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Conserved domains on  [gi|2462547419|ref|XP_054235524|]
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dynein axonemal assembly factor 1 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 3.66e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 154.56  E-value: 3.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340    87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547419 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
PHA03169 super family cl27451
hypothetical protein; Provisional
 296-508 9.32e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.88  E-value: 9.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 374
Cdd:PHA03169   26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 375 aEGKEEPPGDRETRQkmELFVKESFEAKEELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 450
Cdd:PHA03169   99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547419 451 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 508
Cdd:PHA03169  175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 3.66e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 154.56  E-value: 3.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340    87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547419 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-279 1.97e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 1.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 187
Cdd:COG4886   117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 188 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 266
Cdd:COG4886   197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                         170
                  ....*....|...
gi 2462547419 267 tvTVRLKHLTYLD 279
Cdd:COG4886   268 --LANLTNLKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
166-302 1.70e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.24  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 166 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRlcVLDLSHNKLSDPEILSILES 243
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLT--ELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547419 244 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 302
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 173-274 6.63e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 6.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 173 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 250
Cdd:PLN00113  475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                          90       100
                  ....*....|....*....|....*...
gi 2462547419 251 NLMGNPVIRQIP----NYRRTVTVRLKH 274
Cdd:PLN00113  553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
PHA03169 PHA03169
hypothetical protein; Provisional
 296-508 9.32e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.88  E-value: 9.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 374
Cdd:PHA03169   26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 375 aEGKEEPPGDRETRQkmELFVKESFEAKEELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 450
Cdd:PHA03169   99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547419 451 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 508
Cdd:PHA03169  175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 3.66e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 154.56  E-value: 3.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340    87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547419 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-279 1.97e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 1.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 187
Cdd:COG4886   117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 188 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 266
Cdd:COG4886   197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                         170
                  ....*....|...
gi 2462547419 267 tvTVRLKHLTYLD 279
Cdd:COG4886   268 --LANLTNLKTLD 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-279 1.36e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419  89 TKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI- 166
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 167 ENLEPLQKLDALNLSNNYIKTI-ENLSCLPVLNTLQMAHNHLETVEDiqHLQECLRLCVLDLSHNKLSDpeILSILESMP 245
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTD--LPEPLANLT 228

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462547419 246 DLRVLNLMGNPvIRQIPNYRrtvtvRLKHLTYLD 279
Cdd:COG4886   229 NLETLDLSNNQ-LTDLPELG-----NLTNLEELD 256
LRR_9 pfam14580
Leucine-rich repeat;
166-302 1.70e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.24  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 166 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRlcVLDLSHNKLSDPEILSILES 243
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLT--ELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547419 244 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 302
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-263 1.78e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTI 188
Cdd:COG4886   186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462547419 189 ENLSCLPVLNTLQMAHNHLETVEdIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPN 263
Cdd:COG4886   266 PPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-279 3.43e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 3.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419  91 SSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLE 170
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 171 PLQKLDALNLSNNyiktiENLSCLPVLNTLQMAHNHLETV-EDIQHLQEcLRlcVLDLSHNKLSDpeILSILESMPDLRV 249
Cdd:COG4886    94 DLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTN-LK--ELDLSNNQLTD--LPEPLGNLTNLKS 163

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462547419 250 LNLMGNPvIRQIPNyrrtVTVRLKHLTYLD 279
Cdd:COG4886   164 LDLSNNQ-LTDLPE----ELGNLTNLKELD 188
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 221-265 3.55e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 46.85  E-value: 3.55e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2462547419 221 RLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPVIRQIPNYR 265
Cdd:pfam12799   2 NLEVLDLSNNQITD---IPPLAKLPNLETLDLSGNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
151-207 1.06e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462547419 151 TELRCLFLQMNLLRKI--ENLEPLQKLDALNLSNNYIKTIEN--LSCLPVLNTLQMAHNHL 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 122-255 1.28e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 122 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMN------LLRKIENLEPLQKLDALNLSNNYIKT-- 187
Cdd:COG5238   229 AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNqigaegAIALAKALQGNTTLTSLDLSVNRIGDeg 308

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547419 188 ----IENLSCLPVLNTLQMAHNHLETVEDI---QHLQECLRLCVLDLSHNKLSDP---EILSILESMPDLRVLNLMGN 255
Cdd:COG5238   309 aialAEGLQGNKTLHTLNLAYNGIGAQGAIalaKALQENTTLHSLDLSDNQIGDEgaiALAKYLEGNTTLRELNLGKN 386
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 151-192 1.31e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.62  E-value: 1.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2462547419 151 TELRCLFLQMNLLRKIENLEPLQKLDALNLS-NNYIKTIENLS 192
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-279 1.97e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 102 LYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLS 181
Cdd:COG4886     6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 182 NNYIKTIENLSCLPVLNtlqmahnhLETVEDIQHLQEclrLCVLDLSHNKLSDpeILSILESMPDLRVLNLMGNPvIRQI 261
Cdd:COG4886    86 LLGLTDLGDLTNLTELD--------LSGNEELSNLTN---LESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LTDL 151

