|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
603-1008 |
5.39e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 163.16 E-value: 5.39e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 603 RHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAmcAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLR 682
Cdd:COG2319 15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLA--AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 683 VLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHP 762
Cdd:COG2319 93 LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 763 TRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQW-HVLRVAADMVcpd 841
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLlRTLTGHSGSV--- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 842 apaspSALAVSRDGRLLAfvgpsrctvtvmgSASLDELLRV-DIGT---LDLASSRLDSAMAVCFGPAalGHLLVSTSSN 917
Cdd:COG2319 250 -----RSVAFSPDGRLLA-------------SGSADGTVRLwDLATgelLRTLTGHSGGVNSVAFSPD--GKLLASGSDD 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 918 RVV-VLDAVSGRIIRELPGvHPEPCPSLTLSEDARFLLIA-AGRTIKVWDYATQASPgpQVYIGHSEPVQAVAFSPDQQQ 995
Cdd:COG2319 310 GTVrLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGsDDGTVRLWDLATGELL--RTLTGHTGAVTSVAFSPDGRT 386
|
410
....*....|....*
gi 2462547845 996 VLSAGD--AVFLWDV 1008
Cdd:COG2319 387 LASGSAdgTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1230-1645 |
9.96e-41 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 156.22 E-value: 9.96e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1230 GRLVVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSttahcqIRVWDVSGGLCQHLIFPHSTTVLALAFSPD 1309
Cdd:COG2319 58 LTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT------VRLWDLATGLLLRTLTGHTGAVRSVAFSPD 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1310 DRLLVTlGDHDGrTLALWGTATYDLVSSTRLPE-PVHGVAFNPwDageltcvGQgtvtfwllqqrgadislqvrrepvpe 1388
Cdd:COG2319 132 GKTLAS-GSADG-TVRLWDLATGKLLRTLTGHSgAVTSVAFSP-D-------GK-------------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1389 avgageltslcygappLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSEL 1466
Cdd:COG2319 176 ----------------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1467 RC-KGSGARSSSVfmehELVLDGA-VVSASFDDSVdmgvvgttagTLWfvSWAEGTSTRLISGHRSKVNEVVFSPGESHC 1544
Cdd:COG2319 240 RTlTGHSGSVRSV----AFSPDGRlLASGSADGTV----------RLW--DLATGELLRTLTGHSGGVNSVAFSPDGKLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1545 ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSppccgrPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTT 1624
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS 377
|
410 420
....*....|....*....|.
gi 2462547845 1625 VAFSTDGQTVLSGDKDGLVAV 1645
Cdd:COG2319 378 VAFSPDGRTLASGSADGTVRL 398
|
|
| CFA20_dom |
pfam05018 |
CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 ... |
13-190 |
3.01e-34 |
|
CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. In Chlamydomonas reinhardtii, it stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats. This domain is also present in the N terminus of uncharacterized protein C3orf67.
Pssm-ID: 461521 Cd Length: 185 Bit Score: 130.40 E-value: 3.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 13 AWQHPFLNVFRHFRV---DEWKRSAKQGDVAVVTDKTLKGAVYRIRGSVSAANYIQLPKSSTQSLGLTGRYLYVLFRPLp 89
Cdd:pfam05018 5 TFQSGFLSIFYSIGSkplQIWSKKVKNGHIKRVTDDDIKSNVLEIVGTNVATTYITCPADPKQSLGIKLPFLVLLVKNL- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 90 SKHFVIHLDVSSKDNQVIRVSFSNLFKEFKSTATWLQFPLVLEartpqrdlvglapsgARWTClqldLQDVLLVYLNRCY 169
Cdd:pfam05018 84 GKYFSFEIQILDDKNVRRRFRFSNFQKVTKVKPFITTMPLRLN---------------EGWNQ----IQFNLADFTRRAY 144
|
170 180
....*....|....*....|....*
gi 2462547845 170 G----HLKSIRLCASLLVRNLYTSD 190
Cdd:pfam05018 145 GtnyvETVRVQIHANCRLRRIYFSD 169
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
707-1007 |
6.52e-31 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 124.37 E-value: 6.52e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 707 RSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEV 786
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 787 LVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAqyscadpQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAfvgpsrc 866
Cdd:cd00200 86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK-------VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVA------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 867 tvtvmgSASLDELLRVdigtLDLASSRL--------DSAMAVCFGPAalGHLLVSTSSNRVV-VLDAVSGRIIRELPGvH 937
Cdd:cd00200 152 ------SSSQDGTIKL----WDLRTGKCvatltghtGEVNSVAFSPD--GEKLLSSSSDGTIkLWDLSTGKCLGTLRG-H 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547845 938 PEPCPSLTLSEDARFLLIAAG-RTIKVWDYATQASpgPQVYIGHSEPVQAVAFSPDQQQVLSAGD--AVFLWD 1007
Cdd:cd00200 219 ENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGEC--VQTLSGHTNSVTSLAWSPDGKRLASGSAdgTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1393-1699 |
