|
Name |
Accession |
Description |
Interval |
E-value |
| CARMIL_C |
pfam16000 |
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ... |
778-1066 |
1.53e-82 |
|
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).
:
Pssm-ID: 464966 [Multi-domain] Cd Length: 299 Bit Score: 272.80 E-value: 1.53e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 778 TQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTSSIVDEILQELYHSHKSLA 857
Cdd:pfam16000 1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 858 RHLTQL-RTLSDPPGCP-GQGQDLSSRGRGRNHDHEETTDDELGTNIDTMAIKKQKR-CRKIRPVSAFISGSPQDMESQL 934
Cdd:pfam16000 81 RHLSQRgRTLLEPESLPdGDRPESSPLGPGKRHEGEIERLEELETPMATLKSKRKSIhSRKLRPVSVAFSVSELDLDKAP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 935 GNLGI--------PPGWFSGLGGSQPTASGSWEGLSELPTHGYKLRHQTQGRPRPPRTTPPGPGRPSMPAPGTRQENGMA 1006
Cdd:pfam16000 161 EEVPIhvedassgPPLPSSSPSEPELSASESLDSLSELPTEGQKLQHLTKGRPKRNKTRAPTRPPGKVGPAQDGEQNGLS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462542017 1007 TRLDEGLEDFFSRRVLEEssSYPRTLRTVRPGLSEAP-LPPLQKKRRRGLFHFRRPWSFKG 1066
Cdd:pfam16000 241 GRVDEGLEDFFSKKVIKL--STPTSPTSEPSSSSLFPdSPKKRKKRKSGFFNFIKPRSSKG 299
|
|
| Carm_PH |
pfam17888 |
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ... |
31-118 |
5.36e-33 |
|
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.
:
Pssm-ID: 436119 Cd Length: 94 Bit Score: 123.16 E-value: 5.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 31 VKLETKPKKFEDRVLALTSWRLHLFLLKVPAKVESSFNVLEIRAFNTLSQNQILVETERGMVSMRLPSAESVDQVTRHVS 110
Cdd:pfam17888 7 VKLETKGDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHIL 86
|
....*...
gi 2462542017 111 SALSKVCP 118
Cdd:pfam17888 87 TALKKIFP 94
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
274-657 |
1.87e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 83.69 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 274 VLHALTLSHNPIEDKGFLSLSQQLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANPA---FASSLRYLDLSKNPGLLAT 350
Cdd:COG5238 88 QLLVVDWEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLIQvlkDPLGGNAVHLLGLAARLGL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 351 DEANALYSFLaQPNALVHLDLSGT---DCVIDLLLGALLHGccSHLTYLNLARNSCshrkGREAPPAFKQFFSSAYTLSH 427
Cdd:COG5238 168 LAAISMAKAL-QNNSVETVYLGCNqigDEGIEELAEALTQN--TTVTTLWLKRNPI----GDEGAEILAEALKGNKSLTT 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 428 VNLSATKLPLEALRALLQGLSLNSHLSdlHLDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNGF-DSDLLTLVPALGK 506
Cdd:COG5238 241 LDLSNNQIGDEGVIALAEALKNNTTVE--TLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIgDEGAIALAEGLQG 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 507 NKSLKHLFLGKNfNVKAKTLEeilhklvqliqeedcslqslsvadsrlklrtsILINALGSNTCLAKVDLSGNGMEDIGA 586
Cdd:COG5238 319 NKTLHTLNLAYN-GIGAQGAI--------------------------------ALAKALQENTTLHSLDLSDNQIGDEGA 365
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462542017 587 KMLSKALQINSSLRTILWDRNNTSALGFLDIARALESNhTLRFMSFPVSDISQAYRSapeRTEDVWQKIQW 657
Cdd:COG5238 366 IALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQ---RLEQLLERIKS 432
|
|
| PRK07764 super family |
cl35613 |
DNA polymerase III subunits gamma and tau; Validated |
1121-1335 |
5.24e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
The actual alignment was detected with superfamily member PRK07764:
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.14 E-value: 5.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1121 GGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRVHGVALPGlerakGWSFDGKREGPGPDQEGSTQAWQKRRSSDDAGPG 1200
Cdd:PRK07764 597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPA-----EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPA 671
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1201 SWKPPPPPQSTKPSFSAMRRAEATwHIAEESAPNHSCQSPSPASQDGEEEKEGTLFPERTLPARNAKDPALAPWPPKPVA 1280
Cdd:PRK07764 672 KAGGAAPAAPPPAPAPAAPAAPAG-AAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPD 750
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1281 VPR-GRQPPQEPGVREEAEAGDAAPgvnkprlrlSSQQDQEEPEV----QGPPDPGRRTA 1335
Cdd:PRK07764 751 PAGaPAQPPPPPAPAPAAAPAAAPP---------PSPPSEEEEMAeddaPSMDDEDRRDA 801
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CARMIL_C |
pfam16000 |
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ... |
778-1066 |
1.53e-82 |
|
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).
