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Conserved domains on  [gi|2088232043|ref|YP_010133400|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Exaiptasia diaphana]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009528)

NADH dehydrogenase subunit 6 (mitochondrion) is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00021
NADH dehydrogenase subunit 6; Validated
 8-201 4.27e-88

NADH dehydrogenase subunit 6; Validated


:

Pssm-ID: 214401 [Multi-domain]  Cd Length: 188  Bit Score: 256.96  E-value: 4.27e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   8 ILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPAFrqG 87
Cdd:MTH00021    1 FFSLGIIGSGIMVISALNPVHSIFWLVVVFVNSAVFFILLGLDFLALMFLIIYVGAIAILFLFVIMLLNLTDFPPAF--G 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  88 GEADMTNYVPIGLAVGTLFFEAIASSWLIMGGPYVYRgmlgaWDLANSWFLKKYHNIEAIGRILYTDCYYLFILVSFILL 167
Cdd:MTH00021   79 GEADMTNYIPIGLIIGTLFFSEIASSWLIIGGPYVER-----WDLAFPWFLISYHNIEALGRILYITCYYLFLLASFILL 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2088232043 168 VAMIGAIVLTQEIGTEIGPTAKRQDIFAQTSRAQ 201
Cdd:MTH00021  154 VAMIGAIVLTQEPGSEVGPLSKKQDIFFQISRAN 187
 
Name Accession Description Interval E-value
ND6 MTH00021
NADH dehydrogenase subunit 6; Validated
 8-201 4.27e-88

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 214401 [Multi-domain]  Cd Length: 188  Bit Score: 256.96  E-value: 4.27e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   8 ILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPAFrqG 87
Cdd:MTH00021    1 FFSLGIIGSGIMVISALNPVHSIFWLVVVFVNSAVFFILLGLDFLALMFLIIYVGAIAILFLFVIMLLNLTDFPPAF--G 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  88 GEADMTNYVPIGLAVGTLFFEAIASSWLIMGGPYVYRgmlgaWDLANSWFLKKYHNIEAIGRILYTDCYYLFILVSFILL 167
Cdd:MTH00021   79 GEADMTNYIPIGLIIGTLFFSEIASSWLIIGGPYVER-----WDLAFPWFLISYHNIEALGRILYITCYYLFLLASFILL 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2088232043 168 VAMIGAIVLTQEIGTEIGPTAKRQDIFAQTSRAQ 201
Cdd:MTH00021  154 VAMIGAIVLTQEPGSEVGPLSKKQDIFFQISRAN 187
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 6-177 8.86e-35

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 120.61  E-value: 8.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   6 FFILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPafr 85
Cdd:COG0839     5 FYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLLDLDKEEL--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  86 qggEADMTNYVPIGLAVGTLFFEAIAssWLIMGGPYVYRGMLGAWDlanswflkkYHNIEAIGRILYTDCYYLFILVSFI 165
Cdd:COG0839    82 ---REGFRKYRPLAALVGLLLLAELA--YVLLSTSWAAAPAAAAAA---------VGNTKALGELLFTDYLLPFELASVL 147

                         170
                  ....*....|..
gi 2088232043 166 LLVAMIGAIVLT 177
Cdd:COG0839   148 LLVAMIGAIVLA 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-176 8.62e-26

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 96.80  E-value: 8.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  18 IMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPAFRQGGeadmtnYVP 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGL------PLA 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2088232043  98 IGLAVGTLFFEAIASSWLIMGGPYVYRGMLGawdlanswflkkYHNIEAIGRILYTDCYYLFILVSFILLVAMIGAIVL 176
Cdd:pfam00499  75 ALLLGLLLLALLLLVLLSASLTPAAAAAAPD------------VGNIEAIGELLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00021
NADH dehydrogenase subunit 6; Validated
 8-201 4.27e-88

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 214401 [Multi-domain]  Cd Length: 188  Bit Score: 256.96  E-value: 4.27e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   8 ILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPAFrqG 87
Cdd:MTH00021    1 FFSLGIIGSGIMVISALNPVHSIFWLVVVFVNSAVFFILLGLDFLALMFLIIYVGAIAILFLFVIMLLNLTDFPPAF--G 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  88 GEADMTNYVPIGLAVGTLFFEAIASSWLIMGGPYVYRgmlgaWDLANSWFLKKYHNIEAIGRILYTDCYYLFILVSFILL 167
Cdd:MTH00021   79 GEADMTNYIPIGLIIGTLFFSEIASSWLIIGGPYVER-----WDLAFPWFLISYHNIEALGRILYITCYYLFLLASFILL 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2088232043 168 VAMIGAIVLTQEIGTEIGPTAKRQDIFAQTSRAQ 201
Cdd:MTH00021  154 VAMIGAIVLTQEPGSEVGPLSKKQDIFFQISRAN 187
ND6 MTH00057
NADH dehydrogenase subunit 6; Provisional
 6-199 4.99e-68

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177129 [Multi-domain]  Cd Length: 186  Bit Score: 206.01  E-value: 4.99e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   6 FFILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFtpafr 85
Cdd:MTH00057    5 FYLFALGVIISGIMVISALNPVHSVLWLIVAFTSASALFILLEVEFIALIFLIVYVGAIAILFLFVIMMLNLTDL----- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  86 qGGEADMTNYVPIGLAVGTLFFEAIASSWLIMGGPYVYrgmlGAWDLanSWFLKKYHNIEAIGRILYTDCYYLFILVSFI 165
Cdd:MTH00057   80 -EGGGDMSNYLPAGFIIGVVFLFEVSSGISLLSSGTKI----GQWDF--PNWIEKESNIEVLGRVLYTDYYYLFILASFI 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2088232043 166 LLVAMIGAIVLTQEIGTEIgptaKRQDIFAQTSR 199
Cdd:MTH00057  153 LLVAMIGAIVLTHDLIIEI----KRQDIFIQTSR 182
PRK06638 PRK06638
NADH-quinone oxidoreductase subunit J;
6-199 1.59e-37