9.27e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 115.12 E-value: 9.27e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1393 GELTSLCYGA-PPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSELRck 1469
Cdd:cd00200 10 GGVTCVAFSPdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETGECVR-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1470 gsgarsssVFMEHElvldGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSE 1549
Cdd:cd00200 88 --------TLTGHT----SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1550 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPpccgrpEQQRLAAGYGDGSLRIFSVsRTAMELK-MHPHPVALTTVAFS 1628
Cdd:cd00200 156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP------DGEKLLSSSSDGTIKLWDL-STGKCLGtLRGHENGVNSVAFS 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462547845 1629 TDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGApisticVTCkecedLGVEGTDLWLA-ASGDQRVSVWA 1699
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS------VTS-----LAWSPDGKRLAsGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
400-777 |
4.59e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 115.78 E-value: 4.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 400 AVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAqARAPSVmRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLC 479
Cdd:COG2319 59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA-SADGTV-RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 480 GVGKDHhgrtMVVAWGTGQvglgGEVVVLAKAHTDfDVQAfrVTFF-DETRMASCGQ-GSVRLWRLRGGVLrscpVDLGE 557
Cdd:COG2319 137 SGSADG----TVRLWDLAT----GKLLRTLTGHSG-AVTS--VAFSpDGKLLASGSDdGTVRLWDLATGKL----LRTLT 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 558 HHALQFTDLAFkqARDGcpepsaAMLFVCSRSGHIleidcqrmvvrharRLLPTRTPggphpQKQTFSSGPGIAISSLSV 637
Cdd:COG2319 202 GHTGAVRSVAF--SPDG------KLLASGSADGTV--------------RLWDLATG-----KLLRTLTGHSGSVRSVAF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 638 SP--AMCAVGSEDGFLRLWPLDFSSVL-LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVL 714
Cdd:COG2319 255 SPdgRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547845 715 ALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVR 777
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
415-738 |
1.82e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 96.64 E-value: 1.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 415 FLGHTDKVSALALDGSSSLLASAQARapSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHhgrtMVVAW 494
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK----TIRLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 495 gtgQVGLGGEVVVLaKAHTDfDVQAfrVTFFDETRMASCG--QGSVRLWRLRGGVLRSCpvdLGEHHAlqftdlafkQAR 572
Cdd:cd00200 79 ---DLETGECVRTL-TGHTS-YVSS--VAFSPDGRILSSSsrDKTIKVWDVETGKCLTT---LRGHTD---------WVN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 573 DGCPEPSAAMLFVCSRSGHILEIDcqrmvVRHARRLlptrtpggphpqkQTFSsGPGIAISSLSVSP--AMCAVGSEDGF 650
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWD-----LRTGKCV-------------ATLT-GHTGEVNSVAFSPdgEKLLSSSSDGT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 651 LRLWPLDFSSVL--LEAeHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATV 728
Cdd:cd00200 201 IKLWDLSTGKCLgtLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
|
330
....*....|
gi 2462547845 729 SQDRTVRIWD 738
Cdd:cd00200 280 SADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1521-1839 |
1.81e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 85.08 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1521 STRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSppccgrPEQQRLAAGYGDGS 1600
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS------ADGTYLASGSSDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1601 LRIFSVS--RTAMELKMHPHPValTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGaPISTICVTckecedl 1678
Cdd:cd00200 75 IRLWDLEtgECVRTLTGHTSYV--SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD-WVNSVAFS------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1679 gvEGTDLWLAASGDQRVSVWASDWLRnhcelvdwlsfpmpattetqghlppslaafcpwdgalLMYVGPGVYKEViiynl 1758
Cdd:cd00200 145 --PDGTFVASSSQDGTIKLWDLRTGK-------------------------------------CVATLTGHTGEV----- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1759 cqkqvvekiplpffaMSLSLSPGTHLLAVGFAECMLRLVDCAMGTA-QDFAGHDNAVHLCRFTPSARLLFTAARNE-ILV 1836
Cdd:cd00200 181 ---------------NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGSEDGtIRV 245
|
...
gi 2462547845 1837 WEV 1839
Cdd:cd00200 246 WDL 248
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1519-1556 |
3.20e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.38 E-value: 3.20e-06
10 20 30
....*....|....*....|....*....|....*...
gi 2462547845 1519 GTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVW 1556
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1519-1556 |
5.78e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.64 E-value: 5.78e-06
10 20 30
....*....|....*....|....*....|....*...
