRR---- 572
Cdd:pfam00038   81 ----RLAAED----FRQK------YEDELNLRTSAENDLVG----LRKDLDEATLARVDleakIESLKEELAFLKKnhee 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  573 EITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQweawrsvlgDEKSQFECRVRELQRMLDTEKQSRA 652
Cdd:pfam00038  143 EVRELQAQVSDTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNRE---------EAEEWYQSKLEELQQAAARNGDALR 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  653 RADQRITESRQVVElavkehkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE-RELKQRLLEE 731
Cdd:pfam00038  214 SAKEEITELRRTIQ-----------SLEIELQSLKKQKASLERQLAETEERYELQLADYQELISELEAElQETRQEMARQ 282


                   ....*....
gi 2462529488  732 QAKLQQQMD 740
Cdd:pfam00038  283 LREYQELLN 291
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1-300 9.89e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 40.66  E-value: 9.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488    1 MMEQEMTRLHRRVSEVEAVLSQKEVELKA----------------SETQRSLLEQDLATyITECSSLKRSLEQARMevsq 64
Cdd:pfam15964  389 ALRKEMKKEREELGATMLALSQNVAQLEAqvekvtreknslvsqlEEAQKQLASQEMDV-TKVCGEMRYQLNQTKM---- 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488   65 EDDKALQLLHDIREQSRKLQEIKEQEyqaqVEEMRLMMNQLEEDLVSARRRsdlyESELRESRLAAEEFKRKATECQHKL 144
Cdd:pfam15964  464 KKDEAEKEHREYRTKTGRQLEIKDQE----IEKLGLELSESKQRLEQAQQD----AARAREECLKLTELLGESEHQLHLT 535

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  145 LKAKDQGKPEVGEYAKLEKINAEQ--QLKIQELQEKLEKAVKASTEATELL--QN--IRQAKERAERELEKLQNREDSSE 218
Cdd:pfam15964  536 RLEKESIQQSFSNEAKAQALQAQQreQELTQKMQQMEAQHDKTVNEQYSLLtsQNtfIAKLKEECCTLAKKLEEITQKSR 615

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529488  219 GIRKKLveAEERRHSLEnkvkRLETMERRENRLKDDIQTKSQQIQQMADKILELEekhREAQVSAQHLEVHLKQKEQHYE 298
Cdd:pfam15964  616 SEVEQL--SQEKEYLQD----RLEKLQKRNEELEEQCVQHGRMHERMKQRLRQLD---KHCQATAQQLVQLLSKQNQLFK 686


                   ..
gi 2462529488  299 EK 300
Cdd:pfam15964  687 ER 688
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH