NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462532832|ref|XP_054228443|]
View 

stabilin-2 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 1331-1423 2.50e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


:

Pssm-ID: 239592  Cd Length: 93  Bit Score: 178.43  E-value: 2.50e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1410
Cdd:cd03515      1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                           90
                   ....*....|...
gi 2462532832 1411 RPNKSEMWDVFCY 1423
Cdd:cd03515     81 RLNLSERWDAYCY 93
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 142-262 9.16e-28

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 109.65  E-value: 9.16e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  142 IFNRWINNASLQPTLSAT-SNLTVLVPSQQATEDMDQDEKSFWLSQSN-IPALIKYHMLLGTYRVADLQTLSSsdmlATS 219
Cdd:pfam02469    5 TFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLLKDKEqLKNLLKYHVVPGRLTSSDLKNGGT----LAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462532832  220 LQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 262
Cdd:pfam02469   81 LQGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 750-859 3.14e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  750 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 825
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2462532832  826 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 859
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 885-1015 3.17e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  885 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 964
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462532832  965 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 1015
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 281-398 3.06e-22

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 93.86  E-value: 3.06e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  281 PDYSIFRGYIIQYNLANAIEAADA-YTVFAPNNNAIENYIRE-----KKVLSLEEDVLRYHVVlEEKLLKNDLHNGMHRE 354
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKLPAGtlnflLKDKEQLKNLLKYHVV-PGRLTSSDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2462532832  355 TMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 398
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1489-1582 1.47e-14

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


:

Pssm-ID: 214719  Cd Length: 97  Bit Score: 70.85  E-value: 1.47e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  1489 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRVGSKLLITASQDPlqptETRFVDGR 1558
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 2462532832  1559 AILQWDIFASNGIIHVISRPLKAP 1582
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 608-644 4.69e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  608 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 644
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1260-1297 1.64e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.75  E-value: 1.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462532832 1260 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 1297
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 692-728 3.56e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.98  E-value: 3.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  692 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 728
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-686 9.88e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 9.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  650 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 686
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1219-1254 2.51e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.59  E-value: 2.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462532832 1219 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 1254
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 90-126 1.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832   90 CLEQTGKCHPLASCQSTSSGVwSCVCQEGYEGDGFLC 126
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 570-602 2.84e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 2.84e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462532832  570 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 602
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 9-41 4.09e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462532832    9 PGGCSRNAECIKTGtGTHTCVCQQGWTGNGRDC 41
Cdd:pfam12947    5 NGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 53-84 9.71e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.35  E-value: 9.71e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462532832   53 GGCHDNASCLYVgPGQNECECKKGFRGNGIDC 84
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 1331-1423 2.50e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 178.43  E-value: 2.50e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1410
Cdd:cd03515      1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                           90
                   ....*....|...
gi 2462532832 1411 RPNKSEMWDVFCY 1423
Cdd:cd03515     81 RLNLSERWDAYCY 93
Xlink pfam00193
Extracellular link domain;
1331-1423 1.62e-37

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 136.16  E-value: 1.62e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1410
Cdd:pfam00193    1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 2462532832 1411 RPNKSEMWDVFCY 1423
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 142-262 9.16e-28

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 109.65  E-value: 9.16e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  142 IFNRWINNASLQPTLSAT-SNLTVLVPSQQATEDMDQDEKSFWLSQSN-IPALIKYHMLLGTYRVADLQTLSSsdmlATS 219
Cdd:pfam02469    5 TFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLLKDKEqLKNLLKYHVVPGRLTSSDLKNGGT----LAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462532832  220 LQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 262
Cdd:pfam02469   81 LQGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 750-859 3.14e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  750 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 825
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2462532832  826 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 859
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 885-1015 3.17e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  885 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 964
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462532832  965 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 1015
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
LINK smart00445
Link (Hyaluronan-binding);
1331-1424 6.65e-27

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 105.89  E-value: 6.65e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  1331 GVFHLRsPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGp 1410
Cdd:smart00445    3 GVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQYG- 80

                            90
                    ....*....|....
gi 2462532832  1411 RPNKSEMWDVFCYR 1424
Cdd:smart00445   81 FPDPTSRYDAYCFN 94
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 754-859 6.91e-24

