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Conserved domains on  [gi|66823225|ref|XP_644967|]
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major facilitator superfamily protein [Dictyostelium discoideum AX4]

Protein Classification

MFS transporter( domain architecture ID 13023689)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 50-453 7.82e-64

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 210.13  E-value: 7.82e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225  50 YLACIFISTFLYDIFIPTLLFHYVEHKFPDLTPqeksskssYYKSYSDGFPFLVMFLFGPLVGYISDRYGRKSNFYLSVL 129
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASG--------YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLA 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 130 TVMFVIMSCFVSMetnNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIPVLFTLCGLSMGLGTTIGSLIYAFVPTDK 209
Cdd:cd17330  73 GSAVSYVLLGLSR---NLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPY 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 210 VPYMMLYISSGFALVSLILVPFLIETihisrennknktfvkksfenpnpfstikslftnngfISWTILLFFSIQYTGQDI 289
Cdd:cd17330 150 GYALPFLVAAALALLNLVLVLFFLPP------------------------------------LRRLLLVYFLIALAFAGL 193

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 290 WSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVPLFLKVLSEKKVITIGFFITFCAHVMLSSSKFSQYLFIFGAI 369
Cdd:cd17330 194 ESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAI 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 370 VSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMVANNLLSHfssdessiYFPQAIYFLNGVVLFIIMI 449
Cdd:cd17330 274 LAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF--------LGPGVPFLLAAGLLLIALF 345


                ....
gi 66823225 450 ISIL 453
Cdd:cd17330 346 LLSL 349
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 50-453 7.82e-64

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 210.13  E-value: 7.82e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225  50 YLACIFISTFLYDIFIPTLLFHYVEHKFPDLTPqeksskssYYKSYSDGFPFLVMFLFGPLVGYISDRYGRKSNFYLSVL 129
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASG--------YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLA 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 130 TVMFVIMSCFVSMetnNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIPVLFTLCGLSMGLGTTIGSLIYAFVPTDK 209
Cdd:cd17330  73 GSAVSYVLLGLSR---NLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPY 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 210 VPYMMLYISSGFALVSLILVPFLIETihisrennknktfvkksfenpnpfstikslftnngfISWTILLFFSIQYTGQDI 289
Cdd:cd17330 150 GYALPFLVAAALALLNLVLVLFFLPP------------------------------------LRRLLLVYFLIALAFAGL 193

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 290 WSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVPLFLKVLSEKKVITIGFFITFCAHVMLSSSKFSQYLFIFGAI 369
Cdd:cd17330 194 ESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAI 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 370 VSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMVANNLLSHfssdessiYFPQAIYFLNGVVLFIIMI 449
Cdd:cd17330 274 LAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF--------LGPGVPFLLAAGLLLIALF 345


                ....
gi 66823225 450 ISIL 453
Cdd:cd17330 346 LLSL 349
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-409 1.67e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 1.67e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRKSNFYLSvlTVMFVIMSCFVSMeTNNIYCFYVFHTIGGLYN-VSNSVVFSFIYDISDEKD 179
Cdd:COG2814  55 LLGAALGAPLAGRLADRFGRRRVLLLG--LLLFALGSLLCAL-APSLWLLLAARFLQGLGAgALFPAALALIADLVPPER 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 180 IPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLI-ETIHISRennknktfvkksfenPNP 258
Cdd:COG2814 132 RGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLpESRPAAR---------------ARL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 259 FSTIKSLFTNNGFIsWTILLFFSIQYTGQDIWSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSvLIVPLFLKVLSEKK 338
Cdd:COG2814 197 RGSLRELLRRPRLL-LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRR 274

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66823225 339 VITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGS 409
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
101-413 4.93e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.89  E-value: 4.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   101 FLVMFLFGPLVGYISDRYGRKSNFYLSVLTVMFVIMSCFVSmetNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISDEKD 179
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA---SSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   180 IPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLietihisRENNKNKTFVKKSFENPNPF 259
Cdd:pfam07690 119 RGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP-------RPPPESKRPKPAEEARLSLI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   260 STIKSLFTNNGFISWTILLFFSIQYTGQDIWSTFYYYSylmYNWNQKTIGLFtLGVGGATILYSVLIVPLFLKVLSEKK- 338
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV---LGLSALLAGLL-LGLGGLLGAIGRLLLGRLSDRLGRRRr 267