                         170
                  ....*....|....*...
gi 2462547419 262 PnyrrTVTVRLKHLTYLD 279
Cdd:COG4886   152 P----EPLGNLTNLKSLD 165
LRR_8 pfam13855
Leucine rich repeat;
195-257 2.06e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462547419 195 PVLNTLQMAHNHLETVED--IQHLQeclRLCVLDLSHNKLS--DPEILSileSMPDLRVLNLMGNPV 257
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLS---NLKVLDLSNNLLTtlSPGAFS---GLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 173-218 4.06e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 4.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462547419 173 QKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLetVEDIQHLQE 218
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-174 1.53e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462547419 129 TGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNllRKIENLEPLQK 174
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 122-257 2.07e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 122 IENLEEYTGLRCLWLQSNGIQK-----IENLEAQTELRCLFLQMNLLRK------IENLEPLQ-KLDALNLSNNyikTIE 189
Cdd:cd00116    74 LQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDrglrllAKGLKDLPpALEKLVLGRN---RLE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 190 NLSC---------LPVLNTLQMAHNHLeTVEDIQHLQECLR----LCVLDLSHNKLSDPEILSI---LESMPDLRVLNLM 253
Cdd:cd00116   151 GASCealakalraNRDLKELNLANNGI-GDAGIRALAEGLKancnLEVLDLNNNGLTDEGASALaetLASLKSLEVLNLG 229


                  ....
gi 2462547419 254 GNPV 257
Cdd:cd00116   230 DNNL 233
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 173-274 6.63e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 6.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 173 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 250
Cdd:PLN00113  475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                          90       100
                  ....*....|....*....|....*...
gi 2462547419 251 NLMGNPVIRQIP----NYRRTVTVRLKH 274
Cdd:PLN00113  553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
PHA03169 PHA03169
hypothetical protein; Provisional
 296-508 9.32e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.88  E-value: 9.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 374
Cdd:PHA03169   26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 375 aEGKEEPPGDRETRQkmELFVKESFEAKEELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 450
Cdd:PHA03169   99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547419 451 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 508
Cdd:PHA03169  175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
PHA03169 PHA03169
hypothetical protein; Provisional
 302-508 1.39e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.49  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQ--------RESQERGMRSAEDNSPRVPLRLGEMTSSDDGENVPA 373
Cdd:PHA03169   53 TSGPQVRAVAEQGHRQTESDTETAEESRHGEKEERGqggpsgsgSESVGSPTPSPSGSAEELASGLSPENTSGSSPESPA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 374 SAEGKEEPPGDRETRQKMElfvKESFEAKEELCPE---KPSGEEPPVEAKREDGGPEPEGTLPAET-LLLSSPVEVKGED 449
Cdd:PHA03169  133 SHSPPPSPPSHPGPHEPAP---PESHNPSPNQQPSsflQPSHEDSPEEPEPPTSEPEPDSPGPPQSeTPTSSPPPQSPPD 209

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547419 450 GDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEG 508
Cdd:PHA03169  210 EPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPPFPGHRSHSYTVVGWKPSTRPGG 268
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 173-279 1.83e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 173 QKLDALNLSNNYIKTI------ENLSCLPVLNTLQMAHNHL---ETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILES 243
Cdd:COG5238   180 NSVETVYLGCNQIGDEgieelaEALTQNTTVTTLWLKRNPIgdeGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462547419 244 MPD---LRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLD 279
Cdd:COG5238   260 LKNnttVETLYLSGNQIGAEGAIALAKALQGNTTLTSLD 298
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 122-275 2.05e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 122 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMNLLRK------IENLEPLQKLDALNLSNNYIKT-- 187
Cdd:COG5238   257 AEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqg 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547419 188 ----IENLSCLPVLNTLQMAHNHL--ETVEDI-QHLQECLRLCVLDLSHNKLSDPEILSILESM--PDLRVLNLMGNPVI 258
Cdd:COG5238   337 aialAKALQENTTLHSLDLSDNQIgdEGAIALaKYLEGNTTLRELNLGKNNIGKQGAEALIDALqtNRLHTLILDGNLIG 416

                         170
                  ....*....|....*..
gi 2462547419 259 RQIpnyRRTVTVRLKHL 275
Cdd:COG5238   417 AEA---QQRLEQLLERI 430
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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