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Conserved domains on  [gi|2462538204|ref|XP_054231054|]
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gamma-glutamylaminecyclotransferase isoform X1 [Homo sapiens]

Protein Classification

gamma-glutamylcyclotransferase family protein( domain architecture ID 10532862)

gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl

CATH:  3.10.490.10
EC:  2.3.2.-
Gene Ontology:  GO:0016746
PubMed:  18515354|20110353
SCOP:  4002485

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGACT pfam06094
Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ...
 4-138 2.77e-24

Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.


:

Pssm-ID: 428763 [Multi-domain]  Cd Length: 118  Bit Score: 90.53  E-value: 2.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538204   4 VFVYGTLKRGQPNHRVLRDGAHGSAAFRArgrTLEPYPLVIAGEHniPWLLhlPGSGRLVEGEVYAVDERMLRFLDDFES 83
Cdd:pfam06094   1 VFVYGTLRRGEPNHHALLLGARFPGLGPA---TLPGYRLYDLGGY--PALV--PGEGERVVGELYEVDDALLARLDELEG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462538204  84 CPALYQRTVLRVQLLEDRapgaeeppaptAVQCFVYSRATFPPEWAQLPHHDSYD 138
Cdd:pfam06094  74 YPNLYEREVVEVEVEDGE-----------PVEAWVYVYNPDDEGGLPRIESGDWL 117
 
Name Accession Description Interval E-value
GGACT pfam06094
Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ...
 4-138 2.77e-24

Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.


Pssm-ID: 428763 [Multi-domain]  Cd Length: 118  Bit Score: 90.53  E-value: 2.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538204   4 VFVYGTLKRGQPNHRVLRDGAHGSAAFRArgrTLEPYPLVIAGEHniPWLLhlPGSGRLVEGEVYAVDERMLRFLDDFES 83
Cdd:pfam06094   1 VFVYGTLRRGEPNHHALLLGARFPGLGPA---TLPGYRLYDLGGY--PALV--PGEGERVVGELYEVDDALLARLDELEG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462538204  84 CPALYQRTVLRVQLLEDRapgaeeppaptAVQCFVYSRATFPPEWAQLPHHDSYD 138
Cdd:pfam06094  74 YPNLYEREVVEVEVEDGE-----------PVEAWVYVYNPDDEGGLPRIESGDWL 117
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 4-119 4.07e-20

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 79.31  E-value: 4.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538204   4 VFVYGTLKRGQPNHRVLrdgahGSAAFRARGRtLEPYPLVIAGEHNIPWLLhlPGSGRLVEGEVYAVDERMLRFLDDFES 83
Cdd:cd06661     1 LFVYGTLMDGEVLHARL-----GRALFLGPAT-LKGYRLVFGGGSGYPGLV--PGPGARVWGELYEVDPEDLARLDAFEG 72

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462538204  84 CPALYQRTVLRVQLLEDRapgaeeppaptAVQCFVY 119
Cdd:cd06661    73 VPGGYRREEVEVELEDGE-----------GVEAWVY 97
YtfP COG2105
Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid ...
 3-97 5.97e-20

Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid transport and metabolism];


Pssm-ID: 441708 [Multi-domain]  Cd Length: 114  Bit Score: 79.55  E-value: 5.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538204   3 LVFVYGTLKRGQPNHRVLRDgahgsAAFRARGRTlePYPLVIAGEHniPWLLhlPGSGRLVEGEVYAVDERMLRFLDDFE 82
Cdd:COG2105     2 LLFVYGTLRRGESNHHLLRG-----ARFLGPATL--EGRLYDLGAY--PALV--PDGGGRVYGELYEVDDALLAALDELE 70

                          90
                  ....*....|....*
gi 2462538204  83 SCPALYQRTVLRVQL 97
Cdd:COG2105    71 GAPNLYRRELVPVET 85
 
Name Accession Description Interval E-value
GGACT pfam06094
Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ...
 4-138 2.77e-24

Gamma-glutamyl cyclotransferase, AIG2-like; GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.


Pssm-ID: 428763 [Multi-domain]  Cd Length: 118  Bit Score: 90.53  E-value: 2.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538204   4 VFVYGTLKRGQPNHRVLRDGAHGSAAFRArgrTLEPYPLVIAGEHniPWLLhlPGSGRLVEGEVYAVDERMLRFLDDFES 83
Cdd:pfam06094   1 VFVYGTLRRGEPNHHALLLGARFPGLGPA---TLPGYRLYDLGGY--PALV--PGEGERVVGELYEVDDALLARLDELEG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462538204  84 CPALYQRTVLRVQLLEDRapgaeeppaptAVQCFVYSRATFPPEWAQLPHHDSYD 138
Cdd:pfam06094  74 YPNLYEREVVEVEVEDGE-----------PVEAWVYVYNPDDEGGLPRIESGDWL 117
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 4-119 4.07e-20

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 79.31  E-value: 4.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538204   4 VFVYGTLKRGQPNHRVLrdgahGSAAFRARGRtLEPYPLVIAGEHNIPWLLhlPGSGRLVEGEVYAVDERMLRFLDDFES 83
Cdd:cd06661     1 LFVYGTLMDGEVLHARL-----GRALFLGPAT-LKGYRLVFGGGSGYPGLV--PGPGARVWGELYEVDPEDLARLDAFEG 72

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462538204  84 CPALYQRTVLRVQLLEDRapgaeeppaptAVQCFVY 119
Cdd:cd06661    73 VPGGYRREEVEVELEDGE-----------GVEAWVY 97
YtfP COG2105
Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid ...
 3-97 5.97e-20

Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid transport and metabolism];


Pssm-ID: 441708 [Multi-domain]  Cd Length: 114  Bit Score: 79.55  E-value: 5.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538204   3 LVFVYGTLKRGQPNHRVLRDgahgsAAFRARGRTlePYPLVIAGEHniPWLLhlPGSGRLVEGEVYAVDERMLRFLDDFE 82
Cdd:COG2105     2 LLFVYGTLRRGESNHHLLRG-----ARFLGPATL--EGRLYDLGAY--PALV--PDGGGRVYGELYEVDDALLAALDELE 70

                          90
                  ....*....|....*
gi 2462538204  83 SCPALYQRTVLRVQL 97
Cdd:COG2105    71 GAPNLYRRELVPVET 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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