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solute carrier family 12 member 1 isoform A [Homo sapiens]
Protein Classification
solute carrier family 12 protein ( domain architecture ID 11489985 )
solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis, or human kidney-specific Na-K-Cl symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation
List of domain hits
Name
Accession
Description
Interval
E-value
2a30
TIGR00930 K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099
0e+00
K-Cl cotransporter; [Transport and binding proteins, Other]
Pssm-ID: 273347 [Multi-domain]
Cd Length: 953
Bit Score: 1506.92
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 104 NT M DAVP K IE Y YRN TGSIS GPK V NRPSL L E I H EQ L A K N V AVTPSS AD RVA NG D G IPGD E Q AE N ---- KE DDQ AG V VKFGW 179
Cdd:TIGR00930 1 NT V DAVP R IE H YRN SEGQG GPK R NRPSL E E L H DL L D K V V SLLGPL AD YTN NG Q G MKEH E E AE D aegt KE KPP AG A VKFGW 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 180 V K GVLV R C M LNIWGV M LF I RLSWIVG E AGIGL GV LIILL STM VT S ITGLS T SAIATNG F V R GGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930 81 V M GVLV P C L LNIWGV I LF L RLSWIVG Q AGIGL SL LIILL CCC VT T ITGLS M SAIATNG V V K GGGAYYLISRSLGPEFGGS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 260 IGLIFAFANAVAVAMYVVGFAETV V DLL K E SD S - M MVDP T NDIRI I G SI TVV I LLGIS V AGMEWE A KAQV IL LVI L L IA I 338
Cdd:TIGR00930 161 IGLIFAFANAVAVAMYVVGFAETV L DLL R E NG S k I MVDP I NDIRI Y G TV TVV V LLGIS F AGMEWE N KAQV LF LVI V L LS I 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 339 A N F F I GT V IP SNN e K KSR GFF NYQAS IF A ENF G P RFTKG EG - FFS V F A IFFP AA TGILAGANISGDL E DPQ D AIP R GT M L 417
Cdd:TIGR00930 241 L N I F V GT I IP AFD - K PAK GFF GLGNE IF S ENF I P GIPGP EG g FFS L F G IFFP SV TGILAGANISGDL K DPQ K AIP K GT L L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 418 AI FI TTV A YLG VAICV GACVVRDATG NM NDT IIS gmn CNG SAAC glgyd FS R C R H EP C Q YGLMNN F QVMS M VS G F G PLIT 497
Cdd:TIGR00930 320 AI LT TTV V YLG SVVLF GACVVRDATG DK NDT LVT --- NCT SAAC ----- FS E C A H NT C S YGLMNN L QVMS L VS P F P PLIT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 498 AGIFSATLSSALASLVSAP KV FQALCKDNIY KA LQFF A KGYGKN N EPLR G Y I LT FL IA MA FILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930 392 AGIFSATLSSALASLVSAP RL FQALCKDNIY PF LQFF G KGYGKN G EPLR A Y L LT AF IA EG FILIAELNTIAPIISNFFLA 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 578 SYALINFSCFHAS YAK SPGWRP AYGI Y NM W V SL F GA V LCCA V MF V I N WWAA VITY VI EF FLY V YVT C KKPDVNWGSSTQA 657
Cdd:TIGR00930 472 SYALINFSCFHAS LLR SPGWRP RFKY Y HW W L SL L GA S LCCA I MF L I S WWAA LVAM VI AL FLY K YVT Y KKPDVNWGSSTQA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 658 LSY VS AL DNA L E L TT VEDHVKN F RPQC I VLTG G P MT RPALLD ITHA FTK NS GL C IC CE V FV GPR KL CVKE MNSGM AK K Q A 737
Cdd:TIGR00930 552 LSY SL AL YSL L R L EE VEDHVKN W RPQC L VLTG P P VC RPALLD FASQ FTK GK GL M IC GS V IQ GPR LE CVKE AQAAE AK I Q T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 738 WL I KNK I KAFYA A V A AD CF R D GVR S L L QASGLGRMKPNTLV I GYKK N WR K A PLTEI E N Y V GIIHDAFD FEIG VV I VR I S Q 817
Cdd:TIGR00930 632 WL E KNK V KAFYA V V V AD DL R E GVR H L I QASGLGRMKPNTLV M GYKK D WR Q A EPRAW E T Y I GIIHDAFD AHLA VV V VR N S E 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 818 G FD IS q VLQVQEELE rleqerlaleatikd N E C E E E S ggirglfkkagklnitkt TPKK DG S I N T SQS MH vgefnqkl V E 897
Cdd:TIGR00930 712 G LP IS - VLQVQEELE --------------- N D C S E D S ------------------ IELN DG K I S T QPD MH -------- L E 749
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 898 ASTQF K KKQ E KGTIDVWWL F DDGGLTLL I PY I LT LR K K WK D CK L RI Y VG G - K IN R I E E EK IV MA S LL S KFRI KFAD I HII 976
Cdd:TIGR00930 750 ASTQF Q KKQ G KGTIDVWWL V DDGGLTLL L PY L LT TK K V WK K CK I RI F VG A q K DD R S E Q EK KD MA T LL Y KFRI DAEV I VVL 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 977 G DIN IR P NK ES WKV FEEMI E P Y RLH ESC KD LTTAE - K LKRET PWKITDAEL EAVKE KSYRQVRLNELL Q E H SR A A N L I VL 1055
Cdd:TIGR00930 830 M DIN AK P QT ES MEA FEEMI R P F RLH KTE KD REAKD p K MTWTK PWKITDAEL QSNVR KSYRQVRLNELL L E Y SR D A A L V VL 909
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 134254459 1056 SLPV A RKGSI S D L LYMAWLE I L TKN LPPVLLVRGNH K NVLTFYS 1099
Cdd:TIGR00930 910 SLPV P RKGSI P D E LYMAWLE V L SED LPPVLLVRGNH R NVLTFYS 953
Name
Accession
Description
Interval
E-value
2a30
TIGR00930 K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099
0e+00
K-Cl cotransporter; [Transport and binding proteins, Other]
Pssm-ID: 273347 [Multi-domain]
Cd Length: 953
Bit Score: 1506.92
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 104 NT M DAVP K IE Y YRN TGSIS GPK V NRPSL L E I H EQ L A K N V AVTPSS AD RVA NG D G IPGD E Q AE N ---- KE DDQ AG V VKFGW 179
Cdd:TIGR00930 1 NT V DAVP R IE H YRN SEGQG GPK R NRPSL E E L H DL L D K V V SLLGPL AD YTN NG Q G MKEH E E AE D aegt KE KPP AG A VKFGW 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 180 V K GVLV R C M LNIWGV M LF I RLSWIVG E AGIGL GV LIILL STM VT S ITGLS T SAIATNG F V R GGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930 81 V M GVLV P C L LNIWGV I LF L RLSWIVG Q AGIGL SL LIILL CCC VT T ITGLS M SAIATNG V V K GGGAYYLISRSLGPEFGGS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 260 IGLIFAFANAVAVAMYVVGFAETV V DLL K E SD S - M MVDP T NDIRI I G SI TVV I LLGIS V AGMEWE A KAQV IL LVI L L IA I 338
Cdd:TIGR00930 161 IGLIFAFANAVAVAMYVVGFAETV L DLL R E NG S k I MVDP I NDIRI Y G TV TVV V LLGIS F AGMEWE N KAQV LF LVI V L LS I 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 339 A N F F I GT V IP SNN e K KSR GFF NYQAS IF A ENF G P RFTKG EG - FFS V F A IFFP AA TGILAGANISGDL E DPQ D AIP R GT M L 417
Cdd:TIGR00930 241 L N I F V GT I IP AFD - K PAK GFF GLGNE IF S ENF I P GIPGP EG g FFS L F G IFFP SV TGILAGANISGDL K DPQ K AIP K GT L L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 418 AI FI TTV A YLG VAICV GACVVRDATG NM NDT IIS gmn CNG SAAC glgyd FS R C R H EP C Q YGLMNN F QVMS M VS G F G PLIT 497
Cdd:TIGR00930 320 AI LT TTV V YLG SVVLF GACVVRDATG DK NDT LVT --- NCT SAAC ----- FS E C A H NT C S YGLMNN L QVMS L VS P F P PLIT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 498 AGIFSATLSSALASLVSAP KV FQALCKDNIY KA LQFF A KGYGKN N EPLR G Y I LT FL IA MA FILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930 392 AGIFSATLSSALASLVSAP RL FQALCKDNIY PF LQFF G KGYGKN G EPLR A Y L LT AF IA EG FILIAELNTIAPIISNFFLA 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 578 SYALINFSCFHAS YAK SPGWRP AYGI Y NM W V SL F GA V LCCA V MF V I N WWAA VITY VI EF FLY V YVT C KKPDVNWGSSTQA 657
Cdd:TIGR00930 472 SYALINFSCFHAS LLR SPGWRP RFKY Y HW W L SL L GA S LCCA I MF L I S WWAA LVAM VI AL FLY K YVT Y KKPDVNWGSSTQA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 658 LSY VS AL DNA L E L TT VEDHVKN F RPQC I VLTG G P MT RPALLD ITHA FTK NS GL C IC CE V FV GPR KL CVKE MNSGM AK K Q A 737
Cdd:TIGR00930 552 LSY SL AL YSL L R L EE VEDHVKN W RPQC L VLTG P P VC RPALLD FASQ FTK GK GL M IC GS V IQ GPR LE CVKE AQAAE AK I Q T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 738 WL I KNK I KAFYA A V A AD CF R D GVR S L L QASGLGRMKPNTLV I GYKK N WR K A PLTEI E N Y V GIIHDAFD FEIG VV I VR I S Q 817
Cdd:TIGR00930 632 WL E KNK V KAFYA V V V AD DL R E GVR H L I QASGLGRMKPNTLV M GYKK D WR Q A EPRAW E T Y I GIIHDAFD AHLA VV V VR N S E 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 818 G FD IS q VLQVQEELE rleqerlaleatikd N E C E E E S ggirglfkkagklnitkt TPKK DG S I N T SQS MH vgefnqkl V E 897
Cdd:TIGR00930 712 G LP IS - VLQVQEELE --------------- N D C S E D S ------------------ IELN DG K I S T QPD MH -------- L E 749
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 898 ASTQF K KKQ E KGTIDVWWL F DDGGLTLL I PY I LT LR K K WK D CK L RI Y VG G - K IN R I E E EK IV MA S LL S KFRI KFAD I HII 976
Cdd:TIGR00930 750 ASTQF Q KKQ G KGTIDVWWL V DDGGLTLL L PY L LT TK K V WK K CK I RI F VG A q K DD R S E Q EK KD MA T LL Y KFRI DAEV I VVL 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 977 G DIN IR P NK ES WKV FEEMI E P Y RLH ESC KD LTTAE - K LKRET PWKITDAEL EAVKE KSYRQVRLNELL Q E H SR A A N L I VL 1055
Cdd:TIGR00930 830 M DIN AK P QT ES MEA FEEMI R P F RLH KTE KD REAKD p K MTWTK PWKITDAEL QSNVR KSYRQVRLNELL L E Y SR D A A L V VL 909
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 134254459 1056 SLPV A RKGSI S D L LYMAWLE I L TKN LPPVLLVRGNH K NVLTFYS 1099
Cdd:TIGR00930 910 SLPV P RKGSI P D E LYMAWLE V L SED LPPVLLVRGNH R NVLTFYS 953
SLC12
pfam03522 Solute carrier family 12;
694-1099
0e+00
Solute carrier family 12;
Pssm-ID: 460955
Cd Length: 414
Bit Score: 596.91
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 694 RPAL L D IT H AF TKN SG L C IC CE V FV G PRKLCVKEMN sg MA K KQA WL I K N KIKAFYA A V AA D CF R D G VRS LLQASGLG RM K 773
Cdd:pfam03522 1 RPAL V D FA H LI TKN VS L M IC GH V VK G RLSQKLRSEL -- QK K AYR WL R K R KIKAFYA L V DG D NL R E G AQA LLQASGLG KL K 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 774 PN T L VI GYK KN WR KAPLT E I E N Y VGI IHDAFD FEIG V V I V R ISQ G F D I S QV LQ V Q EEL E RLEQERLALEATIKDN E CEEE 853
Cdd:pfam03522 79 PN I L LM GYK SD WR TCDKE E L E E Y FNV IHDAFD LQYA V A I L R LPE G L D V S HL LQ D Q DTE E LGLGDETNSSYAEQSS E EQST 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 854 S GGIRGLF K KAGK --------- LNITKTT P KKDG S INTSQSMHVGEF -------- NQKLVEAS TQF K KKQ E KGTIDVWWL 916
Cdd:pfam03522 159 S NSKQDDD K SKLS kkdsnlsls PDKSTKN P SGKD S SKSDKLKKKSPS iilrtasn EKEILNNI TQF Q KKQ K KGTIDVWWL 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 917 F DDGGLTLL I PYIL TL R K KW K DCKLR IYVG G - KINRI EEE KIV MASLLSKFRI KFA D IHI I G DI NIR P N KE SW K V F E E M I 995
Cdd:pfam03522 239 Y DDGGLTLL L PYIL ST R S KW S DCKLR VFAL G n RKDEL EEE QRN MASLLSKFRI DYS D LTV I P DI TKK P K KE TK K F F D E L I 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 996 EP Y RLHE SC K DL ttaeklkr E TPW KITD A ELEA V KEK SY RQ V RL N ELL Q EHS RA ANLIV LS LP VA RKG SI S DL LYMAWLE 1075
Cdd:pfam03522 319 EP F RLHE DD K EE -------- E SAE KITD S ELEA L KEK TN RQ L RL R ELL L EHS SD ANLIV MT LP MP RKG TV S AP LYMAWLE 390
410 420
....*....|....*....|....
