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Conserved domains on  [gi|2462546690|ref|XP_054235173|]
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sodium/potassium/calcium exchanger 1 isoform X5 [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-1022 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1453.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690    1 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 80
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690   81 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 159
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  160 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 238
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  239 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 318
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  319 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 398
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  399 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 478
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  479 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 558
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  559 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKpgdgaiav 638
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  639 delqdnkklklpslltrgssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPA 718
Cdd:TIGR00927  633 ------------------------------------------------------------GDVAEAEHTGERTGEEGERP 652

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  719 klpavTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPG---------------EEGETAGEGETEEKSGGETQPEG-- 781
Cdd:TIGR00927  653 -----TEAEGENGEESGGEAEQEGETETKGENESEGEIPAerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGte 727

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  782 -EGETETQGKGEE--------CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------- 826
Cdd:TIGR00927  728 dEGEIETGEEGEEvedegegeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkveheget 807

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  827 -----------------------ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEE 883
Cdd:TIGR00927  808 eagekdehegqsetqaddtevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEE 887

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  884 EEeeeeekgNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVG 963
Cdd:TIGR00927  888 EE-------NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVG 960

                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462546690  964 ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGV---WLLL 1022
Cdd:TIGR00927  961 ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLpvpWLLF 1022
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-1022 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1453.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690    1 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 80
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690   81 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 159
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  160 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 238
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  239 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 318
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  319 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 398
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  399 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 478
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  479 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 558
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  559 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKpgdgaiav 638
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  639 delqdnkklklpslltrgssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPA 718
Cdd:TIGR00927  633 ------------------------------------------------------------GDVAEAEHTGERTGEEGERP 652

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  719 klpavTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPG---------------EEGETAGEGETEEKSGGETQPEG-- 781
Cdd:TIGR00927  653 -----TEAEGENGEESGGEAEQEGETETKGENESEGEIPAerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGte 727

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  782 -EGETETQGKGEE--------CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------- 826
Cdd:TIGR00927  728 dEGEIETGEEGEEvedegegeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkveheget 807

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  827 -----------------------ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEE 883
Cdd:TIGR00927  808 eagekdehegqsetqaddtevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEE 887

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  884 EEeeeeekgNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVG 963
Cdd:TIGR00927  888 EE-------NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVG 960

                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462546690  964 ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGV---WLLL 1022
Cdd:TIGR00927  961 ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLpvpWLLF 1022
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 458-602 8.62e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.17  E-value: 8.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  458 HVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 537
Cdd:pfam01699    1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462546690  538 FVIGTCSLFSREILNLTW----WPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKW 602
Cdd:pfam01699   81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
475-600 1.36e-24

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 105.22  E-value: 1.36e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  475 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSReiLNLT 554
Cdd:COG0530      2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462546690  555 WWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTM 600
Cdd:COG0530     80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 967-1034 3.18e-13

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 71.99  E-value: 3.18e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462546690  967 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITvgVWLLLPRLVCNGVISAH 1034
Cdd:PRK10734   205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIV--IVLGLPALISPGEINPL 270
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-1022 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1453.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690    1 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 80
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690   81 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 159
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  160 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 238
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  239 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 318
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  319 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 398
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  399 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 478
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  479 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 558
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  559 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKpgdgaiav 638
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  639 delqdnkklklpslltrgssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPA 718
Cdd:TIGR00927  633 ------------------------------------------------------------GDVAEAEHTGERTGEEGERP 652

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  719 klpavTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPG---------------EEGETAGEGETEEKSGGETQPEG-- 781
Cdd:TIGR00927  653 -----TEAEGENGEESGGEAEQEGETETKGENESEGEIPAerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGte 727

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  782 -EGETETQGKGEE--------CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------- 826
Cdd:TIGR00927  728 dEGEIETGEEGEEvedegegeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkveheget 807

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  827 -----------------------ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEE 883
Cdd:TIGR00927  808 eagekdehegqsetqaddtevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEE 887

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  884 EEeeeeekgNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVG 963
Cdd:TIGR00927  888 EE-------NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVG 960

                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462546690  964 ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGV---WLLL 1022
Cdd:TIGR00927  961 ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLpvpWLLF 1022
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 457-611 7.49e-45

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 164.42  E-value: 7.49e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  457 LHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNI 536
Cdd:TIGR00367    1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462546690  537 LFVIGTCSLFSrEILNLTWWpLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYvftMKWNKHIEVWVK 611
Cdd:TIGR00367   81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY---LLFLVKNERWVK 150
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 932-1026 4.06e-33

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 130.52  E-value: 4.06e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  932 ESRKFFVFTFL---GSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVG 1008
Cdd:TIGR00367  163 NRRPQIFFSLVlliIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIG 242

                           90       100
                   ....*....|....*....|.
gi 2462546690 1009 SNIFDITVGV---WLLLPRLV 1026
Cdd:TIGR00367  243 SNIFNILVGLgvpSLFMPIPV 263
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 458-602 8.62e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.17  E-value: 8.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  458 HVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 537
Cdd:pfam01699    1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462546690  538 FVIGTCSLFSREILNLTW----WPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKW 602
Cdd:pfam01699   81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
475-600 1.36e-24

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 105.22  E-value: 1.36e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  475 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSReiLNLT 554
Cdd:COG0530      2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462546690  555 WWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTM 600
Cdd:COG0530     80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 936-1026 4.23e-24

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 99.21  E-value: 4.23e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  936 FFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 1015
Cdd:pfam01699    1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                           90
                   ....*....|....
gi 2462546690 1016 VGV---WLLLPRLV 1026
Cdd:pfam01699   81 LVLglsALIGPVKV 94
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
925-1016 1.81e-20

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 92.89  E-value: 1.81e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  925 VPDVRRQESRKFFVFTFLGSIMwIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 1004
Cdd:COG0530    142 LEEKPKMSLWKALLLLVLGLAL-LVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVG 220

                           90
                   ....*....|..
gi 2462546690 1005 SSVGSNIFDITV 1016
Cdd:COG0530    221 NIIGSNIFNILL 232
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
462-600 7.23e-18

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 85.18  E-value: 7.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  462 MMYVFVALA--IVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFV 539
Cdd:COG0530    154 LLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462546690  540 IGTCSLFSReiLNLTWWPLFRDVSFYILDLIMLILFFL-DSLIAWWESLLLLLAYAFYVFTM 600
Cdd:COG0530    234 LGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLALYLAYLALL 293
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 967-1034 3.18e-13

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 71.99  E-value: 3.18e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462546690  967 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITvgVWLLLPRLVCNGVISAH 1034
Cdd:PRK10734   205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIV--IVLGLPALISPGEINPL 270
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 465-586 1.06e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 70.05  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  465 VFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCS 544
Cdd:TIGR00367  177 IGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPS 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2462546690  545 LFSR-EILNLTwwpLFRDVSFYILDLIMLILFF-LDSLIAWWES 586
Cdd:TIGR00367  257 LFMPiPVEPLA---YNLDAPVMVIVTLLLMLFFkTSMKLGRWEG 297
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
959-1016 1.76e-11

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 66.31  E-value: 1.76e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462546690  959 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITV 1016
Cdd:COG0530      8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILL 65
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 962-1014 9.42e-10

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 61.19  E-value: 9.42e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462546690  962 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDI 1014
Cdd:TIGR00367   28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 462-543 1.23e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 62.50  E-value: 1.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  462 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGV----FIS 519
Cdd:TIGR00845   82 MVYMFLGVSIIADR-FMASIEVITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA 160

                           90       100
                   ....*....|....*....|....
gi 2462546690  520 hSNVGIGTIVGSAVFNILFVIGTC 543
Cdd:TIGR00845  161 -GDLGPSTIVGSAAFNMFIIIAIC 183
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 483-547 1.35e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 54.65  E-value: 1.35e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462546690  483 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFS 547
Cdd:PRK10734   199 VLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 955-1014 3.34e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 53.50  E-value: 3.34e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  955 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDI 1014
Cdd:PRK10734    22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNI 81
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 453-605 1.37e-06

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 52.46  E-value: 1.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  453 GWVVLHVFgMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSlIGVFISHS--NVGIGTIVG 530
Cdd:PLN03151   139 GYAVLGVW-LVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLG 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  531 SAVFNILFVIGTCSL-FSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWN----KH 605
Cdd:PLN03151   217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANeilrKH 296
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 924-1018 4.82e-04

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 43.98  E-value: 4.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  924 TVPDvrrQESRKFFVFTFLG----SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlG 999
Cdd:PLN03151   471 TEPD---RPPRRFLIPWVLGgfimSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-G 546

                           90       100
                   ....*....|....*....|..
gi 2462546690 1000 D---MAVSSSVGSNIFDITVGV 1018
Cdd:PLN03151   547 DgvqIAMSGCYAGPMFNTLVGL 568
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 103-360 3.56e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 3.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  103 TLSMTVENIPSMPK-----RTAKMIPTTT----------KNNYSPTAAGTERRKEDT----PTSSRTLTYYTSTSSR--- 160
Cdd:pfam05109  388 TFDITVSGLGTAPKtliitRTATNATTTThkvifskapeSTTTSPTLNTTGFAAPNTttglPSSTHVPTNLTAPASTgpt 467

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  161 -QIVKKYTPTPRGEMKSYSPTqvrekvkyTPSPRGRRVGTYVPSTFMTMETSHAITPrtTVKDSDITATYKILETNSLKR 239
Cdd:pfam05109  468 vSTADVTSPTPAGTTSGASPV--------TPSPSPRDNGTESKAPDMTSPTSAVTTP--TPNATSPTPAVTTPTPNATSP 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  240 IMEETTPTTLKgmfdSTPTfltheveanvltsprsvmeKNNLFPPRRVESNSSAHPWGLVGKSNPKTpqgTVLLHTPATS 319
Cdd:pfam05109  538 TLGKTSPTSAV----TTPT-------------------PNATSPTPAVTTPTPNATIPTLGKTSPTS---AVTTPTPNAT 591

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2462546690  320 EGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTA 360
Cdd:pfam05109  592 SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTG 632
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 940-1018 6.37e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 40.55  E-value: 6.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  940 TFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGV 1018
Cdd:TIGR00845  758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 490-582 6.63e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 40.75  E-value: 6.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546690  490 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDL 569
Cdd:TIGR00927  965 ISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVL 1044

                           90
                   ....*....|...
gi 2462546690  570 IMLILFFLDSLIA 582
Cdd:TIGR00927 1045 LFLMLLFVISSIA 1057
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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