gi 2462547845 1519 GTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVW 1556
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
707-738 |
7.61e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.83 E-value: 7.61e-04
10 20 30
....*....|....*....|....*....|..
gi 2462547845 707 RSHTAPVLALAMEQRRGQLATVSQDRTVRIWD 738
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
988-1133 |
1.75e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.33 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 988 AFSPDQQqvlsAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPCQASPPRLGVCARPP 1067
Cdd:PRK12323 344 ALAPDEY----AGFTMTLLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAV 419
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547845 1068 EGGDGTLSPSDEEGPCEESCDPEGLGQASGPPVLTEEEAGRAGDGAWAAAVGSWGLALPPRSPGQP 1133
Cdd:PRK12323 420 AAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP 485
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
603-1008 |
5.39e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 163.16 E-value: 5.39e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 603 RHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAmcAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLR 682
Cdd:COG2319 15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLA--AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 683 VLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHP 762
Cdd:COG2319 93 LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 763 TRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQW-HVLRVAADMVcpd 841
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLlRTLTGHSGSV--- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 842 apaspSALAVSRDGRLLAfvgpsrctvtvmgSASLDELLRV-DIGT---LDLASSRLDSAMAVCFGPAalGHLLVSTSSN 917
Cdd:COG2319 250 -----RSVAFSPDGRLLA-------------SGSADGTVRLwDLATgelLRTLTGHSGGVNSVAFSPD--GKLLASGSDD 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 918 RVV-VLDAVSGRIIRELPGvHPEPCPSLTLSEDARFLLIA-AGRTIKVWDYATQASPgpQVYIGHSEPVQAVAFSPDQQQ 995
Cdd:COG2319 310 GTVrLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGsDDGTVRLWDLATGELL--RTLTGHTGAVTSVAFSPDGRT 386
|
410
....*....|....*
gi 2462547845 996 VLSAGD--AVFLWDV 1008
Cdd:COG2319 387 LASGSAdgTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1230-1645 |
9.96e-41 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 156.22 E-value: 9.96e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1230 GRLVVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSttahcqIRVWDVSGGLCQHLIFPHSTTVLALAFSPD 1309
Cdd:COG2319 58 LTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT------VRLWDLATGLLLRTLTGHTGAVRSVAFSPD 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1310 DRLLVTlGDHDGrTLALWGTATYDLVSSTRLPE-PVHGVAFNPwDageltcvGQgtvtfwllqqrgadislqvrrepvpe 1388
Cdd:COG2319 132 GKTLAS-GSADG-TVRLWDLATGKLLRTLTGHSgAVTSVAFSP-D-------GK-------------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1389 avgageltslcygappLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSEL 1466
Cdd:COG2319 176 ----------------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1467 RC-KGSGARSSSVfmehELVLDGA-VVSASFDDSVdmgvvgttagTLWfvSWAEGTSTRLISGHRSKVNEVVFSPGESHC 1544
Cdd:COG2319 240 RTlTGHSGSVRSV----AFSPDGRlLASGSADGTV----------RLW--DLATGELLRTLTGHSGGVNSVAFSPDGKLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1545 ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSppccgrPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTT 1624
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS 377
|
410 420
....*....|....*....|.
gi 2462547845 1625 VAFSTDGQTVLSGDKDGLVAV 1645
Cdd:COG2319 378 VAFSPDGRTLASGSADGTVRL 398
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1263-1698 |
9.12e-38 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 147.75 E-value: 9.12e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1263 QVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDhDGRTLALWGTATYDLVSSTRLPE 1342
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAG-DLTLLLLDAAAGALLATLLGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1343 PVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVpeavgagelTSLCYgAP--PLLYCGTSSGQVCVWDT 1420
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV---------RSVAF-SPdgKTLASGSADGTVRLWDL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1421 RAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSELR-CKGSGARSSSVfmehELVLDGA-VVSASFD 1496
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSV----AFSPDGKlLASGSAD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1497 DSVdmgvvgttagTLWfvSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLC 1576
Cdd:COG2319 226 GTV----------RLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1577 LAWSppccgrPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRV 1656
Cdd:COG2319 294 VAFS------PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 2462547845 1657 LSDHQGaPISTICVTckecedlgveGTDLWLA-ASGDQRVSVW 1698
Cdd:COG2319 368 LTGHTG-AVTSVAFS----------PDGRTLAsGSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
634-1008 |
3.04e-37 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 146.21 E-value: 3.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 634 SLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAP 712
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLgLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 713 VLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTC 792
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 793 HRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQW-HVLRVAADMVcpdapaspSALAVSRDGRLLAfvgpsrctvtvm 871
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAV--------RSVAFSPDGKLLA------------ 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 872 gSASLDELLRVdigtLDLASSRL--------DSAMAVCFGPAalGHLLVSTSSNRVVVL-DAVSGRIIRELPGvHPEPCP 942
Cdd:COG2319 221 -SGSADGTVRL----WDLATGKLlrtltghsGSVRSVAFSPD--GRLLASGSADGTVRLwDLATGELLRTLTG-HSGGVN 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547845 943 SLTLSEDARFLLIA-AGRTIKVWDYATQASpgPQVYIGHSEPVQAVAFSPDQQQVLSAGD--AVFLWDV 1008
Cdd:COG2319 293 SVAFSPDGKLLASGsDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFSPDGKTLASGSDdgTVRLWDL 359
|
|
| CFA20_dom |
pfam05018 |
CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 ... |
13-190 |
3.01e-34 |
|
CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. In Chlamydomonas reinhardtii, it stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats. This domain is also present in the N terminus of uncharacterized protein C3orf67.