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66823225   339 --VITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGA 413
Cdd:pfam07690 268 llLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
102-235 6.39e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 45.72  E-value: 6.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   102 LVMFLFGPLVGYISDRYGRKSNFYLSVLTVMFVIMSCFVSmetNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISDEKDI 180
Cdd:TIGR00880   9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALS---SNITVLIIARFLQGFgAAFALVAGAALIADIYPPEER 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 66823225   181 PVLFTL----CGLSMGLGTTIGSLIYAFVPTDkvpyMMLYISSGFALVSLILVPFLIET 235
Cdd:TIGR00880  86 GVALGLmsagIALGPLLGPPLGGVLAQFLGWR----APFLFLAILALAAFILLAFLLPE 140
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 50-453 7.82e-64

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 210.13  E-value: 7.82e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225  50 YLACIFISTFLYDIFIPTLLFHYVEHKFPDLTPqeksskssYYKSYSDGFPFLVMFLFGPLVGYISDRYGRKSNFYLSVL 129
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASG--------YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLA 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 130 TVMFVIMSCFVSMetnNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIPVLFTLCGLSMGLGTTIGSLIYAFVPTDK 209
Cdd:cd17330  73 GSAVSYVLLGLSR---NLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPY 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 210 VPYMMLYISSGFALVSLILVPFLIETihisrennknktfvkksfenpnpfstikslftnngfISWTILLFFSIQYTGQDI 289
Cdd:cd17330 150 GYALPFLVAAALALLNLVLVLFFLPP------------------------------------LRRLLLVYFLIALAFAGL 193

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 290 WSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVPLFLKVLSEKKVITIGFFITFCAHVMLSSSKFSQYLFIFGAI 369
Cdd:cd17330 194 ESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAI 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 370 VSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMVANNLLSHfssdessiYFPQAIYFLNGVVLFIIMI 449
Cdd:cd17330 274 LAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF--------LGPGVPFLLAAGLLLIALF 345


                ....
gi 66823225 450 ISIL 453
Cdd:cd17330 346 LLSL 349
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 102-457 1.73e-23

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 101.56  E-value: 1.73e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 102 LVMFLFGPLVGYISDRYGRKSNFYLSVL--TVMFVIMSCfvsmeTNNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKD 179
Cdd:cd17388  49 LMQFIFAPILGALSDRFGRRPVLLLSLAgaALDYLLMAF-----APTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQ 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 180 IPVLFTLCGLSMGLGTTIGSLIYAFVpTDKVPYMMLYISSGFALVSLILVPFLIETihiSRENNKNKTFVKKSFenpNPF 259
Cdd:cd17388 124 RARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLVAAGLNGLNFLLGLFVLPE---SLPPERRRAFRWRRA---NPF 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 260 STIKSLFTNNGFISWtILLFFSIQYTGQDIWSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVPLFLKVLSEKKV 339
Cdd:cd17388 197 GSLRWLTGFPGLLGL-LAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRA 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 340 ITIGFFITFCAHVMLSSSKFSQYLF---IFGAIVSSIVPCvsnlLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMVA 416
Cdd:cd17388 276 ILLGLAADALGFLLLAFATQGWMVFpilILLALGGIAGPA----LQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLF 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 66823225 417 NNLLSHFSSdessiYFPQAIYFLnGVVLFIimIISILVWRF 457
Cdd:cd17388 352 TGIFAASPA-----TWPGLAWII-GAALYL--ICLVLAYRF 384
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-409 1.67e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 1.67e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRKSNFYLSvlTVMFVIMSCFVSMeTNNIYCFYVFHTIGGLYN-VSNSVVFSFIYDISDEKD 179
Cdd:COG2814  55 LLGAALGAPLAGRLADRFGRRRVLLLG--LLLFALGSLLCAL-APSLWLLLAARFLQGLGAgALFPAALALIADLVPPER 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 180 IPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLI-ETIHISRennknktfvkksfenPNP 258
Cdd:COG2814 132 RGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLpESRPAAR---------------ARL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 259 FSTIKSLFTNNGFIsWTILLFFSIQYTGQDIWSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSvLIVPLFLKVLSEKK 338
Cdd:COG2814 197 RGSLRELLRRPRLL-LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRR 274

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66823225 339 VITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGS 409
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 101-453 3.59e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 70.68  E-value: 3.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRKSNFYLSVLTVMFVIMSCFVSmetNNIYCFYVFHTIGGLYNVSNSVV-FSFIYDISDEKD 179
Cdd:cd17325  41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA---TSYWQLLLARFLQGLASAAVWPAaMALIADIAPPEE 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 180 IPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLIETIHISRENNKNKtfvkksfenPNPF 259
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVS---------AARL 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 260 STIKSLFTNNGFISWTILLFFSIQYTGQDIWSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVPLFLKVlSEKKV 339
Cdd:cd17325 189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPL 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 340 ITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMVANNL 419
Cdd:cd17325 268 ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347

                       330       340       350
                ....*....|....*....|....*....|....
gi 66823225 420 LSHFSsdessiyfPQAIYFLNGVVLFIIMIISIL 453
Cdd:cd17325 348 YDAFG--------FATPFLAAAALLLLAAVLFLL 373
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 100-445 6.87e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.76  E-value: 6.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 100 PFLVMFLFGPLVGYISDRYGRKSNFYLSVLtvmFVIMSCFVSMETNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISDEK 178
Cdd:cd06174  40 FSLGYALLQPLAGLLADRFGRRPVLLLGLL---LFALGALLFAFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPER 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 179 DIPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVP--YMMLYISSGFALVSLILVPFLIETIHISRENNknktfvKKSFENP 256
Cdd:cd06174 117 ERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAALALLAAILLLLVVPDPPESARAK------NEEASSK 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 257 NPFSTIKSLFTNNGFisWTILLFFSIQYTGQDIWSTFYYYSYLMY-NWNQKTIGLFTLGVGGATILYSVLIVPLFLKVLS 335
Cdd:cd06174 191 SVLKLLKRVLKNPGL--WLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 336 EKKVITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMV 415
Cdd:cd06174 269 RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348

                       330       340       350
                ....*....|....*....|....*....|
gi 66823225 416 ANNLLSHFSSDESSIYFPQAIYFLNGVVLF 445
Cdd:cd06174 349 AGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 101-453 5.85e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 63.79  E-value: 5.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRK-----SNFYLSVLTVMFVIMSCFVSMETNNIYCFYVFHTIGGlyNVSNSVVFSFIYDIS 175
Cdd:cd06173  44 FLPFLLFSPFAGVLADRFDRRrllilADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIAS--AFFGPARQALLPELV 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 176 DEKDIP---VLFTLCG-LSMGLGTTIGSLIYAFVPtdkvPYMMLYISSGFALVSLILVPFLIETihisrennKNKTFVKK 251
Cdd:cd06173 122 PKEQLVranALNSLATqLARIIGPALGGLLVALLG----PGGAFAINALSFLLSALLLLFIRRP--------PPAAPGES 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 252 SFENPNPFSTIKSLFTNNGFISWTILLFFSIQYTGQDIWSTFYYYSYLMYNWNQKTIGLFtLGVGGATILYSVLIVPLFL 331
Cdd:cd06173 190 SSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL-LAAFGVGALLGALLLGRLS 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 332 KVLSEKKVITIGFFITFCAHVMLSSSkFSQYLFIFGAIVSSIVPCVSNLLC-SVISKSTPQEVQGSVLTGLQSVKALGSF 410
Cdd:cd06173 269 KRRRRGRLLLIGALLLGLALLVLGLS-PSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMP 347

                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 66823225 411 AGAMVANNLLSHFSsdessiyfPQAIYFLNGVVLFIIMIISIL 453
Cdd:cd06173 348 LGALLAGLLADALG--------LSAVFLLAGALLLLAALLLLL 382
MFS_1 pfam07690
Major Facilitator Superfamily;
101-413 4.93e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.89  E-value: 4.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   101 FLVMFLFGPLVGYISDRYGRKSNFYLSVLTVMFVIMSCFVSmetNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISDEKD 179
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA---SSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   180 IPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLietihisRENNKNKTFVKKSFENPNPF 259
Cdd:pfam07690 119 RGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP-------RPPPESKRPKPAEEARLSLI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   260 STIKSLFTNNGFISWTILLFFSIQYTGQDIWSTFYYYSylmYNWNQKTIGLFtLGVGGATILYSVLIVPLFLKVLSEKK- 338
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV---LGLSALLAGLL-LGLGGLLGAIGRLLLGRLSDRLGRRRr 267

