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Conserved domains on  [gi|1631929364|ref|YP_009607162|]
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nicotinamide phosphoribosyl transferase [Enterobacter phage phiEap-3]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
nadV PHA02594
nicotinamide phosphoribosyl transferase; Provisional
1-477 0e+00

nicotinamide phosphoribosyl transferase; Provisional


:

Pssm-ID: 222898 [Multi-domain]  Cd Length: 470  Bit Score: 736.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364   1 MNNktFEELNSIITSVDSYKVSHWSQYPTGSEEALFYIESRGGKF-DQVVTAGCNRLAQI-LSRPVTMENVDFANRLYKM 78
Cdd:PHA02594    1 MST--FLANVNIILMTDSYKLSHWSQYPKGTDYVMFYLEPRGGKFfDKVVVFGIQYFVKKyFFEPITMEVVEEAHELVKA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  79 HFGREIFNYKGWKEIAELGYIPLEFRAIPEGTPVAVKNPVATFHAGKN-ALWLAGHVETLAIRGVWFPSTVATLSRECKK 157
Cdd:PHA02594   79 HLGKDVFNREHWEALHDLGYLPIEVRAVPEGTVVPVKVPVLTIENTHPdFFWLAGYLETVILRGVWYPSTVATLSRECKK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 158 VLKKYLKKTSDLEgeafDMVLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAISLFEDcqkafdDGEMAA 237
Cdd:PHA02594  159 ILKKYLKETSDNE----DEVLDFQLHDFGARGMSSGESAALGGLAHLYNFKGTDTVEALYMAKRYYGD------DEVEMA 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 238 GISIPAREHSTTVSYGKENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIA-EYKDSILSKGGTLVVRPDSGDMVDNI 316
Cdd:PHA02594  229 GISVPAREHSTMCSYGAENEDEAFKNSLTLYGTGIYSIVSDTYDFKRAVTEILpELKDEIMARGGKLVIRPDSGDPVDII 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 317 MYALEELGRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMK 396
Cdd:PHA02594  309 CGALETLGEIFGGTVNSKGYKVLDEHVRLIQGDGIT-LERINRILTRMKENGFASENVAFGMGGGLLQMVTRDTFKFAMK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 397 MCAIKINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKTIDTLEQKVPEGWKDAMITYYVNGKITARDTLEEIRNRAG 476
Cdd:PHA02594  388 ATAIKINGKWKGVFKNPKTDEGKKSKKGRLARVKDGGSFKTVDGLEEQSEADLNDALVTYFDDGKLVRYQSLAEIRERSD 467

                  .
gi 1631929364 477 I 477
Cdd:PHA02594  468 I 468
 
Name Accession Description Interval E-value
nadV PHA02594
nicotinamide phosphoribosyl transferase; Provisional
1-477 0e+00

nicotinamide phosphoribosyl transferase; Provisional


Pssm-ID: 222898 [Multi-domain]  Cd Length: 470  Bit Score: 736.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364   1 MNNktFEELNSIITSVDSYKVSHWSQYPTGSEEALFYIESRGGKF-DQVVTAGCNRLAQI-LSRPVTMENVDFANRLYKM 78
Cdd:PHA02594    1 MST--FLANVNIILMTDSYKLSHWSQYPKGTDYVMFYLEPRGGKFfDKVVVFGIQYFVKKyFFEPITMEVVEEAHELVKA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  79 HFGREIFNYKGWKEIAELGYIPLEFRAIPEGTPVAVKNPVATFHAGKN-ALWLAGHVETLAIRGVWFPSTVATLSRECKK 157
Cdd:PHA02594   79 HLGKDVFNREHWEALHDLGYLPIEVRAVPEGTVVPVKVPVLTIENTHPdFFWLAGYLETVILRGVWYPSTVATLSRECKK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 158 VLKKYLKKTSDLEgeafDMVLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAISLFEDcqkafdDGEMAA 237
Cdd:PHA02594  159 ILKKYLKETSDNE----DEVLDFQLHDFGARGMSSGESAALGGLAHLYNFKGTDTVEALYMAKRYYGD------DEVEMA 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 238 GISIPAREHSTTVSYGKENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIA-EYKDSILSKGGTLVVRPDSGDMVDNI 316
Cdd:PHA02594  229 GISVPAREHSTMCSYGAENEDEAFKNSLTLYGTGIYSIVSDTYDFKRAVTEILpELKDEIMARGGKLVIRPDSGDPVDII 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 317 MYALEELGRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMK 396
Cdd:PHA02594  309 CGALETLGEIFGGTVNSKGYKVLDEHVRLIQGDGIT-LERINRILTRMKENGFASENVAFGMGGGLLQMVTRDTFKFAMK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 397 MCAIKINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKTIDTLEQKVPEGWKDAMITYYVNGKITARDTLEEIRNRAG 476
Cdd:PHA02594  388 ATAIKINGKWKGVFKNPKTDEGKKSKKGRLARVKDGGSFKTVDGLEEQSEADLNDALVTYFDDGKLVRYQSLAEIRERSD 467

                  .
gi 1631929364 477 I 477
Cdd:PHA02594  468 I 468
PBEF_like cd01569
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of ...
13-424 3.98e-180

pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis.


Pssm-ID: 238803 [Multi-domain]  Cd Length: 407  Bit Score: 510.28  E-value: 3.98e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  13 ITSVDSYKVSHWSQYPTGSEEALFYIESRGGK-FDQVVTAGCNRLAQ-ILSRPVTME-NVDFANRLYKMHFGREI--FNY 87
Cdd:cd01569     1 LLATDSYKVSHRLQYPPGTTAVYSYLEPRGGKyYDQTVFFGLQYFLKkYLIDPVNRDfFIDEAEAVFEAHFGMNDlpFNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  88 KGWKEIAEL--GYIPLEFRAIPEGTPVAVKNPVATF-HAGKNALWLAGHVETLAIRGVWFPSTVATLSRECKKVLKKYLK 164
Cdd:cd01569    81 DGWRHILELhdGYLPIEIRAVPEGTVVPTKNVLMTVeNTDPDFFWLTNYLETILLRNVWYPSTVATISREYKKILRKYAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 165 KTSDlegeaFDMVLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAIslfedcqKAFDDGEMAaGISIPAR 244
Cdd:cd01569   161 ETSD-----NLEFLPFQLHDFGMRGMSSLESAALGGAAHLVNFKGTDTIPALDAAY-------AYYYEDPMA-GFSIPAA 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 245 EHSTTVSYGKENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIA-EYKDSILSKGGTLVVRPDSGDMVDNIMYALEEL 323
Cdd:cd01569   228 EHSTMTAWGRERELEAFRNLLEQFGPGIVSVVSDSYDFWNALTLWGpRLKDEILARGGTLVIRPDSGDPVDIICGVLEIL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 324 GRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMKMCAIKIN 403
Cdd:cd01569   308 GEIFGGTVNSKGYKVLNPHVRIIQGDGIT-LERIEEILERLKAKGFASENIVFGMGGGLLQKVTRDTQGFAMKASAIEIN 386
                         410       420
                  ....*....|....*....|.
gi 1631929364 404 GVWTGVYKCPKGAEWKKSKKG 424
Cdd:cd01569   387 GKWRDVFKDPKTDPGKKSKKG 407
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
10-475 5.94e-78

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 250.06  E-value: 5.94e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  10 NSIITSVDSYKVSHWSQY-PTGSEEALFYIESRGGKF----DQVVTAGCNRLAQILSR-PVTMENVDFANRLykmhfgrE 83
Cdd:COG1488     2 DNLALLTDLYKLTMAQAYlPEGTANRRAVFELFFRRLpfgrGYVVFAGLQRFLKYLENlRFTEEDIAYLRSL-------G 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  84 IFNYKGWKEIAELGyIPLEFRAIPEGTPVAVKNPV----ATFhagKNALWLaghvETLAIRGVWFPSTVATLSRECKKvl 159
Cdd:COG1488    75 VFDEDFLDYLADFR-FPGDIRAVPEGTVVFPGEPLltveGTL---PEAQLL----ETLLLNILNYPTLIATKAARIVQ-- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 160 kkylkkTSDlegeafdmvlRTRLHDFGARGTSSAESA-GIGGLAHLYNFLGTDTVEAlimaislfedcQKAFddgemaaG 238
Cdd:COG1488   145 ------AAG----------GRPLHDFGLRRAHGLEAAvAAARAAYLAGFAGTSNVLA-----------GRYY-------G 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 239 I-SIPAREHSTTVSYgkENEDLAYKNSIEIFGEGMyACVYDSWDFKAAVRRIAEYKDSILSKGGTLVVRPDSGDMVDNIM 317
Cdd:COG1488   191 IpSVGTMAHSFVQAH--DDELEAFRAFAEAYPDGT-TLLVDTYDTLSGVPNAIELAKELLARGGLLGIRLDSGDLAYLSK 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 318 YALEELgrifgytvNSKGYkvlhPAVRIIQGDEIHgPETINRVLnwmeSNRWASEniAFGMGGGLLQEVTRDTQKYAMKM 397
Cdd:COG1488   268 QARELL--------DEAGL----PDVRIIASDDLD-EYRIAALL----EQGAPID--VFGVGTRLVTSSDRPTLGFVYKL 328
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 398 CAIKINGVWTGVYKCPKGAEwKKSKKGLLMTITDGVNFK----TIDTLEQKVPEGWKDAMITYYVNGKITAR-DTLEEIR 472
Cdd:COG1488   329 VAVEGDGEWRPVIKLSETPG-KKSKPGRKQVYRRDEDGKatadLVALEDEPLPGEPEPLLVPVFRDGKLVYElPSLEEIR 407