Pssm-ID: 461521 Cd Length: 185 Bit Score: 130.40 E-value: 3.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 13 AWQHPFLNVFRHFRV---DEWKRSAKQGDVAVVTDKTLKGAVYRIRGSVSAANYIQLPKSSTQSLGLTGRYLYVLFRPLp 89
Cdd:pfam05018 5 TFQSGFLSIFYSIGSkplQIWSKKVKNGHIKRVTDDDIKSNVLEIVGTNVATTYITCPADPKQSLGIKLPFLVLLVKNL- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 90 SKHFVIHLDVSSKDNQVIRVSFSNLFKEFKSTATWLQFPLVLEartpqrdlvglapsgARWTClqldLQDVLLVYLNRCY 169
Cdd:pfam05018 84 GKYFSFEIQILDDKNVRRRFRFSNFQKVTKVKPFITTMPLRLN---------------EGWNQ----IQFNLADFTRRAY 144
|
170 180
....*....|....*....|....*
gi 2462547845 170 G----HLKSIRLCASLLVRNLYTSD 190
Cdd:pfam05018 145 GtnyvETVRVQIHANCRLRRIYFSD 169
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
598-968 |
8.68e-34 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 135.81 E-value: 8.68e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 598 QRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCV 676
Cdd:COG2319 49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 677 SPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPC 756
Cdd:COG2319 129 SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 757 AVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQ-WHVLRVAA 835
Cdd:COG2319 209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHS 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 836 DMVcpdapaspSALAVSRDGRLLAfvgpsrctvtvmgSASLDELLRV-DIGTLDLA---SSRLDSAMAVCFGPAalGHLL 911
Cdd:COG2319 289 GGV--------NSVAFSPDGKLLA-------------SGSDDGTVRLwDLATGKLLrtlTGHTGAVRSVAFSPD--GKTL 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547845 912 VSTSSNRVVVL-DAVSGRIIRELPGvHPEPCPSLTLSEDARFLLIAAG-RTIKVWDYAT 968
Cdd:COG2319 346 ASGSDDGTVRLwDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSAdGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
386-818 |
4.80e-31 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 127.72 E-value: 4.80e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 386 LWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHV 465
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 466 VCSLSFSDSGALLCGVGKDHHgrtmVVAWGTgqvgLGGEVVVLAKAHTDfDVQAfrVTFF-DETRMASCGQ-GSVRLWRL 543
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGT----VRLWDL----ATGLLLRTLTGHTG-AVRS--VAFSpDGKTLASGSAdGTVRLWDL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 544 RGGVLrscpVDLGEHHALQFTDLAFkqARDGcpepsaAMLFVCSRSGHIleidcqRMVVRHARRLLPTRTpggphpqkqt 623
Cdd:COG2319 150 ATGKL----LRTLTGHSGAVTSVAF--SPDG------KLLASGSDDGTV------RLWDLATGKLLRTLT---------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 624 fssGPGIAISSLSVSP--AMCAVGSEDGFLRLWPLDFSSVLLE-AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSR 700
Cdd:COG2319 202 ---GHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 701 VYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFS 780
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
|
410 420 430
....*....|....*....|....*....|....*...
