NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2589146412|ref|XP_059933454|]
View 

leucine-rich repeat transmembrane protein FLRT2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 1.02e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886   230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                         250       260
                  ....*....|....*....|....*
gi 2589146412 286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLL 330
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 2589146412  359 S 359
Cdd:TIGR00864   77 D 77
fn3 pfam00041
Fibronectin type III domain;
426-494 1.29e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 1.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2589146412 426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 3.95e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*...
gi 2589146412  35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 1.02e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886   230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                         250       260
                  ....*....|....*....|....*
gi 2589146412 286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLL 330
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-265 7.05e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.67  E-value: 7.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  54 LTSVPLGIPEGVTVLYLHNNQINNagFPAELHNvqSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR---AALA 130
Cdd:PRK15370  190 LTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPErlpSALQ 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 131 QLL---------------KLEELHLDDNSISTVG-------VEDGAFREAIS---------LKLLFLSKNHLSSVPVGLP 179
Cdd:PRK15370  266 SLDlfhnkisclpenlpeELRYLSVYDNSIRTLPahlpsgiTHLNVQSNSLTalpetlppgLKTLEAGENALTSLPASLP 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 180 VDLQELRVDENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHL 254
Cdd:PRK15370  346 PELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQP 417

                         250
                  ....*....|.
gi 2589146412 255 IRLYLQDNQIN 265
Cdd:PRK15370  418 TRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 2.35e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.59  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  89 SVHTVYLYGNQLDEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340     3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340    77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2589146412 246 ppdlpgthlirLYLQDNQINHipLTAFSNLRKLERLDISNNQLRMLTQ--GVFDNLSNLKQLTARNNP 311
Cdd:cd21340   125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
252-311 2.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 252 THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 2589146412  359 S 359
Cdd:TIGR00864   77 D 77
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 1.07e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.07e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2589146412  310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
fn3 pfam00041
Fibronectin type III domain;
426-494 1.29e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 1.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2589146412 426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 2.95e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.95e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2589146412   35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 3.95e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*...
gi 2589146412  35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.20e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 2589146412 336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 1.02e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886   230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                         250       260
                  ....*....|....*....|....*
gi 2589146412 286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-313 1.96e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  48 YCNERSLTSVPLGIPE--GVTVLYLHNNQINNagFPAELHNVQSVHTVYLYGNQLDEFPMNL--PKNVRVLHLQENNIQT 123
Cdd:COG4886   142 DLSNNQLTDLPEPLGNltNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 124 ISrAALAQLLKLEELHLDDNSISTVGvedgAFREAISLKLLFLSKNHLSSVPVGLPVD-LQELRVDENRIAVISDMAFQN 202
Cdd:COG4886   220 LP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELEL 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 203 LTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLD 282
Cdd:COG4886   295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2589146412 283 ISNNQLRMLTQGVFDNLSNLKQLTARNNPWF 313
Cdd:COG4886   375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-265 7.05e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.67  E-value: 7.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  54 LTSVPLGIPEGVTVLYLHNNQINNagFPAELHNvqSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR---AALA 130
Cdd:PRK15370  190 LTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPErlpSALQ 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 131 QLL---------------KLEELHLDDNSISTVG-------VEDGAFREAIS---------LKLLFLSKNHLSSVPVGLP 179
Cdd:PRK15370  266 SLDlfhnkisclpenlpeELRYLSVYDNSIRTLPahlpsgiTHLNVQSNSLTalpetlppgLKTLEAGENALTSLPASLP 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 180 VDLQELRVDENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHL 254
Cdd:PRK15370  346 PELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQP 417

                         250
                  ....*....|.
gi 2589146412 255 IRLYLQDNQIN 265
Cdd:PRK15370  418 TRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 2.35e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.59  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  89 SVHTVYLYGNQLDEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340     3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340    77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2589146412 246 ppdlpgthlirLYLQDNQINHipLTAFSNLRKLERLDISNNQLRMLTQ--GVFDNLSNLKQLTARNNP 311
Cdd:cd21340   125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-310 9.52e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 9.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 105 MNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQE 184
Cdd:COG4886    15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 185 LRVDEnRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAegtFSHLTKLKEFSIVRNSLSHPPPDLPG-THLIRLYLQDNQ 263
Cdd:COG4886    95 LTNLT-ELDLSGNEELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGNlTNLKSLDLSNNQ 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2589146412 264 INHIPlTAFSNLRKLERLDISNNQLRMLTQgVFDNLSNLKQLTARNN 310
Cdd:COG4886   171 LTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-246 3.16e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 3.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  47 VYCNERSLTSVP-LGIPEGVTVLYLHNNQINNAgfpAELHNVQSVHTVYLYGNQLDEFPM--NLpKNVRVLHLQENNIQT 123
Cdd:cd21340     7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNNQIEKIENleNL-VNLKKLYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 124 ISraALAQLLKLEELHL-------------DDNSISTVgvedgafreAISLKLLFLSKNHLSsvpvglpvDLQELrvden 190
Cdd:cd21340    83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNID--------SLEPL----- 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2589146412 191 riavisdmafQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Cdd:cd21340   139 ----------APLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
200-311 4.12e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 200 FQNLTSLERLIVDGNLltnkgiaegTFSHLTKLKEFSIVRNSLSHPPPDLPG-THLIRLYLQDNQINHIPlTAFSNLRKL 278
Cdd:COG4886    92 LGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDLP-EPLGNLTNL 161

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2589146412 279 ERLDISNNQLRMLTQgVFDNLSNLKQLTARNNP 311
Cdd:COG4886   162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
252-311 2.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 252 THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-223 2.86e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.89  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  65 VTVLYLHNNQINNAGFPA---ELHNVQSVHTVYLYGNQLDEFPMNL-------PKNVRVLHLQENNIQTISRAALAQLLK 134
Cdd:COG5238   238 LTTLDLSNNQIGDEGVIAlaeALKNNTTVETLYLSGNQIGAEGAIAlakalqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 135 ----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISdmAFQNLTSL 206
Cdd:COG5238   318 gnktLHTLNLAYNGIGAQGAI--ALAKALqentTLHSLDLSDNQIG---------------DEGAIALAK--YLEGNTTL 378

                         170
                  ....*....|....*..
gi 2589146412 207 ERLIVDGNLLTNKGIAE 223
Cdd:COG5238   379 RELNLGKNNIGKQGAEA 395
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-289 5.22e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 5.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 110 NVRVLHLQENNIQTISRAALAQLLK----LEELHLDDN----SISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGL--- 178
Cdd:cd00116    24 CLQVLRLEGNTLGEEAAKALASALRpqpsLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVles 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 179 ---PVDLQELRVDENRIAvisDMAFQNLT--------SLERLIVDGNLLTNKGIAE--GTFSHLTKLKEFSIVRNSLSHP 245
Cdd:cd00116   104 llrSSSLQELKLNNNGLG---DRGLRLLAkglkdlppALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDA 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2589146412 246 -----PPDLPG-THLIRLYLQDNQINHIPLTA----FSNLRKLERLDISNNQLR 289
Cdd:cd00116   181 giralAEGLKAnCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLT 234
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 2589146412  359 S 359
Cdd:TIGR00864   77 D 77
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
23-268 5.67e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.94  E-value: 5.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  23 SLGLYSQVSKLLACPSVCRCDRNfvyCNERSLTSVPLGIPEGVTVLYLHNNQINN-AGFPAELHnvqsvhTVYLYGNQLD 101
Cdd:PRK15387  185 SRGRAAVVQKMRACLNNGNAVLN---VGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELR------TLEVSGNQLT 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 102 EFPMnLPKNVRVLHLQENNIQTISR--AALAQLL--------------KLEELHLDDNSISTVgvedgafrEAISLKL-- 163
Cdd:PRK15387  256 SLPV-LPPGLLELSIFSNPLTHLPAlpSGLCKLWifgnqltslpvlppGLQELSVSDNQLASL--------PALPSELck 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 164 LFLSKNHLSSVPVgLPVDLQELRVDENRIAVISDM--------AFQN-LTS-------LERLIVDGNLLTNKGIAEgtfs 227
Cdd:PRK15387  327 LWAYNNQLTSLPT-LPSGLQELSVSDNQLASLPTLpselyklwAYNNrLTSlpalpsgLKELIVSGNRLTSLPVLP---- 401

