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Conserved domains on  [gi|118572596|ref|NP_000313|]
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peripherin-2 [Homo sapiens]

Protein Classification

peripherin_like_LEL domain-containing protein( domain architecture ID 10123579)

peripherin_like_LEL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 120-262 3.58e-107

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


:

Pssm-ID: 239415  Cd Length: 143  Bit Score: 309.36  E-value: 3.58e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSN 199
Cdd:cd03162    1 FIMRGSLEESLKTGLKNAMKFYKDTDTPGRCFLKKTIDMLQIEFQCCGNNGYRDWFEIQWISNRYLDFSSKEVKDRIKSN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 118572596 200 VDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLM 262
Cdd:cd03162   81 VDGRYLTDGVPFSCCNPSSPRPCIQHQITDNSAHYNYDYQTEELNLWTRGCREALLEYYTSKM 143
Tetraspanin pfam00335
Tetraspanin family;
16-181 1.86e-15

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 73.51  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596   16 LAQGLWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSeSHFVPNSLIGMGVLSCVFnSLAGkiCYDALdpaKYARWk 95
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEA-SAYIPILLIVLGAVIFLV-GFLG--CCGAL---KENRC- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596   96 pWLKPYLAICVLFNIILFLVALCCFLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGN--NGFRD 173
Cdd:pfam00335  73 -LLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCGGckEKLLE 151


                  ....*...
gi 118572596  174 WFEIQWIS 181
Cdd:pfam00335 152 WLRKNLKI 159
 
Name Accession Description Interval E-value
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 120-262 3.58e-107

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 309.36  E-value: 3.58e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSN 199
Cdd:cd03162    1 FIMRGSLEESLKTGLKNAMKFYKDTDTPGRCFLKKTIDMLQIEFQCCGNNGYRDWFEIQWISNRYLDFSSKEVKDRIKSN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 118572596 200 VDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLM 262
Cdd:cd03162   81 VDGRYLTDGVPFSCCNPSSPRPCIQHQITDNSAHYNYDYQTEELNLWTRGCREALLEYYTSKM 143
Tetraspanin pfam00335
Tetraspanin family;
16-181 1.86e-15

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 73.51  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596   16 LAQGLWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSeSHFVPNSLIGMGVLSCVFnSLAGkiCYDALdpaKYARWk 95
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEA-SAYIPILLIVLGAVIFLV-GFLG--CCGAL---KENRC- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596   96 pWLKPYLAICVLFNIILFLVALCCFLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGN--NGFRD 173
Cdd:pfam00335  73 -LLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCGGckEKLLE 151


                  ....*...
gi 118572596  174 WFEIQWIS 181
Cdd:pfam00335 152 WLRKNLKI 159
 
Name Accession Description Interval E-value
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 120-262 3.58e-107

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 309.36  E-value: 3.58e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSN 199
Cdd:cd03162    1 FIMRGSLEESLKTGLKNAMKFYKDTDTPGRCFLKKTIDMLQIEFQCCGNNGYRDWFEIQWISNRYLDFSSKEVKDRIKSN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 118572596 200 VDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLM 262
Cdd:cd03162   81 VDGRYLTDGVPFSCCNPSSPRPCIQHQITDNSAHYNYDYQTEELNLWTRGCREALLEYYTSKM 143
Tetraspanin pfam00335
Tetraspanin family;
16-181 1.86e-15

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 73.51  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596   16 LAQGLWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSeSHFVPNSLIGMGVLSCVFnSLAGkiCYDALdpaKYARWk 95
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEA-SAYIPILLIVLGAVIFLV-GFLG--CCGAL---KENRC- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596   96 pWLKPYLAICVLFNIILFLVALCCFLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGN--NGFRD 173
Cdd:pfam00335  73 -LLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCGGckEKLLE 151


                  ....*...
gi 118572596  174 WFEIQWIS 181
Cdd:pfam00335 152 WLRKNLKI 159
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 126-224 1.98e-13

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 65.83  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 126 LENTLGQGLKNGM-KYYRDTDTPGRcfmKKTIDMLQIEFKCCGNNGFRDWFEIQWISNryldfsskevkdrikSNVDGRY 204
Cdd:cd03155    7 LEDELKESLKRTMqENYGQSGEEAL---TLTVDELQQEFKCCGSNNYTDWQDSEWINS---------------NEANGRL 68

                         90       100
                 ....*....|....*....|
gi 118572596 205 lvdgVPFSCCNPSSPRPCIQ 224
Cdd:cd03155   69 ----VPDSCCKTVVDRCGCL 84
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 120-262 6.44e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 60.98  E-value: 6.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTpgrcfMKKTIDMLQIEFKCCGNNGFRDWfeiqwisnryldfsskevkdriksn 199
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEYYVDDD-----FQEAMDALQSTFECCGVNGPTDY------------------------- 50

