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Conserved domains on  [gi|2568139604|ref|XP_058988277|]
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LOW QUALITY PROTEIN: transcription factor Ouib-like [Musca domestica]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
4-75 1.40e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.39  E-value: 1.40e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568139604   4 ICRTCAKEQINGKALKLFDRRHKELLAQIEDITGLLLENS-GLPKLMCSTCHQNLRQAYQFRENVIRAQALLS 75
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTGIELDPNdLLPKQICERCLSKLQEFYSFRERCLESQELLQ 73
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-319 9.59e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 9.59e-06
                          10        20
                  ....*....|....*....|....*
gi 2568139604 295 ELRRHMRKHTGERPFACQFCDRKFT 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
307-358 2.32e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.54  E-value: 2.32e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2568139604 307 RPFaCQFCDRKFTDYSTRIKHQRTHTnerpFTCSQCGKSFTSTYILK*HMLT 358
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-374 3.54e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|...
gi 2568139604 352 LK*HMLTHTGERHFRCDVCDKAF 374
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
240-316 5.18e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 38.85  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 240 KKRKKEKADNPNRFICDQCGNY---FTCSH--YFKLHLRRH--AGDRQCA------CELCPDKFFTNSELRRHMRkhtgE 306
Cdd:COG5236   167 KELKKHYKAQHGFVLCSECIGNkkdFWNEIrlFRSSTLRDHknGGLEEEGfkghplCIFCKIYFYDDDELRRHCR----L 242
                          90
                  ....*....|
gi 2568139604 307 RPFACQFCDR 316
Cdd:COG5236   243 RHEACHICDM 252
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
4-75 1.40e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.39  E-value: 1.40e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568139604   4 ICRTCAKEQINGKALKLFDRRHKELLAQIEDITGLLLENS-GLPKLMCSTCHQNLRQAYQFRENVIRAQALLS 75
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTGIELDPNdLLPKQICERCLSKLQEFYSFRERCLESQELLQ 73
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
4-74 1.92e-08

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 50.98  E-value: 1.92e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568139604    4 ICRTCAKEqiNGKALKLFDRRHKELLAQ-IEDITGL-LLENSGLPKLMCSTCHQNLRQAYQFRENVIRAQALL 74
Cdd:smart00868   1 VCRLCLSE--SENLVSIFDESSEASLAEkIEECTGIeIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELL 71
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-319 9.59e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 9.59e-06
                          10        20
                  ....*....|....*....|....*
gi 2568139604 295 ELRRHMRKHTGERPFACQFCDRKFT 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
307-358 2.32e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.54  E-value: 2.32e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2568139604 307 RPFaCQFCDRKFTDYSTRIKHQRTHTnerpFTCSQCGKSFTSTYILK*HMLT 358
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-374 3.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|...
gi 2568139604 352 LK*HMLTHTGERHFRCDVCDKAF 374
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-348 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 2568139604 326 KHQRTHTNERPFTCSQCGKSFTS 348
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-345 1.22e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 278 DRQCACELCPDKFFTNSELRRHMRKHTGERPFACQF--CDRKFTDYSTRIKHQRTHTNERPFTCSQCGKS 345
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
240-316 5.18e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 38.85  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 240 KKRKKEKADNPNRFICDQCGNY---FTCSH--YFKLHLRRH--AGDRQCA------CELCPDKFFTNSELRRHMRkhtgE 306
Cdd:COG5236   167 KELKKHYKAQHGFVLCSECIGNkkdFWNEIrlFRSSTLRDHknGGLEEEGfkghplCIFCKIYFYDDDELRRHCR----L 242
                          90
                  ....*....|
gi 2568139604 307 RPFACQFCDR 316
Cdd:COG5236   243 RHEACHICDM 252
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-383 9.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 9.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 251 NRFICDQCGNYFTCSHYFKLHLR--RHAGD----RQCACELCPDKFFTNSELRRHMRKHTGERPFACQFCDRKFTDYS-- 322
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslkpFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPll 367
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 323 -----TRIKHQRTHTNERPFTC--SQCGKSFTSTYILK*HMLTHTGER--HFRCDVCDKAFGRRTHLVVH 383
Cdd:COG5048   368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPH 437
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
4-75 1.40e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.39  E-value: 1.40e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568139604   4 ICRTCAKEQINGKALKLFDRRHKELLAQIEDITGLLLENS-GLPKLMCSTCHQNLRQAYQFRENVIRAQALLS 75
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTGIELDPNdLLPKQICERCLSKLQEFYSFRERCLESQELLQ 73
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
4-74 1.92e-08

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 50.98  E-value: 1.92e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2568139604    4 ICRTCAKEqiNGKALKLFDRRHKELLAQ-IEDITGL-LLENSGLPKLMCSTCHQNLRQAYQFRENVIRAQALL 74
Cdd:smart00868   1 VCRLCLSE--SENLVSIFDESSEASLAEkIEECTGIeIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELL 71
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-319 9.59e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 9.59e-06
                          10        20
                  ....*....|....*....|....*
gi 2568139604 295 ELRRHMRKHTGERPFACQFCDRKFT 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
307-358 2.32e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.54  E-value: 2.32e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2568139604 307 RPFaCQFCDRKFTDYSTRIKHQRTHTnerpFTCSQCGKSFTSTYILK*HMLT 358
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-374 3.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|...
gi 2568139604 352 LK*HMLTHTGERHFRCDVCDKAF 374
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-348 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 2568139604 326 KHQRTHTNERPFTCSQCGKSFTS 348
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-345 1.22e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 278 DRQCACELCPDKFFTNSELRRHMRKHTGERPFACQF--CDRKFTDYSTRIKHQRTHTNERPFTCSQCGKS 345
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
240-316 5.18e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 38.85  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 240 KKRKKEKADNPNRFICDQCGNY---FTCSH--YFKLHLRRH--AGDRQCA------CELCPDKFFTNSELRRHMRkhtgE 306
Cdd:COG5236   167 KELKKHYKAQHGFVLCSECIGNkkdFWNEIrlFRSSTLRDHknGGLEEEGfkghplCIFCKIYFYDDDELRRHCR----L 242
                          90
                  ....*....|
gi 2568139604 307 RPFACQFCDR 316
Cdd:COG5236   243 RHEACHICDM 252
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-383 9.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 9.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 251 NRFICDQCGNYFTCSHYFKLHLR--RHAGD----RQCACELCPDKFFTNSELRRHMRKHTGERPFACQFCDRKFTDYS-- 322
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslkpFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPll 367
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2568139604 323 -----TRIKHQRTHTNERPFTC--SQCGKSFTSTYILK*HMLTHTGER--HFRCDVCDKAFGRRTHLVVH 383
Cdd:COG5048   368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPH 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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