Eukaryotic translation initiation factor 3 subunit 7 (eIF-3); This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilization of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery. The gene coding for the protein has been implicated in cancer in mammals.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545834 720 SEYLAPQEGNFVYK----LFSLQDLLLLVRCSVQRIETRPRSKkrkkirrQFPVYVLPKVEYQACYGVEALTESELCRLW 795
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462545834 796 TESLLHSNSSFYVGRCSRKSLEVLLKVEIagpTLECL 832
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKL---TLESL 107

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545834 720 SEYLAPQEGNFVYK----LFSLQDLLLLVRCSVQRIETRPRSKkrkkirrQFPVYVLPKVEYQACYGVEALTESELCRLW 795
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462545834 796 TESLLHSNSSFYVGRCSRKSLEVLLKVEIagpTLECL 832
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKL---TLESL 107

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545834 720 SEYLAPQEGNFVYK----LFSLQDLLLLVRCSVQRIETRPRSKkrkkirrQFPVYVLPKVEYQACYGVEALTESELCRLW 795
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462545834 796 TESLLHSNSSFYVGRCSRKSLEVLLKVEIagpTLECL 832
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKL---TLESL 107