                  ...
gi 1631929364 473 NRA 475
Cdd:COG1488   408 ERA 410
NAPRTase pfam04095
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ...
181-437 4.89e-42

Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.


Pssm-ID: 397974 [Multi-domain]  Cd Length: 235  Bit Score: 149.45  E-value: 4.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 181 RLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEAlimaislfedcqkafddgemAAGISIPAREHSTTVSYGKENE-DL 259
Cdd:pfam04095   2 KLHDFGTRRRSSLESQEIVGLAHLVNFLGTSNVHF--------------------AAKYSIPPAGTSAHEWWGAHQElDA 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 260 AYKNSIEIfgegmyacVYDSWdfkaavrrIAEY--------KDSILSKGGT-----------LVVRPDSGDMVDnimyAL 320
Cdd:pfam04095  62 NLRQFQKD--------ALDLW--------HAEYrgnlgialTDTVTMDAFLkdfdlyfaklyLGVRPDSGDPVE----WG 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 321 EELGRIFGYTVNSKGYKVlhpavRIIQGDEIHgPETINRVLNWMESNRWaseNIAFGMGGGLLQEVTRDTQKYAMKMCAI 400
Cdd:pfam04095 122 EKLIAHYGSTLNIDGYTK-----RLIFSDGLD-VEKIIELLEYFKGKGF---NIAFGIGTNLTQDLNRDTLGFAVKATPL 192
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1631929364 401 KINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKT 437
Cdd:pfam04095 193 NIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRT 229
 
Name Accession Description Interval E-value
nadV PHA02594
nicotinamide phosphoribosyl transferase; Provisional
1-477 0e+00

nicotinamide phosphoribosyl transferase; Provisional


Pssm-ID: 222898 [Multi-domain]  Cd Length: 470  Bit Score: 736.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364   1 MNNktFEELNSIITSVDSYKVSHWSQYPTGSEEALFYIESRGGKF-DQVVTAGCNRLAQI-LSRPVTMENVDFANRLYKM 78
Cdd:PHA02594    1 MST--FLANVNIILMTDSYKLSHWSQYPKGTDYVMFYLEPRGGKFfDKVVVFGIQYFVKKyFFEPITMEVVEEAHELVKA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  79 HFGREIFNYKGWKEIAELGYIPLEFRAIPEGTPVAVKNPVATFHAGKN-ALWLAGHVETLAIRGVWFPSTVATLSRECKK 157
Cdd:PHA02594   79 HLGKDVFNREHWEALHDLGYLPIEVRAVPEGTVVPVKVPVLTIENTHPdFFWLAGYLETVILRGVWYPSTVATLSRECKK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 158 VLKKYLKKTSDLEgeafDMVLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAISLFEDcqkafdDGEMAA 237
Cdd:PHA02594  159 ILKKYLKETSDNE----DEVLDFQLHDFGARGMSSGESAALGGLAHLYNFKGTDTVEALYMAKRYYGD------DEVEMA 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 238 GISIPAREHSTTVSYGKENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIA-EYKDSILSKGGTLVVRPDSGDMVDNI 316
Cdd:PHA02594  229 GISVPAREHSTMCSYGAENEDEAFKNSLTLYGTGIYSIVSDTYDFKRAVTEILpELKDEIMARGGKLVIRPDSGDPVDII 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 317 MYALEELGRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMK 396
Cdd:PHA02594  309 CGALETLGEIFGGTVNSKGYKVLDEHVRLIQGDGIT-LERINRILTRMKENGFASENVAFGMGGGLLQMVTRDTFKFAMK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 397 MCAIKINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKTIDTLEQKVPEGWKDAMITYYVNGKITARDTLEEIRNRAG 476
Cdd:PHA02594  388 ATAIKINGKWKGVFKNPKTDEGKKSKKGRLARVKDGGSFKTVDGLEEQSEADLNDALVTYFDDGKLVRYQSLAEIRERSD 467

                  .
gi 1631929364 477 I 477
Cdd:PHA02594  468 I 468
PBEF_like cd01569
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of ...
13-424 3.98e-180

pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis.


Pssm-ID: 238803 [Multi-domain]  Cd Length: 407  Bit Score: 510.28  E-value: 3.98e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  13 ITSVDSYKVSHWSQYPTGSEEALFYIESRGGK-FDQVVTAGCNRLAQ-ILSRPVTME-NVDFANRLYKMHFGREI--FNY 87
Cdd:cd01569     1 LLATDSYKVSHRLQYPPGTTAVYSYLEPRGGKyYDQTVFFGLQYFLKkYLIDPVNRDfFIDEAEAVFEAHFGMNDlpFNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  88 KGWKEIAEL--GYIPLEFRAIPEGTPVAVKNPVATF-HAGKNALWLAGHVETLAIRGVWFPSTVATLSRECKKVLKKYLK 164
Cdd:cd01569    81 DGWRHILELhdGYLPIEIRAVPEGTVVPTKNVLMTVeNTDPDFFWLTNYLETILLRNVWYPSTVATISREYKKILRKYAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 165 KTSDlegeaFDMVLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAIslfedcqKAFDDGEMAaGISIPAR 244
Cdd:cd01569   161 ETSD-----NLEFLPFQLHDFGMRGMSSLESAALGGAAHLVNFKGTDTIPALDAAY-------AYYYEDPMA-GFSIPAA 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 245 EHSTTVSYGKENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIA-EYKDSILSKGGTLVVRPDSGDMVDNIMYALEEL 323
Cdd:cd01569   228 EHSTMTAWGRERELEAFRNLLEQFGPGIVSVVSDSYDFWNALTLWGpRLKDEILARGGTLVIRPDSGDPVDIICGVLEIL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 324 GRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMKMCAIKIN 403
Cdd:cd01569   308 GEIFGGTVNSKGYKVLNPHVRIIQGDGIT-LERIEEILERLKAKGFASENIVFGMGGGLLQKVTRDTQGFAMKASAIEIN 386
                         410       420
                  ....*....|....*....|.
gi 1631929364 404 GVWTGVYKCPKGAEWKKSKKG 424
Cdd:cd01569   387 GKWRDVFKDPKTDPGKKSKKG 407
PRK09198 PRK09198
putative nicotinate phosphoribosyltransferase; Provisional
8-475 2.06e-176

putative nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 236407 [Multi-domain]  Cd Length: 463  Bit Score: 502.89  E-value: 2.06e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364   8 ELNSIITSVDSYKVSHWSQYPTGSEEALFYIESR-GGKFDQVVTAGCNRLAQ-ILSRPVTMENVDFANRLYKMHFgrEIF 85
Cdd:PRK09198    3 MLLNPILNTDSYKASHRLQYPPGTTYLYSYLESRsGGRYDKVVFFGLQYFLKeYLIQPITEAFIDEAKALLVAHG--LPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  86 NYKGWKEIAE--LGYIPLEFRAIPEGTPVAVKNPVATF-HAGKNALWLAGHVETLAIRGVWFPSTVATLSRECKKVLKKY 162
Cdd:PRK09198   81 NRAGWRRIVDkyGGYLPLRIKAVPEGSVVPVHNVLMTIeNTDPEFFWLPNYLETLLLRNVWYPSTVATISWEYKQLIRQY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 163 LKKTSDLEGEafdmvLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALIMAislfedcqKAFDDGEMAAGiSIP 242
Cdd:PRK09198  161 LEKTADDLDF-----LPFQLHDFGARGMSSLESAALGGAAHLVSFLGTDTIPALLYA--------ERYYNADMAGF-SIP 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 243 AREHSTTVSYGKENEDLAYKNSIEIFGE-GMYACVYDSWDFKAAVRRI--AEYKDSILSKGGTLVVRPDSGDMVDNIMYA 319
Cdd:PRK09198  227 ATEHSVMTSWGREGELEAYRNMIEQFYPgGIVSIVSDSYDLWNAITEPwgGELKDEILARGGTLVIRPDSGDPVTIICGT 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 320 LEELGRIFGYTVNSKGYKVLHPAVRIIQGDEIHgPETINRVLNWMESNRWASENIAFGMGGGLLQEVTRDTQKYAMKMCA 399
Cdd:PRK09198  307 LELLDEIFGGTVNSKGYKVLNPHVGVIQGDGIT-LDSIEAILEALKAKGFAAENIVFGMGGALLQYVNRDTQGFAMKASA 385
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1631929364 400 IKINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKTIDtlEQKVPEGWKDAMITYYVNGKITARDTLEEIRNRA 475
Cdd:PRK09198  386 IEVNGEWRDIFKDPITDQGKKSKKGRLKLIKDNGEYRTVD--LDEAGDENDDLLQTVFENGKLLVEYSLAEIRARL 459
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
10-475 5.94e-78

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 250.06  E-value: 5.94e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  10 NSIITSVDSYKVSHWSQY-PTGSEEALFYIESRGGKF----DQVVTAGCNRLAQILSR-PVTMENVDFANRLykmhfgrE 83
Cdd:COG1488     2 DNLALLTDLYKLTMAQAYlPEGTANRRAVFELFFRRLpfgrGYVVFAGLQRFLKYLENlRFTEEDIAYLRSL-------G 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  84 IFNYKGWKEIAELGyIPLEFRAIPEGTPVAVKNPV----ATFhagKNALWLaghvETLAIRGVWFPSTVATLSRECKKvl 159
Cdd:COG1488    75 VFDEDFLDYLADFR-FPGDIRAVPEGTVVFPGEPLltveGTL---PEAQLL----ETLLLNILNYPTLIATKAARIVQ-- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 160 kkylkkTSDlegeafdmvlRTRLHDFGARGTSSAESA-GIGGLAHLYNFLGTDTVEAlimaislfedcQKAFddgemaaG 238
Cdd:COG1488   145 ------AAG----------GRPLHDFGLRRAHGLEAAvAAARAAYLAGFAGTSNVLA-----------GRYY-------G 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 239 I-SIPAREHSTTVSYgkENEDLAYKNSIEIFGEGMyACVYDSWDFKAAVRRIAEYKDSILSKGGTLVVRPDSGDMVDNIM 317
Cdd:COG1488   191 IpSVGTMAHSFVQAH--DDELEAFRAFAEAYPDGT-TLLVDTYDTLSGVPNAIELAKELLARGGLLGIRLDSGDLAYLSK 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 318 YALEELgrifgytvNSKGYkvlhPAVRIIQGDEIHgPETINRVLnwmeSNRWASEniAFGMGGGLLQEVTRDTQKYAMKM 397
Cdd:COG1488   268 QARELL--------DEAGL----PDVRIIASDDLD-EYRIAALL----EQGAPID--VFGVGTRLVTSSDRPTLGFVYKL 328
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 398 CAIKINGVWTGVYKCPKGAEwKKSKKGLLMTITDGVNFK----TIDTLEQKVPEGWKDAMITYYVNGKITAR-DTLEEIR 472
Cdd:COG1488   329 VAVEGDGEWRPVIKLSETPG-KKSKPGRKQVYRRDEDGKatadLVALEDEPLPGEPEPLLVPVFRDGKLVYElPSLEEIR 407

                  ...
gi 1631929364 473 NRA 475
Cdd:COG1488   408 ERA 410
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
17-396 1.32e-66

