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Conserved domains on  [gi|2462544416|ref|XP_054234075|]
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P protein isoform X25 [Homo sapiens]

Protein Classification

ArsB/NhaD family transporter( domain architecture ID 10100037)

ArsB/NhaD family transporter translocates substrates such as sodium, arsenate, sulfate, and organic anions across membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 338-732 8.19e-127

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


:

Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 383.91  E-value: 8.19e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 338 LAGVYALIIFER-----------------------PSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLS 394
Cdd:cd01116     1 FIITYALIIFEKvhrtvaalagalwlvilglatlsPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 395 RGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqel 474
Cdd:cd01116    81 KGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 475 rKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllgk 554
Cdd:cd01116   157 -AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA---------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 555 vlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVpgiHLDLGWIAILGA 634
Cdd:cd01116   202 -----------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPL---GVSLGWIALLGA 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 635 IWLLILADIHDFEIILHRVEWATLLFFAALFVLME--------------------------------------------- 669
Cdd:cd01116   250 LLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGgleelgiiewiaellvgvilgriavavililwisallsafidnip 329

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462544416 670 -----IPVLLNLSHdpEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFR 732
Cdd:cd01116   330 vtatmIPIVKDLAS--QLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLK 395
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 338-732 8.19e-127

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 383.91  E-value: 8.19e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 338 LAGVYALIIFER-----------------------PSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLS 394
Cdd:cd01116     1 FIITYALIIFEKvhrtvaalagalwlvilglatlsPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 395 RGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqel 474
Cdd:cd01116    81 KGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 475 rKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllgk 554
Cdd:cd01116   157 -AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA---------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 555 vlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVpgiHLDLGWIAILGA 634
Cdd:cd01116   202 -----------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPL---GVSLGWIALLGA 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 635 IWLLILADIHDFEIILHRVEWATLLFFAALFVLME--------------------------------------------- 669
Cdd:cd01116   250 LLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGgleelgiiewiaellvgvilgriavavililwisallsafidnip 329

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462544416 670 -----IPVLLNLSHdpEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFR 732
Cdd:cd01116   330 vtatmIPIVKDLAS--QLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLK 395
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
330-733 2.46e-82

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 268.15  E-value: 2.46e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 330 QVTIATAILAGVYALIIFERP---------------------SLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAV 388
Cdd:COG1055     1 MMILALAIFVLTYLLIILEPRglnravaallgaalllllgvvSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 389 KAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII 468
Cdd:COG1055    81 KLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 469 VSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRltaqrispasreetavr 548
Cdd:COG1055   161 AS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRR----------------- 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 549 rlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgiLLAKCLTVLGFVIFMFFLNSFvpgIHLDLGW 628
Cdd:COG1055   217 -------------------------------------------------LLRISLLVLALLLVGFVLHSF---LGLPPAL 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 629 IAILGAIWLLILADIHDFEiILHRVEWATLLFFAALFVLME--------------------------------------- 669
Cdd:COG1055   245 IALLGAAVLLLLARVDVRE-VLKKVDWSTLLFFIGLFVVVGglentglldllaellasltggnlllaallilwlsailsa 323

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462544416 670 ----IPV---LLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRK 733
Cdd:COG1055   324 vvdnVPLvaaLLPLIPDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKV 394
CitMHS pfam03600
Citrate transporter;
333-670 2.02e-53

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 187.90  E-value: 2.02e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 333 IATAILAGVyALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVL 412
Cdd:pfam03600  12 DVVALLGAV-LLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 413 SAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkMGLDFAGFTAHMFIGI 492
Cdd:pfam03600  91 SAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----LGLSFGDFGFFMFPPV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 493 CLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKheihvwrltaqrispasreetavrrlllgkvlalehllarrlhtfhr 571
Cdd:pfam03600 166 GVALLLvGLLPLLLIFRKLLPVRKEEEAELEEL----------------------------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 572 qisqedknwetniqelqKKHRISDGILLAKCLTVLGFVIFMFFLNSfvpgihldlgwIAILGAIWLLILADIHDFEIILH 651
Cdd:pfam03600 199 -----------------RKRAIKDKLLLAISALVLALVILGFLLLS-----------VLALAGALLLLLTGVLDPEEALK 250

                         330
                  ....*....|....*....
gi 2462544416 652 RVEWATLLFFAALFVLMEI 670
Cdd:pfam03600 251 AVDWSTLLFFAGLFILVGA 269
PLN00136 PLN00136
silicon transporter; Provisional
 334-666 1.60e-17