gi 2462547845 781 LEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSL 818
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
707-1007 |
6.52e-31 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 124.37 E-value: 6.52e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 707 RSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEV 786
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 787 LVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAqyscadpQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAfvgpsrc 866
Cdd:cd00200 86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK-------VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVA------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 867 tvtvmgSASLDELLRVdigtLDLASSRL--------DSAMAVCFGPAalGHLLVSTSSNRVV-VLDAVSGRIIRELPGvH 937
Cdd:cd00200 152 ------SSSQDGTIKL----WDLRTGKCvatltghtGEVNSVAFSPD--GEKLLSSSSDGTIkLWDLSTGKCLGTLRG-H 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547845 938 PEPCPSLTLSEDARFLLIAAG-RTIKVWDYATQASpgPQVYIGHSEPVQAVAFSPDQQQVLSAGD--AVFLWD 1007
Cdd:cd00200 219 ENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGEC--VQTLSGHTNSVTSLAWSPDGKRLASGSAdgTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1393-1699 |
9.27e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 115.12 E-value: 9.27e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1393 GELTSLCYGA-PPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSELRck 1469
Cdd:cd00200 10 GGVTCVAFSPdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETGECVR-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1470 gsgarsssVFMEHElvldGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSE 1549
Cdd:cd00200 88 --------TLTGHT----SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1550 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPpccgrpEQQRLAAGYGDGSLRIFSVsRTAMELK-MHPHPVALTTVAFS 1628
Cdd:cd00200 156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP------DGEKLLSSSSDGTIKLWDL-STGKCLGtLRGHENGVNSVAFS 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462547845 1629 TDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGApisticVTCkecedLGVEGTDLWLA-ASGDQRVSVWA 1699
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS------VTS-----LAWSPDGKRLAsGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
400-777 |
4.59e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 115.78 E-value: 4.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 400 AVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAqARAPSVmRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLC 479
Cdd:COG2319 59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA-SADGTV-RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 480 GVGKDHhgrtMVVAWGTGQvglgGEVVVLAKAHTDfDVQAfrVTFF-DETRMASCGQ-GSVRLWRLRGGVLrscpVDLGE 557
Cdd:COG2319 137 SGSADG----TVRLWDLAT----GKLLRTLTGHSG-AVTS--VAFSpDGKLLASGSDdGTVRLWDLATGKL----LRTLT 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 558 HHALQFTDLAFkqARDGcpepsaAMLFVCSRSGHIleidcqrmvvrharRLLPTRTPggphpQKQTFSSGPGIAISSLSV 637
Cdd:COG2319 202 GHTGAVRSVAF--SPDG------KLLASGSADGTV--------------RLWDLATG-----KLLRTLTGHSGSVRSVAF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 638 SP--AMCAVGSEDGFLRLWPLDFSSVL-LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVL 714
Cdd:COG2319 255 SPdgRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547845 715 ALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVR 777
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
304-741 |
6.17e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 115.39 E-value: 6.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 304 VSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESAEVPVARTGSCEGFLPDPVLRLKGVIGFGGHGTR 383
Cdd:COG2319 2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 384 QAL-WTPDGAAVVYPCHAVIVVLL-VDTGEQRFFL-GHTDKVSALALDGSSSLLASAQAraPSVMRLWDFQTGRCLCLFR 460
Cdd:COG2319 82 LSVaFSPDGRLLASASADGTVRLWdLATGLLLRTLtGHTGAVRSVAFSPDGKTLASGSA--DGTVRLWDLATGKLLRTLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 461 SPMHVVCSLSFSDSGallcgvgkdhhgRTMVVAWGTGQVGL----GGEVVVLAKAHTDFdvqAFRVTF-FDETRMASCGQ 535
Cdd:COG2319 160 GHSGAVTSVAFSPDG------------KLLASGSDDGTVRLwdlaTGKLLRTLTGHTGA---VRSVAFsPDGKLLASGSA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 536 -GSVRLWRLRGGVLrscpVDLGEHHALQFTDLAFkqARDGcpepsaAMLFVCSRSGHIleidcqrmvvrharRLLPTRTP 614
Cdd:COG2319 225 dGTVRLWDLATGKL----LRTLTGHSGSVRSVAF--SPDG------RLLASGSADGTV--------------RLWDLATG 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 615 ggphpQKQTFSSGPGIAISSLSVSP--AMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSATSSGH 691
Cdd:COG2319 279 -----ELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGT 353
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 2462547845 692 LGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLAT 741
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1244-1605 |
2.69e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 110.89 E-value: 2.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1244 QHWSGHSAEISTLALSHSAQVLASASGRSSttahcqIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDhdGRT 1323
Cdd:cd00200 3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGT------IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1324 LALW----GTATYDLVSSTrlpEPVHGVAFNPwdageltcvgqgtvtfwllqqrgadislqvrrepvpeavgageltslc 1399
Cdd:cd00200 75 IRLWdletGECVRTLTGHT---SYVSSVAFSP------------------------------------------------ 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1400 ygAPPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSR--LVSGSSTGRLRLWAVgavSELRCKGsgarsss 1477
Cdd:cd00200 104 --DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTIKLWDL---RTGKCVA------- 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1478 VFMEHElvldGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWA 1557
Cdd:cd00200 172 TLTGHT----GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2462547845 1558 LASMELVIQFQVLNQSCLCLAWSppccgrPEQQRLAAGYGDGSLRIFS 1605
Cdd:cd00200 248 LRTGECVQTLSGHTNSVTSLAWS------PDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
626-882 |
8.99e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 109.35 E-value: 8.99e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 626 SGPGIAISSLSVSPAMcAVGSEDGFLRLWPLDFSSVLLE-AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHM 704
Cdd:cd00200 51 TGPVRDVAASADGTYL-ASGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 705 LARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAA 784
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 785 EVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAqyscadpQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAfvgps 864
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR-------VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA----- 277
|
250
....*....|....*...
