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Conserved domains on  [gi|937408800|ref|YP_009167000|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Choloepus hoffmanni]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 1.70e-66

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 200.80  E-value: 1.70e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800  81 AWGSNVVVLGGLLVGLLVEGLVVILFLGGDGVGFVsCGFKCMEDWAVFGGGEEGFVREDCVGVSALYSYGVWFVVMAGWA 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVV-FNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 937408800 161 LLVSVVIVVEVTRGG 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 1.70e-66

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 200.80  E-value: 1.70e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800  81 AWGSNVVVLGGLLVGLLVEGLVVILFLGGDGVGFVsCGFKCMEDWAVFGGGEEGFVREDCVGVSALYSYGVWFVVMAGWA 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVV-FNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 937408800 161 LLVSVVIVVEVTRGG 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-162 4.19e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 4.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   17 VGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPEAWGSNVVVLGGLLVGL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 937408800   97 LVEGLVVILFLGGDGVGFVSCGFKCMEDWAVFGggeegfvredcvgvSALYSYGVWFVVMAGWALL 162
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGNIEAIG--------------ELLFTDYLLPFELASVLLL 132
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 1.70e-66

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 200.80  E-value: 1.70e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800  81 AWGSNVVVLGGLLVGLLVEGLVVILFLGGDGVGFVsCGFKCMEDWAVFGGGEEGFVREDCVGVSALYSYGVWFVVMAGWA 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVV-FNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 937408800 161 LLVSVVIVVEVTRGG 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-162 1.55e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 111.77  E-value: 1.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800  81 AWGSNVVVLGGLLVGLLVEGLVVILFLGGDGVGFVSCGfkcmedwavfGGGEEGFVREDCVGVSALYSYGVWFVVMAGWA 160
Cdd:MTH00138  81 SWGSWSVLGYVVGYLVGVVLAAGLFWGGWYEGSWVVVD----------ELKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150


                 ..
gi 937408800 161 LL 162
Cdd:MTH00138 151 LL 152
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-162 3.17e-30

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 108.40  E-value: 3.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800  81 AWGSnvvvlggllvgLLVEGLVVILFLGGDGVGFVSCGFKCMEDWAVFGGGEEGFVREDCVGVSALYSYGVWFVVMAGWA 160
Cdd:MTH00065  81 AWGS-----------WSVLVYVLFYLLLLIVGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWV 149


                 ..
gi 937408800 161 LL 162
Cdd:MTH00065 150 LL 151
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-162 3.25e-24

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 92.89  E-value: 3.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800  81 AWGSNVVVLGGLLVGLLVEGLVVILFLGGDGVGFVScgfkcmedwAVFGGGEEGFVREDCVGVSALYSYGVWFVVMAGWA 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGV---------VTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWG 151


                 ..
gi 937408800 161 LL 162
Cdd:MTH00115 152 LL 153
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-162 5.22e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 68.48  E-value: 5.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800  81 AWGSnvvvlggllvgLLVEGLVVILFLGGDGVGFVSCGFKCMEDWavfgGGEEGFVREDCVGVSALYSYGVWFVVMAGWA 160
Cdd:MTH00214  81 SWGG-----------WSVLLFFLFYLLGLGFVGFYFYGGWEMLSW----MGVDEANNLDLSGVSDLYSRGFFLLLLGGVV 145


                 ..
gi 937408800 161 LL 162
Cdd:MTH00214 146 LF 147
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-79 1.60e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 56.45  E-value: 1.60e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937408800   1 MMYIVFLLSVIFVVSFVGFSCkpSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYP 79
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP 77
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-162 4.19e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 4.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   17 VGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEYPEAWGSNVVVLGGLLVGL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 937408800   97 LVEGLVVILFLGGDGVGFVSCGFKCMEDWAVFGggeegfvredcvgvSALYSYGVWFVVMAGWALL 162
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGNIEAIG--------------ELLFTDYLLPFELASVLLL 132
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 7-78 6.96e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 38.45  E-value: 6.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 937408800   7 LLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   5 LLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 5-74 1.93e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 37.17  E-value: 1.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408800   5 VFLLSVIFVVSFVGFSCKPSPIYGGLGLIVSGGVGCGMVMSLGGSFLGLVVFLVYLGGMLVVFGYTTAMA 74
Cdd:MTH00152   3 LMILLSVCFSLFLLLPLSKQPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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