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 86.20  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 334 ATAILAGVYaLIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVL 412
Cdd:PLN00136   37 AGALLSAVL-MIVFHVISPDDAYASIDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 413 SAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG- 491
Cdd:PLN00136  114 SALFTNDTCCVVLTEFVLELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGm 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 492 -ICLVLLVCfpllrlLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRIS-PASREETAVRRLLLGKVLALEHLLARRLHTF 569
Cdd:PLN00136  193 aVNMVMLLC------MYWKDLDGGAELSVDGKQMEAVEEGRSPASAKStKQQSPALLQAGLNGDGNGDMSSMMSENISTK 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 570 HRqisqedknWETNIQELQKKHRISDgilLAKCLTVLGFVIFMFFLNsfvpgihldLGWIAILGAIwLLILADIHDFEII 649
Cdd:PLN00136  267 HP--------WFMQCTEHRRKLFLKS---FAYVVTVGMVVAYMVGLN---------MSWTAITTAI-ALVVVDFRDAEPC 325

                         330
                  ....*....|....*..
gi 2462544416 650 LHRVEWATLLFFAALFV 666
Cdd:PLN00136  326 LDTVSYSLLVFFSGMFI 342
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 339-503 1.36e-05

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 48.11  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 339 AGVYALIIFERPSLTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIA 409
Cdd:TIGR00785 272 ASVVALLAVVLMLFLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFY 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 410 AVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgf 484
Cdd:TIGR00785 352 IILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG-- 429

                         170
                  ....*....|....*....
gi 2462544416 485 tahmFIGICLVLLVCFPLL 503
Cdd:TIGR00785 430 ----IVGLIVLLLVGTLWW 444
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 338-732 8.19e-127

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 383.91  E-value: 8.19e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 338 LAGVYALIIFER-----------------------PSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLS 394
Cdd:cd01116     1 FIITYALIIFEKvhrtvaalagalwlvilglatlsPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 395 RGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqel 474
Cdd:cd01116    81 KGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 475 rKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllgk 554
Cdd:cd01116   157 -AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA---------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 555 vlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVpgiHLDLGWIAILGA 634
Cdd:cd01116   202 -----------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPL---GVSLGWIALLGA 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 635 IWLLILADIHDFEIILHRVEWATLLFFAALFVLME--------------------------------------------- 669
Cdd:cd01116   250 LLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGgleelgiiewiaellvgvilgriavavililwisallsafidnip 329

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462544416 670 -----IPVLLNLSHdpEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFR 732
Cdd:cd01116   330 vtatmIPIVKDLAS--QLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLK 395
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
330-733 2.46e-82

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 268.15  E-value: 2.46e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 330 QVTIATAILAGVYALIIFERP---------------------SLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAV 388
Cdd:COG1055     1 MMILALAIFVLTYLLIILEPRglnravaallgaalllllgvvSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 389 KAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII 468
Cdd:COG1055    81 KLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 469 VSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRltaqrispasreetavr 548
Cdd:COG1055   161 AS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRR----------------- 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 549 rlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgiLLAKCLTVLGFVIFMFFLNSFvpgIHLDLGW 628
Cdd:COG1055   217 -------------------------------------------------LLRISLLVLALLLVGFVLHSF---LGLPPAL 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 629 IAILGAIWLLILADIHDFEiILHRVEWATLLFFAALFVLME--------------------------------------- 669
Cdd:COG1055   245 IALLGAAVLLLLARVDVRE-VLKKVDWSTLLFFIGLFVVVGglentglldllaellasltggnlllaallilwlsailsa 323

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462544416 670 ----IPV---LLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRK 733
Cdd:COG1055   324 vvdnVPLvaaLLPLIPDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKV 394
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 333-732 8.37e-72

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 239.46  E-value: 8.37e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 333 IATAILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVL 412
Cdd:cd00625    11 RAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLLMLLTAALS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 413 SAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQelrkmGLDFAGFTAHMFIGI 492
Cdd:cd00625    91 AFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLS-----GLGFLDFLAFMAPPA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 493 CLVLLVCFPLLRLLYWnrklynkepseivelkheihvwrltaqrispasreetavrrlllgkvlalehllarrlhtfhRQ 572
Cdd:cd00625   166 LGLLLLLLGLLYLLFR--------------------------------------------------------------KK 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 573 ISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLnsfvpgihLDLGWIAILGAIWLLILADI-HDFEIILH 651
Cdd:cd00625   184 LLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFL--------IPLGLIALLGALLLLLLLVRgLDPEEVLK 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 652 RVEWATLLFFAALFVLME-------------------------IPVLLNL---------SHDPEVGL---------PAPP 688
Cdd:cd00625   256 SVDWGTLLFFAGLFVLVGalestgllewlaellvalvglpplaALLLIGLlsallsnfiSNVPTVALllpiaaslaPPEP 335

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2462544416 689 LMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFR 732
Cdd:cd00625   336 AWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLK 379
CitMHS pfam03600
Citrate transporter;
333-670 2.02e-53

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 187.90  E-value: 2.02e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 333 IATAILAGVyALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVL 412
Cdd:pfam03600  12 DVVALLGAV-LLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 413 SAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkMGLDFAGFTAHMFIGI 492
Cdd:pfam03600  91 SAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----LGLSFGDFGFFMFPPV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 493 CLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKheihvwrltaqrispasreetavrrlllgkvlalehllarrlhtfhr 571
Cdd:pfam03600 166 GVALLLvGLLPLLLIFRKLLPVRKEEEAELEEL----------------------------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 572 qisqedknwetniqelqKKHRISDGILLAKCLTVLGFVIFMFFLNSfvpgihldlgwIAILGAIWLLILADIHDFEIILH 651
Cdd:pfam03600 199 -----------------RKRAIKDKLLLAISALVLALVILGFLLLS-----------VLALAGALLLLLTGVLDPEEALK 250

                         330
                  ....*....|....*....
gi 2462544416 652 RVEWATLLFFAALFVLMEI 670
Cdd:pfam03600 251 AVDWSTLLFFAGLFILVGA 269
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 323-732 1.07e-40

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 153.59  E-value: 1.07e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 323 LRGSVETQVTIATAILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGrVWAMI 402
Cdd:cd01117     3 LGRVPGLRLDRWAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGS-PRRLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 403 IMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqelrKMGLDFA 482
Cdd:cd01117    82 FLLVLLSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIAS-----ESGISFP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 483 GFTAHM--FIGICLVLLVCfpLLRLLYWnRKLYNKEPSEIVELKHEIHVWRltaqrispasreetAVRRLLLgkvlaleh 560
Cdd:cd01117   157 FFLAAMapLALLGLLLLLI--LLLVLFP-GELKGLPLDKATKEEGVGARKL--------------AVKLLVL-------- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 561 llarrlhtfhrqisqedknwetniqelqkkhrisdgillakCLTVLGFVIFMFFLNSFvpgihldlgWIAILGAIWLLIL 640
Cdd:cd01117   212 -----------------------------------------ILLLLVAFLALLGVIPL---------WTAALVAAVLLLL 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 641 ADIHDFEIILhRVEWATLLFFAALFVLME-------------------------------------IPVLLNLShdPEVG 683
Cdd:cd01117   242 TRLKPRRVLK-KVDWGLLLFFAGLFILVGgfaqglpleglsrllplldsvlslflvsiglsqlisnVPAVLLLL--PFLP 318

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2462544416 684 LPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFR 732
Cdd:cd01117   319 SADEKDWLLLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFLK 367
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
368-667 1.73e-20

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 94.07  E-value: 1.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 368 FGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLD-----PRQ 442
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 443 VLIAEVIFTNIGGAATAIGDPPNVIIVSN-QELRKMGLDFAGFTAHMF-IGICLVLLVCFPLLRLLywnrklynkePSEI 520
Cdd:COG0471    81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLlEEATGIPISFFEWMLVGLpVALVGLLLLWLVLYRLL----------PPEI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 521 VELKHEIHVWRLTAQRISPASREETAVrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgilla 600
Cdd:COG0471   151 KEVPGSKEVIREELAELGPLSRREKIA----------------------------------------------------- 177

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462544416 601 kcLTVLGFVIFMFFLNSFvpgIHLDLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVL 667
Cdd:COG0471   178 --LAIFALTVLLWITGSL---HGIPIAVVALLGAV-LLLLTGVLTWKDAYKSIPWGVLLLFGGGLAL 238
PLN00136 PLN00136
silicon transporter; Provisional
 334-666 1.60e-17

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 86.20  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 334 ATAILAGVYaLIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVL 412
Cdd:PLN00136   37 AGALLSAVL-MIVFHVISPDDAYASIDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 413 SAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG- 491
Cdd:PLN00136  114 SALFTNDTCCVVLTEFVLELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGm 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 492 -ICLVLLVCfpllrlLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRIS-PASREETAVRRLLLGKVLALEHLLARRLHTF 569
Cdd:PLN00136  193 aVNMVMLLC------MYWKDLDGGAELSVDGKQMEAVEEGRSPASAKStKQQSPALLQAGLNGDGNGDMSSMMSENISTK 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 570 HRqisqedknWETNIQELQKKHRISDgilLAKCLTVLGFVIFMFFLNsfvpgihldLGWIAILGAIwLLILADIHDFEII 649
Cdd:PLN00136  267 HP--------WFMQCTEHRRKLFLKS---FAYVVTVGMVVAYMVGLN---------MSWTAITTAI-ALVVVDFRDAEPC 325