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2589146412 228 hlTKLKEFSIVRNSLSHPPPdLPgTHLIRLYLQDNQINHIP 268
Cdd:PRK15387  402 --SELKELMVSGNRLTSLPM-LP-SGLLSLSVYRNQLTRLP 438
LRR_8 pfam13855
Leucine rich repeat;
204-288 1.31e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 204 TSLERLIVDGNLLTNkgIAEGTFSHLTKLKEfsivrnslshpppdlpgthlirLYLQDNQINHIPLTAFSNLRKLERLDI 283
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKV----------------------LDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 2589146412 284 SNNQL 288
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
182-242 4.30e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2589146412 182 LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTnkGIAEGTFSHLTKLKEFSIVRNSL 242
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-171 9.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 9.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2589146412 110 NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTvgVEDGAFREAISLKLLFLSKNHL 171
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 1.07e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.07e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2589146412  310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
fn3 pfam00041
Fibronectin type III domain;
426-494 1.29e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 1.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2589146412 426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-192 2.24e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  52 RSLTSVPlgipEGVTVLYLHNNQINNAGFPA---ELHNVQSVHTVYLYGNQLDE---------FPMNlpKNVRVLHLQEN 119
Cdd:cd00116   130 KGLKDLP----PALEKLVLGRNRLEGASCEAlakALRANRDLKELNLANNGIGDagiralaegLKAN--CNLEVLDLNNN 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 120 -----NIQTISrAALAQLLKLEELHLDDNSISTVGVE---DGAFREAISLKLLFLSKNHLSSVPV-----GLP--VDLQE 184
Cdd:cd00116   204 gltdeGASALA-ETLASLKSLEVLNLGDNNLTDAGAAalaSALLSPNISLLTLSLSCNDITDDGAkdlaeVLAekESLLE 282


                  ....*...
gi 2589146412 185 LRVDENRI 192
Cdd:cd00116   283 LDLRGNKF 290
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 129-310 2.68e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 2.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 129 LAQLLKLEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSSVPVGL---------PVDLQELRVDENRIAVI 195
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEEAAK--ALASALrpqpSLKELCLSLNETGRIPRGLqsllqgltkGCGLQELDLSDNALGPD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 196 SDMAFQNLTSLERLivdGNL-LTNKGIAEGTFSHLTKlkefsivrnSLSHPPPDLPgthliRLYLQDNQINHIPLT---- 270
Cdd:cd00116    97 GCGVLESLLRSSSL---QELkLNNNGLGDRGLRLLAK---------GLKDLPPALE-----KLVLGRNRLEGASCEalak 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2589146412 271 AFSNLRKLERLDISNNQL-----RMLTQGVFDNlSNLKQLTARNN 310
Cdd:cd00116   160 ALRANRDLKELNLANNGIgdagiRALAEGLKAN-CNLEVLDLNNN 203
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-288 4.13e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  53 SLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFP-------MNLPKNVRVLHLQENNIQTIS 125
Cdd:COG5238   145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGieelaeaLTQNTTVTTLWLKRNPIGDEG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 126 RAALAQLLK----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISd 197
Cdd:COG5238   225 AEILAEALKgnksLTTLDLSNNQIGDEGVI--ALAEALknntTVETLYLSGNQIG---------------AEGAIALAK- 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 198 mAFQNLTSLERLIVDGNLLTNKG---IAEGtfshltklkefsivrnslshpppdLPGTHLIR-LYLQDNQINH---IPL- 269
Cdd:COG5238   287 -ALQGNTTLTSLDLSVNRIGDEGaiaLAEG------------------------LQGNKTLHtLNLAYNGIGAqgaIALa 341

                         250
                  ....*....|....*....
gi 2589146412 270 TAFSNLRKLERLDISNNQL 288
Cdd:COG5238   342 KALQENTTLHSLDLSDNQI 360
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-288 5.20e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 5.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  81 PAELHNVQSVHTVYLYGNQL-DEFPMNL--PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSIStvGVEDGAFRE 157
Cdd:PLN00113  253 PSSLGNLKNLQYLFLYQNKLsGPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--GKIPVALTS 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 158 AISLKLLFLSKNHLSSvpvGLPVDLQElrvdENRIAVIsDMAFQNLTSlerLIVDGnlLTNKGiaegtfsHLTKLKEFSi 237
Cdd:PLN00113  331 LPRLQVLQLWSNKFSG---EIPKNLGK----HNNLTVL-DLSTNNLTG---EIPEG--LCSSG-------NLFKLILFS- 389

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2589146412 238 vrNSL-SHPPPDLPGTH-LIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQL 288
Cdd:PLN00113  390 --NSLeGEIPKSLGACRsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
LRR_8 pfam13855
Leucine rich repeat;
134-216 8.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 134 KLEELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvglpvdlqelrvdenriavISDMAFQNLTSLERLIVDG 213
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTT---------------------LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 2589146412 214 NLL 216
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-206 1.83e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  47 VYCNerSLTSVPLGIPEGVTVLYLHNNQINnaGFPAELHnvQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIqtisr 126
Cdd:PRK15370  290 VYDN--SIRTLPAHLPSGITHLNVQSNSLT--ALPETLP--PGLKTLEAGENALTSLPASLPPELQVLDVSKNQI----- 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 127 AALAQLL--KLEELHLDDNSISTVGVEDGAfreaiSLKLLFLSKNHLSSVPVGLPVDLQElRVDENRIAV----ISDMAF 200
Cdd:PRK15370  359 TVLPETLppTITTLDVSRNALTNLPENLPA-----ALQIMQASRNNLVRLPESLPHFRGE-GPQPTRIIVeynpFSERTI 432


