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Conserved domains on  [gi|2554491085|ref|YP_010892812|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Melanotaenia fluviatilis]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009582)

NADH dehydrogenase subunit 6 (mitochondrion) is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 6.15e-80

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 177196  Cd Length: 173  Bit Score: 234.65  E-value: 6.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFGLILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  81 GWGSWPVLGMMLIYLLGVGAVAGGFWGGWYEGSWISADELSEVSMFRGDISGIALMYLAGGKLLIMGAWVLLLTLFVVLE 160
Cdd:MTH00138   81 SWGSWSVLGYVVGYLVGVVLAAGLFWGGWYEGSWVVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLE 160

                         170
                  ....*....|...
gi 2554491085 161 LTRGLSRGALRAV 173
Cdd:MTH00138  161 LTRGLSRGALRAV 173
 
Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 6.15e-80

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 234.65  E-value: 6.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFGLILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  81 GWGSWPVLGMMLIYLLGVGAVAGGFWGGWYEGSWISADELSEVSMFRGDISGIALMYLAGGKLLIMGAWVLLLTLFVVLE 160
Cdd:MTH00138   81 SWGSWSVLGYVVGYLVGVVLAAGLFWGGWYEGSWVVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLE 160

                         170
                  ....*....|...
gi 2554491085 161 LTRGLSRGALRAV 173
Cdd:MTH00138  161 LTRGLSRGALRAV 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-118 2.88e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.19  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  18 AVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAAL-AAEPYPEGWGSWPVLGMMLIYLL 96
Cdd:pfam00499   2 GVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLL 81

                          90       100
                  ....*....|....*....|..
gi 2554491085  97 GVGAVAGGFWGGWYEGSWISAD 118
Cdd:pfam00499  82 LLALLLLVLLSASLTPAAAAAA 103
 
Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 6.15e-80

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 234.65  E-value: 6.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFGLILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  81 GWGSWPVLGMMLIYLLGVGAVAGGFWGGWYEGSWISADELSEVSMFRGDISGIALMYLAGGKLLIMGAWVLLLTLFVVLE 160
Cdd:MTH00138   81 SWGSWSVLGYVVGYLVGVVLAAGLFWGGWYEGSWVVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLE 160

                         170
                  ....*....|...
gi 2554491085 161 LTRGLSRGALRAV 173
Cdd:MTH00138  161 LTRGLSRGALRAV 173
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 3.12e-49

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 156.55  E-value: 3.12e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFGLILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  81 GWGSWPVLGMMLIYLLGVGaVAGGFWGGWYEGSWISADELSEVSMFRGDISGIALMYLAGGKLLIMGAWVLLLTLFVVLE 160
Cdd:MTH00065   81 AWGSWSVLVYVLFYLLLLI-VGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLLLTLFVVLE 159

                         170
                  ....*....|...
gi 2554491085 161 LTRGLSRGALRAV 173
Cdd:MTH00065  160 VTRGLSRGSLRAV 172
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 5.45e-36

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 122.93  E-value: 5.45e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFGLILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  81 GWGSWPVLGMMLIYLLGVGAVAGGFWGGW-YEGSWISADELSEVSMFRGDISGIALMYLAGGKLLIMGAWVLLLTLFVVL 159
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWgMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGLLLTLFVVL 160

                         170
                  ....*....|....
gi 2554491085 160 ELTRGLSRGALRAV 173
Cdd:MTH00115  161 ELVRGLSRGALRAF 174
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 1.03e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 106.61  E-value: 1.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFGLILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  81 GWGSWPVLGMMLIYLLGVGAVAGGFWGGWYEGSWISADELSEVSMfrgdiSGIALMYLAGGKLLIMGAWVLLLTLFVVLE 160
Cdd:MTH00214   81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDEANNLDL-----SGVSDLYSRGFFLLLLGGVVLFLVLFVVLE 155

                         170
                  ....*....|...
gi 2554491085 161 LTRGLSRGALRAV 173
Cdd:MTH00214  156 LVRGLSRGALRVV 168
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-149 2.60e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 98.34  E-value: 2.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFglILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00109    4 YIVFILSVLF--VLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2554491085  81 GWGS-WPVLGMMLIYLLGVGAVAGGFWGGWYEGSWISADELS--------EVSMFRGDISGIALMYLAGGKLLIMGAW 149
Cdd:MTH00109   82 TWVSnKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGdwviydtgGSGFFSEDAMGVAALYSYGTWLVVVTGW 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-172 4.20e-13

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 63.39  E-value: 4.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLfgLILGLAAVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAALAAEPYPe 80
Cdd:MTH00045    1 MVFYLFLIL--MLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  81 gwGSWPVLGMMLIYLLGVgavaggFWGGWYEGSWISADELSEVSMFRGDISGIALMYLAGGKLLIMGAWVLLLTLFVVLE 160
Cdd:MTH00045   78 --SVSNLGEVLVLSLLLS------LWVFISFDNFLELSNNNWSLVSLSDLVGSSELYNSGGLYLLLGGFILLVALVVALV 149

                         170
                  ....*....|..
gi 2554491085 161 LTRGLSRGALRA 172
Cdd:MTH00045  150 ISFGHEYSSLRA 161
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-118 2.88e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.19  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085  18 AVASNPSPYFAALGLVVVAGTGFGVLVGHGGSFLSLILFLIYLGGMLVVFAYSAAL-AAEPYPEGWGSWPVLGMMLIYLL 96
Cdd:pfam00499   2 GVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLL 81

                          90       100
                  ....*....|....*....|..
gi 2554491085  97 GVGAVAGGFWGGWYEGSWISAD 118
Cdd:pfam00499  82 LLALLLLVLLSASLTPAAAAAA 103
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-137 3.60e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 39.10  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2554491085   1 MVFFMFSLLFGLILGLAAVASNPSPYFAALGLVVVAGtgfGVLVGH-GGSFLSLILFLIYLGGMLVVFAYSAALAaePYP 79
Cdd:MTH00152    1 MSLMILLSVCFSLFLLLPLSKQPLSLGLVLLLLSLFV---CVEIGLtLSSWYGYLLFLVYVGGLLVMFAYVVSLS--PNP 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2554491085  80 EGWGSWPVLGMMLIYLLGVGAVagGFWGGWYEGSWISADELSEVSMFRGDISGIALMY 137
Cdd:MTH00152   76 LFGSNFKFVFFSLTLFGFLGLF--FFFLYLYSSGGLSLSSLFDGSSGSLSFGGGLYSS 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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