gi 2462547845 865 rctvtvmgSASLDELLRV 882
Cdd:cd00200 278 --------SGSADGTIRI 287
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1418-1841 |
3.93e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.00 E-value: 3.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1418 WDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRckgsgarsssvfmeHELVLDGAVVSASFDD 1497
Cdd:COG2319 23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA--------------TLLGHTAAVLSVAFSP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1498 SVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCL 1577
Cdd:COG2319 89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1578 AWSppccgrPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVL 1657
Cdd:COG2319 169 AFS------PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1658 SDHQGAPISticvtckecedLGVEGTDLWLA-ASGDQRVSVWasdwlrnhcelvDWLSFPMPATTETQGHLPPSLaAFCP 1736
Cdd:COG2319 243 TGHSGSVRS-----------VAFSPDGRLLAsGSADGTVRLW------------DLATGELLRTLTGHSGGVNSV-AFSP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1737 wDGALLMYVGPGvyKEVIIYNLCQKQVVEKIPLPFFA-MSLSLSPGTHLLAVGFAECMLRLVDCAMGTA-QDFAGHDNAV 1814
Cdd:COG2319 299 -DGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDGKTLASGSDDGTVRLWDLATGELlRTLTGHTGAV 375
|
410 420
....*....|....*....|....*...
gi 2462547845 1815 HLCRFTPSARLLFTAAR-NEILVWEVPG 1841
Cdd:COG2319 376 TSVAFSPDGRTLASGSAdGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
632-965 |
1.69e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 99.72 E-value: 1.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 632 ISSLSVSPA--MCAVGSEDGFLRLWPLDFSSVLLE-AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDT----LSRVYHM 704
Cdd:cd00200 12 VTCVAFSPDgkLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLetgeCVRTLTG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 705 larsHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAA 784
Cdd:cd00200 92 ----HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 785 EVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHvlrvaadMVCPDAPASPSALAVSRDGRLLAfvgps 864
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-------GTLRGHENGVNSVAFSPDGYLLA----- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 865 rctvtvmgSASLDELLRVDigtldlassrldsamavcfgpaalghllvstssnrvvvlDAVSGRIIRELPGvHPEPCPSL 944
Cdd:cd00200 236 --------SGSEDGTIRVW---------------------------------------DLRTGECVQTLSG-HTNSVTSL 267
|
330 340
....*....|....*....|..
gi 2462547845 945 TLSEDARFLLIAAG-RTIKVWD 965
Cdd:cd00200 268 AWSPDGKRLASGSAdGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
415-738 |
1.82e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 96.64 E-value: 1.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 415 FLGHTDKVSALALDGSSSLLASAQARapSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHhgrtMVVAW 494
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK----TIRLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 495 gtgQVGLGGEVVVLaKAHTDfDVQAfrVTFFDETRMASCG--QGSVRLWRLRGGVLRSCpvdLGEHHAlqftdlafkQAR 572
Cdd:cd00200 79 ---DLETGECVRTL-TGHTS-YVSS--VAFSPDGRILSSSsrDKTIKVWDVETGKCLTT---LRGHTD---------WVN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 573 DGCPEPSAAMLFVCSRSGHILEIDcqrmvVRHARRLlptrtpggphpqkQTFSsGPGIAISSLSVSP--AMCAVGSEDGF 650
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWD-----LRTGKCV-------------ATLT-GHTGEVNSVAFSPdgEKLLSSSSDGT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 651 LRLWPLDFSSVL--LEAeHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATV 728
Cdd:cd00200 201 IKLWDLSTGKCLgtLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
|
330
....*....|
gi 2462547845 729 SQDRTVRIWD 738
Cdd:cd00200 280 SADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1217-1459 |
3.07e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 90.09 E-value: 3.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1217 VWRPDTGFFAyTCG--RLVVVEDLHSGAQQH-WSGHSAEISTLALSHSAQVLASASgrssttAHCQIRVWDVSGGLCQHL 1293
Cdd:cd00200 58 AASADGTYLA-SGSsdKTIRLWDLETGECVRtLTGHTSYVSSVAFSPDGRILSSSS------RDKTIKVWDVETGKCLTT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1294 IFPHSTTVLALAFSPDDRLLVTlGDHDGrTLALW----GTATYDLVSSTRlpePVHGVAFNPwDAGEL-TCVGQGTVTFW 1368
Cdd:cd00200 131 LRGHTDWVNSVAFSPDGTFVAS-SSQDG-TIKLWdlrtGKCVATLTGHTG---EVNSVAFSP-DGEKLlSSSSDGTIKLW 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1369 LLQQRGADISLQVRREPVpeavgagelTSLCYGAPPLLYCGTSS-GQVCVWDTRAGRCFLSWEADDGGIGLLLFS--GSR 1445
Cdd:cd00200 205 DLSTGKCLGTLRGHENGV---------NSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKR 275
|
250
....*....|....