                  ....*.
gi 2589146412 201 QNLTSL 206
Cdd:PRK15370  433 QNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
88-145 1.23e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2589146412  88 QSVHTVYLYGNQL----DEFPMNLPkNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSI 145
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-309 1.68e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  59 LGIPEGVTVLYLHNNQINNAgFPAELHNVQSVHTVYLYGNQLD-EFPMNLP--KNVRVLHLQENNIQTISRAALAQLLKL 135
Cdd:PLN00113  352 LGKHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLV 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 136 EELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvGLP-----VDLQELRVDENRIAVISDMAFQNLTSLERLI 210
Cdd:PLN00113  431 YFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFG---GLPdsfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 211 VDGNLLTNKgIAEgtfshltklkEFSIVRNslshpppdlpgthLIRLYLQDNQIN-HIPLTaFSNLRKLERLDISNNQlr 289
Cdd:PLN00113  506 LSENKLSGE-IPD----------ELSSCKK-------------LVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQ-- 558

                         250       260
                  ....*....|....*....|
gi 2589146412 290 mLTQGVFDNLSNLKQLTARN 309
Cdd:PLN00113  559 -LSGEIPKNLGNVESLVQVN 577
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-242 2.77e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 112 RVLHLQENNI-----QTISRAALAQLLKLEELHLDDNSISTVGVED--GAFREAISLKLLFLSKNHLS-----SVPVGLP 179
Cdd:cd00116   111 QELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGdagirALAEGLK 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2589146412 180 VD--LQELRVDENRI----AVISDMAFQNLTSLERLIVDGNLLTNKGIAE---GTFSHLTKLKEFSIVRNSL 242
Cdd:cd00116   191 ANcnLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAAlasALLSPNISLLTLSLSCNDI 262
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 2.95e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.95e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2589146412   35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 3.95e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*...
gi 2589146412  35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 111-288 7.42e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 7.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 111 VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTvGVEDGAFREAISLKLLFLSKNHLS-SVPVGLPVDLQELRVDE 189
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 190 N--------RIAVISDMAF----------------QNLTSLERLIVDGNLLTN------------KGIAEG--------- 224
Cdd:PLN00113  150 NmlsgeipnDIGSFSSLKVldlggnvlvgkipnslTNLTSLEFLTLASNQLVGqiprelgqmkslKWIYLGynnlsgeip 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2589146412 225 -TFSHLTKLKEFSIVRNSLSHPPP----DLPGTHLIRLYlQDNQINHIPLTAFSnLRKLERLDISNNQL 288
Cdd:PLN00113  230 yEIGGLTSLNHLDLVYNNLTGPIPsslgNLKNLQYLFLY-QNKLSGPIPPSIFS-LQKLISLDLSDNSL 296
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 195-306 9.92e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412 195 ISDMAFQNlTSLERLIVDGNLLTnkgIAEGTFSHLTKLKEFSIvrnslshpPPDLP--------GTHLIRLYLQDNqINH 266
Cdd:pfam13306   3 IGSYAFYN-CSLTSITIPSSLTS---IGEYAFSNCTSLKSITL--------PSSLTsigsyafyNCSLTSITIPSS-LTS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2589146412 267 IPLTAFSNLRKLERLDISNNqLRMLTQGVFDNlSNLKQLT 306
Cdd:pfam13306  70 IGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSIT 107
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-145 1.43e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2589146412  65 VTVLYLHNNQINNAGFPAELHNVQ---SVHTVYLYGNQLD--------EFPMNLPkNVRVLHLQENNIQTISRAALAQLL 133
Cdd:COG5238   322 LHTLNLAYNGIGAQGAIALAKALQentTLHSLDLSDNQIGdegaialaKYLEGNT-TLRELNLGKNNIGKQGAEALIDAL 400

                          90
                  ....*....|....*
gi 2589146412 134 KLEELH---LDDNSI 145
Cdd:COG5238   401 QTNRLHtliLDGNLI 415
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.20e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 2589146412 336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH