|
Name |
Accession |
Description |
Interval |
E-value |
| nadV |
PHA02594 |
nicotinamide phosphoribosyl transferase; Provisional |
1-477 |
0e+00 |
|
nicotinamide phosphoribosyl transferase; Provisional
Pssm-ID: 222898 [Multi-domain] Cd Length: 470 Bit Score: 736.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 1 MNNktFEELNSIITSVDSYKVSHWSQYPTGSEEALFYIESRGGKF-DQVVTAGCNRLAQI-LSRPVTMENVDFANRLYKM 78
Cdd:PHA02594 1 MST--FLANVNIILMTDSYKLSHWSQYPKGTDYVMFYLEPRGGKFfDKVVVFGIQYFVKKyFFEPITMEVVEEAHELVKA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 79 HFGREIFNYKGWKEIAELGYIPLEFRAIPEGTPVAVKNPVATFHAGKN-ALWLAGHVETLAIRGVWFPSTVATLSRECKK 157
Cdd:PHA02594 79 HLGKDVFNREHWEALHDLGYLPIEVRAVPEGTVVPVKVPVLTIENTHPdFFWLAGYLETVILRGVWYPSTVATLSRECKK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 158 VLKKYLKKTSDLEgeafDMVLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAISLFEDcqkafdDGEMAA 237
Cdd:PHA02594 159 ILKKYLKETSDNE----DEVLDFQLHDFGARGMSSGESAALGGLAHLYNFKGTDTVEALYMAKRYYGD------DEVEMA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 238 GISIPAREHSTTVSYGKENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIA-EYKDSILSKGGTLVVRPDSGDMVDNI 316
Cdd:PHA02594 229 GISVPAREHSTMCSYGAENEDEAFKNSLTLYGTGIYSIVSDTYDFKRAVTEILpELKDEIMARGGKLVIRPDSGDPVDII 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 317 MYALEELGRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMK 396
Cdd:PHA02594 309 CGALETLGEIFGGTVNSKGYKVLDEHVRLIQGDGIT-LERINRILTRMKENGFASENVAFGMGGGLLQMVTRDTFKFAMK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 397 MCAIKINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKTIDTLEQKVPEGWKDAMITYYVNGKITARDTLEEIRNRAG 476
Cdd:PHA02594 388 ATAIKINGKWKGVFKNPKTDEGKKSKKGRLARVKDGGSFKTVDGLEEQSEADLNDALVTYFDDGKLVRYQSLAEIRERSD 467
|
.
gi 1631929364 477 I 477
Cdd:PHA02594 468 I 468
|
|
| PBEF_like |
cd01569 |
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of ... |
13-424 |
3.98e-180 |
|
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis.
Pssm-ID: 238803 [Multi-domain] Cd Length: 407 Bit Score: 510.28 E-value: 3.98e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 13 ITSVDSYKVSHWSQYPTGSEEALFYIESRGGK-FDQVVTAGCNRLAQ-ILSRPVTME-NVDFANRLYKMHFGREI--FNY 87
Cdd:cd01569 1 LLATDSYKVSHRLQYPPGTTAVYSYLEPRGGKyYDQTVFFGLQYFLKkYLIDPVNRDfFIDEAEAVFEAHFGMNDlpFNE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 88 KGWKEIAEL--GYIPLEFRAIPEGTPVAVKNPVATF-HAGKNALWLAGHVETLAIRGVWFPSTVATLSRECKKVLKKYLK 164
Cdd:cd01569 81 DGWRHILELhdGYLPIEIRAVPEGTVVPTKNVLMTVeNTDPDFFWLTNYLETILLRNVWYPSTVATISREYKKILRKYAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 165 KTSDlegeaFDMVLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAIslfedcqKAFDDGEMAaGISIPAR 244
Cdd:cd01569 161 ETSD-----NLEFLPFQLHDFGMRGMSSLESAALGGAAHLVNFKGTDTIPALDAAY-------AYYYEDPMA-GFSIPAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 245 EHSTTVSYGKENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIA-EYKDSILSKGGTLVVRPDSGDMVDNIMYALEEL 323
Cdd:cd01569 228 EHSTMTAWGRERELEAFRNLLEQFGPGIVSVVSDSYDFWNALTLWGpRLKDEILARGGTLVIRPDSGDPVDIICGVLEIL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 324 GRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMKMCAIKIN 403
Cdd:cd01569 308 GEIFGGTVNSKGYKVLNPHVRIIQGDGIT-LERIEEILERLKAKGFASENIVFGMGGGLLQKVTRDTQGFAMKASAIEIN 386
|
410 420
....*....|....*....|.
gi 1631929364 404 GVWTGVYKCPKGAEWKKSKKG 424
Cdd:cd01569 387 GKWRDVFKDPKTDPGKKSKKG 407
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
8-475 |
2.06e-176 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 502.89 E-value: 2.06e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 8 ELNSIITSVDSYKVSHWSQYPTGSEEALFYIESR-GGKFDQVVTAGCNRLAQ-ILSRPVTMENVDFANRLYKMHFgrEIF 85
Cdd:PRK09198 3 MLLNPILNTDSYKASHRLQYPPGTTYLYSYLESRsGGRYDKVVFFGLQYFLKeYLIQPITEAFIDEAKALLVAHG--LPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 86 NYKGWKEIAE--LGYIPLEFRAIPEGTPVAVKNPVATF-HAGKNALWLAGHVETLAIRGVWFPSTVATLSRECKKVLKKY 162
Cdd:PRK09198 81 NRAGWRRIVDkyGGYLPLRIKAVPEGSVVPVHNVLMTIeNTDPEFFWLPNYLETLLLRNVWYPSTVATISWEYKQLIRQY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 163 LKKTSDLEGEafdmvLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAislfedcqKAFDDGEMAAGiSIP 242
Cdd:PRK09198 161 LEKTADDLDF-----LPFQLHDFGARGMSSLESAALGGAAHLVSFLGTDTIPALLYA--------ERYYNADMAGF-SIP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 243 AREHSTTVSYGKENEDLAYKNSIEIFGE-GMYACVYDSWDFKAAVRRI--AEYKDSILSKGGTLVVRPDSGDMVDNIMYA 319
Cdd:PRK09198 227 ATEHSVMTSWGREGELEAYRNMIEQFYPgGIVSIVSDSYDLWNAITEPwgGELKDEILARGGTLVIRPDSGDPVTIICGT 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 320 LEELGRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMKMCA 399
Cdd:PRK09198 307 LELLDEIFGGTVNSKGYKVLNPHVGVIQGDGIT-LDSIEAILEALKAKGFAAENIVFGMGGALLQYVNRDTQGFAMKASA 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1631929364 400 IKINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKTIDtlEQKVPEGWKDAMITYYVNGKITARDTLEEIRNRA 475
Cdd:PRK09198 386 IEVNGEWRDIFKDPITDQGKKSKKGRLKLIKDNGEYRTVD--LDEAGDENDDLLQTVFENGKLLVEYSLAEIRARL 459
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
10-475 |
5.94e-78 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 250.06 E-value: 5.94e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 10 NSIITSVDSYKVSHWSQY-PTGSEEALFYIESRGGKF----DQVVTAGCNRLAQILSR-PVTMENVDFANRLykmhfgrE 83
Cdd:COG1488 2 DNLALLTDLYKLTMAQAYlPEGTANRRAVFELFFRRLpfgrGYVVFAGLQRFLKYLENlRFTEEDIAYLRSL-------G 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 84 IFNYKGWKEIAELGyIPLEFRAIPEGTPVAVKNPV----ATFhagKNALWLaghvETLAIRGVWFPSTVATLSRECKKvl 159
Cdd:COG1488 75 VFDEDFLDYLADFR-FPGDIRAVPEGTVVFPGEPLltveGTL---PEAQLL----ETLLLNILNYPTLIATKAARIVQ-- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 160 kkylkkTSDlegeafdmvlRTRLHDFGARGTSSAESA-GIGGLAHLYNFLGTDTVEAlimaislfedcQKAFddgemaaG 238
Cdd:COG1488 145 ------AAG----------GRPLHDFGLRRAHGLEAAvAAARAAYLAGFAGTSNVLA-----------GRYY-------G 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 239 I-SIPAREHSTTVSYgkENEDLAYKNSIEIFGEGMyACVYDSWDFKAAVRRIAEYKDSILSKGGTLVVRPDSGDMVDNIM 317
Cdd:COG1488 191 IpSVGTMAHSFVQAH--DDELEAFRAFAEAYPDGT-TLLVDTYDTLSGVPNAIELAKELLARGGLLGIRLDSGDLAYLSK 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 318 YALEELgrifgytvNSKGYkvlhPAVRIIQGDEIHgPETINRVLnwmeSNRWASEniAFGMGGGLLQEVTRDTQKYAMKM 397
Cdd:COG1488 268 QARELL--------DEAGL----PDVRIIASDDLD-EYRIAALL----EQGAPID--VFGVGTRLVTSSDRPTLGFVYKL 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 398 CAIKINGVWTGVYKCPKGAEwKKSKKGLLMTITDGVNFK----TIDTLEQKVPEGWKDAMITYYVNGKITAR-DTLEEIR 472
Cdd:COG1488 329 VAVEGDGEWRPVIKLSETPG-KKSKPGRKQVYRRDEDGKatadLVALEDEPLPGEPEPLLVPVFRDGKLVYElPSLEEIR 407
|
...