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 118572596 200 vdgRYLVDGVPFSCCNPSSPRPCiqyqitnnsahysydhqteeLNLWVRGCRAALLSYYSSLM 262
Cdd:cd03127   51 ---LDLRLLVPSSCCKGTDGNCG--------------------LNLYTEGCLEKLVDFLRSNL 90
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 120-178 1.20e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 54.68  E-value: 1.20e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTPGrcfMKKTIDMLQIEFKCCGNNGFRDWFEIQ 178
Cdd:cd03165    1 FVFREKVDLTAKDDLKEGLELYGTRNNRG---LTNAWDITQTEFRCCGVTNYTDWYEVL 56
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 120-214 4.20e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 51.15  E-value: 4.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMK-YYRDTDTpgrcfmKKTIDMLQIEFKCCGNNGFRDWfeiQWisNRYLDFSSkevkdrikS 198
Cdd:cd03158    1 FIFSNQTIDLLEENIRKAIVhYYDDLDL------QNIIDFVQKEFKCCGGDDYRDW---SK--NMYFNCSS--------P 61

                         90
                 ....*....|....*.
gi 118572596 199 NVdgryLVDGVPFSCC 214
Cdd:cd03158   62 NP----EACGVPYSCC 73
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 120-214 1.65e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 45.93  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTpgrcfMKKTIDMLQIEFKCCGNNGFRDWfeiqwisnRYLDFSSKevkdriksn 199
Cdd:cd03166    1 YVFRDKVMSEFNDSFNQMISNYNKTND-----FRKILDRMQKDLKCCGANNYTDW--------ENIPSLDT--------- 58

                         90
                 ....*....|....*
gi 118572596 200 vdgrylvDGVPFSCC 214
Cdd:cd03166   59 -------DSVPDSCC 66
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 120-217 3.29e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 42.41  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTPGRcfmkkTIDMLQIEFKCCGNNGFRDWFEIQWISNRyldfsskevkdriKSN 199
Cdd:cd03163    2 YVYRAKVEDELNPSIDKVFNKYNGTNAESR-----AVDYLQRQLQCCGIHNYTDWENTPWFKES-------------KNN 63

                         90
                 ....*....|....*...
gi 118572596 200 vdgrylvdGVPFSCCNPS 217
Cdd:cd03163   64 --------SVPLSCCKET 73
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 138-257 6.76e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 41.75  E-value: 6.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 138 MKYYRDTDTPGRCFMKkTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKevkdriksnvdgrylvdgVPFSCCNPS 217
Cdd:cd03156   18 KNNYGNYNSTGDAITS-TWNRVMIELKCCGVNGPTDFVDSTSFFRQKNEPNSP------------------YPESCCKRN 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 118572596 218 SPRPCIQYQITNNSAHYSYDHQteelnlwvrGCRAALLSY 257
Cdd:cd03156   79 SNSQIVDLDCPKLGSPNSYNKK---------GCYEKLSNP 109
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 120-214 2.63e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 37.44  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTdtPGRCFMkktIDMLQIEFKCCGNNGFRDwfeiqWISNRYLDFSSKEVKdriksn 199
Cdd:cd03167    1 VALWGPLQDGLEHTLRLAIAHYQDD--PDLRFL---IDQVQLGLQCCGASSYQD-----WQQNLYFNCSSPGVQ------ 64

                         90
                 ....*....|....*
gi 118572596 200 vdgrylVDGVPFSCC 214
Cdd:cd03167   65 ------ACSLPASCC 73
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 120-174 2.98e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 36.30  E-value: 2.98e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 118572596 120 FLLRGSLENTLGQGLKNGM-KYYRDTDTpgrcfmKKTIDMLQIEFKCCGNNGFRDW 174
Cdd:cd03164    1 FVYEKKLNNYVKEGLTDSLeQYHKDNNT------SEAWDMIQSNLQCCGINGTTDW 50
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 120-215 3.52e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 36.57  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDtpGRcfmKKTIDMLQIEFKCCGNNGFRDWFEIQWisnryldfsskevkdriksn 199
Cdd:cd03161    1 FVFRHEIKGTFLRTYNEAVSNYNGDD--ER---SDAVDTVQRTLHCCGVENYTDWLNSPY-------------------- 55

                         90
                 ....*....|....*.
gi 118572596 200 vdgrYLVDGVPFSCCN 215
Cdd:cd03161   56 ----FLEKGIPLSCCK 67
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 120-217 5.03e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 36.63  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572596 120 FLLRGSLENTLGQGLKNGMKYYRDTDTpgrcfMKKTIDMLQIEFKCCGNNGFRDWFeiqwiSNRYLDFSSkEVKDRIKSn 199
Cdd:cd03159    1 FVFKDWIKDQLTEFLNNNIRAYRDDID-----LQNLIDFLQEYWQCCGARGPDDWN-----LNIYFNCTD-SNPSRERC- 68

                         90
                 ....*....|....*...
gi 118572596 200 vdgrylvdGVPFSCCNPS 217
Cdd:cd03159   69 --------GVPFSCCVKD 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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