Pssm-ID: 464966 [Multi-domain] Cd Length: 299 Bit Score: 272.80 E-value: 1.53e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 778 TQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTSSIVDEILQELYHSHKSLA 857
Cdd:pfam16000 1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 858 RHLTQL-RTLSDPPGCP-GQGQDLSSRGRGRNHDHEETTDDELGTNIDTMAIKKQKR-CRKIRPVSAFISGSPQDMESQL 934
Cdd:pfam16000 81 RHLSQRgRTLLEPESLPdGDRPESSPLGPGKRHEGEIERLEELETPMATLKSKRKSIhSRKLRPVSVAFSVSELDLDKAP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 935 GNLGI--------PPGWFSGLGGSQPTASGSWEGLSELPTHGYKLRHQTQGRPRPPRTTPPGPGRPSMPAPGTRQENGMA 1006
Cdd:pfam16000 161 EEVPIhvedassgPPLPSSSPSEPELSASESLDSLSELPTEGQKLQHLTKGRPKRNKTRAPTRPPGKVGPAQDGEQNGLS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462542017 1007 TRLDEGLEDFFSRRVLEEssSYPRTLRTVRPGLSEAP-LPPLQKKRRRGLFHFRRPWSFKG 1066
Cdd:pfam16000 241 GRVDEGLEDFFSKKVIKL--STPTSPTSEPSSSSLFPdSPKKRKKRKSGFFNFIKPRSSKG 299
|
|
| Carm_PH |
pfam17888 |
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ... |
31-118 |
5.36e-33 |
|
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.
Pssm-ID: 436119 Cd Length: 94 Bit Score: 123.16 E-value: 5.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 31 VKLETKPKKFEDRVLALTSWRLHLFLLKVPAKVESSFNVLEIRAFNTLSQNQILVETERGMVSMRLPSAESVDQVTRHVS 110
Cdd:pfam17888 7 VKLETKGDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHIL 86
|
....*...
gi 2462542017 111 SALSKVCP 118
Cdd:pfam17888 87 TALKKIFP 94
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
274-657 |
1.87e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 83.69 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 274 VLHALTLSHNPIEDKGFLSLSQQLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANPA---FASSLRYLDLSKNPGLLAT 350
Cdd:COG5238 88 QLLVVDWEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLIQvlkDPLGGNAVHLLGLAARLGL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 351 DEANALYSFLaQPNALVHLDLSGT---DCVIDLLLGALLHGccSHLTYLNLARNSCshrkGREAPPAFKQFFSSAYTLSH 427
Cdd:COG5238 168 LAAISMAKAL-QNNSVETVYLGCNqigDEGIEELAEALTQN--TTVTTLWLKRNPI----GDEGAEILAEALKGNKSLTT 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 428 VNLSATKLPLEALRALLQGLSLNSHLSdlHLDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNGF-DSDLLTLVPALGK 506
Cdd:COG5238 241 LDLSNNQIGDEGVIALAEALKNNTTVE--TLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIgDEGAIALAEGLQG 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 507 NKSLKHLFLGKNfNVKAKTLEeilhklvqliqeedcslqslsvadsrlklrtsILINALGSNTCLAKVDLSGNGMEDIGA 586
Cdd:COG5238 319 NKTLHTLNLAYN-GIGAQGAI--------------------------------ALAKALQENTTLHSLDLSDNQIGDEGA 365
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462542017 587 KMLSKALQINSSLRTILWDRNNTSALGFLDIARALESNhTLRFMSFPVSDISQAYRSapeRTEDVWQKIQW 657
Cdd:COG5238 366 IALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQ---RLEQLLERIKS 432
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
339-600 |