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66823225   339 --VITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGA 413
Cdd:pfam07690 268 llLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
109-458 5.63e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.99  E-value: 5.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 109 PLVGYISDRYGR---KSNFYLSVLTVMFVIMSCFV------SMETNNIYcFYVFHTIGGL-YNVSNSVVFSFIYDIS-DE 177
Cdd:COG2211  64 PLIGALSDRTRTrwgRRRPWILIGAIPLALSFVLLftapdlSPTGKLIY-ALVTYLLLGLaYTLVNIPYSALGAELTpDY 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 178 KDIPVLFTLCGLSMGLGTTIGS-----LIYAFVPTDKVPYMMLYISSGFALVSLILVPFLietihISRENNKNKTfvkks 252
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASvlpppLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFF-----GTKERPVPEE----- 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 253 fENPNPFSTIKSLFTNNGFisWTILLFFSIQYTGQDIWSTFYYYsYLMYNWNQKT--IGLFTLGVGGATILySVLIVPLF 330
Cdd:COG2211 213 -EKVSLKESLKALLKNRPF--LLLLLAYLLFFLALALVAALLLY-YFKYVLGLSAalVGLLLALYFLAALL-GAPLWPRL 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 331 LKVLSEKKVITIGFFITFCAHVMLSSSKFSQY------LFIFGAIVSSIVPCVSNLLCSVISKS---TPQEVQGSVLTGL 401
Cdd:COG2211 288 AKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLwlllvlAALAGIGLGAILVLPWAMLADVVDYDewkTGRRREGLYFGIF 367

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 402 QSVKALGSFAGAMVANNLLSHFSSDESSIYFPQA---IYFLNGVVLFIIMIISILVWRFY 458
Cdd:COG2211 368 TFAIKLGQALAGALAGLLLALFGYVAGAAQSPSAltgIRLLFFLLPAVLLLLAALLLLFY 427
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 102-450 4.42e-08

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 54.97  E-value: 4.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 102 LVMFLFGPLVGYISDRYGRKSnfyLSVLTVMFVIMSCFVSMETNNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIP 181
Cdd:cd17389  75 LLQFLSSPITGAASDVYGRKP---VLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRS 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 182 VLFTLCGLSMGLGTTIGSLIYAFVPT-----DKVPYMMLYI-SSGFALVSLILVP-FLIETIHisrennknktfvkksfe 254
Cdd:cd17389 152 KGMALIGVAFSLGFIIGPMIGAYFASftrslGEVFFSMPALfALVLALADLLFIFfFLPETLP----------------- 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 255 npnpfSTIKSLftnnGFISWTILLFFS-IQYTgqdiwSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLivpLFLKV 333
Cdd:cd17389 215 -----SNLRRL----GLVYFLYLFLFSgLEFT-----LTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYV---RRIKP 277

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 334 LSEKKVITIGFFITFCAHVM--LSSSKFSQY--LFIFGAIVSSIVPCvsnlLCSVISKSTPQEVQGSVLTGLQSVKALGS 409
Cdd:cd17389 278 GKEKKAVLQGLILLIPAFLLigWASSVTVLYagLFLYSFAAATVVPC----LTTLVSGYGSDDQKGTVMGIFRSLGALAR 353

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 66823225 410 FAGAMVAnnllshfssdeSSIYF---PQAIYFLNGVVLFIIMII 450
Cdd:cd17389 354 ALGPIVA-----------CTVYWlagSEACYTIGALLFLLPLLL 386
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 101-453 4.68e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.91  E-value: 4.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRKSNFYLSVLtvMFVImSCFVSMETNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISDEKD 179
Cdd:cd17489  41 TLAALLARPFAGRLLDRFGRKRLLLIGLL--IFAL-ATLLYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSR 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 180 IPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLIETIHISRENNKNKTFVKKSFENPnpf 259
Cdd:cd17489 118 RGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEK--- 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 260 stikslftnNGFISWTILLFFSIQYTGqdiWSTF---YYYSYLMYNwnqktIGLFTLGVGGATILYSVLIVPLFLKVlSE 336
Cdd:cd17489 195 ---------KVLPPALILFLASIAYGA---ISTFlplYAAERGISN-----AGLFFTVYAIALLLSRPFSGKLSDRK-GP 256

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 337 KKVITIGFFITFCAHVMLSSSKFSQYLFIFGAIV----SSIVPCvsnlLCSVISKSTPQEVQGSVLTGLQSVKALGSFAG 412
Cdd:cd17489 257 KTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYglgfGLLFPA----LQALAVDLVPPHRRGAANGTFFIFFDLGIGLG 332

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 66823225 413 AMVANNLLSHFSsdessiyfPQAIYFLNGVVLFIIMIISIL 453
Cdd:cd17489 333 GLLLGLVAELFG--------YRAMFLLAAVVVLLALVLYIF 365
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 98-446 5.14e-08

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 54.96  E-value: 5.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225  98 GFPFLVMFLFGPLVGYISDRYGRKSnFYLSVLTVMFVIMSC--FVSmetnNIYCFYVFHTIGGLYNVSNSVVFSFIYDIS 175
Cdd:cd17391  43 SSTFLVSAIFSPIWGRLADRYGRKP-MLLRASLGMAIVIGLmaFVT----NVWQLLILRLLQGVFSGYVPNATALIASQT 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 176 D-EKDIPVLFTlcgLSMGL--GTTIGSLIYAFVPtDKVPY-MMLYISSGFALVSLILVPFLIETIHiSRENNKNKTFVKK 251
Cdd:cd17391 118 PkEKSGWALGT---LSTGVvaGTLIGPLLGGFLA-DLFGIrNVFFITGGLLFLAFLLTLFFVKEDF-KPVEKKKMVSTKE 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 252 SFEN-PNPfSTIKSLFtnngfiswtiLLFFSIQYTGQDIWSTF-YYYSYLMYnwNQKTIGLFTLGVGGATILYSVLIVPl 329
Cdd:cd17391 193 VWNSvPNP-SLLISLF----------VTTFIIQLANQSIEPILtLYIRQLMG--DASNLAFISGLVFSATGVSSLLSAP- 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 330 FLKVLSEK----KVITIG----FFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSnllcSVISKSTPQEVQGSVLTGL 401
Cdd:cd17391 259 RLGKLGDRighhRILLGAllasALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAIN----SLLAKITPKEVAGRIFGYN 334

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 66823225 402 QSVKALGSFAGAMVANNLLSHFSSdeSSIYFPQAI-YFLNGVVLFI 446
Cdd:cd17391 335 QSFQYLGNVAGPLLGSAIAAHFGY--RAVFVVTALlVLLNAIWSFI 378
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 101-450 7.66e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 54.11  E-value: 7.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRKSNFYLSVLTvmFVIMSCFVSMeTNNIYCFYVFHTIGGLYNVS-NSVVFSFIYDISDEKD 179
Cdd:cd17474  44 TLPAAVLMPVAGVLADRFGRKKVLLPGLLL--FGIGGLLCGL-SDSFALLLAGRALQGIGAAGlGPLALTLIGDLFEGGE 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 180 IPVLFTLCGLSMGLGTTIGSLIYAFVPTD--KVPYMMLYISSGFALVSLILvpFLIETIHISRENNKNKTFVKKSFENPN 257
Cdd:cd17474 121 RAKAMGLYEAALGLGIAVGPLLGGLLAAIswRYPFFLLAALIPVAFLAILF--LLPEPKEKAKSSSATKLRDLKKALRGR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 258 PFSTIkslftnnGFISWT-ILLFFSIQYTGQDIWSTFYYYSYLMynwnqktIGLFTLGVGGATILYSVLIVPLFLKVLSE 336
Cdd:cd17474 199 GLLTF-------LVSAFLyFFLYFAFLTYLPFLLELLYGISPII-------IGLLFAGWSVLLALGSLFVGRLLKKRFGA 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 337 KKVITIGFFITFCAHVMLSSSkFSQYLFIFGAIVSSIVPCVSN-LLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMV 415
Cdd:cd17474 265 RRILVIGLLLYALSLLLLGFV-PSLALLLIAIVLFGLGLGLNLpLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLL 343

                       330       340       350
                ....*....|....*....|....*....|....*
gi 66823225 416 ANNLLSHFSsdessiyfPQAIYFLNGVVLFIIMII 450
Cdd:cd17474 344 FGLLLEIFG--------LSAPFLVGAAIALAAAVL 370
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 112-455 1.14e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 53.76  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 112 GYISDRYGRKS--NFYLSVLTVMFVImsCFVSmetNNIYCFYVFHTIGGLYNVSnSVVFSFIYDISDEKDIPVLFTLCGL 189
Cdd:cd17472  53 GLLSDRIGRKPviLFGLLLFIAGSLL--AAYA---TSIYGLILGRALQGSGAIS-SVVMALLADLTREENRTKAMALIGA 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 190 SMG----LGTTIGSLIYAFVPTDKvpymMLYISSGFALVSLILVPFLI-ETIHISRENNKNKTFVKKSFENPNPFSTIKS 264
Cdd:cd17472 127 SIGiafaISMVLGPLLAAHLGVSG----LFLITAILSLVSLLILLFFVpDPPKIVQISEKEKKKLKKLLKNKRLLRLDFS 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 265 LFTNNGFISwtillffsiqytgqdiwSTFYYYSYLMYNWNQKTIGLFTlgVGGATILYSVLIVPLFLKVL----SEKKVI 340
Cdd:cd17472 203 IFILHFVLM-----------------AFFYILPLLLTQLGGGKGQLWK--VYLPAILIGFILMVPFVIYAekkgKMKQVF 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 341 TIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSI-VPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMVANNL 419
Cdd:cd17472 264 VSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIgFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLL 343

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 66823225 420 LSHFSSdessiyfpQAIYFLNGVVLFIIMIISILVW 455
Cdd:cd17472 344 WGLLGY--------SSVFLTILILALLWLLVSFLLP 371
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 108-455 2.44e-07

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 52.67  E-value: 2.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 108 GPLVGYISDRYGRKSNFYLSVLTVM--FVIMSCFVSMETNNIYCFY----VFHTIGGLYNVSNSVVFSFIYDISDEKDIP 181
Cdd:cd17386  47 SLFLGSWSDRYGRKPPLLMSLVGLLlsSLILVLIVYFTTVPSVWWFylsaIPLALFGGFTAFLSASFAYISDISSEKKRT 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 182 VLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLIETIhisrennknktfvkksfenpnpfst 261
Cdd:cd17386 127 YRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFLTLL------------------------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 262 ikslftnngfiswtILLFFSIQYTGQD---IWSTFYYYSYLMYNWNQKTIGLFtLGVGGATILYSVLIVPLFLKVL---S 335
Cdd:cd17386 182 --------------ILLLLAAFLTIFVlsgESDVLYLFVLEKFAWNVKDFSYF-STLGSLIYLTGMLGGVLLLRCLlkmS 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 336 EKKVITIGFFITFCAHVMLSSSKFSQYLFIfGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMV 415
Cdd:cd17386 247 DSTLAMLGLASHILSSLLFAFATNTWMMYL-AAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPI 325

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 66823225 416 ANNLLShfssdESSIYFPQAIYFLNGVVLFIIMIISILVW 455
Cdd:cd17386 326 YNNIYK-----ATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
102-234 4.16e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.72  E-value: 4.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 102 LVMFLFGPLVGYISDRYGRKSnfylsVLTVMFVIMSC---FVSMETNNIYCFYV-FHTIGGLYNVSNSVVFSFIYDISDE 177
Cdd:COG2223 252 LLGALGRPLGGWLSDRIGGRR-----VLLIVFALMALgllLLALALGSLWLFLVlFLLLGLALGGGNGAVFALVPDIFPT 326

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66823225 178 KDIPVLFTLCGLSMGLGTTIGSLIYAFV-PTDKVPYMMLYISSGFALVSLILVPFLIE 234
Cdd:COG2223 327 KNAGAVYGLVGAAGGLGGFLGPLLFGALlDATGSYTAAFLVFAVLALVALVLTLLLYR 384
2_A_01_02 TIGR00880
Multidrug resistance protein;
102-235 6.39e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 45.72  E-value: 6.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225   102 LVMFLFGPLVGYISDRYGRKSNFYLSVLTVMFVIMSCFVSmetNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISDEKDI 180
Cdd:TIGR00880   9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALS---SNITVLIIARFLQGFgAAFALVAGAALIADIYPPEER 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 66823225   181 PVLFTL----CGLSMGLGTTIGSLIYAFVPTDkvpyMMLYISSGFALVSLILVPFLIET 235
Cdd:TIGR00880  86 GVALGLmsagIALGPLLGPPLGGVLAQFLGWR----APFLFLAILALAAFILLAFLLPE 140
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 105-402 8.40e-06

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 47.80  E-value: 8.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 105 FLFGPLVGYISDRYGRKSNFYLSVLTVMFVImscfvSMETNNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIPVLF 184
Cdd:cd17387  50 FLSAPLIGALSDVWGRKSFLLLTVFFTCAPI-----PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAY 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 185 TLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSgfaLVSLILVPFLIETIHISRENNKNKTFV--KKSFENPNPFSTI 262
Cdd:cd17387 125 GLVSATFAASLVTSPALGAYLSESYGDNLVVLVAT---IVALLDICFILLAVPESLPEKMRPASWgaPISWEQADPFASL 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 263 KSLFTNNGFISWTILLFFSI-QYTGQDiwSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVPLFLKVLSEKKVIT 341
Cdd:cd17387 202 RKVGKDKTVLLICITVFLSYlPEAGQY--SSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTIL 279

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66823225 342 IG--FFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQ 402
Cdd:cd17387 280 LGlgFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIR 342
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
41-233 7.85e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 7.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225  41 LIQYIILYAYLACIFISTFLYDIFIPTLLfhyveHKFPDLTPQEKSSKSsyyksysdGFPFLVMFLFGPLVGYISDRYGR 120
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYL-----VEVRGLSLAQAGLLL--------SLPFLAGIVGSLLGGWLSDRLGR 245