gi 134254459 1076 I LTK N LPP V LLVRGN HKN VLTFYS 1099
Cdd:pfam03522 391 T LTK D LPP F LLVRGN QTS VLTFYS 414
PotE
COG0531 Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
190-649
2.36e-37
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
Pssm-ID: 440297 [Multi-domain]
Cd Length: 438
Bit Score: 146.58
E-value: 2.36e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 190 N I W G VML F IRLSWIV G E AG i GLGV L II L LSTMVTSITG LS TSAI A TN g F V R G GGAY YLIS R S LGP EF G GSI G LIFAFANA 269
Cdd:COG0531 25 A I I G AGI F VLPGLAA G L AG - PAAI L AW L IAGLLALLVA LS YAEL A SA - F P R A GGAY TYAR R A LGP LL G FLA G WALLLSYV 102
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 270 V AVA MYV V G F AETVVD L L kesdsmmvd P TNDIRI I GSITVVI L LGISVA G MEWE AK AQV IL L V IL L IAIAN F FIG tvips 349
Cdd:COG0531 103 L AVA AVA V A F GGYLSS L F --------- P AGGSVL I ALVLILL L TLLNLR G VKES AK VNN IL T V LK L LVLLL F IVV ----- 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 350 nnekksr G F F NYQASI F A e N F G P RFTKGE G FFSVF A IF F P A A TG IL A G AN ISGDLED P QDA IPR GTM L AIF I TT V A Y LG V 429
Cdd:COG0531 169 ------- G L F AFDPAN F T - P F L P AGGGLS G VLAAL A LA F F A F TG FE A I AN LAEEAKN P KRN IPR AII L SLL I VG V L Y IL V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 430 AICVGAC V VR D ATGNMNDTI isgmncngsaacglgydfsrcrhepcqyglmnn FQVMSM V S G -- FGP LI TA G IFSAT L SS 507
Cdd:COG0531 241 SLALTGV V PY D ELAASGAPL --------------------------------- ADAAEA V F G pw GAI LI AL G ALLSL L GA 287
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 508 AL AS LVS A PKVFQ A LCK D NI yk ALQF FAK GYGKNNE P LRGYI LT FL IA MAFI L I -- A ELNTI A PII S NFF L AS Y A L INFS 585
Cdd:COG0531 288 LN AS ILG A SRLLY A MAR D GL -- LPKV FAK VHPRFGT P VNAIL LT GV IA LLLL L L ga A SFTAL A SLA S VGV L LA Y L L VALA 365
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134254459 586 CFHASY a KS P GWRPAYGIYNMWVSLF G AV LC CAVMFVINWW A --- AVITYV I EFF LY VYVTCKK P DV 649
Cdd:COG0531 366 VIVLRR - RR P DLPRPFRVPLPLIPIL G IL LC LFLLYLLGPG A lli GLVLLA I GLL LY LLYRRRH P KL 431
Name
Accession
Description
Interval
E-value
2a30
TIGR00930 K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099
0e+00
K-Cl cotransporter; [Transport and binding proteins, Other]
Pssm-ID: 273347 [Multi-domain]
Cd Length: 953
Bit Score: 1506.92
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 104 NT M DAVP K IE Y YRN TGSIS GPK V NRPSL L E I H EQ L A K N V AVTPSS AD RVA NG D G IPGD E Q AE N ---- KE DDQ AG V VKFGW 179
Cdd:TIGR00930 1 NT V DAVP R IE H YRN SEGQG GPK R NRPSL E E L H DL L D K V V SLLGPL AD YTN NG Q G MKEH E E AE D aegt KE KPP AG A VKFGW 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 180 V K GVLV R C M LNIWGV M LF I RLSWIVG E AGIGL GV LIILL STM VT S ITGLS T SAIATNG F V R GGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930 81 V M GVLV P C L LNIWGV I LF L RLSWIVG Q AGIGL SL LIILL CCC VT T ITGLS M SAIATNG V V K GGGAYYLISRSLGPEFGGS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 260 IGLIFAFANAVAVAMYVVGFAETV V DLL K E SD S - M MVDP T NDIRI I G SI TVV I LLGIS V AGMEWE A KAQV IL LVI L L IA I 338
Cdd:TIGR00930 161 IGLIFAFANAVAVAMYVVGFAETV L DLL R E NG S k I MVDP I NDIRI Y G TV TVV V LLGIS F AGMEWE N KAQV LF LVI V L LS I 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 339 A N F F I GT V IP SNN e K KSR GFF NYQAS IF A ENF G P RFTKG EG - FFS V F A IFFP AA TGILAGANISGDL E DPQ D AIP R GT M L 417
Cdd:TIGR00930 241 L N I F V GT I IP AFD - K PAK GFF GLGNE IF S ENF I P GIPGP EG g FFS L F G IFFP SV TGILAGANISGDL K DPQ K AIP K GT L L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 418 AI FI TTV A YLG VAICV GACVVRDATG NM NDT IIS gmn CNG SAAC glgyd FS R C R H EP C Q YGLMNN F QVMS M VS G F G PLIT 497
Cdd:TIGR00930 320 AI LT TTV V YLG SVVLF GACVVRDATG DK NDT LVT --- NCT SAAC ----- FS E C A H NT C S YGLMNN L QVMS L VS P F P PLIT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 498 AGIFSATLSSALASLVSAP KV FQALCKDNIY KA LQFF A KGYGKN N EPLR G Y I LT FL IA MA FILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930 392 AGIFSATLSSALASLVSAP RL FQALCKDNIY PF LQFF G KGYGKN G EPLR A Y L LT AF IA EG FILIAELNTIAPIISNFFLA 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 578 SYALINFSCFHAS YAK SPGWRP AYGI Y NM W V SL F GA V LCCA V MF V I N WWAA VITY VI EF FLY V YVT C KKPDVNWGSSTQA 657
Cdd:TIGR00930 472 SYALINFSCFHAS LLR SPGWRP RFKY Y HW W L SL L GA S LCCA I MF L I S WWAA LVAM VI AL FLY K YVT Y KKPDVNWGSSTQA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 658 LSY VS AL DNA L E L TT VEDHVKN F RPQC I VLTG G P MT RPALLD ITHA FTK NS GL C IC CE V FV GPR KL CVKE MNSGM AK K Q A 737
Cdd:TIGR00930 552 LSY SL AL YSL L R L EE VEDHVKN W RPQC L VLTG P P VC RPALLD FASQ FTK GK GL M IC GS V IQ GPR LE CVKE AQAAE AK I Q T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 738 WL I KNK I KAFYA A V A AD CF R D GVR S L L QASGLGRMKPNTLV I GYKK N WR K A PLTEI E N Y V GIIHDAFD FEIG VV I VR I S Q 817
Cdd:TIGR00930 632 WL E KNK V KAFYA V V V AD DL R E GVR H L I QASGLGRMKPNTLV M GYKK D WR Q A EPRAW E T Y I GIIHDAFD AHLA VV V VR N S E 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 818 G FD IS q VLQVQEELE rleqerlaleatikd N E C E E E S ggirglfkkagklnitkt TPKK DG S I N T SQS MH vgefnqkl V E 897
Cdd:TIGR00930 712 G LP IS - VLQVQEELE --------------- N D C S E D S ------------------ IELN DG K I S T QPD MH -------- L E 749
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 898 ASTQF K KKQ E KGTIDVWWL F DDGGLTLL I PY I LT LR K K WK D CK L RI Y VG G - K IN R I E E EK IV MA S LL S KFRI KFAD I HII 976
Cdd:TIGR00930 750 ASTQF Q KKQ G KGTIDVWWL V DDGGLTLL L PY L LT TK K V WK K CK I RI F VG A q K DD R S E Q EK KD MA T LL Y KFRI DAEV I VVL 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 977 G DIN IR P NK ES WKV FEEMI E P Y RLH ESC KD LTTAE - K LKRET PWKITDAEL EAVKE KSYRQVRLNELL Q E H SR A A N L I VL 1055
Cdd:TIGR00930 830 M DIN AK P QT ES MEA FEEMI R P F RLH KTE KD REAKD p K MTWTK PWKITDAEL QSNVR KSYRQVRLNELL L E Y SR D A A L V VL 909
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 134254459 1056 SLPV A RKGSI S D L LYMAWLE I L TKN LPPVLLVRGNH K NVLTFYS 1099
Cdd:TIGR00930 910 SLPV P RKGSI P D E LYMAWLE V L SED LPPVLLVRGNH R NVLTFYS 953
SLC12
pfam03522 Solute carrier family 12;
694-1099
0e+00
Solute carrier family 12;
Pssm-ID: 460955
Cd Length: 414
Bit Score: 596.91
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 694 RPAL L D IT H AF TKN SG L C IC CE V FV G PRKLCVKEMN sg MA K KQA WL I K N KIKAFYA A V AA D CF R D G VRS LLQASGLG RM K 773
Cdd:pfam03522 1 RPAL V D FA H LI TKN VS L M IC GH V VK G RLSQKLRSEL -- QK K AYR WL R K R KIKAFYA L V DG D NL R E G AQA LLQASGLG KL K 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 774 PN T L VI GYK KN WR KAPLT E I E N Y VGI IHDAFD FEIG V V I V R ISQ G F D I S QV LQ V Q EEL E RLEQERLALEATIKDN E CEEE 853
Cdd:pfam03522 79 PN I L LM GYK SD WR TCDKE E L E E Y FNV IHDAFD LQYA V A I L R LPE G L D V S HL LQ D Q DTE E LGLGDETNSSYAEQSS E EQST 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 854 S GGIRGLF K KAGK --------- LNITKTT P KKDG S INTSQSMHVGEF -------- NQKLVEAS TQF K KKQ E KGTIDVWWL 916
Cdd:pfam03522 159 S NSKQDDD K SKLS kkdsnlsls PDKSTKN P SGKD S SKSDKLKKKSPS iilrtasn EKEILNNI TQF Q KKQ K KGTIDVWWL 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 917 F DDGGLTLL I PYIL TL R K KW K DCKLR IYVG G - KINRI EEE KIV MASLLSKFRI KFA D IHI I G DI NIR P N KE SW K V F E E M I 995
Cdd:pfam03522 239 Y DDGGLTLL L PYIL ST R S KW S DCKLR VFAL G n RKDEL EEE QRN MASLLSKFRI DYS D LTV I P DI TKK P K KE TK K F F D E L I 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 996 EP Y RLHE SC K DL ttaeklkr E TPW KITD A ELEA V KEK SY RQ V RL N ELL Q EHS RA ANLIV LS LP VA RKG SI S DL LYMAWLE 1075
Cdd:pfam03522 319 EP F RLHE DD K EE -------- E SAE KITD S ELEA L KEK TN RQ L RL R ELL L EHS SD ANLIV MT LP MP RKG TV S AP LYMAWLE 390
410 420
....*....|....*....|....