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 217.52  E-value: 1.32e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  17 DSYKVSHWSQ--YPTGSEEALFYIESRGGKF--DQVVTAGCNRLAQ-ILSRPVTMENVDFANRlykmhfgreiFNYKGWK 91
Cdd:cd01567     5 DLYKLTMMQAylYPYPNTRVVFEFTFRSNPFggDYIVFAGLEEVLKlLENLRFTEEEIEYLKK----------LLIFGEF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  92 EIAE--LGYIPLEFRAIPEGTPVAVKNPVATFhagKNALWLAGHVETlAIRGVWFPSTVATLSRECKKVLKKYLKKTSDL 169
Cdd:cd01567    75 FLYLlfLGKLPLEIYALPEGTVVFPKEPLLTI---EGPWPEAGLLET-PLLAIWNEATSIATKAARKKLAAGGLLETKDN 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 170 EGEafdmvLRTRLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEALimaislfedcqkafddGEMAAGISIPAREHSTT 249
Cdd:cd01567   151 LEE-----LGFKLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAA----------------AKKLGIPPIGTMAHSWI 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 250 VSYG--KENEDLAYKNSIEIFGEGMYACVYDSWDFKAAVRRIAEYKDSILSKGGTLVVRPDSGDMVDNIMYALEELGRIF 327
Cdd:cd01567   210 QAFGalEEAAFEAFARWLPQFGGGLGIALIDTYDTDNGFLNALKLAKALGAGGGLLGVRLDSGDPVELIKKVRKHLDELG 289
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631929364 328 GYtvnskgykvLHPAVRIIQGDeIHGPETINRVLNWMesnrwASENIAFGMGGGLLQEVTRDTQKYAMK 396
Cdd:cd01567   290 ID---------LNKKKIIISGD-LDTEEAIELLLEQG-----ASPNDAFGVGTSLTNDLGRPPLGFVYK 343
NAPRTase pfam04095
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ...
181-437 4.89e-42

Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.


Pssm-ID: 397974 [Multi-domain]  Cd Length: 235  Bit Score: 149.45  E-value: 4.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 181 RLHDFGARGTSSAESAGIGGLAHLYNFLGTDTVEAlimaislfedcqkafddgemAAGISIPAREHSTTVSYGKENE-DL 259
Cdd:pfam04095   2 KLHDFGTRRRSSLESQEIVGLAHLVNFLGTSNVHF--------------------AAKYSIPPAGTSAHEWWGAHQElDA 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 260 AYKNSIEIfgegmyacVYDSWdfkaavrrIAEY--------KDSILSKGGT-----------LVVRPDSGDMVDnimyAL 320
Cdd:pfam04095  62 NLRQFQKD--------ALDLW--------HAEYrgnlgialTDTVTMDAFLkdfdlyfaklyLGVRPDSGDPVE----WG 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 321 EELGRIFGYTVNSKGYKVlhpavRIIQGDEIHgPETINRVLNWMESNRWaseNIAFGMGGGLLQEVTRDTQKYAMKMCAI 400
Cdd:pfam04095 122 EKLIAHYGSTLNIDGYTK-----RLIFSDGLD-VEKIIELLEYFKGKGF---NIAFGIGTNLTQDLNRDTLGFAVKATPL 192
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1631929364 401 KINGVWTGVYKCPKGAEWKKSKKGLLMTITDGVNFKT 437
Cdd:pfam04095 193 NIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRT 229
NAMPT_N pfam18127
Nicotinamide phosphoribosyltransferase, N-terminal domain; This is the N-terminal domain found ...
12-102 9.54e-27

Nicotinamide phosphoribosyltransferase, N-terminal domain; This is the N-terminal domain found in Nicotinamide phosphoribosyltransferase (NAMPT) present in Homo sapiens. NAMPT captures nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD+) pool during ADP-ribosylation and transferase reactions.


Pssm-ID: 436293 [Multi-domain]  Cd Length: 97  Bit Score: 103.22  E-value: 9.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  12 IITSVDSYKVSHWSQYPTGSEEALFYIESRGGKFDQVVTAGcnrLAQILSR-----PVTMENVDFANRLYKMHFGREIFN 86
Cdd:pfam18127   2 ILLATDSYKVSHWKQYPPGTEKVYSYLESRGGKFPETVFFG---LQYILKKylegqVVTKEKIDEAKRFYKAHFGDEVFN 78
                          90
                  ....*....|....*...
gi 1631929364  87 YKGWKEIAE--LGYIPLE 102
Cdd:pfam18127  79 EKGWQYILDkhDGRLPVK 96
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
17-396 2.02e-21

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 93.84  E-value: 2.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  17 DSYKVSHWSQYPTGSEEALFYIESRGGKFdqVVTAGCNRLAQILsrpvtmENVDFanrlykmhfgreifnykgwkeiael 96
Cdd:cd00516     1 DLYKLTMIQAYPPPDTRATAEFTAREDPY--GVLAGLEEALELL------ELLRF------------------------- 47
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  97 gYIPLEFRAIPEGTPVAVKNPVATFhagKNALWLAGHVETLAIRGVWFPSTVATLSRECKkvlkkylkktsDLEGEAfdm 176
Cdd:cd00516    48 -PGPLVILAVPEGTVVEPGEPLLTI---EGPARELLLLERVLLNLLQRLSGIATATARYV-----------EAAKGA--- 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 177 vlRTRLHDFGARGTSSaESAGIGGLAHLYNFLGTDTVEAlimaislfedcqkafDDGEMaAGISIPAREHSTTVSYGKEN 256
Cdd:cd00516   110 --NTKVHDFGTRKTTP-GLRLLEKYAVLIGGGDGHRNGL---------------SDAIL-IKDNHGTMAHSIIQAFGELA 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 257 EDLAYKNSIeifgEGMYACVYDSWD--FKAAVRRIAEykdsilskGGTLVVRPDSG-----DMVDNIMYALEELgrifgy 329
Cdd:cd00516   171 AVKALRRWL----PELFIALIDVEVdtLEEALEAAKA--------GGADGIRLDSGspeelDPAVLILKARAHL------ 232
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1631929364 330 tvnskGYKVLHPAVRIIQGDEIhgPETINRVLnwmesnrwASENIAFGMGGGLLQevtRDTQKYAMK 396
Cdd:cd00516   233 -----DGKGLPRVKIEASGGLD--EENIRAYA--------ETGVDVFGVGTLLHS---APPLDIVLK 281
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
102-314 2.02e-06

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 50.13  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 102 EFRAIPEGTPVAVKNPVATFHAgknALWLAGHVETLAIRGVWFPSTVATLSRECkkvlkkylkktsdlegeafdmVLRTR 181
Cdd:PRK12484   91 DVRAVPEGTVVFPNEPLLEVTA---PLIEAQLVETFLLNQINHQSLIASKAARC---------------------VLAAA 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 182 ---LHDFGARGTSSAESA-GIGGLAHLYNFLGTDTVEAlimaislfedcQKAFD---DGEMAagisipareHSTTVSYGK 254
Cdd:PRK12484  147 grpVVDFGARRAHGTDAAcYVARASYLAGAAGTSNVLA-----------ARQYGipaSGTMA---------HSFVEAFPD 206
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631929364 255 ENEdlAYKNSIEIFGEgmyACVY--DSWDFKAAVRRIAEYKDSILSKGGTLVVRPDSGDMVD 314
Cdd:PRK12484  207 EVA--AFRAFARLYPD---ATTLlvDTYDTLRGVRNAIEVAKELGNRFDPRGVRLDSGDLAE 263
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
31-313 8.28e-03

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 38.32  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364  31 SEEALFYIESR----GGKFdqVVTAGcnrLAQILSRpvtMENVDFANR----LYKMH-FGREIFNY-KGWKeiaelgyIP 100
Cdd:cd01570    22 NKPAVFELFFRklpfGGGY--AVFAG---LEELLEY---LENFRFTEEdidyLRSLGiFDEEFLDYlRGFR-------FT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 101 LEFRAIPEGTPVAVKNPVATFHAgknALWLAGHVETLAIRGVWFPSTVATlsreckkvlkkylkktsdlegEAFDMVLRT 180
Cdd:cd01570    87 GTIYAIPEGEVVFPNEPLLTVEG---PLIEAQLLETLLLNLINFQTLIAT---------------------KAARVRLAA 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631929364 181 ---RLHDFGAR-------GTSSAESAGIGGlahlynFLGTDTVEAlimaislfedcQKAFDdgemaagisIPAR---EHS 247
Cdd:cd01570   143 ggrPLLEFGLRraqgpdaALSAARAAYIGG------FDGTSNVLA-----------GKLYG---------IPVSgtmAHS 196
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631929364 248 TTVSYGKENEdlAYKNSIEIFGEGMYACV--YDSWdfKAAVRRIAEYKDSILSKGGTLV-VRPDSGDMV 313
Cdd:cd01570   197 FVQAFDDELA--AFRAFAEAYPDNFTLLVdtYDTL--RSGLPNAIAVAKELGALGYRLVgVRIDSGDLA 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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