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 121 KSNFYLSVLTVMFVIMSCFVSMETNNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIPVLFTLCGLSMGLGTTIGSL 200
Cdd:COG2271 246 RRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL 325

                       170       180       190
                ....*....|....*....|....*....|...
gi 66823225 201 IYAFVPTDKVPYMMLYISSGFALVSLILVPFLI 233
Cdd:COG2271 326 LVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 98-229 1.87e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.72  E-value: 1.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225  98 GFPFLVMFLFGPLVGYISDRYGRKSNFYLSvLTVMFVIMSCFVSMetNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISD 176
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIG-LLLSAVALLLLPLA--TSFWLLLLLLALLGLgLGLVFPATLALLADIVP 318

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 66823225 177 EKDIPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILV 229
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 102-454 2.40e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 43.36  E-value: 2.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 102 LVMFLFGPLVGYISDRYGRKSNFYLSVL--TVMFVIMSCfvsmeTNNIYCFY------VF-HTIGGLYNVsnsvvfsfIY 172
Cdd:cd17331  46 VLQLVGGPLFGRFGDLFGPRAALVLSFLssALSYLLLAF-----ASSVPMLFlsrlpsVFmHAMQAAQMV--------VT 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 173 DISDEKDIPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLIET-IHISRENNKNKTFVKK 251
Cdd:cd17331 113 DLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSnTKSKREKEAKESASPP 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 252 SFENPNPFSTIKSlFTNNGFISWTILLF---FSIQYtgqdiwSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVP 328
Cdd:cd17331 193 SVFNLKEILRLLR-LPGVAFLLLVKLLSglpIGMFQ------SMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVG 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 329 LFLKVLSEKKVI---TIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNllcSVISKSTPQEVQGSVLTGLQSVK 405
Cdd:cd17331 266 PLTKRFGERSLLklsVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVIT---SLLTKAVPPEDTGTALGLSHALF 342

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 66823225 406 ALGSFAGAMVANNLLSHFSsdessiyfPQAIYFLnGVVLFIIMIISILV 454
Cdd:cd17331 343 SLVRTVSPTIGGALLQAYG--------FPSFGLL-GAAINGLLTVYLLL 382
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 101-370 2.92e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.95  E-value: 2.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLV-GYISDRYGRKSNFYLSVLtvMFVImSCFVSMETNNIYCFYVFHTIGGLYNVSNSVV-FSFIYDISDEK 178
Cdd:cd17320  43 YLLGFALGQLLyGPLSDRFGRRPVLLAGLL--LFIL-ASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGA 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 179 DIPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLIETihiSRENNKNKTFVKKSFENpnp 258
Cdd:cd17320 120 ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPE---TLPEEKRKPLLSSLLRA--- 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 259 fstIKSLFTNNGFISWTILL------FFSIQYTGQDIWSTFYYYSYLMYnwnqktiGLFTLGVGGATILYSvLIVPLFLK 332
Cdd:cd17320 194 ---YKRVLKNRRFLGYALALglsfagLFAYLAAAPFIYIEQLGLSPAQF-------GLLFALNAIALILGS-LLNGRLVR 262

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 66823225 333 VLSEKKVITIGFFITFCAHVMLSSSKFSQYLFIFGAIV 370
Cdd:cd17320 263 RFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVA 300
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 101-235 4.52e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.11  E-value: 4.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRKSNFYLSVLtvMFVIMSCFVSMeTNNIYCFYVFHTIGGLYN-VSNSVVFSFIYDISDEKD 179
Cdd:COG0477  59 LLGRAIGLLLFGRLGDRYGRKRVLLIGLL--LFGLASLLCGL-APSPELLIAARALQGIGAgGLMPGALALIAELFPARE 135

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 180 IPVLFTLCGLSMGLGTTIGSLIYAFVptdkVPYM----MLYISSGFALVSLILVPFLIET 235
Cdd:COG0477 136 RGRALGLWGAAIGLGLALGPLLGGLL----VAALgwrwIFLINAPLGLLALVLRLRLPES 191
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 105-388 6.86e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 41.84  E-value: 6.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 105 FLFGPLVGYISDR----YGRKSNFYL--SVLTVMFVIM----SCFVSMETNNIYCFYVFHTIGG--LYNVSNSVVF---- 168
Cdd:cd17313  48 LFVQPLVGSLSDRcnsrIGRRRPFILvgAPLAALGLILipnaADIGLALGDGPRTWALVLFVLGivLLDFAMNVCQgpvr 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 169 SFIYDISDEKDIPVLFTLCGLSMGLGTTIGSLI--------YAFVPTDKVPYMMLYISSGFALVSLILVPFLIE------ 234
Cdd:cd17313 128 ALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLgailwdhnWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKepplsp 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 235 ---TIHISRENNKNKTFVKKSFENpNPFSTIKSLFTN-NGFISWTILLFFSIQYTGQDIWSTfyyYSYLMYNWNQ-KTIG 309
Cdd:cd17313 208 eagEHSENPSLGEVLKSLLKLLKI-MPRSLLRLLLVIfFWWIAFFPFELFFTDYMGEEVYHG---TSAASSHYGAgVRMG 283