gi 134254459 1076 I LTK N LPP V LLVRGN HKN VLTFYS 1099
Cdd:pfam03522 391 T LTK D LPP F LLVRGN QTS VLTFYS 414
AA_permease
pfam00324 Amino acid permease;
182-685
2.59e-126
Amino acid permease;
Pssm-ID: 366028 [Multi-domain]
Cd Length: 467
Bit Score: 393.99
E-value: 2.59e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 182 G V LVRCMLNIW G VM LF IRLSWIV G E AG IGLGV L II L L S TM V TSITG LS TSA I A TNG F V r G GG A Y YLI SR S LGP EF G GSI G 261
Cdd:pfam00324 1 H V QMIALGGVI G TG LF VGSGSVL G Q AG PAGAL L GY L I S GV V IFLVM LS LGE I S TNG P V - S GG F Y TYA SR F LGP SL G FAT G 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 262 L ------ I FAF A NAVAV A MYVVG F A E T V V D LLKES dsmmvdptndir II G SITV V I L LG I SVA G ME W EAK A QVILLV I LL 335
Cdd:pfam00324 80 W nywlsw I TVL A LELTA A SILIQ F W E L V P D IPYLW ------------ VW G AVFL V L L TI I NLV G VK W YGE A EFWFAL I KI 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 336 IAI AN F F I GTV I PSNNEKKSR G -- F FNYQASIFAE NF G P R F T KG eg F F SVF A I F F P A A TGI LAGANIS G DLED P QDA IP R 413
Cdd:pfam00324 148 IAI IG F I I VGI I LLSGGNPND G ai F RYLGDNGGKN NF P P G F G KG -- F I SVF V I A F F A F TGI ELVGIAA G EVKN P EKS IP K 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 414 GTMLA I FIT T VA Y LGVAICV G AC V VRDAT G NM ND TIIS gmncngsaacglgydfsrcrhepcq YGLMNN F QVMSMV SG FG 493
Cdd:pfam00324 226 AILQV I WRI T IF Y ILSLLAI G LL V PWNDP G LL ND SASA ------------------------- ASPFVI F FKFLGI SG LA 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 494 PLI T A G I FS A T LS S A LA SL V S APKVFQA L CK D NIYK alq F F A K GYG K NNE PLR GYILTFL I AMAFI L I A E LN TI ap I IS N 573
Cdd:pfam00324 281 PLI N A V I LT A A LS A A NS SL Y S GSRMLYS L AR D GLAP --- K F L K KVD K RGV PLR AILVSMV I SLLAL L L A S LN PA -- I VF N 355
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 574 F F LA SYA L INFSCFHASYAKSPGW R P A YGIYNMWVSLFGAVLCCAVMF VI NWW AA V I TYV I EF FLY VYVTCKKPDV NWG S 653
Cdd:pfam00324 356 F L LA ISG L SGLIVWGLISLSHLRF R K A FKYQGRSIDELPFKAPLGPLG VI LGL AA I I IIL I IQ FLY AFLPVPGGPK NWG A 435
490 500 510
....*....|....*....|....*....|..
gi 134254459 654 STQ A LS Y VSA L DNALE L TT V ED HVKN FR PQ CI 685
Cdd:pfam00324 436 GSF A AA Y LIV L LFLII L IG V KL HVKN WK PQ LL 467
PotE
COG0531 Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
190-649
2.36e-37
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
Pssm-ID: 440297 [Multi-domain]
Cd Length: 438
Bit Score: 146.58
E-value: 2.36e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 190 N I W G VML F IRLSWIV G E AG i GLGV L II L LSTMVTSITG LS TSAI A TN g F V R G GGAY YLIS R S LGP EF G GSI G LIFAFANA 269
Cdd:COG0531 25 A I I G AGI F VLPGLAA G L AG - PAAI L AW L IAGLLALLVA LS YAEL A SA - F P R A GGAY TYAR R A LGP LL G FLA G WALLLSYV 102
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 270 V AVA MYV V G F AETVVD L L kesdsmmvd P TNDIRI I GSITVVI L LGISVA G MEWE AK AQV IL L V IL L IAIAN F FIG tvips 349
Cdd:COG0531 103 L AVA AVA V A F GGYLSS L F --------- P AGGSVL I ALVLILL L TLLNLR G VKES AK VNN IL T V LK L LVLLL F IVV ----- 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 350 nnekksr G F F NYQASI F A e N F G P RFTKGE G FFSVF A IF F P A A TG IL A G AN ISGDLED P QDA IPR GTM L AIF I TT V A Y LG V 429
Cdd:COG0531 169 ------- G L F AFDPAN F T - P F L P AGGGLS G VLAAL A LA F F A F TG FE A I AN LAEEAKN P KRN IPR AII L SLL I VG V L Y IL V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 430 AICVGAC V VR D ATGNMNDTI isgmncngsaacglgydfsrcrhepcqyglmnn FQVMSM V S G -- FGP LI TA G IFSAT L SS 507
Cdd:COG0531 241 SLALTGV V PY D ELAASGAPL --------------------------------- ADAAEA V F G pw GAI LI AL G ALLSL L GA 287
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 508 AL AS LVS A PKVFQ A LCK D NI yk ALQF FAK GYGKNNE P LRGYI LT FL IA MAFI L I -- A ELNTI A PII S NFF L AS Y A L INFS 585
Cdd:COG0531 288 LN AS ILG A SRLLY A MAR D GL -- LPKV FAK VHPRFGT P VNAIL LT GV IA LLLL L L ga A SFTAL A SLA S VGV L LA Y L L VALA 365
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134254459 586 CFHASY a KS P GWRPAYGIYNMWVSLF G AV LC CAVMFVINWW A --- AVITYV I EFF LY VYVTCKK P DV 649
Cdd:COG0531 366 VIVLRR - RR P DLPRPFRVPLPLIPIL G IL LC LFLLYLLGPG A lli GLVLLA I GLL LY LLYRRRH P KL 431
AA_permease_N
pfam08403 Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
90-157
1.37e-36
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.
Pssm-ID: 429977
Cd Length: 70
Bit Score: 132.18
E-value: 1.37e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 90 D S H TN TYYLQTFGHNT M DAVP K I EY YRNTGS I SG P K VN RPSL L E I H E QL A KN V -- AV TPS S A D R V A NGDG 157
Cdd:pfam08403 1 D T H GS TYYLQTFGHNT L DAVP R I DF YRNTGS V SG V K KS RPSL A E L H S QL K KN S al AV AEG S V D G V E NGDG 70
AA_permease_2
pfam13520 Amino acid permease;
207-643
1.14e-15
Amino acid permease;
Pssm-ID: 404414 [Multi-domain]
Cd Length: 427
Bit Score: 80.82
E-value: 1.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 207 A G IGLGVLIILLSTMVT S ITGLSTS A IATNGFV R G GG A Y YLISRSL G PEFGGSI G LIFA FA NAVAV A MYVVGF A ETVVDL 286
Cdd:pfam13520 27 S G GPALIVWGWIAAIIF S LAVGLVY A ELSSALP R S GG I Y VYLENAF G KFVAFLA G WSNW FA YVLGL A SSASVA A SYLLSA 106
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 287 L KES dsm M V DP T NDIRI I GSITVV I LLG I SVA G MEWE AK A Q V IL LVIL L IAIANFF I GTVIP snne KKSR G F FN Y q A S IF 366
Cdd:pfam13520 107 L GPD --- L V PT T WLTYG I AIAILI I FAI I NIR G VRES AK I Q N IL GILK L LLPLILI I ILGLV ---- TADG G G FN L - L S GE 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 367 AEN F G P RFTK G eg F F SV F AIFFPAA TG ILAG AN I S G dl E DPQDAI P RGTMLAIF I TT V A Y LG V A I CVGAC V VR D ATGNMN 446
Cdd:pfam13520 179 WHT F F P DGWP G -- V F AG F LGVLWSF TG FESA AN V S E -- E VKKRNV P KAIFIGVI I VG V L Y IL V N I AFFGV V PD D EIALSS 254
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 447 DTIISG mncngsaacglgydfsrcrhepcqy G L MNNFQVMSMVSGF gpl ITAGIFSAT L SSALASL V S A PKVFQ AL CK D N 526
Cdd:pfam13520 255 GLGQVA ------------------------- A L LFQAVGGKWGAII --- VVILLALSL L GAVNTAI V G A SRLLY AL AR D G 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134254459 527 IYKALQ FFAK g YG K NNE P L R GY ILT FLIAMAFI L I ----- A EL N TIAPIISNFF L A SY A L INFSCFHASYAKSPGW R pay 601
Cdd:pfam13520 307 VLPFSR FFAK - VN K FGS P I R AI ILT AILSLILL L L fllsp A AY N ALLSLSAYGY L L SY L L PIIGLLILRKKRPDLG R --- 382
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 134254459 602 g I YNM W VSLFGAV L CCAVMF V INWWAA V ITYVIEFFL Y VYVT 643
Cdd:pfam13520 383 - I PGR W PVAIFGI L FSLFLI V ALFFPP V GPATGSSLN Y AIIL 423
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