                         330
                  ....*....|....*..
gi 2462544416 650 LHRVEWATLLFFAALFV 666
Cdd:PLN00136  326 LDTVSYSLLVFFSGMFI 342
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
329-508 4.28e-16

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 81.33  E-value: 4.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 329 TQVTIATAILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLI 408
Cdd:COG1055   238 LGLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 409 AAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPrqVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHM 488
Cdd:COG1055   318 SAILSAVVDNVPLVAALLPLIPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKVG 395

                         170       180
                  ....*....|....*....|
gi 2462544416 489 FIGICLVLLVCFPLLRLLYW 508
Cdd:COG1055   396 LPLTLLTLLIALLYLLLLYF 415
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 332-503 4.50e-14

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 74.59  E-value: 4.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 332 TIATAILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAV 411
Cdd:cd00625   230 GLIALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSAL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 412 LSAFLDNVTTMLLFTPVTIRLcevlnLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIG 491
Cdd:cd00625   310 LSNFISNVPTVALLLPIAASL-----APPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPL 384

                         170
                  ....*....|..
gi 2462544416 492 ICLVLLVCFPLL 503
Cdd:cd00625   385 TLLSLVVSLLYL 396
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 366-507 5.30e-14

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 74.54  E-value: 5.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 366 LLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 445
Cdd:cd01115    51 LFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLM 130

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462544416 446 AEVIFTNIGGAATAIGDPPNVIIVSnqELRKMGLDFAGFTAHMFIGIcLVLLVCFPLLRLLY 507
Cdd:cd01115   131 PLAFAASIGGMLTLIGTPPNLVASG--YLESLGGQGFSFFEFTPIGL-PLLIIGLLYLWFIF 189
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
331-505 7.94e-13

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 70.57  E-value: 7.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 331 VTIATAILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIA 409
Cdd:COG0471   196 IPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGlSPLLLLLLLALLT 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 410 AVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAeVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFagf 484
Cdd:COG0471   276 LLLTEFASNTATAALLLPIAISLAQALGVNPLPLALA-VAFAASCAFLLPVGTPPNAIVygsgyYKFKDFLKVGLPL--- 351

                         170       180
                  ....*....|....*....|.
gi 2462544416 485 tahMFIGICLVLLVCFPLLRL 505
Cdd:COG0471   352 ---NLIGLVVLLLLGPLWWPL 369
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 367-732 1.12e-12

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 70.76  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 367 LFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIA 446
Cdd:cd01118    58 LIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPF 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 447 EVIFTNIGGAATA---IGDPPNVIIVSNqelrkMGLDFAGFTAHMFIGICLVLLVCFPLLRLLY-------WNRKLYNKE 516
Cdd:cd01118   138 LYACAFIADAASLplpISNLVNIVTAGY-----FGIGFTEYAALMFLPSIVSILATYVVLYLFFrralpkrLETASVKKP 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 517 PSEIVELKHEIHVWRLTA-QRISPASREETAVRRLLLGKVLALEHLLARRLHTFhrqisqedknweTNIQELQKKhrISD 595
Cdd:cd01118   213 SLAIKDPLLFGLAWTLLVlLVVSAFGVDILLIPPSFIAGVLALIFLLLARRGGA------------INPLKVLKE--APW 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 596 GILLakcltvlgFVIFMFFLnsfVPGIHlDLGWIAILGAiWLLILADIHDFEIIlhrveWATLLFFAALFVLM-EIPVLL 674
Cdd:cd01118   279 GVLL--------FSLGLYVV---VFGLK-NAGLTAILAD-LLNWLVSQGLLAAI-----LGVGLLAAFLSNVMnNLPAVL 340

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462544416 675 nlshdpeVGLPA-------PPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFR 732
Cdd:cd01118   341 -------IGALAlaaghapEALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSWGYYLK 398
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 336-484 2.49e-11

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 66.51  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 336 AILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAF 415
Cdd:cd01116   245 ALLGALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAF 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462544416 416 LDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGF 484
Cdd:cd01116   325 IDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEF 393
CitMHS pfam03600
Citrate transporter;
331-445 1.26e-09

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 60.40  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 331 VTIATAILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSrgRVWAMIIMLCLIAA 410
Cdd:pfam03600 224 LLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLSA 301

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462544416 411 VLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 445
Cdd:pfam03600 302 LLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 333-507 6.94e-09

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 58.37  E-value: 6.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 333 IATAILAGVYALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIAAV 411
Cdd:cd01115   213 VSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGlPPFAILLLLCLLTLV 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 412 LSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIftnIGGAA--TAIGDPPNVIIVSNQELRKMglDFagFTAHMF 489
Cdd:cd01115   293 LTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAI---GASCAfmLPVGTPPNAIVLGPGGYKFS--DF--AKVGLP 365

                         170
                  ....*....|....*...
gi 2462544416 490 IGIcLVLLVCFPLLRLLY 507
Cdd:cd01115   366 LSI-LSLVVSVTMIPLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
655-731 1.53e-07

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 54.00  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 655 WATLLFFAALFVL-----------MEIPVLLNLSH---DPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAE- 719
Cdd:COG0471    33 RLLLGLMLATALLsafisntaraaMMLPIALSIAAalgSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEe 112

                          90
                  ....*....|..
gi 2462544416 720 QHGYGFSFMEFF 731
Cdd:COG0471   113 ATGIPISFFEWM 124
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
335-444 8.92e-07

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 52.10  E-value: 8.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 335 TAILAGVYALiiferpsLTHVVEWIDFE---------TLALLfGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIML 405
Cdd:PRK15445   26 SALLGAVLAL-------LTGVVSLGDVPvvwgivwnaTLTFI-AIIIISLLLDEAGFFEWAALHVARWAKGNGRKLFVYI 97

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462544416 406 CLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVL 444
Cdd:PRK15445   98 VLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATL 136
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 339-503 1.36e-05

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 48.11  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 339 AGVYALIIFERPSLTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIA 409
Cdd:TIGR00785 272 ASVVALLAVVLMLFLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFY 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 410 AVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgf 484
Cdd:TIGR00785 352 IILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG-- 429

                         170
                  ....*....|....*....
gi 2462544416 485 tahmFIGICLVLLVCFPLL 503
Cdd:TIGR00785 430 ----IVGLIVLLLVGTLWW 444
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 666-732 2.84e-04

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 43.73  E-value: 2.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462544416 666 VLMEIPVLLNLSHdpEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYG-FSFMEFFR 732
Cdd:cd01115   107 VAIMLPVALGLAA--KLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQgFSFFEFTP 172
CitMHS pfam03600
Citrate transporter;
660-731 7.33e-04

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 42.30  E-value: 7.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462544416 660 FFAALF-----VLMEIPVLLNLSHdpEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFF 731
Cdd:pfam03600  89 LLSAFLsndgtVLIMIPIVLALAR--RLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDFGFFMFP 163
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 337-468 1.35e-03

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 41.97  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 337 ILAGVYALIIFERPSLTHVVEWID-------FETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAM--IIMLCL 407
Cdd:pfam00939 291 IDATTVAIIGLALMLLLRILDWKDivknkgaWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMafIIILSL 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462544416 408 IAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIF-TNIGGAATAIGDPPNVII 468
Cdd:pfam00939 371 FYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPPLLAALLLGFaISLGGFLTPYGTGPGPIY 432
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 333-503 4.10e-03

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 40.34  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 333 IATAILAGVyALIIFERPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRgrvwamIIMLCLIAAVL 412
Cdd:cd01117   228 LWTAALVAA-VLLLLTRLKPRRVLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPLLDS------VLSLFLVSIGL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 413 SAFLDNVTTMLLFTPVTIRLcevlnldPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGF---TAHMF 489
Cdd:cd01117   301 SQLISNVPAVLLLLPFLPSA-------DEKDWLLLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFlkyGVPLT 373

                         170
                  ....*....|....
gi 2462544416 490 IgicLVLLVCFPLL 503
Cdd:cd01117   374 L---LTAAIGILWL 384
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 624-728 4.69e-03

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 39.93  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544416 624 LDLGWIAILGAIWLLILADIHDFEIiLHRVEWATLLFFAALFVL------------------------------------ 667
Cdd:cd00625     9 LPRAVVALLGAVLLVLLGVVSPKEA-LSAIDWETILLLFGMMILsaaleetglfdrlaaklaraskgsrrlllllmllta 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462544416 668 -------------MEIPVLLNLSHdPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFM 728
Cdd:cd00625    88 alsaffsndatavLLTPIVLALLR-KLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFLDFLAF 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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