NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462546978|ref|XP_054235308|]
View 

cadherin-5 isoform X1 [Homo sapiens]

Protein Classification

Cadherin_repeat and Cadherin_C domain-containing protein( domain architecture ID 11254411)

Cadherin_repeat and Cadherin_C domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 2.35e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGrIITITKSLDREKQARYEIVVEARDa 232
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTG-EITTAKPLDREEQSSYTLTVTATD- 76

                          90       100
                  ....*....|....*....|..
gi 2462546978 233 QGLRGDSGTATVLVTLQDINDN 254
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 725-784 7.83e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.99  E-value: 7.83e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 725 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 784
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
272-373 1.81e-24

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 1.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 272 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDP 351
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 2462546978 352 TidlrymSPPAGNRAQVIINIT 373
Cdd:pfam00028  77 G------GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-484 1.35e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 386 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 462
Cdd:cd11304     2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|..
gi 2462546978 463 GTPtGKESIVQVHIEVLDENDN 484
Cdd:cd11304    78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-585 1.30e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 491 PYQPKVCENAVHGQLVLQISAIDKDItPRNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 567
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 2462546978 568 DNGMPSRTGTSTLTVAVC 585
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-149 1.31e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.31e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462546978   79 NAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 149
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 2.35e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGrIITITKSLDREKQARYEIVVEARDa 232
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTG-EITTAKPLDREEQSSYTLTVTATD- 76

                          90       100
                  ....*....|....*....|..
gi 2462546978 233 QGLRGDSGTATVLVTLQDINDN 254
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 725-784 7.83e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.99  E-value: 7.83e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 725 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 784
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
272-373 1.81e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 1.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 272 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDP 351
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 2462546978 352 TidlrymSPPAGNRAQVIINIT 373
Cdd:pfam00028  77 G------GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-377 1.69e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 1.69e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 272 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETnpahNEGIIKPMKPLDYEYIQQYSFIVEATDP 351
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDP----STGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*.
gi 2462546978 352 TidlrymSPPAGNRAQVIINITDVDE 377
Cdd:cd11304    78 G------GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
156-249 2.60e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 2.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKGKEY--FAIDNSGRIITITKSLDREKQARYEIVVEARDaQ 233
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATD-S 76

                          90
                  ....*....|....*.
gi 2462546978 234 GLRGDSGTATVLVTLQ 249
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 174-256 1.22e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  174 TAVDADDptvGDHASVMYQILKG--KEYFAIDNSGRIITITKSLDREKQARYEIVVEARDaQGLRGDSGTATVLVTLQDI 251
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                   ....*
gi 2462546978  252 NDNFP 256
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-484 1.35e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 386 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 462
Cdd:cd11304     2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|..
gi 2462546978 463 GTPtGKESIVQVHIEVLDENDN 484
Cdd:cd11304    78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
386-479 5.13e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 386 YHFQLKENQK-KPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDstg 463
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--- 77

                          90
                  ....*....|....*.
gi 2462546978 464 tPTGKESIVQVHIEVL 479
Cdd:pfam00028  78 -GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-585 1.30e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 491 PYQPKVCENAVHGQLVLQISAIDKDItPRNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 567
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 2462546978 568 DNGMPSRTGTSTLTVAVC 585
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-379 7.68e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 7.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  291 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDPTidlrymSPPAGNRAQVII 370
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTATVTI 71

                           90
                   ....*....|
gi 2462546978  371 NITDV-DEPP 379
Cdd:smart00112  72 TVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-149 1.31e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.31e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462546978   79 NAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 149
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 404-486 2.91e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  404 AMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKelDSTGTPtgKESIVQVHIEVLDEN 482
Cdd:smart00112   2 ATDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLDVN 77


                   ....
gi 2462546978  483 DNAP 486
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
53-142 2.68e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 2.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  53 QMHIDEEKNT-SLPHHVGKI-KSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGEN 130
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATdPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GPP 80