gi 1631929364 473 NRA 475
Cdd:COG1488 408 ERA 410
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
17-396 |
1.32e-66 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 217.52 E-value: 1.32e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 17 DSYKVSHWSQ--YPTGSEEALFYIESRGGKF--DQVVTAGCNRLAQ-ILSRPVTMENVDFANRlykmhfgreiFNYKGWK 91
Cdd:cd01567 5 DLYKLTMMQAylYPYPNTRVVFEFTFRSNPFggDYIVFAGLEEVLKlLENLRFTEEEIEYLKK----------LLIFGEF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 92 EIAE--LGYIPLEFRAIPEGTPVAVKNPVATFhagKNALWLAGHVETlAIRGVWFPSTVATLSRECKKVLKKYLKKTSDL 169
Cdd:cd01567 75 FLYLlfLGKLPLEIYALPEGTVVFPKEPLLTI---EGPWPEAGLLET-PLLAIWNEATSIATKAARKKLAAGGLLETKDN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 170 EGEafdmvLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALimaislfedcqkafddGEMAAGISIPAREHSTT 249
Cdd:cd01567 151 LEE-----LGFKLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAA----------------AKKLGIPPIGTMAHSWI 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 250 VSYG--KENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIAEYKDSILSKGGTLVVRPDSGDMVDNIMYALEELGRIF 327
Cdd:cd01567 210 QAFGalEEAAFEAFARWLPQFGGGLGIALIDTYDTDNGFLNALKLAKALGAGGGLLGVRLDSGDPVELIKKVRKHLDELG 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631929364 328 GYtvnskgykvLHPAVRIIQGDeIHGPETINRVLNWMesnrwASENIAFGMGGGLLQEVTRDTQKYAMK 396
Cdd:cd01567 290 ID---------LNKKKIIISGD-LDTEEAIELLLEQG-----ASPNDAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
181-437 |
4.89e-42 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 149.45 E-value: 4.89e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 181 RLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEAlimaislfedcqkafddgemAAGISIPAREHSTTVSYGKENE-DL 259
Cdd:pfam04095 2 KLHDFGTRRRSSLESQEIVGLAHLVNFLGTSNVHF--------------------AAKYSIPPAGTSAHEWWGAHQElDA 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 260 AYKNSIEIfgegmyacVYDSWdfkaavrrIAEY--------KDSILSKGGT-----------LVVRPDSGDMVDnimyAL 320
Cdd:pfam04095 62 NLRQFQKD--------ALDLW--------HAEYrgnlgialTDTVTMDAFLkdfdlyfaklyLGVRPDSGDPVE----WG 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 321 EELGRIFGYTVNSKGYKVlhpavRIIQGDEIHgPETINRVLNWMESNRWaseNIAFGMGGGLLQEVTRDTQKYAMKMCAI 400
Cdd:pfam04095 122 EKLIAHYGSTLNIDGYTK-----RLIFSDGLD-VEKIIELLEYFKGKGF---NIAFGIGTNLTQDLNRDTLGFAVKATPL 192
|
250 260 270
....*....|....*....|....*....|....*..
gi 1631929364 401 KINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKT 437
Cdd:pfam04095 193 NIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRT 229
|
|
| NAMPT_N |
pfam18127 |
Nicotinamide phosphoribosyltransferase, N-terminal domain; This is the N-terminal domain found ... |
12-102 |
9.54e-27 |
|
Nicotinamide phosphoribosyltransferase, N-terminal domain; This is the N-terminal domain found in Nicotinamide phosphoribosyltransferase (NAMPT) present in Homo sapiens. NAMPT captures nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD+) pool during ADP-ribosylation and transferase reactions.
Pssm-ID: 436293 [Multi-domain] Cd Length: 97 Bit Score: 103.22 E-value: 9.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 12 IITSVDSYKVSHWSQYPTGSEEALFYIESRGGKFDQVVTAGcnrLAQILSR-----PVTMENVDFANRLYKMHFGREIFN 86
Cdd:pfam18127 2 ILLATDSYKVSHWKQYPPGTEKVYSYLESRGGKFPETVFFG---LQYILKKylegqVVTKEKIDEAKRFYKAHFGDEVFN 78
|
90
....*....|....*...
gi 1631929364 87 YKGWKEIAE--LGYIPLE 102
Cdd:pfam18127 79 EKGWQYILDkhDGRLPVK 96
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
17-396 |
2.02e-21 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 93.84 E-value: 2.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 17 DSYKVSHWSQYPTGSEEALFYIESRGGKFdqVVTAGCNRLAQILsrpvtmENVDFanrlykmhfgreifnykgwkeiael 96
Cdd:cd00516 1 DLYKLTMIQAYPPPDTRATAEFTAREDPY--GVLAGLEEALELL------ELLRF------------------------- 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 97 gYIPLEFRAIPEGTPVAVKNPVATFhagKNALWLAGHVETLAIRGVWFPSTVATLSRECKkvlkkylkktsDLEGEAfdm 176
Cdd:cd00516 48 -PGPLVILAVPEGTVVEPGEPLLTI---EGPARELLLLERVLLNLLQRLSGIATATARYV-----------EAAKGA--- 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 177 vlRTRLHDFGARGTSSaESAGIGGLAHLYNFLGTDTVEAlimaislfedcqkafDDGEMaAGISIPAREHSTTVSYGKEN 256
Cdd:cd00516 110 --NTKVHDFGTRKTTP-GLRLLEKYAVLIGGGDGHRNGL---------------SDAIL-IKDNHGTMAHSIIQAFGELA 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 257 EDLAYKNSIeifgEGMYACVYDSWD--FKAAVRRIAEykdsilskGGTLVVRPDSG-----DMVDNIMYALEELgrifgy 329
Cdd:cd00516 171 AVKALRRWL----PELFIALIDVEVdtLEEALEAAKA--------GGADGIRLDSGspeelDPAVLILKARAHL------ 232
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1631929364 330 tvnskGYKVLHPAVRIIQGDEIhgPETINRVLnwmesnrwASENIAFGMGGGLLQevtRDTQKYAMK 396
Cdd:cd00516 233 -----DGKGLPRVKIEASGGLD--EENIRAYA--------ETGVDVFGVGTLLHS---APPLDIVLK 281
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
102-314 |
2.02e-06 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 50.13 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 102 EFRAIPEGTPVAVKNPVATFHAgknALWLAGHVETLAIRGVWFPSTVATLSRECkkvlkkylkktsdlegeafdmVLRTR 181
Cdd:PRK12484 91 DVRAVPEGTVVFPNEPLLEVTA---PLIEAQLVETFLLNQINHQSLIASKAARC---------------------VLAAA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 182 ---LHDFGARGTSSAESA-GIGGLAHLYNFLGTDTVEAlimaislfedcQKAFD---DGEMAagisipareHSTTVSYGK 254
Cdd:PRK12484 147 grpVVDFGARRAHGTDAAcYVARASYLAGAAGTSNVLA-----------ARQYGipaSGTMA---------HSFVEAFPD 206
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631929364 255 ENEdlAYKNSIEIFGEgmyACVY--DSWDFKAAVRRIAEYKDSILSKGGTLVVRPDSGDMVD 314
Cdd:PRK12484 207 EVA--AFRAFARLYPD---ATTLlvDTYDTLRGVRNAIEVAKELGNRFDPRGVRLDSGDLAE 263
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
31-313 |
8.28e-03 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 38.32 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 31 SEEALFYIESR----GGKFdqVVTAGcnrLAQILSRpvtMENVDFANR----LYKMH-FGREIFNY-KGWKeiaelgyIP 100
Cdd:cd01570 22 NKPAVFELFFRklpfGGGY--AVFAG---LEELLEY---LENFRFTEEdidyLRSLGiFDEEFLDYlRGFR-------FT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 101 LEFRAIPEGTPVAVKNPVATFHAgknALWLAGHVETLAIRGVWFPSTVATlsreckkvlkkylkktsdlegEAFDMVLRT 180
Cdd:cd01570 87 GTIYAIPEGEVVFPNEPLLTVEG---PLIEAQLLETLLLNLINFQTLIAT---------------------KAARVRLAA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 181 ---RLHDFGAR-------GTSSAESAGIGGlahlynFLGTDTVEAlimaislfedcQKAFDdgemaagisIPAR---EHS 247
Cdd:cd01570 143 ggrPLLEFGLRraqgpdaALSAARAAYIGG------FDGTSNVLA-----------GKLYG---------IPVSgtmAHS 196
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631929364 248 TTVSYGKENEdlAYKNSIEIFGEGMYACV--YDSWdfKAAVRRIAEYKDSILSKGGTLV-VRPDSGDMV 313
Cdd:cd01570 197 FVQAFDDELA--AFRAFAEAYPDNFTLLVdtYDTL--RSGLPNAIAVAKELGALGYRLVgVRIDSGDLA 261
|
|
|