gi 2462547845 1446 LVSGSSTGRLRLWA 1459
Cdd:cd00200 276 LASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1521-1839 |
1.81e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 85.08 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1521 STRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSppccgrPEQQRLAAGYGDGS 1600
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS------ADGTYLASGSSDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1601 LRIFSVS--RTAMELKMHPHPValTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGaPISTICVTckecedl 1678
Cdd:cd00200 75 IRLWDLEtgECVRTLTGHTSYV--SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD-WVNSVAFS------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1679 gvEGTDLWLAASGDQRVSVWASDWLRnhcelvdwlsfpmpattetqghlppslaafcpwdgalLMYVGPGVYKEViiynl 1758
Cdd:cd00200 145 --PDGTFVASSSQDGTIKLWDLRTGK-------------------------------------CVATLTGHTGEV----- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1759 cqkqvvekiplpffaMSLSLSPGTHLLAVGFAECMLRLVDCAMGTA-QDFAGHDNAVHLCRFTPSARLLFTAARNE-ILV 1836
Cdd:cd00200 181 ---------------NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGSEDGtIRV 245
|
...
gi 2462547845 1837 WEV 1839
Cdd:cd00200 246 WDL 248
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
789-1010 |
3.51e-14 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 75.06 E-value: 3.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 789 EHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQW-HVLRVAADmvcpdapaSPSALAVSRDGRLLAfvgpsrct 867
Cdd:cd00200 4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELlRTLKGHTG--------PVRDVAASADGTYLA-------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 868 vtvmgSASLDELLRV-DIGTLDLASS---RLDSAMAVCFGPAalGHLLVSTSSNRVVVL-DAVSGRIIRELPGvHPEPCP 942
Cdd:cd00200 68 -----SGSSDKTIRLwDLETGECVRTltgHTSYVSSVAFSPD--GRILSSSSRDKTIKVwDVETGKCLTTLRG-HTDWVN 139
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462547845 943 SLTLSEDARFLLIAAG-RTIKVWDYATqASPGpQVYIGHSEPVQAVAFSPDQQQVLSAGD--AVFLWDVLA 1010
Cdd:cd00200 140 SVAFSPDGTFVASSSQdGTIKLWDLRT-GKCV-ATLTGHTGEVNSVAFSPDGEKLLSSSSdgTIKLWDLST 208
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
413-542 |
1.19e-09 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 61.58 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 413 RFFLGHTDKVSALALDGSSSLLASAQARapSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDhhgRTMVV 492
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSD--GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED---GTIRV 245
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2462547845 493 aWgtgQVGLGGEVVVLaKAHTDFdVQAFRVTfFDETRMASCGQ-GSVRLWR 542
Cdd:cd00200 246 -W---DLRTGECVQTL-SGHTNS-VTSLAWS-PDGKRLASGSAdGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1519-1556 |
3.20e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.38 E-value: 3.20e-06
10 20 30
....*....|....*....|....*....|....*...
gi 2462547845 1519 GTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVW 1556
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1519-1556 |
5.78e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.64 E-value: 5.78e-06
10 20 30
....*....|....*....|....*....|....*...
gi 2462547845 1519 GTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVW 1556
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
841-968 |
1.12e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 45.84 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 841 DAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGtldlassrlDSAMAVCFGPAAlGHLLVS-TSSNR- 918
Cdd:COG3391 107 PVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG---------AGPHGIAVDPDG-KRLYVAnSGSNTv 176
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547845 919 ---VVVLDAVSGRIIRELP-GVHPEpcpSLTLSEDARFLLIA---------AGRTIKVWDYAT 968
Cdd:COG3391 177 sviVSVIDTATGKVVATIPvGGGPV---GVAVSPDGRRLYVAnrgsntsngGSNTVSVIDLAT 236
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
746-929 |
4.25e-04 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 44.24 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 746 YDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCAD 825
Cdd:COG4257 10 YPVPAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 826 PQwhVLRVAAdmvcPDAPASPSALAVSRDGRLLafvgpsrctVTVMGSaslDELLRVDIGT----LDLASSRLDSAMAVC 901
Cdd:COG4257 90 GE--ITTFAL----PGGGSNPHGIAFDPDGNLW---------FTDQGG---NRIGRLDPATgevtEFPLPTGGAGPYGIA 151
|
170 180
....*....|....*....|....*....