                          90
                  ....*....|..
gi 2462546978 131 LETPSSFTIKVH 142
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-147 3.76e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  53 QMHIDEekNTSLPHHVGKIKS----SVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtG 128
Cdd:cd11304     3 EVSVPE--NAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*....
gi 2462546978 129 ENLETPSSFTIKVHDVNDN 147
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
496-585 7.59e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 496 VCENAVHGQLVLQISAIDKDITPrNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVISDNGMP 572
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGP-NGRIFYSIlggGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 2462546978 573 SRTGTSTLTVAVC 585
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-589 9.86e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 9.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  510 SAIDKDiTPRNVKFKFTLNTENNFTLTDNHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 589
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 2.35e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGrIITITKSLDREKQARYEIVVEARDa 232
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTG-EITTAKPLDREEQSSYTLTVTATD- 76

                          90       100
                  ....*....|....*....|..
gi 2462546978 233 QGLRGDSGTATVLVTLQDINDN 254
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 725-784 7.83e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.99  E-value: 7.83e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 725 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 784
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
272-373 1.81e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 1.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 272 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDP 351
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 2462546978 352 TidlrymSPPAGNRAQVIINIT 373
Cdd:pfam00028  77 G------GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-377 1.69e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 1.69e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 272 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETnpahNEGIIKPMKPLDYEYIQQYSFIVEATDP 351
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDP----STGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*.
gi 2462546978 352 TidlrymSPPAGNRAQVIINITDVDE 377
Cdd:cd11304    78 G------GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
156-249 2.60e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 2.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 156 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKGKEY--FAIDNSGRIITITKSLDREKQARYEIVVEARDaQ 233
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATD-S 76

                          90
                  ....*....|....*.
gi 2462546978 234 GLRGDSGTATVLVTLQ 249
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 174-256 1.22e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  174 TAVDADDptvGDHASVMYQILKG--KEYFAIDNSGRIITITKSLDREKQARYEIVVEARDaQGLRGDSGTATVLVTLQDI 251
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                   ....*
gi 2462546978  252 NDNFP 256
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-484 1.35e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 386 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 462
Cdd:cd11304     2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|..
gi 2462546978 463 GTPtGKESIVQVHIEVLDENDN 484
Cdd:cd11304    78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
386-479 5.13e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 386 YHFQLKENQK-KPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDstg 463
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--- 77

                          90
                  ....*....|....*.
gi 2462546978 464 tPTGKESIVQVHIEVL 479
Cdd:pfam00028  78 -GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-585 1.30e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 491 PYQPKVCENAVHGQLVLQISAIDKDItPRNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 567
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 2462546978 568 DNGMPSRTGTSTLTVAVC 585
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-379 7.68e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 7.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  291 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPahneGIIKPMKPLDYEYIQQYSFIVEATDPTidlrymSPPAGNRAQVII 370
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTATVTI 71

                           90
                   ....*....|
gi 2462546978  371 NITDV-DEPP 379
Cdd:smart00112  72 TVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 79-149 1.31e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.31e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462546978   79 NAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 149
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 404-486 2.91e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  404 AMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKelDSTGTPtgKESIVQVHIEVLDEN 482
Cdd:smart00112   2 ATDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLDVN 77


                   ....
gi 2462546978  483 DNAP 486
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
53-142 2.68e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 2.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  53 QMHIDEEKNT-SLPHHVGKI-KSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGEN 130
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATdPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GPP 80

                          90
                  ....*....|..
gi 2462546978 131 LETPSSFTIKVH 142
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-147 3.76e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  53 QMHIDEekNTSLPHHVGKIKS----SVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtG 128
Cdd:cd11304     3 EVSVPE--NAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*....
gi 2462546978 129 ENLETPSSFTIKVHDVNDN 147
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
496-585 7.59e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978 496 VCENAVHGQLVLQISAIDKDITPrNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVISDNGMP 572
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGP-NGRIFYSIlggGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 2462546978 573 SRTGTSTLTVAVC 585
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-589 9.86e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 9.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  510 SAIDKDiTPRNVKFKFTLNTENNFTLTDNHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 589
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 61-147 1.32e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 47.34  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546978  61 NTSLPHHVGKIKSSV---SRKNAKYLLKG-EYVGKVFRVDAETGDVFAIERLDRENISEYHLTaVIVDKDTGENLETPSS 136
Cdd:cd00031     9 GRSRGSFRVSIPTDLiasSGEIIKISAAGkEALPSWLHWEPHSGILEGLEKLDREDKGVHYIS-VSAASLGANVPQTSSV 87

                          90
                  ....*....|.
gi 2462546978 137 FTIKVHDVNDN 147
Cdd:cd00031    88 FSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH