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Conserved domains on  [gi|2462539499|ref|XP_054231681|]
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phosphofurin acidic cluster sorting protein 2 isoform X11 [Homo sapiens]

Protein Classification

phosphofurin acidic cluster sorting protein( domain architecture ID 10563031)

phosphofurin acidic cluster sorting (PACS) protein similar to human PACS1, a coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pacs-1 pfam10254
PACS-1 cytosolic sorting protein; PACS-1 is a cytosolic sorting protein that directs the ...
 465-877 0e+00

PACS-1 cytosolic sorting protein; PACS-1 is a cytosolic sorting protein that directs the localization of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef.


:

Pssm-ID: 463027  Cd Length: 416  Bit Score: 815.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 465 VYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIA 544
Cdd:pfam10254   1 VYDQLNHILISDDQLPENIILVNTSDWQGQYLADVLQEHTLPVVCTCSTADVQAAFSAIVSRIQKYCNCNSQPPKPVKVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 545 VAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVqDTPD 624
Cdd:pfam10254  81 VAGGQSYLSAVLRVFVEQLSNKPPDWLNYMRFLVVPLGSHPVARYLGSVDYRYNSLFQDLAWRDLFERLEAPNTA-DTLD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 625 IVSRITQYIAGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGT-LSSTPPS 703
Cdd:pfam10254 160 VVGRITQYITGANCTHQLPIAEAMLTYKQKSPDEDSSQKFIPFVGVVKVGIVEQSSATSGDSDDGVAGCSSSvLSSSPPS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 704 -ASPAAKEASPTPPSSPSVSG--GLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRL 780
Cdd:pfam10254 240 sSSPIGKESTTPPSSPSVSSGlwGPSSPSSGHGAELMELQVDYWTAAQPTERKREGEKKDLPTGKNTLKCTFRSLQVSRL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 781 PSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLRVLIDGVECSDVKFFQLAA 860
Cdd:pfam10254 320 PSSGEAGATPTMSMTVVTKEKKKKVMFLGKKTKEKEVESKSQCIEGISRLICSAKNQQTPLRVSIDGVEWNDVKFFQLAA 399

                         410
                  ....*....|....*..
gi 2462539499 861 QWSSHVKHFPICIFGHS 877
Cdd:pfam10254 400 QWQTHIKHFPVGIFGHS 416
 
Name Accession Description Interval E-value
Pacs-1 pfam10254
PACS-1 cytosolic sorting protein; PACS-1 is a cytosolic sorting protein that directs the ...
 465-877 0e+00

PACS-1 cytosolic sorting protein; PACS-1 is a cytosolic sorting protein that directs the localization of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef.


Pssm-ID: 463027  Cd Length: 416  Bit Score: 815.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 465 VYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIA 544
Cdd:pfam10254   1 VYDQLNHILISDDQLPENIILVNTSDWQGQYLADVLQEHTLPVVCTCSTADVQAAFSAIVSRIQKYCNCNSQPPKPVKVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 545 VAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVqDTPD 624
Cdd:pfam10254  81 VAGGQSYLSAVLRVFVEQLSNKPPDWLNYMRFLVVPLGSHPVARYLGSVDYRYNSLFQDLAWRDLFERLEAPNTA-DTLD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 625 IVSRITQYIAGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGT-LSSTPPS 703
Cdd:pfam10254 160 VVGRITQYITGANCTHQLPIAEAMLTYKQKSPDEDSSQKFIPFVGVVKVGIVEQSSATSGDSDDGVAGCSSSvLSSSPPS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 704 -ASPAAKEASPTPPSSPSVSG--GLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRL 780
Cdd:pfam10254 240 sSSPIGKESTTPPSSPSVSSGlwGPSSPSSGHGAELMELQVDYWTAAQPTERKREGEKKDLPTGKNTLKCTFRSLQVSRL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 781 PSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLRVLIDGVECSDVKFFQLAA 860
Cdd:pfam10254 320 PSSGEAGATPTMSMTVVTKEKKKKVMFLGKKTKEKEVESKSQCIEGISRLICSAKNQQTPLRVSIDGVEWNDVKFFQLAA 399

                         410
                  ....*....|....*..
gi 2462539499 861 QWSSHVKHFPICIFGHS 877
Cdd:pfam10254 400 QWQTHIKHFPVGIFGHS 416
 
Name Accession Description Interval E-value
Pacs-1 pfam10254
PACS-1 cytosolic sorting protein; PACS-1 is a cytosolic sorting protein that directs the ...
 465-877 0e+00

PACS-1 cytosolic sorting protein; PACS-1 is a cytosolic sorting protein that directs the localization of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef.


Pssm-ID: 463027  Cd Length: 416  Bit Score: 815.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 465 VYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIA 544
Cdd:pfam10254   1 VYDQLNHILISDDQLPENIILVNTSDWQGQYLADVLQEHTLPVVCTCSTADVQAAFSAIVSRIQKYCNCNSQPPKPVKVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 545 VAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVqDTPD 624
Cdd:pfam10254  81 VAGGQSYLSAVLRVFVEQLSNKPPDWLNYMRFLVVPLGSHPVARYLGSVDYRYNSLFQDLAWRDLFERLEAPNTA-DTLD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 625 IVSRITQYIAGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGT-LSSTPPS 703
Cdd:pfam10254 160 VVGRITQYITGANCTHQLPIAEAMLTYKQKSPDEDSSQKFIPFVGVVKVGIVEQSSATSGDSDDGVAGCSSSvLSSSPPS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 704 -ASPAAKEASPTPPSSPSVSG--GLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRL 780
Cdd:pfam10254 240 sSSPIGKESTTPPSSPSVSSGlwGPSSPSSGHGAELMELQVDYWTAAQPTERKREGEKKDLPTGKNTLKCTFRSLQVSRL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539499 781 PSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLRVLIDGVECSDVKFFQLAA 860
Cdd:pfam10254 320 PSSGEAGATPTMSMTVVTKEKKKKVMFLGKKTKEKEVESKSQCIEGISRLICSAKNQQTPLRVSIDGVEWNDVKFFQLAA 399

                         410
                  ....*....|....*..
gi 2462539499 861 QWSSHVKHFPICIFGHS 877
Cdd:pfam10254 400 QWQTHIKHFPVGIFGHS 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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