5.63e-13 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 71.62 E-value: 5.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 339 LDLSKNpgLLATDEANALYSFLAQPNALVHLDLS-----GTDCVIDLLLGALLHGCCshLTYLNLARNSCShrkgrEAPP 413
Cdd:cd00116 28 LRLEGN--TLGEEAAKALASALRPQPSLKELCLSlnetgRIPRGLQSLLQGLTKGCG--LQELDLSDNALG-----PDGC 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 414 AFKQFFSSAYTLSHVNLSATKLPLEALRALLQGL-SLNSHLSDLhlDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNG 492
Cdd:cd00116 99 GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLkDLPPALEKL--VLGRNRLEGASCEALAKALRANRDLKELNLANNG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 493 F-DSDLLTLVPALGKNKSLKHLFLGKNF--NVKAKTLEEILHKLVQL--IQEEDCSLQSLSVADsrlklrtsiLINALGS 567
Cdd:cd00116 177 IgDAGIRALAEGLKANCNLEVLDLNNNGltDEGASALAETLASLKSLevLNLGDNNLTDAGAAA---------LASALLS 247
|
250 260 270
....*....|....*....|....*....|....
gi 2462542017 568 -NTCLAKVDLSGNGMEDIGAKMLSKALQINSSLR 600
Cdd:cd00116 248 pNISLLTLSLSCNDITDDGAKDLAEVLAEKESLL 281
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1121-1335 |
5.24e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.14 E-value: 5.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1121 GGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRVHGVALPGlerakGWSFDGKREGPGPDQEGSTQAWQKRRSSDDAGPG 1200
Cdd:PRK07764 597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPA-----EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPA 671
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1201 SWKPPPPPQSTKPSFSAMRRAEATwHIAEESAPNHSCQSPSPASQDGEEEKEGTLFPERTLPARNAKDPALAPWPPKPVA 1280
Cdd:PRK07764 672 KAGGAAPAAPPPAPAPAAPAAPAG-AAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPD 750
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1281 VPR-GRQPPQEPGVREEAEAGDAAPgvnkprlrlSSQQDQEEPEV----QGPPDPGRRTA 1335
Cdd:PRK07764 751 PAGaPAQPPPPPAPAPAAAPAAAPP---------PSPPSEEEEMAeddaPSMDDEDRRDA 801
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
1138-1358 |
1.74e-04 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 45.92 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1138 EPGEGGP-APGTAQQPRVHGVALPGLERAKGWSFDGKREGPGPDQEGSTQAwQKRRSSDDAGPGSWKPPPPPQSTKPSfs 1216
Cdd:NF033839 286 EPGNKKPsAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQP-EKPKPEVKPQLETPKPEVKPQPEKPK-- 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1217 amrraeatwhiaEESAPNHSCQSPSPASQDGEEEKEGTLFPERTLParnakDPALAPWPPKPVAVPRGRQPpqEPGVREE 1296
Cdd:NF033839 363 ------------PEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKP-----EVKPQPEKPKPEVKPQPEKP--KPEVKPQ 423
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462542017 1297 AEAG--DAAPGVNKPRLRLSSQQDQEEPEVQ---GPPDPGRRTAPLKPKRTRRAQScDKLEPDRRRP 1358
Cdd:NF033839 424 PEKPkpEVKPQPEKPKPEVKPQPEKPKPEVKpqpETPKPEVKPQPEKPKPEVKPQP-EKPKPDNSKP 489
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CARMIL_C |
pfam16000 |
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ... |
778-1066 |
1.53e-82 |
|
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).
