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Conserved domains on  [gi|1327848674|ref|NP_000369|]
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Wilms tumor protein isoform A [Homo sapiens]

Protein Classification

WT1 and COG5048 domain-containing protein( domain architecture ID 12031809)

WT1 and COG5048 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WT1 pfam02165
Wilm's tumour protein;
74-377 3.58e-168

Wilm's tumour protein;


:

Pssm-ID: 460471  Cd Length: 289  Bit Score: 476.29  E-value: 3.58e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674  74 MGSDVRDLNALLPAVP---SLGGGGGCALPVSGAAQWAPVLDFAPpgASAYGSLGGPapppapppppppppHSFIKQEPS 150
Cdd:pfam02165   1 MGSDVRDLNLLLPAVPvssLPGGGGSCGLPVSGAPQWAPVLDFHP--GSPYSSLPSH--------------HSFIKQEPS 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 151 WGGAEPHEE-QC-LSAFTVHFSGQFTGTaGACRYGPFGPPPPSQAssgqaRMFPNAPYLPSCLESQPAIRNQGYSTVTFD 228
Cdd:pfam02165  65 WGTADPHEDpHCgLGAFTVHFSGQFTGT-GACRYGAFGEPPSSQP-----RMFPNGPYLPSCMDSQPPPRNQGYGAVAFD 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 229 GTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLEC 308
Cdd:pfam02165 139 GNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNLYQMASQLEC 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1327848674 309 MTWNQMN-LGATLKGHSTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSaSETSEKR 377
Cdd:pfam02165 219 VTWNQMNsLASTIKSHATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRVPGITPPIVKS-SEASEKR 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
437-495 2.33e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1327848674 437 KPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNM 495
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-459 1.93e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 374 SEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCqRKFSRSDH 453
Cdd:COG5048   382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                  ....*.
gi 1327848674 454 LKTHTR 459
Cdd:COG5048   461 LSNHGK 466
 
Name Accession Description Interval E-value
WT1 pfam02165
Wilm's tumour protein;
74-377 3.58e-168

Wilm's tumour protein;


Pssm-ID: 460471  Cd Length: 289  Bit Score: 476.29  E-value: 3.58e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674  74 MGSDVRDLNALLPAVP---SLGGGGGCALPVSGAAQWAPVLDFAPpgASAYGSLGGPapppapppppppppHSFIKQEPS 150
Cdd:pfam02165   1 MGSDVRDLNLLLPAVPvssLPGGGGSCGLPVSGAPQWAPVLDFHP--GSPYSSLPSH--------------HSFIKQEPS 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 151 WGGAEPHEE-QC-LSAFTVHFSGQFTGTaGACRYGPFGPPPPSQAssgqaRMFPNAPYLPSCLESQPAIRNQGYSTVTFD 228
Cdd:pfam02165  65 WGTADPHEDpHCgLGAFTVHFSGQFTGT-GACRYGAFGEPPSSQP-----RMFPNGPYLPSCMDSQPPPRNQGYGAVAFD 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 229 GTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLEC 308
Cdd:pfam02165 139 GNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNLYQMASQLEC 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1327848674 309 MTWNQMN-LGATLKGHSTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSaSETSEKR 377
Cdd:pfam02165 219 VTWNQMNsLASTIKSHATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRVPGITPPIVKS-SEASEKR 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-494 1.30e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 185 FGPPPPSQASSGQARMFPNAPYLPSCLesqpaIRNQGYSTVTFDGTPSYGHTPSHHaaQFPNHSFKHEDPMGQQGSLGEq 264
Cdd:COG5048   119 DNNLLSSHSLPPSSRDPQLPDLLSISN-----LRNNPLPGNNSSSVNTPQSNSLHP--PLPANSLSKDPSSNLSLLISS- 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 265 qySVPPPVYgchTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLG-ATLKGHSTGYESDNHTTPILCgaqyr 343
Cdd:COG5048   191 --NVSTSIP---SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsLLSQSPSSLSSSDSSSSASES----- 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 344 ihthgvFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYpgCNKRYFKLSHLQMHSRK--HTGE--KPYQCDFKDCERR 419
Cdd:COG5048   261 ------PRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQ--CNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKL 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 420 FSRSDQLKRHQRRHTGVKPFQCKT-------------------------------------CQRKFSRSDHLKTHTRTHT 462
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHL 412

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1327848674 463 GEKPFSCRWPSCQKKFARSDELVRHHNMHQRN 494
Cdd:COG5048   413 SFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
437-495 2.33e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1327848674 437 KPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNM 495
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-459 1.93e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 374 SEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCqRKFSRSDH 453
Cdd:COG5048   382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                  ....*.
gi 1327848674 454 LKTHTR 459
Cdd:COG5048   461 LSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-450 2.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.48e-05
                          10        20
                  ....*....|....*....|....*
gi 1327848674 426 LKRHQRRHTGVKPFQCKTCQRKFSR 450
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-422 1.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.12e-04
                          10        20
                  ....*....|....*....|....*...
gi 1327848674 395 HLQMHSRKHTGEKPYQCDFkdCERRFSR 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 416-457 2.27e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1327848674 416 CERRFSRSDQLKRHQR-RHtgvkpFQCKTCQRKFSRSDHLKTH 457
Cdd:cd20908     7 CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
WT1 pfam02165
Wilm's tumour protein;
74-377 3.58e-168

Wilm's tumour protein;


Pssm-ID: 460471  Cd Length: 289  Bit Score: 476.29  E-value: 3.58e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674  74 MGSDVRDLNALLPAVP---SLGGGGGCALPVSGAAQWAPVLDFAPpgASAYGSLGGPapppapppppppppHSFIKQEPS 150
Cdd:pfam02165   1 MGSDVRDLNLLLPAVPvssLPGGGGSCGLPVSGAPQWAPVLDFHP--GSPYSSLPSH--------------HSFIKQEPS 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 151 WGGAEPHEE-QC-LSAFTVHFSGQFTGTaGACRYGPFGPPPPSQAssgqaRMFPNAPYLPSCLESQPAIRNQGYSTVTFD 228
Cdd:pfam02165  65 WGTADPHEDpHCgLGAFTVHFSGQFTGT-GACRYGAFGEPPSSQP-----RMFPNGPYLPSCMDSQPPPRNQGYGAVAFD 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 229 GTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLEC 308
Cdd:pfam02165 139 GNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNLYQMASQLEC 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1327848674 309 MTWNQMN-LGATLKGHSTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSaSETSEKR 377
Cdd:pfam02165 219 VTWNQMNsLASTIKSHATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRVPGITPPIVKS-SEASEKR 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-494 1.30e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 185 FGPPPPSQASSGQARMFPNAPYLPSCLesqpaIRNQGYSTVTFDGTPSYGHTPSHHaaQFPNHSFKHEDPMGQQGSLGEq 264
Cdd:COG5048   119 DNNLLSSHSLPPSSRDPQLPDLLSISN-----LRNNPLPGNNSSSVNTPQSNSLHP--PLPANSLSKDPSSNLSLLISS- 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 265 qySVPPPVYgchTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLG-ATLKGHSTGYESDNHTTPILCgaqyr 343
Cdd:COG5048   191 --NVSTSIP---SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsLLSQSPSSLSSSDSSSSASES----- 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 344 ihthgvFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYpgCNKRYFKLSHLQMHSRK--HTGE--KPYQCDFKDCERR 419
Cdd:COG5048   261 ------PRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQ--CNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKL 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 420 FSRSDQLKRHQRRHTGVKPFQCKT-------------------------------------CQRKFSRSDHLKTHTRTHT 462
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHL 412

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1327848674 463 GEKPFSCRWPSCQKKFARSDELVRHHNMHQRN 494
Cdd:COG5048   413 SFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
437-495 2.33e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1327848674 437 KPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNM 495
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-494 2.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 369 SASETSEKRPFMCayPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKT--CQR 446
Cdd:COG5048    24 LKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLS 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1327848674 447 KFSRSDHLKTHTRTHT--GEKPFSCRWPSCQKKFARSDELVRHHNMHQRN 494
Cdd:COG5048   102 NSKASSSSLSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPL 151
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-494 8.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 246 NHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGHST 325
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVST 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 326 GYesDNHTTPILCGAQYRIHTHGVFR------GIQDVRRVPGVAPTLVRSASETSEKRPFMCAYP-------GCNKRYFK 392
Cdd:COG5048   195 SI--PSSSENSPLSSSYSIPSSSSDQnlenssSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAsesprssLPTASSQS 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 393 LSHLQMHSRKHTG-EKPYQCdfKDCERRFSRSDQLKRHQR--RHTG--VKPFQC--KTCQRKFSRSDHLKTHTRTHTGEK 465
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         250       260
                  ....*....|....*....|....*....
gi 1327848674 466 PFSCRWPSCQKKFARSDELVRHHNMHQRN 494
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQQYK 379
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-459 1.93e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 374 SEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCqRKFSRSDH 453
Cdd:COG5048   382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                  ....*.
gi 1327848674 454 LKTHTR 459
Cdd:COG5048   461 LSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-450 2.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.48e-05
                          10        20
                  ....*....|....*....|....*
gi 1327848674 426 LKRHQRRHTGVKPFQCKTCQRKFSR 450
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-422 1.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.12e-04
                          10        20
                  ....*....|....*....|....*...
gi 1327848674 395 HLQMHSRKHTGEKPYQCDFkdCERRFSR 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 439-461 1.78e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|...
gi 1327848674 439 FQCKTCQRKFSRSDHLKTHTRTH 461
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 373-462 3.92e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848674 373 TSEKRPFMCAYPGCNKRYFKLSHLQMHsRKHTGEKPYQCDFKDCErrfsrsdqlkRHQRRHTGVKPFQCKTCQRKFSRSD 452
Cdd:COG5189   344 VKDGKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE----------KMNIFSAKDKPYRCEVCDKRYKNLN 412

                          90
                  ....*....|
gi 1327848674 453 HLKTHtRTHT 462
Cdd:COG5189   413 GLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 409-433 1.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|....*
gi 1327848674 409 YQCdfKDCERRFSRSDQLKRHQRRH 433
Cdd:pfam00096   1 YKC--PDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 416-457 2.27e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1327848674 416 CERRFSRSDQLKRHQR-RHtgvkpFQCKTCQRKFSRSDHLKTH 457
Cdd:cd20908     7 CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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