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 310 LFTLGVGGATILYSVLIVPLFLKVLSEKKVITIG---FFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVS-NLLCSVI 385
Cdd:cd17313 284 AWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGlvlFAVGMALMALVHNVTVALVLFALGGIGWATININPyPLVSDYH 363


                ...
gi 66823225 386 SKS 388
Cdd:cd17313 364 SES 366
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 102-453 7.12e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.83  E-value: 7.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 102 LVMFLFGPLVGYISDRYGRKSNFYLSVLTVMFVIMSCFVSMETNNIYCFYVFHTIGGlyNVSNSVVFSFIYDISDEKDIP 181
Cdd:cd17329  46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGG--GLFEPASEAMIADVTTPENRT 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 182 VLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLIETIHISRENNKnktfvKKSFENPNPFST 261
Cdd:cd17329 124 RAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEK-----TEILRGYKIVLR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 262 IKSLFTnngFISWTILLFFsiqytgqdIWSTFYYYsYLMYNWNQKTIGLFTLG----VGGATILYSVLIVPLFLKVLSEK 337
Cdd:cd17329 199 DRAFLL---FLLASFLISL--------IYFQLEST-LPVYVVEILGLGESLLGlllaLNALLIVLLQFPVARLVERFRLR 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 338 KVITIGFFITFCAHVMLSSSKFSQYLFIFGAI--VSSIVpcVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMV 415
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVltLGEML--VFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLV 344

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 66823225 416 ANNLLSHfssdessiYFPQAIYFLNGVVLFIIMIISIL 453
Cdd:cd17329 345 GGLLLDL--------LGPGLPWLILAALGLIAAALLLG 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
101-231 2.41e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.27  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 101 FLVMFLFGPLVGYISDRYGRKSNFYLSVLtVMFVIMSCFVSMETNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDISDEKD 179
Cdd:COG2211 274 FLAALLGAPLWPRLAKRFGKKKAFIIGLL-LAALGLLLLFFLGPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDE 352

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66823225 180 IPV----------LFTLC-GLSMGLGTTIGSLIYA---FVPTDKVP--------YMMLYISSGFALVSLILVPF 231
Cdd:COG2211 353 WKTgrrreglyfgIFTFAiKLGQALAGALAGLLLAlfgYVAGAAQSpsaltgirLLFFLLPAVLLLLAALLLLF 426
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 320-453 4.39e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.13  E-value: 4.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 320 ILYSVLIVPLFLKVLSEKKVITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLT 399
Cdd:cd17490 244 ALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMG 323

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 66823225 400 GLQSVKALGSFAGAMVANNLLSHFSSdessiyfpQAIYFLNGVVLFIIMIISIL 453
Cdd:cd17490 324 FFQAIYALGMFLGPVLVGIISEAFGL--------QTGFFVIGVIALLAAILSLA 369
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 105-233 4.56e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.13  E-value: 4.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225 105 FLFGPLVGYISDRYGRKSNFYLSVL--TVMFVIMSCfvsmeTNNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIPV 182
Cdd:cd17390  45 LFSSPLVGSWSDVVGRRPVLLICLLltALGYVLLGF-----STSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSR 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 66823225 183 LFTLCGLSMGLGTTIGSLIYAF-VPTDKVPYMMLYISSGFALVSLILVPFLI 233
Cdd:cd17390 120 VLGRFNAASSLGFILGPVVGGHlAETDGGFYYVALLCSAIFILNAGLVWFLL 171
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 97-177 6.95e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 38.83  E-value: 6.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66823225    97 DGFPFLVMFLFGPLVGYISDRYGRKsNFYLSVLTVMFVIMSCFVSMETNNIYCFYVFHTIGGL-YNVSNSVVFSFIYDIS 175
Cdd:pfam13347 265 PLVFTIGALLGIPLWPPLAKRIGKK-NTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFgYGSSFFLPWSMLADVV 343


                  ..
gi 66823225   176 DE 177
Cdd:pfam13347 344 DY 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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