Pssm-ID: 464966 [Multi-domain] Cd Length: 299 Bit Score: 272.80 E-value: 1.53e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 778 TQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTSSIVDEILQELYHSHKSLA 857
Cdd:pfam16000 1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 858 RHLTQL-RTLSDPPGCP-GQGQDLSSRGRGRNHDHEETTDDELGTNIDTMAIKKQKR-CRKIRPVSAFISGSPQDMESQL 934
Cdd:pfam16000 81 RHLSQRgRTLLEPESLPdGDRPESSPLGPGKRHEGEIERLEELETPMATLKSKRKSIhSRKLRPVSVAFSVSELDLDKAP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 935 GNLGI--------PPGWFSGLGGSQPTASGSWEGLSELPTHGYKLRHQTQGRPRPPRTTPPGPGRPSMPAPGTRQENGMA 1006
Cdd:pfam16000 161 EEVPIhvedassgPPLPSSSPSEPELSASESLDSLSELPTEGQKLQHLTKGRPKRNKTRAPTRPPGKVGPAQDGEQNGLS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462542017 1007 TRLDEGLEDFFSRRVLEEssSYPRTLRTVRPGLSEAP-LPPLQKKRRRGLFHFRRPWSFKG 1066
Cdd:pfam16000 241 GRVDEGLEDFFSKKVIKL--STPTSPTSEPSSSSLFPdSPKKRKKRKSGFFNFIKPRSSKG 299
|
|
| Carm_PH |
pfam17888 |
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ... |
31-118 |
5.36e-33 |
|
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.
Pssm-ID: 436119 Cd Length: 94 Bit Score: 123.16 E-value: 5.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 31 VKLETKPKKFEDRVLALTSWRLHLFLLKVPAKVESSFNVLEIRAFNTLSQNQILVETERGMVSMRLPSAESVDQVTRHVS 110
Cdd:pfam17888 7 VKLETKGDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHIL 86
|
....*...
gi 2462542017 111 SALSKVCP 118
Cdd:pfam17888 87 TALKKIFP 94
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
274-657 |
1.87e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 83.69 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 274 VLHALTLSHNPIEDKGFLSLSQQLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANPA---FASSLRYLDLSKNPGLLAT 350
Cdd:COG5238 88 QLLVVDWEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLIQvlkDPLGGNAVHLLGLAARLGL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 351 DEANALYSFLaQPNALVHLDLSGT---DCVIDLLLGALLHGccSHLTYLNLARNSCshrkGREAPPAFKQFFSSAYTLSH 427
Cdd:COG5238 168 LAAISMAKAL-QNNSVETVYLGCNqigDEGIEELAEALTQN--TTVTTLWLKRNPI----GDEGAEILAEALKGNKSLTT 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 428 VNLSATKLPLEALRALLQGLSLNSHLSdlHLDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNGF-DSDLLTLVPALGK 506
Cdd:COG5238 241 LDLSNNQIGDEGVIALAEALKNNTTVE--TLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIgDEGAIALAEGLQG 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 507 NKSLKHLFLGKNfNVKAKTLEeilhklvqliqeedcslqslsvadsrlklrtsILINALGSNTCLAKVDLSGNGMEDIGA 586
Cdd:COG5238 319 NKTLHTLNLAYN-GIGAQGAI--------------------------------ALAKALQENTTLHSLDLSDNQIGDEGA 365
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462542017 587 KMLSKALQINSSLRTILWDRNNTSALGFLDIARALESNhTLRFMSFPVSDISQAYRSapeRTEDVWQKIQW 657
Cdd:COG5238 366 IALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQ---RLEQLLERIKS 432
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
189-477 |
7.41e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.60 E-value: 7.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 189 REFNLLDFSHLESRDLALMVAALAYNQWFTKLYCKDLRLGSEVLEQVLHTLSKSGSLEELVLDNAGLKTDFVQKLAGVFG 268
Cdd:COG5238 154 NAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALK 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 269 ENGScvLHALTLSHNPIEDKGFLSLSqQLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANPafasSLRYLDLSKNPgll 348
Cdd:COG5238 234 GNKS--LTTLDLSNNQIGDEGVIALA-EALKNNTTVETLYLSGNQIGAEGAIALAKALQGNT----TLTSLDLSVNR--- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 349 ATDE-ANALYSFLAQPNALVHLDLS----GTDCVIdLLLGALLHGccSHLTYLNLARNscshRKGREAPPAFKQFFSSAY 423
Cdd:COG5238 304 IGDEgAIALAEGLQGNKTLHTLNLAyngiGAQGAI-ALAKALQEN--TTLHSLDLSDN----QIGDEGAIALAKYLEGNT 376
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2462542017 424 TLSHVNLSATKLPLEALRALLQGLSLNShlsdLH-LDLSSCELRSAGAQALQEQL 477
Cdd:COG5238 377 TLRELNLGKNNIGKQGAEALIDALQTNR----LHtLILDGNLIGAEAQQRLEQLL 427
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
339-600 |
5.63e-13 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 71.62 E-value: 5.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 339 LDLSKNpgLLATDEANALYSFLAQPNALVHLDLS-----GTDCVIDLLLGALLHGCCshLTYLNLARNSCShrkgrEAPP 413
Cdd:cd00116 28 LRLEGN--TLGEEAAKALASALRPQPSLKELCLSlnetgRIPRGLQSLLQGLTKGCG--LQELDLSDNALG-----PDGC 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 414 AFKQFFSSAYTLSHVNLSATKLPLEALRALLQGL-SLNSHLSDLhlDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNG 492
Cdd:cd00116 99 GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLkDLPPALEKL--VLGRNRLEGASCEALAKALRANRDLKELNLANNG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 493 F-DSDLLTLVPALGKNKSLKHLFLGKNF--NVKAKTLEEILHKLVQL--IQEEDCSLQSLSVADsrlklrtsiLINALGS 567
Cdd:cd00116 177 IgDAGIRALAEGLKANCNLEVLDLNNNGltDEGASALAETLASLKSLevLNLGDNNLTDAGAAA---------LASALLS 247
|
250 260 270
....*....|....*....|....*....|....
gi 2462542017 568 -NTCLAKVDLSGNGMEDIGAKMLSKALQINSSLR 600
Cdd:cd00116 248 pNISLLTLSLSCNDITDDGAKDLAEVLAEKESLL 281
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
428-628 |
7.04e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 65.07 E-value: 7.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 428 VNLSATKLPLEALRALlqGLSLNSHLSDLHLDLSSCELRS--AGAQALQEQLGAVTCVGSLDLSDNGFDSDLLTLVPALG 505
Cdd:cd00116 28 LRLEGNTLGEEAAKAL--ASALRPQPSLKELCLSLNETGRipRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 506 KNKSLKHLFLGKN------FNVKAKTLEEILHKLVQLIQE-----------------EDCSLQSLSVADSRLKLR-TSIL 561
Cdd:cd00116 106 RSSSLQELKLNNNglgdrgLRLLAKGLKDLPPALEKLVLGrnrlegascealakalrANRDLKELNLANNGIGDAgIRAL 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462542017 562 INALGSNTCLAKVDLSGNGMEDIGAKMLSKALQINSSLRTILWDRNNTSALGFLDIARALES-NHTLR 628
Cdd:cd00116 186 AEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLL 253
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
334-663 |
1.00e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 62.26 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 334 SSLRYLDLSKNPGLlatdeanalysflAQPNALVHLDLSGTDCV-IDLLLGALlhgccSHLTYLNLARNSCShrkgrEAP 412
Cdd:COG4886 96 TNLTELDLSGNEEL-------------SNLTNLESLDLSGNQLTdLPEELANL-----TNLKELDLSNNQLT-----DLP 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 413 PAFKQFFSsaytLSHVNLSATKL-----PLEALRALlQGLSL-NSHLSDLHLDLSSCelrsagaQALQEqlgavtcvgsL 486
Cdd:COG4886 153 EPLGNLTN----LKSLDLSNNQLtdlpeELGNLTNL-KELDLsNNQITDLPEPLGNL-------TNLEE----------L 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 487 DLSDNGFDSdlltLVPALGKNKSLKHLFLGKNfnvKAKTLEEILhklvQLIqeedcSLQSLSVADSRLKLrtsilINALG 566
Cdd:COG4886 211 DLSGNQLTD----LPEPLANLTNLETLDLSNN---QLTDLPELG----NLT-----NLEELDLSNNQLTD-----LPPLA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 567 SNTCLAKVDLSGNGMEDIGAKMLSKALQINSSLRTILWDRNNTSALGFLDIARALESNHTLRFMSFPVSDISQAYRSAPE 646
Cdd:COG4886 270 NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349
|
330
....*....|....*..
gi 2462542017 647 RTEDVWQKIQWCLVRNN 663
Cdd:COG4886 350 LTLLLLLNLLSLLLTLL 366
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
210-493 |
1.47e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 55.05 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 210 ALAYNQWFTKLYCKDLRLGS--EVLEQVLHTLSKSGSLEELVLDNAGLKTDFVQKLAGVFGengSCVLHALTLSHNPIED 287
Cdd:cd00116 46 ALRPQPSLKELCLSLNETGRipRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR---SSSLQELKLNNNGLGD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 288 KGFLSLSQQLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANPafasSLRYLDLSKNPglLATDEANALYSFLAQPNALV 367
Cdd:cd00116 123 RGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANR----DLKELNLANNG--IGDAGIRALAEGLKANCNLE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 368 HLDLSgtDCVID-----LLLGALLHGCCshLTYLNLARNSCSHRKGREAPPAFKqffSSAYTLSHVNLSATKLPLEALRA 442
Cdd:cd00116 197 VLDLN--NNGLTdegasALAETLASLKS--LEVLNLGDNNLTDAGAAALASALL---SPNISLLTLSLSCNDITDDGAKD 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2462542017 443 LLQGLSLNSHLsdLHLDLSSCELRSAGAQALQEQLGAVTC-VGSLDLSDNGF 493
Cdd:cd00116 270 LAEVLAEKESL--LELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
185-501 |
2.80e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 53.90 E-value: 2.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 185 AEDNREFNLLDFS--HLESRDLALMVAALAYnQWFTKLYCKDLR------LGSEVLEQVLHtlskSGSLEELVLDNAGLK 256
Cdd:cd00116 47 LRPQPSLKELCLSlnETGRIPRGLQSLLQGL-TKGCGLQELDLSdnalgpDGCGVLESLLR----SSSLQELKLNNNGLG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 257 TDFVQKLAGVFGENgSCVLHALTLSHNPIEDKGFLSLSQqLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANpafaSSL 336
Cdd:cd00116 122 DRGLRLLAKGLKDL-PPALEKLVLGRNRLEGASCEALAK-ALRANRDLKELNLANNGIGDAGIRALAEGLKAN----CNL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 337 RYLDLSKNpgLLATDEANALYSFLAQPNALVHLDLSgtDCVIDLLlgallhgCCSHLtylnlarnscshrkgreappafk 416
Cdd:cd00116 196 EVLDLNNN--GLTDEGASALAETLASLKSLEVLNLG--DNNLTDA-------GAAAL----------------------- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 417 qffssaytlshvnlsatklpLEALRALLQGLslnshlsdLHLDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNGFDSD 496
Cdd:cd00116 242 --------------------ASALLSPNISL--------LTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEE 293
|
....*
gi 2462542017 497 LLTLV 501
Cdd:cd00116 294 GAQLL 298
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1121-1335 |
5.24e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.14 E-value: 5.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1121 GGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRVHGVALPGlerakGWSFDGKREGPGPDQEGSTQAWQKRRSSDDAGPG 1200
Cdd:PRK07764 597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPA-----EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPA 671
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1201 SWKPPPPPQSTKPSFSAMRRAEATwHIAEESAPNHSCQSPSPASQDGEEEKEGTLFPERTLPARNAKDPALAPWPPKPVA 1280
Cdd:PRK07764 672 KAGGAAPAAPPPAPAPAAPAAPAG-AAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPD 750
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1281 VPR-GRQPPQEPGVREEAEAGDAAPgvnkprlrlSSQQDQEEPEV----QGPPDPGRRTA 1335
Cdd:PRK07764 751 PAGaPAQPPPPPAPAPAAAPAAAPP---------PSPPSEEEEMAeddaPSMDDEDRRDA 801
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
239-576 |
5.99e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.24 E-value: 5.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 239 LSKSGSLEELVLDNAGLKT--DFVQKLAGvfgengscvLHALTLSHNPIEDkgflsLSQQLLCFPSgLTKLCLAKTAIS- 315
Cdd:COG4886 109 LSNLTNLESLDLSGNQLTDlpEELANLTN---------LKELDLSNNQLTD-----LPEPLGNLTN-LKSLDLSNNQLTd 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 316 -PRGLQALgqtfganpafaSSLRYLDLSKNPgllATDEANAlysfLAQPNALVHLDLSGTD-CVIDLLLGALlhgccSHL 393
Cdd:COG4886 174 lPEELGNL-----------TNLKELDLSNNQ---ITDLPEP----LGNLTNLEELDLSGNQlTDLPEPLANL-----TNL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 394 TYLNLARNscshrKGREAPpafkqFFSSAYTLSHVNLSATKlplealralLQGLSLNSHLSDL-HLDLSSCELRSAGAQA 472
Cdd:COG4886 231 ETLDLSNN-----QLTDLP-----ELGNLTNLEELDLSNNQ---------LTDLPPLANLTNLkTLDLSNNQLTDLKLKE 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 473 LQE-------QLGAVTCVGSLDLSDNGFDSDLLTLVPALGKNKSLKHLFLGKNFNVKAKTLEEILHKLVQLIQEEDCSLQ 545
Cdd:COG4886 292 LELllglnslLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
|
330 340 350
....*....|....*....|....*....|.
gi 2462542017 546 SLSVADSRLKLRTSILINALGSNTCLAKVDL 576
Cdd:COG4886 372 LGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1187-1368 |
6.06e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.56 E-value: 6.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1187 AWQKRRSSDDAGPGSWKPPPPPQSTkPSFSAMRRAEATwHIAEESAPNHSCQSPSPASQDGEEEKEGTLFPERTLPARNA 1266
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAAPVAQPA-PAAAAPAAAAPA-PAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQA 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1267 KD---PALAPWPPKPVAVPRGRQPPQEPGVREEAEAGDAAPGVNKPRLRLSSQQDQEEPEVQGPPDPGRRTAPLKPKRTR 1343
Cdd:PRK12323 440 SArgpGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA 519
|
170 180
....*....|....*....|....*
gi 2462542017 1344 RAQSCDKLEPDRRRPPDPTAGTSEP 1368
Cdd:PRK12323 520 GWVAESIPDPATADPDDAFETLAPA 544
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
1122-1334 |
8.58e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 46.50 E-value: 8.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1122 GGRGPSFRRKMGTEGSEPGEGGPAPGTA--QQPRVHGVALPGLERAKGWSF----DGKREGPGPDQEGSTQAWQKRRSSD 1195
Cdd:PHA03169 34 GRRRGTAARAAKPAPPAPTTSGPQVRAVaeQGHRQTESDTETAEESRHGEKeergQGGPSGSGSESVGSPTPSPSGSAEE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1196 DAGPGSWKPPPPPQSTKP-SFSAMRRAEATWHIAEESAPNHSCQSP--SPASQDGEEEKEGTLFPE--RTLPARNAKDPa 1270
Cdd:PHA03169 114 LASGLSPENTSGSSPESPaSHSPPPSPPSHPGPHEPAPPESHNPSPnqQPSSFLQPSHEDSPEEPEppTSEPEPDSPGP- 192
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462542017 1271 laPWPPKPVAVPRGRQPPQEPGvREEAEAGDAAPGVNKPRlRLSSQQDQEEPEVQGPPDPGRRT 1334
Cdd:PHA03169 193 --PQSETPTSSPPPQSPPDEPG-EPQSPTPQQAPSPNTQQ-AVEHEDEPTEPEREGPPFPGHRS 252
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
1138-1358 |
1.74e-04 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 45.92 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1138 EPGEGGP-APGTAQQPRVHGVALPGLERAKGWSFDGKREGPGPDQEGSTQAwQKRRSSDDAGPGSWKPPPPPQSTKPSfs 1216
Cdd:NF033839 286 EPGNKKPsAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQP-EKPKPEVKPQLETPKPEVKPQPEKPK-- 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1217 amrraeatwhiaEESAPNHSCQSPSPASQDGEEEKEGTLFPERTLParnakDPALAPWPPKPVAVPRGRQPpqEPGVREE 1296
Cdd:NF033839 363 ------------PEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKP-----EVKPQPEKPKPEVKPQPEKP--KPEVKPQ 423
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462542017 1297 AEAG--DAAPGVNKPRLRLSSQQDQEEPEVQ---GPPDPGRRTAPLKPKRTRRAQScDKLEPDRRRP 1358
Cdd:NF033839 424 PEKPkpEVKPQPEKPKPEVKPQPEKPKPEVKpqpETPKPEVKPQPEKPKPEVKPQP-EKPKPDNSKP 489
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1119-1364 |
5.36e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.93 E-value: 5.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1119 GFGGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRVHGVALPGLERAKgwsfdgkreGPGPDQEGSTQAWQKRRSSDDAG 1198
Cdd:PHA03247 262 GEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLAL---------PAPPDPPPPAPAGDAEEEDDEDG 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1199 PGSWKPPPPPQSTKPSFSAMRRAEATW----HIAEESAPNHSCQSPSPASQDGEEEKEG-TLFPERT----LPARNAKDP 1269
Cdd:PHA03247 333 AMEVVSPLPRPRQHYPLGFPKRRRPTWtppsSLEDLSAGRHHPKRASLPTRKRRSARHAaTPFARGPggddQTRPAAPVP 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1270 ALAPwPPKPVAVPRGRQPPQEPGVREEAEAGDAAPGVnkprlrlssqqdqeEPEVQGPPDPGRRTAPLKPKRTRRAqscd 1349
Cdd:PHA03247 413 ASVP-TPAPTPVPASAPPPPATPLPSAEPGSDDGPAP--------------PPERQPPAPATEPAPDDPDDATRKA---- 473
|
250
....*....|....*.
gi 2462542017 1350 kLEPDR-RRPPDPTAG 1364
Cdd:PHA03247 474 -LDALReRRPPEPPGA 488
|
|
| PRK11633 |
PRK11633 |
cell division protein DedD; Provisional |
1278-1361 |
1.80e-03 |
|
cell division protein DedD; Provisional
Pssm-ID: 236940 [Multi-domain] Cd Length: 226 Bit Score: 41.53 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1278 PVAVPRGRQPPqePGVREEAEAGDAAPGVNKP-RLRLSSQQDQEEPEVQGPPDPGRRTAPlKPKRTRRAQSCDKLEPdrr 1356
Cdd:PRK11633 58 AATQALPTQPP--EGAAEAVRAGDAAAPSLDPaTVAPPNTPVEPEPAPVEPPKPKPVEKP-KPKPKPQQKVEAPPAP--- 131
|
....*
gi 2462542017 1357 rPPDP 1361
Cdd:PRK11633 132 -KPEP 135
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1109-1371 |
5.33e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.31 E-value: 5.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1109 SPEEESSLLPGFGGGRGPSFRRKMgTEGSEPGEGGPAPGTAQQPRVHGVALPGLE-RAKGWSFDGKREGPGPDQEGSTQA 1187
Cdd:PHA03307 188 SPPAEPPPSTPPAAASPRPPRRSS-PISASASSPAPAPGRSAADDAGASSSDSSSsESSGCGWGPENECPLPRPAPITLP 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1188 WQKRRSSDDAGPGSWKPPPPPQS--------TKPSFSAMRRAEATWHIAEESAPNHSCQSPSPASQDgeeekegtlFPER 1259
Cdd:PHA03307 267 TRIWEASGWNGPSSRPGPASSSSsprerspsPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSS---------ESSR 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462542017 1260 TLPARNAKDPALAPWPPKPVAVPRGRQPPQEPGVREEAEAGDAAPGVNKPRLRLSSQQDQEEPEVQGPPDPGRRTAPLKP 1339
Cdd:PHA03307 338 GAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPL 417
|
250 260 270
....*....|....*....|....*....|..
gi 2462542017 1340 KRTRRAQScdklePDRRRPPDPTAGTSEPGTD 1371
Cdd:PHA03307 418 DAGAASGA-----FYARYPLLTPSGEPWPGSP 444
|
|
| |