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 99.98  E-value: 6.91e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  754 VKDLVGPGPFTVFAPLSAAFDE--EARVKDWDK---YGLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQS 828
Cdd:COG2335     56 VDTLSGEGPFTVFAPTDAAFAAlpAGTLDALLKpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGG 134

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462532832  829 TVYINNkAKIISSDIISTNGIVHIIDKLLSP 859
Cdd:COG2335    135 GVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
764-860 2.12e-22

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 93.20  E-value: 2.12e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   764 TVFAPLSAAFDE-EARVKDWDKYgLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQ--STVYINNkAKIIS 840
Cdd:smart00554    1 TVFAPTDEAFQKlPPDLNSLLAD-KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVE 77

                            90       100
                    ....*....|....*....|
gi 2462532832   841 SDIISTNGIVHIIDKLLSPK 860
Cdd:smart00554   78 ADIAATNGVVHVIDRVLLPP 97
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 281-398 3.06e-22

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 93.86  E-value: 3.06e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  281 PDYSIFRGYIIQYNLANAIEAADA-YTVFAPNNNAIENYIRE-----KKVLSLEEDVLRYHVVlEEKLLKNDLHNGMHRE 354
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKLPAGtlnflLKDKEQLKNLLKYHVV-PGRLTSSDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2462532832  355 TMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 398
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 133-262 3.61e-21

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 91.89  E-value: 3.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  133 ELSFLSEAaifnrwINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPAL---IKYHMLLGTYRVADLQT 209
Cdd:COG2335     42 DFSTLVAA------LKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPENKATLtkiLTYHVVPGKVTAADLKD 115

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462532832  210 LSSsdmlATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 262
Cdd:COG2335    116 GKT----LTTLQGQTLTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
911-1017 2.65e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.64  E-value: 2.65e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   911 TLFWPTDQALHALPAEQQDFLfnqdnKDKLKEYLKFHVIRDaKVLAVDLPTSTAWKTLQGSELSVKCgaGRDIGDLFLNG 990
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR--SGGSGTVTVNG 72

                            90       100
                    ....*....|....*....|....*..
gi 2462532832   991 QtcRIVQRELLFDLGVAYGIDCLLIDP 1017
Cdd:smart00554   73 A--RIVEADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 875-1015 1.56e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.79  E-value: 1.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  875 QNLTTLATNNGyiKFSNL---IQDSGLLSVITDPihTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIrD 951
Cdd:COG2335     31 KNIVETAANNP--DFSTLvaaLKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVV-P 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462532832  952 AKVLAVDLPTSTAWKTLQGSELSVKcgagRDIGDLFLNGQTcrIVQRELLFDLGVAYGIDCLLI 1015
Cdd:COG2335    106 GKVTAADLKDGKTLTTLQGQTLTVT----VSGGGVTVNGAN--VITADIEASNGVIHVIDKVLL 163
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
163-262 9.65e-16

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 74.32  E-value: 9.65e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   163 TVLVPSQQATEDMDQDEKSFWLSQsnIPALIKYHMLLGTYRVADLQtlssSDMLATSLQGN--FLHLAKVDGNITIEGAS 240
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADK--LKNLLLYHVVPGRLSSADLL----NGGTLPTLAGSklRITRSGGSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|..
gi 2462532832   241 IVDGDNAATNGVIHIINKVLVP 262
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLP 96
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 271-398 1.73e-15

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 75.71  E-value: 1.73e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  271 PNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIrEKKVLSLEED--------VLRYHVVlEEKL 342
Cdd:COG2335     31 KNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALP-AGTLDALLKPenkatltkILTYHVV-PGKV 108

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462532832  343 LKNDLHNGMHRETMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 398
Cdd:COG2335    109 TAADLKDGKTLTTLQGQT--LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVL 162
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1489-1582 1.47e-14

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 70.85  E-value: 1.47e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  1489 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRVGSKLLITASQDPlqptETRFVDGR 1558
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 2462532832  1559 AILQWDIFASNGIIHVISRPLKAP 1582
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
306-398 7.49e-12

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 63.15  E-value: 7.49e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   306 TVFAPNNNAIENYIREKKVLSLE--EDVLRYHVVlEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTN 383
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADklKNLLLYHVV-PGRLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 2462532832   384 VATDKGVIHGLGKVL 398
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 608-644 4.69e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  608 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 644
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1260-1297 1.64e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.75  E-value: 1.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462532832 1260 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 1297
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1489-1579 3.40e-07

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 50.71  E-value: 3.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1489 TLFVPQNSGLGE------NETLSGRD-----IEHHLANvSMFFYNDLVNGTTLQTRVGSKLLITASQDPLqptetrFVDG 1557
Cdd:pfam02469   27 TVFAPTNEAFAKlpagtlNFLLKDKEqlknlLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVTGGSV------TVNG 99

                           90       100
                   ....*....|....*....|..
gi 2462532832 1558 RAILQWDIFASNGIIHVISRPL 1579
Cdd:pfam02469  100 ARVVQADIEATNGVIHVIDKVL 121
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 692-728 3.56e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.98  E-value: 3.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  692 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 728
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1428-1579 6.19e-06

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 47.98  E-value: 6.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1428 VNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNfLTEVLAYSNssargraflehLTD-LSIRG--TLFVPQNS-----GLG 1499
Cdd:COG2335     14 AACASSAAAEGAAMAPTKNIVETAANNPDFST-LVAALKAAG-----------LVDtLSGEGpfTVFAPTDAafaalPAG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1500 ENETLSG-------RDI-EHHLANvSMFFYNDLVNGTTLQTRVGSKLLITASQDPLQptetrfVDGRAILQWDIFASNGI 1571
Cdd:COG2335     82 TLDALLKpenkatlTKIlTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT------VNGANVITADIEASNGV 154


                   ....*...
gi 2462532832 1572 IHVISRPL 1579
Cdd:COG2335    155 IHVIDKVL 162
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-686 9.88e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 9.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  650 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 686
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1219-1254 2.51e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.59  E-value: 2.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462532832 1219 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 1254
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 90-126 1.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832   90 CLEQTGKCHPLASCQSTSSGVwSCVCQEGYEGDGFLC 126
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 570-602 2.84e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 2.84e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462532832  570 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 602
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 9-41 4.09e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462532832    9 PGGCSRNAECIKTGtGTHTCVCQQGWTGNGRDC 41
Cdd:pfam12947    5 NGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 53-84 9.71e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.35  E-value: 9.71e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462532832   53 GGCHDNASCLYVgPGQNECECKKGFRGNGIDC 84
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 1331-1423 2.50e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 178.43  E-value: 2.50e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1410
Cdd:cd03515      1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                           90
                   ....*....|...
gi 2462532832 1411 RPNKSEMWDVFCY 1423
Cdd:cd03515     81 RLNLSERWDAYCY 93
Xlink pfam00193
Extracellular link domain;
1331-1423 1.62e-37

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 136.16  E-value: 1.62e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1410
Cdd:pfam00193    1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 2462532832 1411 RPNKSEMWDVFCY 1423
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 142-262 9.16e-28

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 109.65  E-value: 9.16e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  142 IFNRWINNASLQPTLSAT-SNLTVLVPSQQATEDMDQDEKSFWLSQSN-IPALIKYHMLLGTYRVADLQTLSSsdmlATS 219
Cdd:pfam02469    5 TFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLLKDKEqLKNLLKYHVVPGRLTSSDLKNGGT----LAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462532832  220 LQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 262
Cdd:pfam02469   81 LQGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 750-859 3.14e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  750 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 825
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2462532832  826 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 859
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 885-1015 3.17e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  885 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 964
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462532832  965 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 1015
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
LINK smart00445
Link (Hyaluronan-binding);
1331-1424 6.65e-27

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 105.89  E-value: 6.65e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  1331 GVFHLRsPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGp 1410
Cdd:smart00445    3 GVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQYG- 80

                            90
                    ....*....|....
gi 2462532832  1411 RPNKSEMWDVFCYR 1424
Cdd:smart00445   81 FPDPTSRYDAYCFN 94
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 1331-1423 6.63e-24

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 97.49  E-value: 6.63e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1410
Cdd:cd01102      1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGRNPGVRSYGN 80

                           90
                   ....*....|...
gi 2462532832 1411 rPNKSEMWDVFCY 1423
Cdd:cd01102     81 -PAPSGRYDAYCF 92
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 754-859 6.91e-24

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 99.98  E-value: 6.91e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  754 VKDLVGPGPFTVFAPLSAAFDE--EARVKDWDK---YGLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQS 828
Cdd:COG2335     56 VDTLSGEGPFTVFAPTDAAFAAlpAGTLDALLKpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGG 134

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462532832  829 TVYINNkAKIISSDIISTNGIVHIIDKLLSP 859
Cdd:COG2335    135 GVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
764-860 2.12e-22

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 93.20  E-value: 2.12e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   764 TVFAPLSAAFDE-EARVKDWDKYgLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQ--STVYINNkAKIIS 840
Cdd:smart00554    1 TVFAPTDEAFQKlPPDLNSLLAD-KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVE 77

                            90       100
                    ....*....|....*....|
gi 2462532832   841 SDIISTNGIVHIIDKLLSPK 860
Cdd:smart00554   78 ADIAATNGVVHVIDRVLLPP 97
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 281-398 3.06e-22

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 93.86  E-value: 3.06e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  281 PDYSIFRGYIIQYNLANAIEAADA-YTVFAPNNNAIENYIRE-----KKVLSLEEDVLRYHVVlEEKLLKNDLHNGMHRE 354
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKLPAGtlnflLKDKEQLKNLLKYHVV-PGRLTSSDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2462532832  355 TMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 398
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 133-262 3.61e-21

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 91.89  E-value: 3.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  133 ELSFLSEAaifnrwINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPAL---IKYHMLLGTYRVADLQT 209
Cdd:COG2335     42 DFSTLVAA------LKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPENKATLtkiLTYHVVPGKVTAADLKD 115

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462532832  210 LSSsdmlATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 262
Cdd:COG2335    116 GKT----LTTLQGQTLTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
911-1017 2.65e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.64  E-value: 2.65e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   911 TLFWPTDQALHALPAEQQDFLfnqdnKDKLKEYLKFHVIRDaKVLAVDLPTSTAWKTLQGSELSVKCgaGRDIGDLFLNG 990
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR--SGGSGTVTVNG 72

                            90       100
                    ....*....|....*....|....*..
gi 2462532832   991 QtcRIVQRELLFDLGVAYGIDCLLIDP 1017
Cdd:smart00554   73 A--RIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 1332-1423 2.12e-17

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 78.99  E-value: 2.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1332 VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNC---GSGVVGIVDY 1408
Cdd:cd03517      2 VFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCygdMDGFPGVRNY 81

                           90
                   ....*....|....*
gi 2462532832 1409 GPRpNKSEMWDVFCY 1423
Cdd:cd03517     82 GVR-DPDELYDVYCY 95
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 1332-1423 4.79e-17

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 77.85  E-value: 4.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1332 VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCG--SGVVGIVDYG 1409
Cdd:cd03518      2 VFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGgkRTVPGLRSYG 81

                           90
                   ....*....|....
gi 2462532832 1410 PRPNKSEMWDVFCY 1423
Cdd:cd03518     82 ERDKMLSRYDAFCF 95
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 875-1015 1.56e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.79  E-value: 1.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  875 QNLTTLATNNGyiKFSNL---IQDSGLLSVITDPihTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIrD 951
Cdd:COG2335     31 KNIVETAANNP--DFSTLvaaLKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVV-P 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462532832  952 AKVLAVDLPTSTAWKTLQGSELSVKcgagRDIGDLFLNGQTcrIVQRELLFDLGVAYGIDCLLI 1015
Cdd:COG2335    106 GKVTAADLKDGKTLTTLQGQTLTVT----VSGGGVTVNGAN--VITADIEASNGVIHVIDKVLL 163
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
163-262 9.65e-16

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 74.32  E-value: 9.65e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   163 TVLVPSQQATEDMDQDEKSFWLSQsnIPALIKYHMLLGTYRVADLQtlssSDMLATSLQGN--FLHLAKVDGNITIEGAS 240
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADK--LKNLLLYHVVPGRLSSADLL----NGGTLPTLAGSklRITRSGGSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|..
gi 2462532832   241 IVDGDNAATNGVIHIINKVLVP 262
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLP 96
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 271-398 1.73e-15

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 75.71  E-value: 1.73e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  271 PNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIrEKKVLSLEED--------VLRYHVVlEEKL 342
Cdd:COG2335     31 KNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALP-AGTLDALLKPenkatltkILTYHVV-PGKV 108

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462532832  343 LKNDLHNGMHRETMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 398
Cdd:COG2335    109 TAADLKDGKTLTTLQGQT--LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVL 162
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1489-1582 1.47e-14

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 70.85  E-value: 1.47e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832  1489 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRVGSKLLITASQDPlqptETRFVDGR 1558
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 2462532832  1559 AILQWDIFASNGIIHVISRPLKAP 1582
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 1332-1423 1.58e-13

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 67.72  E-value: 1.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1332 VFHLRSPlgqYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVG---IVDY 1408
Cdd:cd03520      2 VFYATAP---EKFTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGGLPGvrtLYRF 78

                           90
                   ....*....|....*...
gi 2462532832 1409 GPR---PNKSEMWDVFCY 1423
Cdd:cd03520     79 PNQtgfPDPHSRFDAYCF 96
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 1331-1423 3.02e-12

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 63.98  E-value: 3.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPLgqyKLTFDKAREACANEAATMATYNQLSYAQK-AKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYG 1409
Cdd:cd03519      1 GVFYLLHPG---KLTFSEAVAACQRDGAQIAKVGQLFAAWKfHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFG 77

                           90
                   ....*....|....
gi 2462532832 1410 PRPNKSEMWDVFCY 1423
Cdd:cd03519     78 FPDKKHKLYGVYCY 91
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
306-398 7.49e-12

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 63.15  E-value: 7.49e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832   306 TVFAPNNNAIENYIREKKVLSLE--EDVLRYHVVlEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTN 383
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADklKNLLLYHVV-PGRLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 2462532832   384 VATDKGVIHGLGKVL 398
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 1331-1427 6.62e-10

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 59.01  E-value: 6.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1331 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYgp 1410
Cdd:cd03516      7 GVFLVEKN-GRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCGKNGTGVYIL-- 83

                           90
                   ....*....|....*..
gi 2462532832 1411 RPNKSEMWDVFCYRMKD 1427
Cdd:cd03516     84 NSNLSSRYDAYCYNSSD 100
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 608-644 4.69e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  608 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 644
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1260-1297 1.64e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.75  E-value: 1.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462532832 1260 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 1297
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1489-1579 3.40e-07

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 50.71  E-value: 3.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1489 TLFVPQNSGLGE------NETLSGRD-----IEHHLANvSMFFYNDLVNGTTLQTRVGSKLLITASQDPLqptetrFVDG 1557
Cdd:pfam02469   27 TVFAPTNEAFAKlpagtlNFLLKDKEqlknlLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVTGGSV------TVNG 99

                           90       100
                   ....*....|....*....|..
gi 2462532832 1558 RAILQWDIFASNGIIHVISRPL 1579
Cdd:pfam02469  100 ARVVQADIEATNGVIHVIDKVL 121
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 692-728 3.56e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.98  E-value: 3.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  692 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 728
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1428-1579 6.19e-06

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 47.98  E-value: 6.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1428 VNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNfLTEVLAYSNssargraflehLTD-LSIRG--TLFVPQNS-----GLG 1499
Cdd:COG2335     14 AACASSAAAEGAAMAPTKNIVETAANNPDFST-LVAALKAAG-----------LVDtLSGEGpfTVFAPTDAafaalPAG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532832 1500 ENETLSG-------RDI-EHHLANvSMFFYNDLVNGTTLQTRVGSKLLITASQDPLQptetrfVDGRAILQWDIFASNGI 1571
Cdd:COG2335     82 TLDALLKpenkatlTKIlTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT------VNGANVITADIEASNGV 154


                   ....*...
gi 2462532832 1572 IHVISRPL 1579
Cdd:COG2335    155 IHVIDKVL 162
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-686 9.88e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 9.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832  650 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 686
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1219-1254 2.51e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.59  E-value: 2.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462532832 1219 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 1254
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 90-126 1.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462532832   90 CLEQTGKCHPLASCQSTSSGVwSCVCQEGYEGDGFLC 126
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 570-602 2.84e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 2.84e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462532832  570 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 602
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 9-41 4.09e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462532832    9 PGGCSRNAECIKTGtGTHTCVCQQGWTGNGRDC 41
Cdd:pfam12947    5 NGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 53-84 9.71e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.35  E-value: 9.71e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462532832   53 GGCHDNASCLYVgPGQNECECKKGFRGNGIDC 84
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH