|
Name |
Accession |
Description |
Interval |
E-value |
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
1.14e-163 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 457.16 E-value: 1.14e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFcrpfrekvlayksqprkkESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDN 119
Cdd:cd02663 1 GLENFGNTCYCNSVLQALYF------------------ENLLTCLKDLFESISEQKKRTGVISPKKFITRLKRENELFDN 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 120 YMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLpngnidNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02663 63 YMHQDAHEFLNFLLNEIAEILDAERKAEKANRKL------NNNNNAEPQPTWVHEIFQGILTNETRCLTCETVSSRDETF 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 200 LDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 279
Cdd:cd02663 137 LDLSIDVEQNTSITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDEQLNRYIKLFYRVV 216
|
250 260 270
....*....|....*....|....*....|.
gi 2462536336 280 FPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02663 217 FPLELRLFNTTDDAENPDRLYELVAVVVHIG 247
|
|
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
39-310 |
9.30e-78 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 239.65 E-value: 9.30e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 39 FGLVNFGNTCYCNSVLQALYFCRPFREKVLAY-----KSQPRKKESLLTCLADLFHSIaTQKKKVGVIPPKKFITRLRKE 113
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRIsplseDSRYNKDINLLCALRDLFKAL-QKNSKSSSVSPKMFKKSLGKL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 114 NELFDNYMQQDAHEFLNYLLNTiadiLQEERKQekqngrlpngnidnenNNSTPDPTWVHEIFQGTLTNETRCLTCETIS 193
Cdd:pfam00443 80 NPDFSGYKQQDAQEFLLFLLDG----LHEDLNG----------------NHSTENESLITDLFRGQLKSRLKCLSCGEVS 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 194 SKDEDFLDLSVDVEQNTSITH------CLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdQ 267
Cdd:pfam00443 140 ETFEPFSDLSLPIPGDSAELKtaslqiCFLQFSKLEELDDEEKYYCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSY--N 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2462536336 268 LHRYTKLSYRVVFPLELRLFNTSGDATNPD----RMYDLVAVVVHCG 310
Cdd:pfam00443 218 RSTWEKLNTEVEFPLELDLSRYLAEELKPKtnnlQDYRLVAVVVHSG 264
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
40-310 |
4.09e-53 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 174.59 E-value: 4.09e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFcrpfrekvlayksqprkkeslltcladlfhsiatqkkkvgvippkkfitrlrkenelfdn 119
Cdd:cd02257 1 GLNNLGNTCYLNSVLQALFS------------------------------------------------------------ 20
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 120 yMQQDAHEFLNYLLNTIADILQEERKQEKqngrlpngnidnennNSTPDPTWVHEIFQGTLTNETRCLTC--ETISSKDE 197
Cdd:cd02257 21 -EQQDAHEFLLFLLDKLHEELKKSSKRTS---------------DSSSLKSLIHDLFGGKLESTIVCLECghESVSTEPE 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 198 DFLDLSVDVEQ--NTSITHCLRGFSNTETLCSEYKYYCEeCRSKQEAHKRMKVKKLPMILALHLKRFKYmDQLHRYTKLS 275
Cdd:cd02257 85 LFLSLPLPVKGlpQVSLEDCLEKFFKEEILEGDNCYKCE-KKKKQEATKRLKIKKLPPVLIIHLKRFSF-NEDGTKEKLN 162
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2462536336 276 YRVVFPLELRLFN------TSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02257 163 TKVSFPLELDLSPylsegeKDSDSDNGSYKYELVAVVVHSG 203
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
38-310 |
6.52e-50 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 168.59 E-value: 6.52e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKE--SLLTCLADLFHSIATQKKKVGVippkkfiTRLRKENE 115
Cdd:cd02659 2 YVGLKNQGATCYMNSLLQQLYMTPEFRNAVYSIPPTEDDDDnkSVPLALQRLFLFLQLSESPVKT-------TELTDKTR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 116 LFDN-----YMQQDAHEFLNYLLntiaDILQEERKQEKQNGRLPngnidnennnstpdptwvhEIFQGTLTNETRCLTCE 190
Cdd:cd02659 75 SFGWdslntFEQHDVQEFFRVLF----DKLEEKLKGTGQEGLIK-------------------NLFGGKLVNYIICKECP 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 191 TISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKY-MDQLH 269
Cdd:cd02659 132 HESEREEYFLDLQVAVKGKKNLEESLDAYVQGETLEGDNKYFCEKCGKKVDAEKGVCFKKLPPVLTLQLKRFEFdFETMM 211
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2462536336 270 RYtKLSYRVVFPLEL-----------RLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02659 212 RI-KINDRFEFPLELdmepytekglaKKEGDSEKKDSESYIYELHGVLVHSG 262
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
2.93e-48 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 163.60 E-value: 2.93e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVL--AYKSQPRKKESLLTCLADLF--HSIATQKKkvgVIPPKKFITRLRKENE 115
Cdd:cd02661 3 GLQNLGNTCFLNSVLQCLTHTPPLANYLLsrEHSKDCCNEGFCMMCALEAHveRALASSGP---GSAPRIFSSNLKQISK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 116 LFDNYMQQDAHEFLNYLLNTiadilqeerkqeKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSK 195
Cdd:cd02661 80 HFRIGRQEDAHEFLRYLLDA------------MQKACLDRFKKLKAVDPSSQETTLVQQIFGGYLRSQVKCLNCKHVSNT 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 196 DEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdqlHRYTKLS 275
Cdd:cd02661 148 YDPFLDLSLDIKGADSLEDALEQFTKPEQLDGENKYKCERCKKKVKASKQLTIHRAPNVLTIHLKRFSN----FRGGKIN 223
|
250 260 270
....*....|....*....|....*....|....*
gi 2462536336 276 YRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02661 224 KQISFPETLDLSPYMSQPNDGPLKYKLYAVLVHSG 258
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
3.26e-38 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 137.55 E-value: 3.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ------------PRKKESLLTCLADLFHSIATQKKKVgvIPPKKFI 107
Cdd:cd02668 1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTedaelknmppdkPHEPQTIIDQLQLIFAQLQFGNRSV--VDPSGFV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 108 TRLRkenelFDNYMQQDAHEFLNYLLNTIADILQeerKQEKQNGRlpngnidnennnstpdpTWVHEIFQGTLTNETRCL 187
Cdd:cd02668 79 KALG-----LDTGQQQDAQEFSKLFLSLLEAKLS---KSKNPDLK-----------------NIVQDLFRGEYSYVTQCS 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 188 TCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQ 267
Cdd:cd02668 134 KCGRESSLPSKFYELELQLKGHKTLEECIDEFLKEEQLTGDNQYFCESCNSKTDATRRIRLTTLPPTLNFQLLRFVFDRK 213
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2462536336 268 LHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02668 214 TGAKKKLNASISFPEILDMGEYLAESDEGSYVYELSGVLIHQG 256
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
7.93e-37 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 134.25 E-value: 7.93e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESL-LTCLA--DLFHSIATQKkkvgviPPKKFITRLRKENEL 116
Cdd:cd02671 26 GLNNLGNTCYLNSVLQVLYFCPGFKHGLKHLVSLISSVEQLqSSFLLnpEKYNDELANQ------APRRLLNALREVNPM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 117 FDNYMQQDAHEFLNYLLNTIADILQEerkqekqngrlpngnidnennnstpdptwvheIFQGTLTNETRCLTCETISSKD 196
Cdd:cd02671 100 YEGYLQHDAQEVLQCILGNIQELVEK--------------------------------DFQGQLVLRTRCLECETFTERR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 197 EDFLDLSVDVE-------------------QNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILAL 257
Cdd:cd02671 148 EDFQDISVPVQeselskseesseispdpktEMKTLKWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKLPEVITI 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462536336 258 HLKRF----KYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDrmYDLVAVVVHCG 310
Cdd:cd02671 228 HLKCFaangSEFDCYGGLSKVNTPLLTPLKLSLEEWSTKPKNDV--YRLFAVVMHSG 282
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
8.90e-37 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 134.04 E-value: 8.90e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA--YKSQPRKKESL--LTC-LADLFHSIATQKKKVGVIPPKKFITRLRKEN 114
Cdd:cd02660 2 GLINLGATCFMNVILQALLHNPLLRNYFLSdrHSCTCLSCSPNscLSCaMDEIFQEFYYSGDRSPYGPINLLYLSWKHSR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 115 ELfDNYMQQDAHEFLNYLLNTIAdilQEERKQEKQNGRLPngnidnennnstPDPTWVHEIFQGTLTNETRCLTCETISS 194
Cdd:cd02660 82 NL-AGYSQQDAHEFFQFLLDQLH---THYGGDKNEANDES------------HCNCIIHQTFSGSLQSSVTCQRCGGVST 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 195 KDEDFLDLSVDVEQNT---------------SITHCLRGFSNTETLCSeYKYYCEECRSKQEAHKRMKVKKLPMILALHL 259
Cdd:cd02660 146 TVDPFLDLSLDIPNKStpswalgesgvsgtpTLSDCLDRFTRPEKLGD-FAYKCSGCGSTQEATKQLSIKKLPPVLCFQL 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 260 KRFKYmDQLHRYTKLSYRVVFPLELRL--FNTSGDAT-------NPDRMYDLVAVVVHCG 310
Cdd:cd02660 225 KRFEH-SLNKTSRKIDTYVQFPLELNMtpYTSSSIGDtqdsnslDPDYTYDLFAVVVHKG 283
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
1.49e-35 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 128.17 E-value: 1.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQalyfcrpfrekvlayksqprkkeslltCLADlfhsiatqkkkvgvippkkfitrlrkenelfdn 119
Cdd:cd02674 1 GLRNLGNTCYMNSILQ---------------------------CLSA--------------------------------- 20
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 120 yMQQDAHEFLNYLLNTIADILQEErkqekqngrlpngnidnennnstpdptwvheiFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02674 21 -DQQDAQEFLLFLLDGLHSIIVDL--------------------------------FQGQLKSRLTCLTCGKTSTTFEPF 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 200 LDLSVDVEQNT------SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdQLHRYTK 273
Cdd:cd02674 68 TYLSLPIPSGSgdapkvTLEDCLRLFTKEETLDGDNAWKCPKCKKKRKATKKLTISRLPKVLIIHLKRFSF--SRGSTRK 145
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462536336 274 LSYRVVFPLE---LRLFNTSGDATNPDRmYDLVAVVVHCG 310
Cdd:cd02674 146 LTTPVTFPLNdldLTPYVDTRSFTGPFK-YDLYAVVNHYG 184
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
7.57e-35 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 128.76 E-value: 7.57e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKE-SLLTCLADLFHSIATQKKKVGViPPKKFITRLRKENelFD 118
Cdd:cd02664 1 GLINLGNTCYMNSVLQALFMAKDFRRQVLSLNLPRLGDSqSVMKKLQLLQAHLMHTQRRAEA-PPDYFLEASRPPW--FT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 119 NYMQQDAHEFLNYLLntiaDILQeerkqekqngrlpngnidnennnstpdpTWVHEIFQGTLTNETRCLTCETISSKDED 198
Cdd:cd02664 78 PGSQQDCSEYLRYLL----DRLH----------------------------TLIEKMFGGKLSTTIRCLNCNSTSARTER 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 199 FLDLSVDVeqnTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRV 278
Cdd:cd02664 126 FRDLDLSF---PSVQDLLNYFLSPEKLTGDNQYYCEKCASLQDAEKEMKVTGAPEYLILTLLRFSYDQKTHVREKIMDNV 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2462536336 279 VFPLELRL-----FNTSGDATNPDRM--------------YDLVAVVVHCG 310
Cdd:cd02664 203 SINEVLSLpvrveSKSSESPLEKKEEesgddgelvtrqvhYRLYAVVVHSG 253
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
1.77e-34 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 126.73 E-value: 1.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALyfcrpfrekvlayksqprkkeSLLTCLADLFHSiatqkkkvgviPPKKFITRLRKENELFDN 119
Cdd:cd02667 1 GLSNLGNTCFFNAVMQNL---------------------SQTPALRELLSE-----------TPKELFSQVCRKAPQFKG 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 120 YMQQDAHEFLNYLLNTIAdilqeerkqekqngrlpngnidnennnstpdpTWVHEIFQGTLTNETRCLTCETISSKDEDF 199
Cdd:cd02667 49 YQQQDSHELLRYLLDGLR--------------------------------TFIDSIFGGELTSTIMCESCGTVSLVYEPF 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 200 LDLS----VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECrskQEAHKRMKVKKLPMILALHLKRFKyMDQLHRYTKLS 275
Cdd:cd02667 97 LDLSlprsDEIKSECSIESCLKQFTEVEILEGNNKFACENC---TKAKKQYLISKLPPVLVIHLKRFQ-QPRSANLRKVS 172
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462536336 276 YRVVFP--LELRLF---NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02667 173 RHVSFPeiLDLAPFcdpKCNSSEDKSSVLYRLYGVVEHSG 212
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-311 |
1.98e-25 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 103.18 E-value: 1.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKES----LLTCLADLFHSIatqKKKVGVIPPKKFITRLRK--- 112
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCLRSVPELRDALKNYNPARRGANQssdnLTNALRDLFDTM---DKKQEPVPPIEFLQLLRMafp 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 113 ---ENELFDNYMQQDAHEFLNYLLNTIADILqeerkqekqngrlpngnidnenNNSTPDPTWVHEIFQGTLTNETRCL-- 187
Cdd:cd02657 78 qfaEKQNQGGYAQQDAEECWSQLLSVLSQKL----------------------PGAGSKGSFIDQLFGIELETKMKCTes 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 188 -TCETISSKDEDFLDLSVDVEQNTSITH--CLRGFSNTETLCSeykyycEECRSKQEAHKRMKVKKLPMILALHLKRFKY 264
Cdd:cd02657 136 pDEEEVSTESEYKLQCHISITTEVNYLQdgLKKGLEEEIEKHS------PTLGRDAIYTKTSRISRLPKYLTVQFVRFFW 209
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2462536336 265 MDQLHRYTKLSYRVVFPLELRLFntsgDATNPDRMYDLVAVVVHCGR 311
Cdd:cd02657 210 KRDIQKKAKILRKVKFPFELDLY----ELCTPSGYYELVAVITHQGR 252
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
38-310 |
3.70e-24 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 103.03 E-value: 3.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKKKVGVippkkfiTRLRKEN-- 114
Cdd:COG5077 193 YVGLRNQGATCYMNSLLQSLFFIAKFRKDVYGIPTDhPRGRDSVALALQRLFYNLQTGEEPVDT-------TELTRSFgw 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 115 ELFDNYMQQDAHEFLNYLLntiaDILQEERKQEKQNGRLpngnidnennnstpdptwvHEIFQGTLTNETRCLTCETISS 194
Cdd:COG5077 266 DSDDSFMQHDIQEFNRVLQ----DNLEKSMRGTVVENAL-------------------NGIFVGKMKSYIKCVNVNYESA 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 195 KDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEEcRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKL 274
Cdd:COG5077 323 RVEDFWDIQLNVKGMKNLQESFRRYIQVETLDGDNRYNAEK-HGLQDAKKGVIFESLPPVLHLQLKRFEYDFERDMMVKI 401
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462536336 275 SYRVVFPLELRLF----NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:COG5077 402 NDRYEFPLEIDLLpfldRDADKSENSDAVYVLYGVLVHSG 441
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-310 |
3.44e-21 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 91.62 E-value: 3.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALY----FCRPFREKVLAYKSQPRKKESLLTC-LADLFHSIATQKKKVGV------------IP 102
Cdd:cd02658 1 GLRNLGNSCYLNSVLQVLFsipsFQWRYDDLENKFPSDVVDPANDLNCqLIKLADGLLSGRYSKPAslksendpyqvgIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 103 PKKFITRLRKENELFDNYMQQDAHEFLNYLLntiaDILQEERKQEkqngrlpngnidnennnSTPDPTwvhEIFQGTLTN 182
Cdd:cd02658 81 PSMFKALIGKGHPEFSTMRQQDALEFLLHLI----DKLDRESFKN-----------------LGLNPN---DLFKFMIED 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 183 ETRCLTCETISSKDEDFLDLSVDVE--------------QNTSITHCLRGFSNTETLcseyKYYCEECRSKQEAHKRMKV 248
Cdd:cd02658 137 RLECLSCKKVKYTSELSEILSLPVPkdeatekeegelvyEPVPLEDCLKAYFAPETI----EDFCSTCKEKTTATKTTGF 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462536336 249 KKLPMILALHLKRFKYMDQlHRYTKLSYRVVFPLELRlfntSGDatnpdrmYDLVAVV------VHCG 310
Cdd:cd02658 213 KTFPDYLVINMKRFQLLEN-WVPKKLDVPIDVPEELG----PGK-------YELIAFIshkgtsVHSG 268
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-311 |
2.86e-20 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 87.81 E-value: 2.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREkvlayksqprkkeslltcladlfhsiatqkkkvgvippkkFITRLRKenelfdn 119
Cdd:cd02662 1 GLVNLGNTCFMNSVLQALASLPSLIE----------------------------------------YLEEFLE------- 33
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 120 ymQQDAHEFLNYLLNTIADILqeerkqekqngrlpngnidnennnSTPdptwvheiFQGTLTNETRCLTCETISSKDED- 198
Cdd:cd02662 34 --QQDAHELFQVLLETLEQLL------------------------KFP--------FDGLLASRIVCLQCGESSKVRYEs 79
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 199 FLDLSVDVEQNTSIT-----HCLRGFSNTETlCSEYKyyCEECRSKqeahkrmkVKKLPMILALHLKRFKYmDQLHRYTK 273
Cdd:cd02662 80 FTMLSLPVPNQSSGSgttleHCLDDFLSTEI-IDDYK--CDRCQTV--------IVRLPQILCIHLSRSVF-DGRGTSTK 147
|
250 260 270
....*....|....*....|....*....|....*...
gi 2462536336 274 LSYRVVFPLELrlfntsgdatnPDRMYDLVAVVVHCGR 311
Cdd:cd02662 148 NSCKVSFPERL-----------PKVLYRLRAVVVHYGS 174
|
|
| UCH_1 |
pfam13423 |
Ubiquitin carboxyl-terminal hydrolase; |
40-308 |
2.93e-16 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 463872 [Multi-domain] Cd Length: 305 Bit Score: 77.70 E-value: 2.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTC-LADLFHSIATQKKK----------VGVIPPKKFIT 108
Cdd:pfam13423 2 GLETHIPNSYTNSLLQLLRFIPPLRNLALSHLATECLKEHCLLCeLGFLFDMLEKAKGKncqasnflraLSSIPEASALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 109 RLRKENELFDNY----MQQDaheFLNYLLNTIAdilQEERKQEKQNgrlpngnidnennnsTPDPTWVHEIFQGTLTNET 184
Cdd:pfam13423 82 LLDEDRETNSAIslssLIQS---FNRFLLDQLS---SEENSTPPNP---------------SPAESPLEQLFGIDAETTI 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 185 RCLTCETISSKDEDF--LDLSV--------DVEQNTSITHCLRGFSNTETLcseYKYYCEECRSKQEAHKRMKVKKLPMI 254
Cdd:pfam13423 141 RCSNCGHESVRESSThvLDLIYprkpssnnKKPPNQTFSSILKSSLERETT---TKAWCEKCKRYQPLESRRTVRNLPPV 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2462536336 255 LALHLKRFkymDQLHRYTKLSYRVvFPLELRLFNTSGDATNPD-RMYDLVAVVVH 308
Cdd:pfam13423 218 LSLNAALT---NEEWRQLWKTPGW-LPPEIGLTLSDDLQGDNEiVKYELRGVVVH 268
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
211-310 |
2.29e-14 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 73.76 E-value: 2.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 211 SIT--HCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYmdQLHRYTKLSYRVVFPL-ELRLF 287
Cdd:COG5560 674 TITlqDCLNEFSKPEQLGLSDSWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSS--VRSFRDKIDDLVEYPIdDLDLS 751
|
90 100
....*....|....*....|...
gi 2462536336 288 NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:COG5560 752 GVEYMVDDPRLIYDLYAVDNHYG 774
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
40-204 |
2.44e-14 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 73.38 E-value: 2.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA--YKSQPRKKE------SLLTCLADLFHSIATQkkKVGVIPPKKFITRLR 111
Cdd:COG5560 267 GLRNLGNTCYMNSALQCLMHTWELRDYFLSdeYEESINEENplgmhgSVASAYADLIKQLYDG--NLHAFTPSGFKKTIG 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 112 KENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEkQNGRLPNGNIDNENNNSTPDPTW----------VHEIFQGTLT 181
Cdd:COG5560 345 SFNEEFSGYDQQDSQEFIAFLLDGLHEDLNRIIKKP-YTSKPDLSPGDDVVVKKKAKECWwehlkrndsiITDLFQGMYK 423
|
170 180
....*....|....*....|...
gi 2462536336 182 NETRCLTCETISSKDEDFLDLSV 204
Cdd:COG5560 424 STLTCPGCGSVSITFDPFMDLTL 446
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
40-310 |
1.39e-11 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 63.67 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPfreKVLAYKSQPRKKeslltcLADLFHSIATQKKKVGVIPPKKFITRLRKENE---- 115
Cdd:COG5533 1 GLPNLGNTCFMNSVLQILALYLP---KLDELLDDLSKE------LKVLKNVIRKPEPDLNQEEALKLFTALWSSKEhkvg 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 116 -LFDNYMQQDAHEFLNYLLNTIadilqeERKQEKQNGRLPNGNIDNENNNSTPDptwvheIFQGTLTNETRclTCETISS 194
Cdd:COG5533 72 wIPPMGSQEDAHELLGKLLDEL------KLDLVNSFTIRIFKTTKDKKKTSTGD------WFDIIIELPDQ--TWVNNLK 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 195 KDEDFLDlsvdveqntsithCLRGFSNTETLCSEYKYYCEECRSKQEAHkrMKVKKLPMILALHLKRFKYmdqLHRYTKL 274
Cdd:COG5533 138 TLQEFID-------------NMEELVDDETGVKAKENEELEVQAKQEYE--VSFVKLPKILTIQLKRFAN---LGGNQKI 199
|
250 260 270
....*....|....*....|....*....|....*.
gi 2462536336 275 SYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCG 310
Cdd:COG5533 200 DTEVDEKFELPVKHDQILNIVKETYYDLVGFVLHQG 235
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
38-310 |
2.45e-11 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 63.88 E-value: 2.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLA---YKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKF---ITRLR 111
Cdd:cd02669 119 FVGLNNIKNNDYANVIIQALSHVKPIRNFFLLyenYENIKDRKSELVKRLSELIRKIWNPRNFKGHVSPHELlqaVSKVS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 112 KENelFDNYMQQDAHEFLNYLLNTIADILQEERKqekqngrlpngnidnennnstPDPTWVHEIFQGTLTNETRCLTCET 191
Cdd:cd02669 199 KKK--FSITEQSDPVEFLSWLLNTLHKDLGGSKK---------------------PNSSIIHDCFQGKVQIETQKIKPHA 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 192 IS-SKDEDFLDLSVDVEQNTSITHCLR---------GFSNTETLCSEY-------KYYCEECRSKQEAHKRMKVKKLPMI 254
Cdd:cd02669 256 EEeGSKDKFFKDSRVKKTSVSPFLLLTldlpppplfKDGNEENIIPQVplkqllkKYDGKTETELKDSLKRYLISRLPKY 335
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462536336 255 LALHLKRFkymdqlhryTKLSYR-------VVFPLELRLF----NTSGDATNPDRMYDLVAVVVHCG 310
Cdd:cd02669 336 LIFHIKRF---------SKNNFFkeknptiVNFPIKNLDLsdyvHFDKPSLNLSTKYNLVANIVHEG 393
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
41-310 |
3.19e-11 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 62.16 E-value: 3.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 41 LVNFGNTCYCNSVLQALyfcrpfrekvlayksqprkkeslltcladlfhsiatqkkkvgvippkkfiTRLRKENELFDNY 120
Cdd:cd02673 2 LVNTGNSCYFNSTMQAL--------------------------------------------------SSIGKINTEFDND 31
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 121 MQQDAHEFLNYLLNTIADILQEERKQEKQNGrlpngnidneNNNSTPDPTwvhEIFQGTLTNETRCLTCETISSKDEDFL 200
Cdd:cd02673 32 DQQDAHEFLLTLLEAIDDIMQVNRTNVPPSN----------IEIKRLNPL---EAFKYTIESSYVCIGCSFEENVSDVGN 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462536336 201 DLSVDVEQNTSITHCLRGFSNTETLCSEYKyyCEECrSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVF 280
Cdd:cd02673 99 FLDVSMIDNKLDIDELLISNFKTWSPIEKD--CSSC-KCESAISSERIMTFPECLSINLKRYKLRIATSDYLKKNEEIMK 175
|
250 260 270
....*....|....*....|....*....|
gi 2462536336 281 PLELRLFNtsgdatnpdrmYDLVAVVVHCG 310
Cdd:cd02673 176 KYCGTDAK-----------YSLVAVICHLG 194
|
|
| Peptidase_C19J |
cd02666 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
40-70 |
1.73e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239131 [Multi-domain] Cd Length: 343 Bit Score: 45.95 E-value: 1.73e-05
10 20 30
....*....|....*....|....*....|.
gi 2462536336 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAY 70
Cdd:cd02666 3 GLDNIGNTCYLNSLLQYFFTIKPLRDLVLNF 33
|
|
| Peptidase_C19P |
cd02672 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
38-92 |
2.62e-03 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239137 [Multi-domain] Cd Length: 268 Bit Score: 38.65 E-value: 2.62e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 2462536336 38 YFGLVNFGNTCYCNSVLQALYFCRPFReKVLAYKSQPRKKES-LLTCLADLFHSIA 92
Cdd:cd02672 15 YAGLENHITNSYCNSLLQLLYFIPPFR-NFTAIILVACPKEScLLCELGYLFSTLI 69
|
|
| |