gi 2462547845 902 FGPAalGHLLV-STSSNRVVVLDAVSGRI 929
Cdd:COG4257 152 VDPD--GNLWVtDFGANAIGRIDPDTGTL 178
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
707-738 |
7.61e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.83 E-value: 7.61e-04
10 20 30
....*....|....*....|....*....|..
gi 2462547845 707 RSHTAPVLALAMEQRRGQLATVSQDRTVRIWD 738
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
830-996 |
8.30e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 43.14 E-value: 8.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 830 VLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGH 909
Cdd:COG3391 2 LVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 910 LLVS-TSSNRVVVLDAVSGRIIRELP-GVHPEpcpSLTLSEDARFLLIAAGR--TIKVWDYATQASPGpQVYIGhSEPVq 985
Cdd:COG3391 82 LYVAnSGSGRVSVIDLATGKVVATIPvGGGPR---GLAVDPDGGRLYVADSGngRVSVIDTATGKVVA-TIPVG-AGPH- 155
|
170
....*....|.
gi 2462547845 986 AVAFSPDQQQV 996
Cdd:COG3391 156 GIAVDPDGKRL 166
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
988-1133 |
1.75e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.33 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 988 AFSPDQQqvlsAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPCQASPPRLGVCARPP 1067
Cdd:PRK12323 344 ALAPDEY----AGFTMTLLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAV 419
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547845 1068 EGGDGTLSPSDEEGPCEESCDPEGLGQASGPPVLTEEEAGRAGDGAWAAAVGSWGLALPPRSPGQP 1133
Cdd:PRK12323 420 AAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP 485
|
|
| WDR74 |
cd22857 |
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ... |
667-745 |
3.12e-03 |
|
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.
Pssm-ID: 439303 [Multi-domain] Cd Length: 325 Bit Score: 41.83 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 667 HEGPVSSVCVSPDGLRVLSATSSGHLGFLD----TLSRVYHMLArshTAPVLALAMEQRRGQLATVSQDRTVRIWDLATL 742
Cdd:cd22857 222 GETPIKAVAEDPDGHTVYVGDTSGDLASIDlrtgKLLGCFKGKC---GGSIRSIARHPELPLIASCGLDRYLRIWDTETR 298
|
...
gi 2462547845 743 QQL 745
Cdd:cd22857 299 QLL 301
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
786-974 |
4.03e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.03 E-value: 4.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 786 VLVEHTCHRGavTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRvaadmvcpDAPASPSALAVSRDGRLLAfvgpsr 865
Cdd:COG3386 1 KLADAGFRLG--EGPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEVFA--------EPSGRPNGLAFDPDGRLLV------ 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 866 ctvtvmgSASLDELLRVDIGT------LDLASSRLDSAMAVCFGPAalGHLLVSTSSN-----RVVVLDAvSGRIIRELP 934
Cdd:COG3386 65 -------ADHGRGLVRFDPADgevtvlADEYGKPLNRPNDGVVDPD--GRLYFTDMGEylptgALYRVDP-DGSLRVLAD 134
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2462547845 935 GVHpepCP-SLTLSEDARFLLIA--AGRTIKVWDYATQASPGP 974
Cdd:COG3386 135 GLT---FPnGIAFSPDGRTLYVAdtGAGRIYRFDLDADGTLGN 174
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
975-1007 |
4.18e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 4.18e-03
10 20 30
....*....|....*....|....*....|....*
gi 2462547845 975 QVYIGHSEPVQAVAFSPDQQQVLSAGD--AVFLWD 1007
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDdgTIKLWD 40
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
953-1144 |
7.76e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.12 E-value: 7.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 953 LLIAAGRTIKVW-----DYATQASP-GPQVYIGHSEPVQAVAFS-PDQQQVLSA-------GDAVFLWdVLAPTESDQSF 1018
Cdd:PRK07764 519 ILAAVPKRSRKTwaillPEATVLGVrGDTLVLGFSTGGLARRFAsPGNAEVLVTalaeelgGDWQVEA-VVGPAPGAAGG 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547845 1019 PGAPPACKTGPGAGPLEDAASRASELPRQQVPKPcQASPPRLGVCARPPEGGDGTLSPSDEEGPceescDPEGLGQASGP 1098
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAG-AAAAPAEASAAPAPGVAAPEHHPKHVAVP-----DASDGGDGWPA 671
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2462547845 1099 PVLTEEEAGRAGDGAWAAAVGSWGlalPPRSPGQPREQWRAGQGRW 1144
Cdd:PRK07764 672 KAGGAAPAAPPPAPAPAAPAAPAG---AAPAQPAPAPAATPPAGQA 714
|
|
| |