NADH-quinone oxidoreductase subunit J;


Pssm-ID: 235844 [Multi-domain]  Cd Length: 198  Bit Score: 128.80  E-value: 1.59e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   6 FFILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLtdftpafR 85
Cdd:PRK06638    8 FYILALLAVLAALGVVTSRNPVHSALFLILTFLSIAGLYFLLGAEFLGVVQIIVYVGAVMVLFLFVVMMLDV-------D 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  86 QGGEADMTNYVPIGLAVGTLffeaIASSWLIMGGPYVYRGMLGAWDLANSwflKKYHNIEAIGRILYTDCYYLFILVSFI 165
Cdd:PRK06638   81 FSEREQLREWLPGGVLIGLV----ILLGLLLLLIVGAIIAASGVNAQGIA---AGEGNTKAIGILLFTDYLLPFELASVL 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2088232043 166 LLVAMIGAIVLTQeigtEIGPTAKRQDIFAQTSR 199
Cdd:PRK06638  154 LLVAMVGAIVLAR----RERARVKRQDVPAQLPD 183
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 6-177 8.86e-35

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 120.61  E-value: 8.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   6 FFILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPafr 85
Cdd:COG0839     5 FYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLLDLDKEEL--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  86 qggEADMTNYVPIGLAVGTLFFEAIAssWLIMGGPYVYRGMLGAWDlanswflkkYHNIEAIGRILYTDCYYLFILVSFI 165
Cdd:COG0839    82 ---REGFRKYRPLAALVGLLLLAELA--YVLLSTSWAAAPAAAAAA---------VGNTKALGELLFTDYLLPFELASVL 147

                         170
                  ....*....|..
gi 2088232043 166 LLVAMIGAIVLT 177
Cdd:COG0839   148 LLVAMIGAIVLA 159
ND6 MTH00213
NADH dehydrogenase subunit 6; Provisional
 15-176 2.26e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177256 [Multi-domain]  Cd Length: 239  Bit Score: 101.13  E-value: 2.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  15 ASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPAFRQGGEADMTN 94
Cdd:MTH00213   12 SSAVTPTYSHNFLASVFWLILTFIGSSGLFIVLGMEFLGLIFLIVYVGAICIIFLFVIMMIPGGAKGFKPTKGNKKEKER 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  95 Y---------------VPIGLAVGTLFFEAIASSWL---------------------------------------IMGGP 120
Cdd:MTH00213   92 KkgeetgrigappaigILIGAILAAELASAVPDSFLnnpsgrggaeryeltnilsdrnrgvssllgsdkesittgIQNNI 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043 121 YVYRGMLGAWDLANSWFLKKY----HNIEAIGRILYTDCYYLFILVSFILLVAMIGAIVL 176
Cdd:MTH00213  172 YMRVGATGAPYLYNDSFFTLNgsggTNLEAIGSVLYINYYYAFILVSFILLVAMIGAIVL 231
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-176 8.62e-26

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 96.80  E-value: 8.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  18 IMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPAFRQGGeadmtnYVP 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGL------PLA 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2088232043  98 IGLAVGTLFFEAIASSWLIMGGPYVYRGMLGawdlanswflkkYHNIEAIGRILYTDCYYLFILVSFILLVAMIGAIVL 176
Cdd:pfam00499  75 ALLLGLLLLALLLLVLLSASLTPAAAAAAPD------------VGNIEAIGELLFTDYLLPFELASVLLLVALVGAIVL 141
ndhG CHL00016
NADH dehydrogenase subunit 6
 6-184 1.37e-12

NADH dehydrogenase subunit 6


Pssm-ID: 214335 [Multi-domain]  Cd Length: 182  Bit Score: 63.39  E-value: 1.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   6 FFILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMMLNLTDFTPAFR 85
Cdd:CHL00016   12 LVFLGSGLILGSLGVVLLTNPIYSAFSLGLVLVCISLFYILLNADFVAAAQLLIYVGAINVLIIFAVMFMNGPEYSKDFN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043  86 QGGEADMTnyvpIGLAVGTLFFEAIA----SSWLimGGPYVYR-GMLGAWDLANswflkkyhNIEAIGRILYTDCYYLFI 160
Cdd:CHL00016   92 LWTVGDGI----TSLVCTSLFFSLITtildTSWY--GIIWTTRsNQIIEQDLIS--------NVQQIGIHLSTDFLLPFE 157

                         170       180
                  ....*....|....*....|....*
gi 2088232043 161 LVSFILLVAMIGAIVLT-QEIGTEI 184
Cdd:CHL00016  158 LISIILLVALIGAITVArQEQVEET 182
PRK06433 PRK06433
NADH dehydrogenase subunit J; Provisional
 3-74 3.16e-10

NADH dehydrogenase subunit J; Provisional


Pssm-ID: 180562 [Multi-domain]  Cd Length: 88  Bit Score: 54.61  E-value: 3.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2088232043   3 TMYFFILSFGVVASGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLFVIMM 74
Cdd:PRK06433    5 TIAFALFALVTVAFSLGVVLSRDVWHSALYLGVALFSVAVLYVMLNAEFLAAVQVLVYVGAVLILITFAVML 76
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-70 1.70e-03

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 37.58  E-value: 1.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088232043   1 MITMYFFILSFGvvasGIMVISALNPVHSVFWLVVAFISSAALFILLGVDFIALMFIIIYVGAIAILFLF 70
Cdd:MTH00045    2 VFYLFLILMLFG----STLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVY 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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